Pyrazolesulfonamide derivative, and herbicide containing it

ABSTRACT

Disclosed are a pyrazolesulfonamide derivative represented by Formula (I): ##STR1## wherein B, D, Q, E, W and G have the same meaning as defined in the specification, 
     a process for its production and a herbicide containing it.

BACKGROUND OF THE INVENTION

This invention relates to a novel pyrazolesulfonamide derivative compound, a process for preparing the compound and a herbicide containing the compounds as an active component.

In order to protect important crops such as rice plants, wheat, cotton, sugar beets, corn and soybean from damages by weeds to achieve an increased yield, it is indispensable to use a herbicide. In recent years in particular, a herbicide having selectivity (or discriminativity) is sought after as it can kill only weeds selectively without damages to crops even when a foliage treatment is applied simultaneously on crops and weeds in a cultivated land wherein useful crops and weeds are grown together. Also, from viewpoints of the prevention of environmental pollution, the transportation, and the economical cost reduction in application of chemicals, studies and researches have been made over many years on such compounds that may achieve a higher herbicidal activity with use of chemicals in a lower amount. Some of the compounds having such a property are presently used as the herbicide having selectivity. Still, however, there are further demands for new compounds having such a property.

SUMMARY OF THE INVENTION

The present inventors have made researches over many years to develop herbicides having the selectivity on important crops, and have examined herbicidal properties of a number of compounds to create compounds having a higher herbicidal effect and the selectivity. As a result, it was found that a pyrazolesulfonamide derivative represented by Formula (I) (hereinafter referred to as "the compound of this invention"): ##STR2## wherein Q represents a group of; ##STR3## wherein R¹, R³, R⁹ and R¹⁰ each represent a hydrogen atom, a halogen atom, a C₁ -C₈ alkyl group, a cyano group or a group of CO₂ R¹³ ;

R² and R₄ each represent a hydrogen atom, a halogen atom, a nitro group, a C₁ -C₈ alkyl group, a halogenated C₁ -C₈ alkyl group or a C₁ -C₈ alkoxy group;

R⁵ represents a hydrogen atom, a halogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkoxy group or a group of S(O)_(n) R¹² ;

R⁶ represents a hydrogen atom, a halogen atom, a nitro group, a C₁ -C₈ alkyl group, a halogenated C₁ -C₈ alkyl group, a C₁ -C₈ alkoxy group or a group of CO₂ R¹³ ;

R⁷ represents a hydrogen atom, a halogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkoxy group or a dialkylamino group;

R⁸ represents a hydrogen atom, a halogen atom, a C₁ -C₈ alkyl group or a nitro group;

R¹¹ represents a hydrogen atom, a halogen atom, a C₁ -C₈ alkyl group or a halogenated C₁ -C₈ alkyl group;

W¹ represents an oxygen atom, a sulfur atom or a group of NR¹³ ;

R¹² represents a C₁ -C₈ alkyl group;

R¹³ represents a hydrogen atom or a C₁ -C₈ alkyl group; and

n represents an integer of 0, 1 or 2;

B and D each independently represent a hydrogen atom, a halogen atom, a nitro group, a C₁ -C₈ alkyl group, a C₁ -C₈ alkenyl group, a C₁ -C₈ alkynyl group, a C₁ -C₈ alkoxy group, a C₁ -C₈ alkoxy-C₁ -C₈ alkyl group, a C₁ -C₈ alkylthio-C₁ -C₈ alkyl group, a halogenated C₁ -C₈ alkyl group, a group of COOR¹⁴, a group of CH₂ COOR¹⁴, a group of CONR¹⁵ R¹⁶, a group of S(O)_(n) R¹⁷, a cyano group, a group of CH₂ CN, a group of NR¹⁸ R¹⁹, a group of SO₂ NR²⁰ R²¹, a group of COR¹³, a group of OH, a benzoyl group which may be substituted (the substituent is selected from a halogen atom or a C₁ -C₈ alkyl group) or a phenyl group which may be substituted (the substituent is selected from a halogen atom, a nitro group, a group of COOR¹³ or a C₁ -C₈ alkyl group);

R¹⁴ represents a hydrogen atom, an unsubstituted C₁ -C₈ alkyl group (or a C₁ -C₈ alkyl group substituted with an unsubstituted C₁ -C₈ alkoxy group or a C₁ -C₈ alkoxy group substituted with a group of OR¹³, a halogenated C₁ -C₈ alkoxy group, a cyano group, a phenoxy group, a C₁ -C₈ alkoxycarbonyl group, a group of NR¹² R¹³, a C₃ -C₇ cycloalkyl group, a C₁ -C₈ alkylthio group or a C₁ -C₈ alkylcarbonyl group), an unsubstituted C₁ -C₈ alkenyl group or a C₁ -C₈ alkenyl group substituted with a halogen atom, an unsubstituted C₁ -C₈ alkynyl group or a C₁ -C₈ alkynyl group substituted with a halogen atom, a halogenated C₁ -C₈ alkyl group, a C₃ -C₇ cycloalkyl group or a benzyl group;

R¹⁵ represents a hydrogen atom, a C₁ -C₈ alkyl group or a phenyl group;

R¹⁶ represents a hydrogen atom, a C₁ -C₈ alkyl group or a C₁ -C₈ alkoxy group;

R¹⁷ represents a C₁ -C₈ alkyl group, a C₁ -C₈ alkoxy group, a phenyl group, a halogenated C₁ -C₈ alkyl group, a C₁ -C₈ alkenyloxy group or a C₁ -C₈ alkynyloxy group; n represents an integer of 0, 1 or 2;

R¹⁸ and R¹⁹ each independently represent a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkylcarbonyl group or a C₁ -C₈ alkylsulfonyl group;

R²⁰ and R²¹ each independently represent a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkenyl group or a C₁ -C₈ alkynyl group;

E represents a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkenyl group, a C₁ -C₈ alkynyl or a C₁ -C₈ alkoxy group;

W represents an oxygen atom, a sulfur atom or a group of NR¹⁶ ;

G represents ##STR4## wherein X and Y each independently represent a hydrogen atom, a halogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkoxy group, a C₁ -C₈ alkoxyalkyl group, a halogenated C₁ -C₈ alkyl group, a halogenated C₁ -C₈ alkoxy group, a group of NR²² R²³, a group of OCH(R¹³)COOR¹³, a group of COOR¹³, a cyclopropyl group, a group of CH(OR²⁴)₂, a C₁ -C₈ alkylthio group or a halogenated C₁ -C₈ alkylthio group;

R²² and R²³ each independently represent a hydrogen atom, a C₁ -C₈ alkyl group or a C₁ -C₈ alkoxy group;

R²⁴ represents a C₁ -C₈ alkyl group; X¹ and Y¹ each independently represent a hydrogen atom, a halogen atom, a C₁ -C₈ alkyl group or a C₁ -C₈ alkoxy group;

X² represents a C₁ -C₈ alkyl group, a C₁ -C₈ alkylthio group or a C₁ -C₈ alkoxy group;

Y² represents a C₁ -C₈ alkyl group;

X³ represents a C₁ -C₈ alkyl group, a C₁ -C₈ alkoxy group, a C₁ -C₈ alkoxy-C₁ -C₈ alkyl group or a halogen atom;

Y³ represents a C₁ -C₈ alkyl group, a C₁ -C₈ alkoxy group, a halogen atom, a monoalkylamino group or a dialkylamino group;

Y⁴ represents a cyano group, a group of CO₂ R¹³, a nitro group, a group of S(O)_(n) R¹², a C₁ -C₈ alkyl group or a halogenated C₁ -C₈ alkyl group;

Z represents a nitrogen atom or a group of C--R²⁵ ;

Z¹ represents a nitrogen atom or a group of CH;

R²⁵ represents a hydrogen atom, a C₁ -C₈ alkyl group, a halogenated C₁ -C₈ alkyl group, a halogen atom, a C₁ -C₈ alkoxy group or a 5-membered ring structure containing an oxygen atom together with Y or Y¹ ;

with the proviso that the group: ##STR5## in Formula (I) is not substituted on the nitrogen atom in the pyrazole ring, and, when Q is not substituted on the nitrogen atom in the pyrazole ring, the substituent for B or D on the nitrogen atom is selected from a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkenyl group, a C₁ -C₈ alkynyl group, a group of --CH₂ CN, a C₁ -C₈ alkoxy-C₁ -C₈ alkyl group, a C₁ -C₈ alkylthio-C₁ -C₈ alkyl group, a group of --CH₂ COOR¹³, a group of --COR¹³, a group of --SO₂ R²⁴, a group of --SO₂ NR¹³ R²⁴ or a phenyl group which may be substituted (the substituent is selected from a halogen atom, a nitro group, a group of COOR¹³ or a C₁ -C₈ alkyl group).

has a strong herbicidal effect to various weeds while retaining high safety to the important crops in either case of the soil treatment or the foliage treatment, whereby this invention has been accomplished. Particularly, some of these compounds show extremely high selectivity to sugar beets. Conventionally, a number of compounds having sulfonylurea structure have been known. Any of these, however, show very strong activities to sugar beets. For example, sugar beets have extremely high sensibility to chlorsulfuron which is known as a herbicide for wheat, and accordingly the sugar beets which are cultured as second crops after wheat are known to be seriously suffered from damages by the agricultural chemicals even after two years, because of a trace amount of the active component remaining in the soil. Also, other sulfonylurea compounds than the chlorsulfuron are also considered to have very particularly strong effect on sugar beets, and, of the sulfonylurea type compounds, almost no compound which may have the selectivity to sugar beets have been hitherto unknown. Also, certain compounds of the compounds of this invention have the selectivity not only to beets but also to rice plants, wheat, cotton, corn, etc. The compound of this invention, on the other hand, shows a high herbicidal activity in an application of a very low amount of the active component as compared with the conventional herbicides, and accordingly it is useful also as a herbicide for orchards and uncultivated lands. As a prior technique, European Patent Publication No. 87,780 discloses a pyrazolesulfonylurea which has the structure similar to the compound of this invention. However, there has been nothing disclosing the compound wherein a fused heterocyclic ring is substituted on a pyrazole ring as the compound of this invention. Thus, the compound of this invention can be said to be a novel one.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

The compound of this invention, represented by Formula (I) can be readily prepared by selecting any of reaction schemes 1 to 3 shown below. ##STR6## wherein W² represents an oxygen atom or a sulfur atom, and B, D, Q, E and G have the same meanings as defined above.

Namely, the pyrazolesulfonyl(thio)isocyanate derivative (II) is dissolved in a sufficiently dried inert solvent such as dioxane and acetonitrile and thereto is added a pyrimidine, triazine or triazole derivative represented by Formula (III), with stirring. Thus, the reactants generally are reacted with each other rapidly to give the compound (I)' which is a part of the compound of this invention. In cases where it is difficult for the reaction to proceed, a trace or small amount of a suitable base, such as triethylamine, triethylenediamine, pyridine, a sodium alkoxide, sodium hydride and the like, may be added to the reaction system to allow the reaction to proceed readily. ##STR7## wherein R represents a C₁ -C₈ alkyl group or a phenyl group and B, D, Q, E, W² and G have the same meanings as defined above.

Namely, the pyrazolesulfonamide derivative (V) is reacted with a chloroformic acid (thio)ester or a carbonic acid (thio)ester in such a solvent as acetone, methyl ethyl ketone and acetonitrile in the presence of a base such as potassium carbonate to give the compound (IV). Then, the resulting compound (IV) is heated with the compound (III) in such a solvent as toluene to give the compound (I)' which is a part of the compound of this invention. ##STR8## wherein B, D, Q, E, G and R¹⁶ have the same meanings as defined above.

Namely, the above sulfonylguanidine type compound which is a part of the compound of this invention can be synthesized in accordance with the process disclosed in Japanese Unexamined Patent Publication No. 167570/1984, No. 6654/1985 and No. 36467/1985.

The starting materials, the pyrazolesulfonyl (thio)isocyanate (II) and the pyrazolesulfonyl (thio)carbamate derivatives (IV) which is used in Reaction Schemes 1 and 2 may be synthesized by selecting appropriately the methods as will be described hereinafter to synthesize the pyrazolesulfonamide (V) and further it can be led to a final product with reference to the methods as described in Published European Patent Application No. 87,780 and Japanese Unexamined Patent Publication No. 13266/1980.

The pyrazolesulfonamide which is an intermediate compound to be used in the present invention is also a novel compound, which can be obtained by selecting appropriately one of the following Reaction schemes 4 to 8. ##STR9## p1 (a) NaNO₂.HCl or NaNO₂.HBr (b) SO₂.Cu salt

(c) NH₄ OH or ammonium carbonate

(d) Cu salt

(e) POCl₃ or POBr₃

(f) P₂ S₅

(g) NaSH

(h) NaOH.NH₄ OH.NaOCl

(i) NaSCH₂ Ph

(j) Cl₂ /CH₃ COOH.H₂ O or NaOCl/HCl

BuLi or LiN(i-Pr)₂ subsequently, Cl₂ or Br₂

(l) Oxidizing agent

(m) (1) ClSO₃ H [2)SOCl₂ or PCl₅ ]

(n) (1) BuLi or LiN(i-Pr)₂

(2) SO₂

(3) N-chlorosuccinimide ClC(═S)NMe₂ /base

(p) heating

(q) RHal/base

wherein B, D, Q and E, have the same meanings as defined above; R represents a C₁ -C₈ alkyl group, a C₁ -C₈ alkenyl group, a C₁ -C₈ alkynyl group, a group, of --CH₂ CN, a C₁ -C₈ alkoxy-C₁ -C₈ alkyl group, a C₁ -C₈ alkylthio-C₁ -C₈ alkyl group, a group of --CH₂ COOR¹³, a group of --COR¹³, a group of --SO₂ R²⁴ or a group of --SO₂ NR¹³ R²⁴ ; and R¹³ and R²⁴ have the same meanings as defined above.

The pyrazolesulfonamide (V) may usually be obtained by reacting a corresponding pyrazolesulfonyl chloride with an aqueous ammonia or ammonium carbonate. In order to introduce a sulfonyl group into a pyrazole, there may be adopted such a method as follows:

(1) The amino group is subjected to diazonium decomposition in the presence of sulfur dioxide to give a pyrazolesulfonyl chloride;

(2) A hydroxypyrazole is converted into an O-pyrazole thiocarbamate, which is then subjected to rearrangement reaction to introduce a sulfur atom in the pyrazole ring followed by oxidation to give a pyrazolesulfonyl chloride;

(3) A sulfur atom is introduced in the pyrazole ring by a nucleophilic substitution reaction with a halogen atom or the like and optionally the resulting compound is further oxidized to give a pyrazolesulfonyl chloride;

(4) A carbanion of a pyrazole is formed by using a base and the sulfur dioxide is reacted therewith followed by halogenation to give a pyrazolesulfonyl chloride;

(5) Chlorosulfonic acid or the like is directly used to give a pyrazolesulfonyl chloride;

(6) The pyrazole derivative, which has been obtained by any of the above-mentioned methods, is functionally modified by utilizing the properties of the pyrazole.

Namely, (1) according to Reaction scheme 4, an aminopyrazole is converted into a diazonium salt by using sodium nitrite or the like in hydrochloric acid, hydrobromic acid or the like and then sulfur dioxide is reacted with the resulting diazonium salt in the presence of a catalyst which is used usually for diazonium decomposition such as a copper salt or the like, to afford a corresponding pyrazolesulfonyl chloride. With the resulting compound was reacted an aqueous ammonia to give the desired pyrazolesulfonamide (V).

(2) According to Reaction scheme 8, starting from a hydroxypyrazole, an O-pyrazole thiocarbamate is obtained and then the resulting compound is rearranged under heating to give an S-pyrazole thiolcarbamate which is then oxidized with chlorine in such a solvent as acetic acid to afford a pyrazolesulfonyl chloride. As in Reaction scheme 4, action of an aqueous ammonia gives the desired pyrazolesulfonamide (V).

Be noted that these Reaction schemes 4 and 8 may be applied without any dependency upon the position(s) of the substituent(s).

(3) In the nucleophilic substitution reaction on the pyrazole, the 5 position on the pyrazole ring is usually reacted most easily, but there may be a case where the nucleophilic substitution reaction further occurs at the 3 position when an electron attracting group is substituted at the 4 position.

By using this property, according to Reaction scheme 5, a pyrazole halogenated at the 5 position is treated with sodium sulfide, sodium salt of benzylmercaptan or the like to introduce a sulfur atom into the 5 position followed by oxidation with chlorine in such a solvent as acetic acid to give a pyrazolesulfonyl chloride. As in Reaction scheme 4, a reaction with an aqueous ammonia gives the desired pyrazolesulfonamide (V). The desired pyrazolesulfonamide may also be obtained by converting the intermediate 5-mercaptopyrazole into a sulfenamide which is then oxidized. The starting material, the pyrazole halogenated at the 5 position, may be obtained by diazo-decomposition of an aminopyrazole; by the reaction of a hydroxypyrazole with phosphorus oxychloride or phosphorus oxybromide; or by formation of an anion at the 5 position by using such a strong base as butyl lithium, lithium diisopropylamide or the like, followed by halogenation.

(4) In cases where there is a substituent at the 1 position, the hydrogen atom at the 5 position on the pyrazole ring has a relatively strong acidity. According to Reaction scheme 7, an anion may be formed by using such a strong base as butyl lithium, lithium diisopropylamide or the like, and the resulting anion may further be treated by sulfur dioxide and subsequently with an N-halogenosuccinimide to form a pyrazolesulfonyl chloride which is then treated with an aqueous ammonia to give the pyrazolesulfonamide (V).

(5) As compared with the nucleophilic substitution reaction, the electrophilic substitution reaction on the pyrazole ring may usually occur more easily at the 4 position. According to Reaction scheme 6, use of chlorosulfonic acid may give directly a pyrazolesulfonyl chloride.

(6) According to Reaction scheme 9, when a pyrazolesulfonamide having no substituent on the 1 position is subjected to alkylation, acylation or sulfonylation, the 1 or 2 position may be alkylated, acylated or sulfonylated, respectively. According to this method, there may be obtained, depending upon the starting material used, a mixture of two kinds of compounds in which substituents on the 3 and 5 positions have been switched with each other. However, these compounds may be separated by recrystallization, column chromatography or the like and used as an intermediate compound for the compound of this invention.

Further, various kinds of pyrazolesulfonamide (V) may be obtained by newly introducing a substituent in the pyrazolesulfonamide or by modifying the introduced substituent, utilizing the properties of a pyrazole.

As to the synthesis of pyrazolesulfonamide in which a hetero ring is substituted on the pyrazole ring, specifications of Japanese Patent Application No. 78784/1985 and No. 236780/1985 can be referred to.

The pyrazoles used as starting materials in the above-mentioned reactions may be synthesized in many cases with reference to A. N. Kost & I. I. Groundberg, Advances in Heterocyclic Chemistry Vol. 6, 347 (1966); T. L. Yacobs, Heterocyclic Compounds, R. C. Elderfield, Vol. 5, 45, Wiley, New York (1957); K. Shofield, M. R. Grimmett and B. R. T. Keene, Heterocyclic Nitrogen Compounds, The Azoles, Cambridge University Press, London, New York, Melbourne (1976); and Kevin T. Potts, Comprehensive Heterocyclic Chemistry, Vol. 5, 167 (1984), Pergamon Press. In cases where Q is substituted at the 1 position of the pyrazole ring, QNHNH₂ may be used in many cases for the synthesis in place of hydrazine, methlyhydrazine, phenylhydrazine and so on as described in the above-mentioned literatures.

A person skilled in the art would be able to obtain an intermediate for the compound of the present invention by investigating reaction conditions and the like taking into consideration the above descriptions and the prior art technologies as mentioned above.

Hereinafter, there will be described Synthesis examples of the present compounds and the intermediate compounds therefor as working examples or referential examples, which however should not be construed to limit the present invention.

REFERENCE EXAMPLE 1 Synthesis of 4-ethoxycarbonyl-1-(2-quinolyl)pyrazole-5-sulfonamide

(1) Synthesis of ethyl 5-amino-1-(2-quinolyl)pyrazole-4-carboxylate:

17.1 g of ethyl ethoxymethylene cyanoacetate was dissolved in 200 ml of n-butyl alcohol and 16 g of 2-hydradinoquinoline was added thereto, followed by stirring at room temperature for 12 hours. The suspension obtained was refluxed for 2.5 hours and then cooled. Crystals precipitated were filtered, washed with n-hexane and dried to obtain 25.7 g of the title compound. m.p.: 146° to 147° C.

(2) Synthesis of ethyl 5-chloro-1-(2-quinolyl)pyrazole-4-carboxylate:

24.7 g of ethyl 5-amino-1-(2-quinolyl)pyrazole-4-carboxylate was suspended in 400 ml of conc. hydrochloric acid, and the suspension obtained was cooled to -5° C., to which 7.9 g of sodium nitrite dissolved in 15 ml of water was added dropwise, and thereafter stirred for 30 minutes, followed by addition of 1.45 g of urea. The solution thus obtained was added dropwise at 5° C. to a solution obtained by adding 14 g of sulfur dioxide and 1.5 g of cuprous chloride to 150 ml of 1,2-dichloroethane. After stirring at room temperature for 1 hour, 1000 ml of ice water was added thereto, followed by extraction with chloroform. Seperation of the layer of chloroform, washing with water, drying and concentration were then carried out to obtain 23 g of the mixture of the title compound and ethyl 1-(2-quinolyl)pyrazole-4-carboxylate (about 3:2). The mixture obtained can be used in the next procedure without purification.

(3) Synthesis of ethyl 5-mercapto-1-(2-quinolyl)-pyrazole-4-carboxylate:

23 g of the mixture of ethyl 5-chloro-1-(2-quinolyl)pyrazole-4-carboxylate and ethyl 1-(2-quinolyl)-pyrazole-4-carboxylate (about 3:2) was dissolved in 100 ml of dimethylformamide, to which 15.3 g of 70% sodium hydrosulfide was added and then heated at 80° to 85° C. for 1.5 hours. After the reaction was completed, ice water was added, followed by the filtration of ethyl 1-(2-quinolyl)pyrazole-4-carboxylate which was insoluble, to make the aqueous layer acidic with use of conc. hydrochloric acid. The orange crystal precipitated was filtered, washed with water and dried to obtain 13.1 g of the title compound. m.p.: 113° to 117° C.

(4) Synthesis of 4-ethoxycarbonyl-1-(2-quinolyl)pyrazole-5-sulfonamide:

13 g of ethyl 5-mercapto-1-(2-quinolyl)pyrazole-4-carboxylate was suspended in 100 ml of 80% acetic acid, into which chlorine was introduced at 5° to 15° C. until it became light yellow homogeneous solution. After the reaction was completed, 500 ml of ice water was added, and crystals precipitated were filtered and washed with water to obtain 4-ethoxycarbonyl-1-(2-quinolyl)pyrazole-5-sulfonylchloride. The sulfonylchloride obtained was dissolved in 50 ml of tetrahydrofuran, followed by addition of 8 ml of 28% aqueous ammonia and stirring at room temperature for 0.5 hour. After solvent was evaporated, crystals precipitated were washed with water and dried to obtain 7 g of the title compound. m.p.: 140° to 141° C.

REFERENCE EXAMPLE 2 Synthesis of 4-ethoxycarbonyl-1-(1-isoquinolyl)pyrazole-5-sulfoamide

Synthesis was carried out following the procedures in Reference Example 1. m.p.: 165° to 170° C.

Each of the intermediates had the following property.

Ethyl 5-amino-1-(1-isoquinolyl)pyrazole-4-carbonylate (it was obtained by heating 1-hydrazinoisoquinoline and ethyl ethoxymethylene cyanoacetate ester in n-butyl alcohol), m.p.: 126° to 128° C.

Ethyl 5-chloro-1-(1-isoquinolyl)pyrazole-4-carboxylate, m.p.: 89° to 90° C.

Ethyl 5-mercapto-1-(1-isoquinolyl)pyrazole-4-carboxylate, m.p.: 121° to 122° C.

EXAMPLE 1 Synthesis of N-[(4,6-dimethoxyprimidine-2-yl)aminocarbonyl]-4-ethoxycarbonyl-1-(2-quinolyl)pyrazole-5-sulfonamide (Compound No. 11)

To a mixture of 6 g of 4-ethoxycarbonyl-1-(2-quinolyl)pyrazole-5-sulfonamide and 3.6 g of anhydrous potassium carbonate dissolved in 40 ml of acetonitrile, was added 1.9 g of n-butylisocyanate at room temperature, followed by heating under reflux for 1.5 hours. After the reaction was completed, acetonitrile was evaporated under reduced pressure, and then the residue was poured into ice water to filter insolubles off, and then the filtrate was precipitated with hydrochloric acid. Crystals precipitated were filtered, washed with water and dried to obtain 7 g of N-(n-butylcarbamoyl)-4-ethoxycarbonyl-1-(2-quinolyl)pyrazole-5-sulfonamide. m.p: 140° to 142° C.

Subsequently, the above compound was added to 70 ml of dried toluene, into which 7.5 g of phosgene was introduced while heating under reflux, and thereafter the reaction mixture was further heated under reflux for 1.5 hours. After the reaction was completed, solvent was evaporated under reduced pressure to obtain 6 g of crude 4-ethoxycarbonyl-1-(2-quinolyl)pyrazole-5-sulfonylisocyanate. 1.0 g of this crude suflonylisocyanate was added to a solution containing 0.37 g of 2-amino-4,6-dimethoxyprimidine dissolved in 5 ml of dried acetonitrile, followed by stirring at room temperature. Crystals precipitated were filtered, washed and dried to obtain 1.2 g of the title compound. m.p: 179° to 182° C.

EXAMPLE 2 Synthesis of N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-4-ethoxycarbonyl-1-(1-isoquinolyl)pyrazole-5-sulfonamide (Compound No. 315)

Synthesis was carried out following the procedures in Example 1. m.p.: 213° to 214° C.

The intermediate of N-(n-butylcarbamoyl)-4-ethoxycarbonyl-1-(1-isoquinolyl)pyrazole-5-sulfonamide had a melting point of 131° to 132° C.

In the following, examples of specific compounds included in the compound of this invention are shown in Table 1 to Table 7 in addition to the compounds synthesized in the above Examples, which, however, should not be construed to limit this invention.

                  TABLE 1                                                          ______________________________________                                          ##STR10##                                                                     No.  A      B      D            X    Y      Z                                  ______________________________________                                         1    Q.sub.1                                                                               H      COOMe        Me   Me     CH                                 2    Q.sub.1                                                                               H      COOMe        Me   OMe    CH                                 3    Q.sub.1                                                                               H      COOMe        OMe  OMe    CH                                 4    Q.sub.1                                                                               H      COOMe        Me   Me     N                                  5    Q.sub.1                                                                               H      COOMe        Me   OMe    N                                  6    Q.sub.1                                                                               H      COOMe        OMe  OMe    N                                  7    Q.sub.1                                                                               H      COOMe        Me   OCHF.sub.2                                                                            CH                                 8    Q.sub.1                                                                               H      COOMe        Cl   OMe    CH                                 9    Q.sub.1                                                                               H      COOEt        Me   Me     CH                                 10   Q.sub.1                                                                               H      COOEt        Me   OMe    CH                                 11   Q.sub.1                                                                               H      COOEt        OMe  OMe    CH                                 12   Q.sub.1                                                                               H      COOEt        Me   Me     N                                  13   Q.sub.1                                                                               H      COOEt        Me   OMe    N                                  14   Q.sub.1                                                                               H      COOEt        OMe  OMe    N                                  15   Q.sub.1                                                                               H      COOEt        Me   OCHF.sub.2                                                                            CH                                 16   Q.sub.1                                                                               H      COOEt        Cl   OMe    CH                                 17   Q.sub.1                                                                               H      COOPrn       Me   OMe    CH                                 18   Q.sub.1                                                                               H      COOPrn       OMe  OMe    CH                                 19   Q.sub.1                                                                               H      COOPrn       Me   OMe    N                                  20   Q.sub.1                                                                               H      COOPri       Me   OMe    CH                                 21   Q.sub.1                                                                               H      COOPri       OMe  OMe    CH                                 22   Q.sub.1                                                                               H      COOPri       Me   OMe    N                                  23   Q.sub.1                                                                               H      COOCH.sub.2 CH.sub.2 Cl                                                                     Me   OMe    CH                                 24   Q.sub.1                                                                               H      COOCH.sub.2 CH.sub.2 Cl                                                                     OMe  OMe    CH                                 25   Q.sub.1                                                                               H      COOCH.sub.2 CH.sub.2 Cl                                                                     Me   OMe    N                                  26   Q.sub.1                                                                               H      COOCH.sub.2 CHCH.sub.2                                                                      Me   OMe    CH                                 27   Q.sub.1                                                                               H      COOCH.sub.2 CHCH.sub.2                                                                      OMe  OMe    CH                                 28   Q.sub.1                                                                               H      COOCH.sub.2 CHCH.sub.2                                                                      Me   OMe    N                                  29   Q.sub.1                                                                               H      COOCH.sub.2 CCH                                                                             Me   OMe    CH                                 30   Q.sub.1                                                                               H      COOCH.sub.2 CCH                                                                             OMe  OMe    CH                                 31   Q.sub.1                                                                               H      COOCH.sub.2 CCH                                                                             Me   OMe    N                                  32   Q.sub.1                                                                               Me     COOMe        Me   Me     CH                                 33   Q.sub.1                                                                               Me     COOMe        Me   OMe    CH                                 34   Q.sub.1                                                                               Me     COOMe        OMe  OMe    CH                                 35   Q.sub.1                                                                               Me     COOMe        Me   OMe    N                                  36   Q.sub.1                                                                               Me     COOMe        OMe  OMe    N                                  37   Q.sub.1                                                                               Me     COOEt        Me   Me     CH                                 38   Q.sub.1                                                                               Me     COOEt        Me   OMe    CH                                 39   Q.sub.1                                                                               Me     COOEt        OMe  OMe    CH                                 40   Q.sub.1                                                                               Me     COOEt        Me   OMe    N                                  41   Q.sub.1                                                                               Me     COOEt        OMe  OMe    N                                  42   Q.sub.1                                                                               Cl     COOMe        Me   OMe    CH                                 43   Q.sub.1                                                                               Cl     COOMe        OMe  OMe    CH                                 44   Q.sub.1                                                                               Cl     COOMe        Me   OMe    N                                  45   Q.sub.1                                                                               Cl     COOEt        Me   OMe    CH                                 46   Q.sub.1                                                                               Cl     COOEt        OMe  OMe    CH                                 47   Q.sub.1                                                                               Cl     COOEt        Me   OMe    N                                  48   Q.sub.1                                                                               OMe    COOMe        Me   OMe    CH                                 49   Q.sub.1                                                                               OMe    COOMe        OMe  OMe    CH                                 50   Q.sub.1                                                                               OMe    COOMe        Me   OMe    N                                  51   Q.sub.1                                                                               OMe    COOEt        Me   OMe    CH                                 52   Q.sub.1                                                                               OMe    COOEt        OMe  OMe    CH                                 53   Q.sub.1                                                                               OMe    COOEt        Me   OMe    N                                  54   Q.sub.1                                                                               H      Cl           Me   OMe    CH                                 55   Q.sub.1                                                                               H      Cl           OMe  OMe    CH                                 56   Q.sub.1                                                                               H      Cl           Me   OMe    N                                  57   Q.sub.1                                                                               H      NO.sub.2     Me   OMe    CH                                 58   Q.sub.1                                                                               H      NO.sub.2     OMe  OMe    CH                                 59   Q.sub.1                                                                               H      NO.sub.2     Me   OMe    N                                  60   Q.sub.1                                                                               H      So.sub.2 NMe.sub.2                                                                          Me   OMe    CH                                 61   Q.sub.1                                                                               H      So.sub.2 NMe.sub.2                                                                          OMe  OMe    CH                                 62   Q.sub.1                                                                               H      So.sub.2 NMe.sub.2                                                                          Me   OMe    N                                  63   Q.sub.1                                                                               H      CN           Me   OMe    CH                                 64   Q.sub.1                                                                               H      CN           OMe  OMe    CH                                 65   Q.sub.1                                                                               H      CN           Me   OMe    N                                  66   Q.sub.1                                                                               Me     CN           Me   OMe    CH                                 67   Q.sub.1                                                                               Me     CN           OMe  OMe    CH                                 68   Q.sub.1                                                                               Me     CN           Me   OMe    N                                  69   Q.sub.1                                                                               H      Me           Me   OMe    CH                                 70   Q.sub.1                                                                               H      Me           OMe  OMe    CH                                 71   Q.sub.1                                                                               H      Me           Me   OMe    N                                  72   Q.sub.1                                                                               H      Et           Me   OMe    CH                                 73   Q.sub.1                                                                               H      Et           OMe  OMe    CH                                 74   Q.sub.1                                                                               H      Et           Me   OMe    N                                  75   Q.sub.1                                                                               H      H            Me   OMe    CH                                 76   Q.sub.1                                                                               H      H            OMe  OMe    CH                                 77   Q.sub.1                                                                               H      H            Me   OMe    N                                  78   Q.sub.1                                                                               H      COPh         Me   OMe    CH                                 79   Q.sub.1                                                                               H      COPh         OMe  OMe    CH                                 80   Q.sub.1                                                                               H      COPh         Me   OMe    N                                  81   Me     Q.sub. 1                                                                              COOMe        Me   OMe    CH                                 82   Me     Q.sub.1                                                                               COOMe        OMe  OMe    CH                                 83   Me     Q.sub.1                                                                               COOMe        Me   OMe    N                                  84   H      H      Q.sub.1      Me   OMe    CH                                 85   H      H      Q.sub.1      OMe  OMe    CH                                 86   H      H      Q.sub.1      Me   OMe    N                                  87   Me     H      Q.sub.1      Me   Me     CH                                 88   Me     H      Q.sub.1      Me   OMe    CH                                 89   Me     H      Q.sub.1      OMe  OMe    CH                                 90   Me     H      Q.sub.1      Me   OMe    N                                  91   Me     H      Q.sub.1      OMe  OMe    N                                  92   Me     Me     Q.sub.1      Me   OMe    CH                                 93   Me     Me     Q.sub.1      OMe  OMe    CH                                 94   Me     Me     Q.sub.1      Me   OMe    N                                  95   Q.sub.2                                                                               H      COOMe        Me   Me     CH                                 96   Q.sub.2                                                                               H      COOMe        Me   OMe    CH                                 97   Q.sub.2                                                                               H      COOMe        OMe  OMe    CH                                 98   Q.sub.2                                                                               H      COOMe        Me   OMe    N                                  99   Q.sub.2                                                                               H      COOMe        OMe  OMe    N                                  100  Q.sub.2                                                                               H      COOEt        Me   Me     CH                                 101  Q.sub.2                                                                               H      COOEt        Me   OMe    CH                                 102  Q.sub.2                                                                               H      COOEt        OMe  OMe    CH                                 103  Q.sub.2                                                                               H      COOEt        Me   OMe    N                                  104  Q.sub.2                                                                               H      COOEt        OMe  OMe    N                                  105  Q.sub.2                                                                               Me     COOMe        Me   OMe    CH                                 106  Q.sub.2                                                                               Me     COOMe        OMe  OMe    CH                                 107  Q.sub.2                                                                               Me     COOMe        Me   OMe    N                                  108  Q.sub.2                                                                               Me     COOEt        Me   OMe    CH                                 109  Q.sub.2                                                                               Me     COOEt        OMe  OMe    CH                                 110  Q.sub.2                                                                               Me     COOEt        Me   OMe    N                                  111  Q.sub.2                                                                               H      CN           Me   OMe    CH                                 112  Q.sub.2                                                                               H      CN           OMe  OMe    CH                                 113  Q.sub.2                                                                               H      CN           Me   OMe    N                                  114  Q.sub.2                                                                               H      H            Me   OMe    CH                                 115  Q.sub.2                                                                               H      H            OMe  OMe    CH                                 116  Q.sub.2                                                                               H      H            Me   OMe    N                                  117  Me     H      Q.sub.2      Me   Me     CH                                 118  Me     H      Q.sub.2      Me   OMe    CH                                 119  Me     H      Q.sub.2      OMe  OMe    CH                                 120  Me     H      Q.sub.2      Me   OMe    N                                  121  Me     H      Q.sub.2      OMe  OMe    N                                  122  Q.sub.3                                                                               H      COOMe        Me   Me     CH                                 123  Q.sub.3                                                                               H      COOMe        Me   OMe    CH                                 124  Q.sub.3                                                                               H      COOMe        OMe  OMe    CH                                 125  Q.sub.3                                                                               H      COOMe        Me   OMe    N                                  126  Q.sub.3                                                                               H      COOMe        OMe  OMe    N                                  127  Q.sub.3                                                                               H      COOEt        Me   Me     CH                                 128  Q.sub.3                                                                               H      COOEt        Me   OMe    CH                                 129  Q.sub.3                                                                               H      COOEt        OMe  OMe    CH                                 130  Q.sub.3                                                                               H      COOEt        Me   OMe    N                                  131  Q.sub.3                                                                               H      COOEt        OMe  OMe    N                                  132  Q.sub.3                                                                               Me     COOMe        Me   OMe    CH                                 133  Q.sub.3                                                                               Me     COOMe        OMe  OMe    CH                                 134  Q.sub.3                                                                               Me     COOMe        Me   OMe    N                                  135  Q.sub.3                                                                               Me     COOEt        Me   OMe    CH                                 136  Q.sub.3                                                                               Me     COOEt        OMe  OMe    CH                                 137  Q.sub.3                                                                               Me     COOEt        Me   OMe    N                                  138  Q.sub.3                                                                               H      CN           Me   OMe    CH                                 139  Q.sub.3                                                                               H      CN           OMe  OMe    CH                                 140  Q.sub.3                                                                               H      CN           Me   OMe    N                                  141  Q.sub.3                                                                               H      H            Me   OMe    CH                                 142  Q.sub.3                                                                               H      H            OMe  OMe    CH                                 143  Q.sub.3                                                                               H      H            Me   OMe    N                                  144  Me     H      Q.sub.3      Me   Me     CH                                 145  Me     H      Q.sub.3      Me   OMe    CH                                 146  Me     H      Q.sub.3      OMe  OMe    CH                                 147  Me     H      Q.sub.3      Me   OMe    N                                  148  Me     H      Q.sub.3      OMe  OMe    N                                  149  Q.sub.4                                                                               H      COOMe        Me   Me     CH                                 150  Q.sub.4                                                                               H      COOMe        Me   OMe    CH                                 151  Q.sub.4                                                                               H      COOMe        OMe  OMe    CH                                 152  Q.sub.4                                                                               H      COOMe        Me   OMe    N                                  153  Q.sub.4                                                                               H      COOMe        OMe  OMe    N                                  154  Q.sub.4                                                                               H      COOEt        Me   Me     CH                                 155  Q.sub.4                                                                               H      COOEt        Me   OMe    CH                                 156  Q.sub.4                                                                               H      COOEt        OMe  OMe    CH                                 157  Q.sub.4                                                                               H      COOEt        Me   OMe    N                                  158  Q.sub.4                                                                               H      COOEt        OMe  OMe    N                                  159  Q.sub.4                                                                               Me     COOMe        Me   OMe    CH                                 160  Q.sub.4                                                                               Me     COOMe        OMe  OMe    CH                                 161  Q.sub.4                                                                               Me     COOMe        Me   OMe    N                                  162  Q.sub.4                                                                               Me     COOEt        Me   OMe    CH                                 163  Q.sub.4                                                                               Me     COOEt        OMe  OMe    CH                                 164  Q.sub.4                                                                               Me     COOEt        Me   OMe    N                                  165  Q.sub.4                                                                               H      CN           Me   OMe    CH                                 166  Q.sub.4                                                                               H      CN           OMe  OMe    CH                                 167  Q.sub.4                                                                               H      CN           Me   OMe    N                                  168  Q.sub.4                                                                               H      H            Me   OMe    CH                                 169  Q.sub.4                                                                               H      H            OMe  OMe    CH                                 170  Q.sub.4                                                                               H      H            Me   OMe    N                                  171  Me     H      Q.sub.4      Me   Me     CH                                 172  Me     H      Q.sub.4      Me   OMe    CH                                 173  Me     H      Q.sub.4      OMe  OMe    CH                                 174  Me     H      Q.sub.4      Me   OMe    N                                  175  Me     H      Q.sub.4      OMe  OMe    N                                  176  Q.sub.5                                                                               H      COOMe        Me   Me     CH                                 177  Q.sub.5                                                                               H      COOMe        Me   OMe    CH                                 178  Q.sub.5                                                                               H      COOMe        OMe  OMe    CH                                 179  Q.sub.5                                                                               H      COOMe        Me   OMe    N                                  180  Q.sub.5                                                                               H      COOMe        OMe  OMe    N                                  181  Q.sub.5                                                                               H      COOEt        Me   Me     CH                                 182  Q.sub.5                                                                               H      COOEt        Me   OMe    CH                                 183  Q.sub.5                                                                               H      COOEt        OMe  OMe    CH                                 184  Q.sub.5                                                                               H      COOEt        Me   OMe    N                                  185  Q.sub.5                                                                               H      COOEt        OMe  OMe    N                                  186  Q.sub.5                                                                               Me     COOMe        Me   OMe    CH                                 187  Q.sub.5                                                                               Me     COOMe        OMe  OMe    CH                                 188  Q.sub.5                                                                               Me     COOMe        Me   OMe    N                                  189  Q.sub.5                                                                               Me     COOEt        Me   OMe    CH                                 190  Q.sub.5                                                                               Me     COOEt        OMe  OMe    CH                                 191  Q.sub.5                                                                               Me     COOEt        Me   OMe    N                                  192  Q.sub.5                                                                               H      CN           Me   OMe    CH                                 193  Q.sub.5                                                                               H      CN           OMe  OMe    CH                                 194  Q.sub.5                                                                               H      CN           Me   OMe    N                                  195  Q.sub.5                                                                               H      H            Me   OMe    CH                                 196  Q.sub.5                                                                               H      H            OMe  OMe    CH                                 197  Q.sub.5                                                                               H      H            Me   OMe    N                                  198  Me     H      Q.sub.5      Me   Me     CH                                 199  Me     H      Q.sub.5      Me   OMe    CH                                 200  Me     H      Q.sub.5      OMe  OMe    CH                                 201  Me     H      Q.sub.5      Me   OMe    N                                  202  Me     H      Q.sub.5      OMe  OMe    N                                  203  Q.sub.6                                                                               H      COOMe        Me   Me     CH                                 204  Q.sub.6                                                                               H      COOMe        Me   OMe    CH                                 205  Q.sub.6                                                                               H      COOMe        OMe  OMe    CH                                 206  Q.sub.6                                                                               H      COOMe        Me   OMe    N                                  207  Q.sub.6                                                                               H      COOMe        OMe  OMe    N                                  208  Q.sub.6                                                                               H      COOEt        Me   Me     CH                                 209  Q.sub.6                                                                               H      COOEt        Me   OMe    CH                                 210  Q.sub.6                                                                               H      COOEt        OMe  OMe    CH                                 211  Q.sub.6                                                                               H      COOEt        Me   OMe    N                                  212  Q.sub.6                                                                               H      COOEt        OMe  OMe    N                                  213  Q.sub.6                                                                               Me     COOMe        Me   OMe    CH                                 214  Q.sub.6                                                                               Me     COOMe        OMe  OMe    CH                                 215  Q.sub.6                                                                               Me     COOMe        Me   OMe    N                                  216  Q.sub.6                                                                               Me     COOEt        Me   OMe    CH                                 217  Q.sub.6                                                                               Me     COOEt        OMe  OMe    CH                                 218  Q.sub.6                                                                               Me     COOEt        Me   OMe    N                                  219  Q.sub.6                                                                               H      CN           Me   OMe    CH                                 220  Q.sub.6                                                                               H      CN           OMe  OMe    CH                                 221  Q.sub.6                                                                               H      CN           Me   OMe    N                                  222  Q.sub.6                                                                               H      H            Me   OMe    CH                                 223  Q.sub.6                                                                               H      H            OMe  OMe    CH                                 224  Q.sub.6                                                                               H      H            Me   OMe    N                                  225  Me     H      Q.sub.6      Me   Me     CH                                 226  Me     H      Q.sub.6      Me   OMe    CH                                 227  Me     H      Q.sub.6      OMe  OMe    CH                                 228  Me     H      Q.sub.6      Me   OMe    N                                  229  Me     H      Q.sub.6      OMe  OMe    N                                  230  Q.sub.7                                                                               H      COOMe        Me   OMe    CH                                 231  Q.sub.7                                                                               H      COOMe        OMe  OMe    CH                                 232  Q.sub.7                                                                               H      COOEt        Me   OMe    CH                                 233  Q.sub.7                                                                               H      COOEt        OMe  OMe    CH                                 234  Q.sub.7                                                                               Me     COOMe        Me   OMe    CH                                 235  Q.sub.7                                                                               Me     COOMe        OMe  OMe    CH                                 236  Q.sub.7                                                                               Me     COOEt        Me   OMe    CH                                 237  Q.sub.7                                                                               Me     COOEt        OMe  OMe    CH                                 238  Q.sub.7                                                                               H      H            Me   OMe    CH                                 239  Q.sub.7                                                                               H      H            OMe  OMe    CH                                 240  Me     H      Q.sub.7      Me   OMe    CH                                 241  Me     H      Q.sub.7      OMe  OMe    CH                                 242  Q.sub.8                                                                               H      COOMe        Me   OMe    CH                                 243  Q.sub.8                                                                               H      COOMe        OMe  OMe    CH                                 244  Q.sub.8                                                                               H      COOEt        Me   OMe    CH                                 245  Q.sub.8                                                                               H      COOEt        OMe  OMe    CH                                 246  Q.sub.8                                                                               Me     COOMe        Me   OMe    CH                                 247  Q.sub.8                                                                               Me     COOMe        OMe  OMe    CH                                 248  Q.sub.8                                                                               Me     COOEt        Me   OMe    CH                                 249  Q.sub.8                                                                               Me     COOEt        OMe  OMe    CH                                 250  Q.sub.8                                                                               H      H            Me   OMe    CH                                 251  Q.sub.8                                                                               H      H            OMe  OMe    CH                                 252  Me     H      Q.sub.8      Me   OMe    CH                                 253  Me     H      Q.sub.8      OMe  OMe    CH                                 254  Q.sub.9                                                                               H      COOMe        Me   OMe    CH                                 255  Q.sub.9                                                                               H      COOMe        OMe  OMe    CH                                 256  Q.sub.9                                                                               H      COOEt        Me   OMe    CH                                 257  Q.sub.9                                                                               H      COOEt        OMe  OMe    CH                                 258  Q.sub.9                                                                               Me     COOMe        Me   OMe    CH                                 259  Q.sub.9                                                                               Me     COOMe        OMe  OMe    CH                                 260  Q.sub.9                                                                               Me     COOEt        Me   OMe    CH                                 261  Q.sub.9                                                                               Me     COOEt        OMe  OMe    CH                                 262  Q.sub.9                                                                               H      H            Me   OMe    CH                                 263  Q.sub.9                                                                               H      H            OMe  OMe    CH                                 264  Me     H      Q.sub.9      Me   OMe    CH                                 265  Me     H      Q.sub.9      OMe  OMe    CH                                 266  Q.sub.10                                                                              H      COOMe        Me   OMe    CH                                 267  Q.sub.10                                                                              H      COOMe        OMe  OMe    CH                                 268  Q.sub.10                                                                              H      COOEt        Me   OMe    CH                                 269  Q.sub.10                                                                              H      COOEt        OMe  OMe    CH                                 270  Q.sub.10                                                                              Me     COOMe        Me   OMe    CH                                 271  Q.sub.10                                                                              Me     COOMe        OMe  OMe    CH                                 272  Q.sub.10                                                                              Me     COOEt        Me   OMe    CH                                 273  Q.sub.10                                                                              Me     COOEt        OMe  OMe    CH                                 274  Q.sub.10                                                                              H      H            Me   OMe    CH                                 275  Q.sub.10                                                                              H      H            OMe  OMe    CH                                 276  Me     H      Q.sub.10     Me   OMe    CH                                 277  Me     H      Q.sub.10     OMe  OMe    CH                                 278  Q.sub.11                                                                              H      COOMe        Me   Me     CH                                 279  Q.sub.11                                                                              H      COOMe        Me   OMe    CH                                 280  Q.sub.11                                                                              H      COOMe        OMe  OMe    CH                                 281  Q.sub.11                                                                              H      COOMe        Me   OMe    N                                  282  Q.sub.11                                                                              H      COOMe        OMe  OMe    N                                  283  Q.sub.11                                                                              H      COOEt        Me   Me     CH                                 284  Q.sub.11                                                                              H      COOEt        Me   OMe    CH                                 285  Q.sub.11                                                                              H      COOEt        OMe  OMe    CH                                 286  Q.sub.11                                                                              H      COOEt        Me   OMe    N                                  287  Q.sub.11                                                                              H      COOEt        OMe  OMe    N                                  288  Q.sub.11                                                                              Me     COOMe        Me   OMe    CH                                 289  Q.sub.11                                                                              Me     COOMe        OMe  OMe    CH                                 290  Q.sub.11                                                                              Me     COOMe        Me   OMe    N                                  291  Q.sub.11                                                                              Me     COOEt        Me   OMe    CH                                 292  Q.sub.11                                                                              Me     COOEt        OMe  OMe    CH                                 293  Q.sub.11                                                                              Me     COOEt        Me   OMe    N                                  294  Q.sub.11                                                                              H      CN           Me   OMe    CH                                 295  Q.sub.11                                                                              H      CN           OMe  OMe    CH                                 296  Q.sub.11                                                                              H      CN           Me   OMe    N                                  297  Q.sub.11                                                                              H      H            Me   OMe    CH                                 298  Q.sub.11                                                                              H      H            OMe  OMe    CH                                 299  Q.sub.11                                                                              H      H            Me   OMe    N                                  300  Me     H      Q.sub.11     Me   Me     CH                                 301  Me     H      Q.sub.11     Me   OMe    CH                                 302  Me     H      Q.sub.11     OMe  OMe    CH                                 303  Me     H      Q.sub.11     Me   OMe    N                                  304  Me     H      Q.sub.11     OMe  OMe    N                                  305  Q.sub.12                                                                              H      COOMe        Me   Me     CH                                 306  Q.sub.12                                                                              H      COOMe        Me   OMe    CH                                 307  Q.sub.12                                                                              H      COOMe        OMe  OMe    CH                                 308  Q.sub.12                                                                              H      COOMe        Me   Me     N                                  309  Q.sub.12                                                                              H      COOMe        Me   OMe    N                                  310  Q.sub.12                                                                              H      COOMe        OMe  OMe    N                                  311  Q.sub.12                                                                              H      COOMe        Me   OCHF.sub.2                                                                            CH                                 312  Q.sub.12                                                                              H      COOMe        Cl   OMe    CH                                 313  Q.sub.12                                                                              H      COOEt        Me   Me     CH                                 314  Q.sub.12                                                                              H      COOEt        Me   OMe    CH                                 315  Q.sub.12                                                                              H      COOEt        OMe  OMe    CH                                 316  Q.sub.12                                                                              H      COOEt        Me   Me     N                                  317  Q.sub.12                                                                              H      COOEt        Me   OMe    N                                  318  Q.sub.12                                                                              H      COOEt        OMe  OMe    N                                  319  Q.sub.12                                                                              H      COOEt        Me   OCHF.sub.2                                                                            CH                                 320  Q.sub.12                                                                              H      COOEt        Cl   OMe    CH                                 321  Q.sub.12                                                                              H      COOPrn       Me   OMe    CH                                 322  Q.sub.12                                                                              H      COOPrn       OMe  OMe    CH                                 323  Q.sub.12                                                                              H      COOPrn       Me   OMe    N                                  324  Q.sub.12                                                                              H      COOPri       Me   OMe    CH                                 325  Q.sub.12                                                                              H      COOPri       OMe  OMe    CH                                 326  Q.sub.12                                                                              H      COOPri       Me   OMe    N                                  327  Q.sub.12                                                                              H      COOCH.sub.2 CH.sub.2 Cl                                                                     Me   OMe    CH                                 328  Q.sub.12                                                                              H      COOCH.sub.2 CH.sub.2 Cl                                                                     OMe  OMe    CH                                 329  Q.sub.12                                                                              H      COOCH.sub.2 CH.sub.2 Cl                                                                     Me   OMe    N                                  330  Q.sub.12                                                                              H      COOCH.sub.2 CHCH.sub.2                                                                      Me   OMe    CH                                 331  Q.sub.12                                                                              H      COOCH.sub.2 CHCH.sub.2                                                                      OMe  OMe    CH                                 332  Q.sub.12                                                                              H      COOCH.sub.2 CHCH.sub.2                                                                      Me   OMe    N                                  333  Q.sub.12                                                                              H      COOCH.sub.2 CCH                                                                             Me   OMe    CH                                 334  Q.sub.12                                                                              H      COOCH.sub.2 CCH                                                                             OMe  OMe    CH                                 335  Q.sub.12                                                                              H      COOCH.sub.2 CCH                                                                             Me   OMe    N                                  336  Q.sub.12                                                                              Me     COOMe        Me   Me     CH                                 337  Q.sub.12                                                                              Me     COOMe        Me   OMe    CH                                 338  Q.sub.12                                                                              Me     COOMe        OMe  OMe    CH                                 339  Q.sub.12                                                                              Me     COOMe        Me   OMe    N                                  340  Q.sub.12                                                                              Me     COOMe        OMe  OMe    N                                  341  Q.sub.12                                                                              Me     COOEt        Me   Me     CH                                 342  Q.sub.12                                                                              Me     COOEt        Me   OMe    CH                                 343  Q.sub.12                                                                              Me     COOEt        OMe  OMe    CH                                 344  Q.sub.12                                                                              Me     COOEt        Me   OMe    N                                  345  Q.sub.12                                                                              Me     COOEt        OMe  OMe    N                                  346  Q.sub.12                                                                              Cl     COOMe        Me   OMe    CH                                 347  Q.sub.12                                                                              Cl     COOMe        OMe  OMe    CH                                 348  Q.sub.12                                                                              Cl     COOMe        Me   OMe    N                                  349  Q.sub.12                                                                              Cl     COOEt        Me   OMe    CH                                 350  Q.sub.12                                                                              Cl     COOEt        OMe  OMe    CH                                 351  Q.sub.12                                                                              Cl     COOEt        Me   OMe    N                                  352  Q.sub.12                                                                              OMe    COOMe        Me   OMe    CH                                 353  Q.sub.12                                                                              OMe    COOMe        OMe  OMe    CH                                 354  Q.sub.12                                                                              OMe    COOMe        Me   OMe    N                                  355  Q.sub.12                                                                              OMe    COOEt        Me   OMe    CH                                 356  Q.sub.12                                                                              OMe    COOEt        OMe  OMe    CH                                 357  Q.sub.12                                                                              OMe    COOEt        Me   OMe    N                                  358  Q.sub.12                                                                              H      Cl           Me   OMe    CH                                 359  Q.sub.12                                                                              H      Cl           OMe  OMe    CH                                 360  Q.sub.12                                                                              H      Cl           Me   OMe    N                                  361  Q.sub.12                                                                              H      NO.sub.2     Me   OMe    CH                                 362  Q.sub.12                                                                              H      NO.sub.2     OMe  OMe    CH                                 363  Q.sub.12                                                                              H      NO.sub.2     Me   OMe    N                                  364  Q.sub.12                                                                              H      SO.sub.2 NMe.sub.2                                                                          Me   OMe    CH                                 365  Q.sub.12                                                                              H      SO.sub.2 NMe.sub.2                                                                          OMe  OMe    CH                                 366  Q.sub.12                                                                              H      SO.sub.2 NMe.sub.2                                                                          Me   OMe    N                                  367  Q.sub.12                                                                              H      CN           Me   OMe    CH                                 368  Q.sub.12                                                                              H      CN           OMe  OMe    CH                                 369  Q.sub.12                                                                              H      CN           Me   OMe    N                                  370  Q.sub.12                                                                              Me     CN           Me   OMe    CH                                 371  Q.sub.12                                                                              Me     CN           OMe  OMe    CH                                 372  Q.sub.12                                                                              Me     CN           Me   OMe    N                                  373  Q.sub.12                                                                              H      Me           Me   OMe    CH                                 374  Q.sub.12                                                                              H      Me           OMe  OMe    CH                                 375  Q.sub.12                                                                              H      Me           Me   OMe    N                                  376  Q.sub.12                                                                              H      Et           Me   OMe    CH                                 377  Q.sub.12                                                                              H      Et           OMe  OMe    CH                                 378  Q.sub.12                                                                              H      Et           Me   OMe    N                                  379  Q.sub.12                                                                              H      H            Me   OMe    CH                                 380  Q.sub.12                                                                              H      H            OMe  OMe    CH                                 381  Q.sub.12                                                                              H      H            Me   OMe    N                                  382  Q.sub.12                                                                              H      COPh         Me   OMe    CH                                 383  Q.sub.12                                                                              H      COPh         OMe  OMe    CH                                 384  Q.sub.12                                                                              H      COPh         Me   OMe    N                                  385  Me     Q.sub.12                                                                              COOMe        Me   OMe    CH                                 386  Me     Q.sub.12                                                                              COOMe        OMe  OMe    CH                                 387  Me     Q.sub.12                                                                              COOMe        Me   OMe    N                                  388  H      H      Q.sub.12     Me   OMe    CH                                 389  H      H      Q.sub.12     OMe  OMe    CH                                 390  H      H      Q.sub.12     Me   OMe    N                                  391  Me     H      Q.sub.12     Me   Me     CH                                 392  Me     H      Q.sub.12     Me   OMe    CH                                 393  Me     H      Q.sub.12     OMe  OMe    CH                                 394  Me     H      Q.sub.12     Me   OMe    N                                  395  Me     H      Q.sub.12     OMe  OMe    N                                  396  Me     Me     Q.sub.12     Me   OMe    CH                                 397  Me     Me     Q.sub.12     OMe  OMe    CH                                 398  Me     Me     Q.sub.12     Me   OMe    N                                  399  Q.sub.13                                                                              H      COOMe        Me   Me     CH                                 400  Q.sub.13                                                                              H      COOMe        Me   OMe    CH                                 401  Q.sub.13                                                                              H      COOMe        OMe  OMe    CH                                 402  Q.sub.13                                                                              H      COOMe        Me   OMe    N                                  403  Q.sub.13                                                                              H      COOMe        OMe  OMe    N                                  404  Q.sub.13                                                                              H      COOEt        Me   Me     CH                                 405  Q.sub.13                                                                              H      COOEt        Me   OMe    CH                                 406  Q.sub.13                                                                              H      COOEt        OMe  OMe    CH                                 407  Q.sub.13                                                                              H      COOEt        Me   OMe    N                                  408  Q.sub.13                                                                              H      COOEt        OMe  OMe    N                                  409  Q.sub.13                                                                              Me     COOMe        Me   OMe    CH                                 410  Q.sub.13                                                                              Me     COOMe        OMe  OMe    CH                                 411  Q.sub.13                                                                              Me     COOMe        Me   OMe    N                                  412  Q.sub.13                                                                              Me     COOEt        Me   OMe    CH                                 413  Q.sub.13                                                                              Me     COOEt        OMe  OMe    CH                                 414  Q.sub.13                                                                              Me     COOEt        Me   OMe    N                                  415  Q.sub.13                                                                              H      CN           Me   OMe    CH                                 416  Q.sub.13                                                                              H      CN           OMe  OMe    CH                                 417  Q.sub.13                                                                              H      CN           Me   OMe    N                                  118  Q.sub.13                                                                              H      H            Me   OMe    CH                                 419  Q.sub.13                                                                              H      H            OMe  OMe    CH                                 420  Q.sub.13                                                                              H      H            Me   OMe    N                                  421  Me     H      Q.sub.13     Me   Me     CH                                 422  Me     H      Q.sub.13     Me   OMe    CH                                 423  Me     H      Q.sub.13     OMe  OMe    CH                                 424  Me     H      Q.sub.13     Me   OMe    N                                  425  Me     H      Q.sub.13     OMe  OMe    N                                  426  Q.sub.14                                                                              H      COOMe        Me   Me     CH                                 427  Q.sub.14                                                                              H      COOMe        Me   OMe    CH                                 428  Q.sub.14                                                                              H      COOMe        OMe  OMe    CH                                 429  Q.sub.14                                                                              H      COOMe        Me   OMe    N                                  430  Q.sub.14                                                                              H      COOMe        OMe  OMe    N                                  431  Q.sub.14                                                                              H      COOEt        Me   Me     CH                                 432  Q.sub.14                                                                              H      COOEt        Me   OMe    CH                                 433  Q.sub.14                                                                              H      COOEt        OMe  OMe    CH                                 434  Q.sub.14                                                                              H      COOEt        Me   OMe    N                                  435  Q.sub.14                                                                              H      COOEt        OMe  OMe    N                                  436  Q.sub.14                                                                              Me     COOMe        Me   OMe    CH                                 437  Q.sub.14                                                                              Me     COOMe        OMe  OMe    CH                                 438  Q.sub.14                                                                              Me     COOMe        Me   OMe    N                                  439  Q.sub.14                                                                              Me     COOEt        Me   OMe    CH                                 440  Q.sub.14                                                                              Me     COOEt        OMe  OMe    CH                                 441  Q.sub.14                                                                              Me     COOEt        Me   OMe    N                                  442  Q.sub.14                                                                              H      CN           Me   OMe    CH                                 443  Q.sub.14                                                                              H      CN           OMe  OMe    CH                                 444  Q.sub.14                                                                              H      CN           Me   OMe    N                                  445  Q.sub.14                                                                              H      H            Me   OMe    CH                                 446  Q.sub.14                                                                              H      H            OMe  OMe    CH                                 447  Q.sub.14                                                                              H      H            Me   OMe    N                                  448  Me     H      Q.sub.14     Me   Me     CH                                 449  Me     H      Q.sub.14     Me   OMe    CH                                 450  Me     H      Q.sub.14     OMe  OMe    CH                                 451  Me     H      Q.sub.14     Me   OMe    N                                  452  Me     H      Q.sub.14     OMe  OMe    N                                  453  Q.sub.15                                                                              H      COOMe        Me   OMe    CH                                 454  Q.sub.15                                                                              H      COOMe        OMe  OMe    CH                                 455  Q.sub.15                                                                              H      COOEt        Me   OMe    CH                                 456  Q.sub.15                                                                              H      COOEt        OMe  OMe    CH                                 457  Q.sub.15                                                                              Me     COOMe        Me   OMe    CH                                 458  Q.sub.15                                                                              Me     COOMe        OMe  OMe    CH                                 459  Q.sub.15                                                                              Me     COOEt        Me   OMe    CH                                 460  Q.sub.15                                                                              Me     COOEt        OMe  OMe    CH                                 461  Q.sub.15                                                                              H      H            Me   OMe    CH                                 462  Q.sub.15                                                                              H      H            OMe  OMe    CH                                 463  Me     H      Q.sub.15     Me   OMe    CH                                 464  Me     H      Q.sub.15     OMe  OMe    CH                                 465  Q.sub.16                                                                              H      COOMe        Me   OMe    CH                                 466  Q.sub.16                                                                              H      COOMe        OMe  OMe    CH                                 467  Q.sub.16                                                                              H      COOEt        Me   OMe    CH                                 468  Q.sub.16                                                                              H      COOEt        OMe  OMe    CH                                 469  Q.sub.16                                                                              Me     COOMe        Me   OMe    CH                                 470  Q.sub.16                                                                              Me     COOMe        OMe  OMe    CH                                 471  Q.sub.16                                                                              Me     COOEt        Me   OMe    CH                                 472  Q.sub.16                                                                              Me     COOEt        OMe  OMe    CH                                 473  Q.sub.16                                                                              H      H            Me   OMe    CH                                 474  Q.sub.16                                                                              H      H            OMe  OMe    CH                                 475  Me     H      Q.sub.16     Me   OMe    CH                                 476  Me     H      Q.sub.16     OMe  OMe    CH                                 477  Q.sub.17                                                                              H      COOMe        Me   OMe    CH                                 478  Q.sub.17                                                                              H      COOMe        OMe  OMe    CH                                 479  Q.sub.17                                                                              H      COOEt        Me   OMe    CH                                 480  Q.sub.17                                                                              H      COOEt        OMe  OMe    CH                                 481  Q.sub.17                                                                              Me     COOMe        Me   OMe    CH                                 482  Q.sub.17                                                                              Me     COOMe        OMe  OMe    CH                                 483  Q.sub.17                                                                              Me     COOEt        Me   OMe    CH                                 484  Q.sub.17                                                                              Me     COOEt        OMe  OMe    CH                                 485  Q.sub.17                                                                              H      H            Me   OMe    CH                                 486  Q.sub.17                                                                              H      H            OMe  OMe    CH                                 487  Me     H      Q.sub.17     Me   OMe    CH                                 488  Me     H      Q.sub.17     OMe  OMe    CH                                 489  Q.sub.18                                                                              H      COOMe        Me   OMe    CH                                 490  Q.sub.18                                                                              H      COOMe        OMe  OMe    CH                                 491  Q.sub.18                                                                              H      COOEt        Me   OMe    CH                                 492  Q.sub.18                                                                              H      CCOOEt       OMe  OMe    CH                                 493  Q.sub.18                                                                              Me     COOMe        Me   OMe    CH                                 494  Q.sub.18                                                                              Me     COOMe        OMe  OMe    CH                                 495  Q.sub.18                                                                              Me     COOEt        Me   OMe    CH                                 496  Q.sub.18                                                                              Me     COOEt        OMe  OMe    CH                                 497  Q.sub.18                                                                              H      H            Me   OMe    CH                                 498  Q.sub.18                                                                              H      H            OMe  OMe    CH                                 499  Me     H      Q.sub.18     Me   OMe    CH                                 500  Me     H      Q.sub.18     OMe  OMe    CH                                 501  Q.sub.19                                                                              H      COOMe        Me   Me     CH                                 502  Q.sub.19                                                                              H      COOMe        Me   OMe    CH                                 503  Q.sub.19                                                                              H      COOMe        OMe  OMe    CH                                 504  Q.sub.19                                                                              H      COOMe        Me   OMe    N                                  505  Q.sub.19                                                                              H      COOMe        OMe  OMe    N                                  506  Q.sub.19                                                                              H      COOEt        Me   Me     CH                                 507  Q.sub.19                                                                              H      COOEt        Me   OMe    CH                                 508  Q.sub.19                                                                              H      COOEt        OMe  OMe    CH                                 509  Q.sub.19                                                                              H      COOEt        Me   OMe    N                                  510  Q.sub.19                                                                              H      COOEt        OMe  OMe    N                                  511  Q.sub.19                                                                              Me     COOMe        Me   OMe    CH                                 512  Q.sub.19                                                                              Me     COOMe        OMe  OMe    CH                                 513  Q.sub.19                                                                              Me     COOMe        Me   OMe    N                                  514  Q.sub.19                                                                              Me     COOEt        Me   OMe    CH                                 515  Q.sub.19                                                                              Me     COOEt        OMe  OMe    CH                                 516  Q.sub.19                                                                              Me     COOEt        Me   OMe    N                                  517  Q.sub.19                                                                              H      CN           Me   OMe    CH                                 518  Q.sub.19                                                                              H      CN           OMe  OMe    CH                                 519  Q.sub.19                                                                              H      CN           Me   OMe    N                                  520  Q.sub.19                                                                              H      H            Me   OMe    CH                                 521  Q.sub.19                                                                              H      H            OMe  OMe    CH                                 522  Q.sub.19                                                                              H      H            Me   OMe    N                                  523  Me     H      Q.sub.19     Me   Me     CH                                 524  Me     H      Q.sub.19     Me   OMe    CH                                 525  Me     H      Q.sub.19     OMe  OMe    CH                                 526  Me     H      Q.sub.19     Me   OMe    N                                  527  Me     H      Q.sub.19     OMe  OMe    N                                  528  Q.sub.20                                                                              H      COOMe        Me   OMe    CH                                 529  Q.sub.10                                                                              H      COOMe        OMe  OMe    CH                                 530  Q.sub.10                                                                              H      COOEt        Me   OMe    CH                                 531  Q.sub.10                                                                              H      COOEt        OMe  OMe    CH                                 532  Q.sub.20                                                                              Me     COOMe        Me   OMe    CH                                 533  Q.sub.20                                                                              Me     COOMe        OMe  OMe    CH                                 534  Q.sub.20                                                                              Me     COOEt        Me   OMe    CH                                 535  Q.sub.20                                                                              Me     COOEt        OMe  OMe    CH                                 536  Q.sub.20                                                                              H      H            Me   OMe    CH                                 537  Q.sub.20                                                                              H      H            OMe  OMe    CH                                 538  Me     H      Q.sub.20     Me   OMe    CH                                 539  Me     H      Q.sub.20     OMe  OMe    CH                                 540  Q.sub.21                                                                              H      COOMe        Me   OMe    CH                                 541  Q.sub.21                                                                              H      COOMe        OMe  OMe    CH                                 542  Q.sub.21                                                                              H      COOEt        Me   OMe    CH                                 543  Q.sub.21                                                                              H      COOEt        OMe  OMe    CH                                 544  Q.sub.21                                                                              Me     COOMe        Me   OMe    CH                                 545  Q.sub.21                                                                              Me     COOMe        OMe  OMe    CH                                 546  Q.sub.21                                                                              Me     COOEt        Me   OMe    CH                                 547  Q.sub.21                                                                              Me     COOEt        OMe  OMe    CH                                 548  Q.sub.21                                                                              H      H            Me   OMe    CH                                 549  Q.sub.21                                                                              H      H            OMe  OMe    CH                                 550  Me     H      Q.sub.21     Me   OMe    CH                                 551  Me     H      Q.sub.21     OMe  OMe    CH                                 552  Q.sub.22                                                                              H      COOMe        Me   Me     CH                                 553  Q.sub.22                                                                              H      COOMe        Me   OMe    CH                                 554  Q.sub.22                                                                              H      COOMe        OMe  OMe    CH                                 555  Q.sub.22                                                                              H      COOMe        Me   Me     N                                  556  Q.sub.22                                                                              H      COOMe        Me   OMe    N                                  557  Q.sub.22                                                                              H      COOMe        OMe  OMe    N                                  558  Q.sub.22                                                                              H      COOMe        Me   OCHF.sub.2                                                                            CH                                 559  Q.sub.22                                                                              H      COOMe        Cl   OMe    CH                                 560  Q.sub.22                                                                              H      COOEt        Me   Me     CH                                 561  Q.sub.22                                                                              H      COOEt        Me   OMe    CH                                 562  Q.sub.22                                                                              H      COOEt        OMe  OMe    CH                                 563  Q.sub.22                                                                              H      COOEt        Me   Me     N                                  564  Q.sub.22                                                                              H      COOEt        Me   OMe    N                                  565  Q.sub.22                                                                              H      COOEt        OMe  OMe    N                                  566  Q.sub.22                                                                              H      COOEt        Me   OCHF.sub.2                                                                            CH                                 567  Q.sub.22                                                                              H      COOEt        Cl   OMe    CH                                 568  Q.sub.22                                                                              H      COOPrn       Me   OMe    CH                                 569  Q.sub.22                                                                              H      COOPrn       OMe  OMe    CH                                 570  Q.sub.22                                                                              H      COOPrn       Me   OMe    N                                  571  Q.sub.22                                                                              H      COOPri       Me   OMe    CH                                 572  Q.sub.22                                                                              H      COOPr i      OMe  OMe    CH                                 573  Q.sub.22                                                                              H      COOPri       Me   OMe    N                                  574  Q.sub.22                                                                              H      COOCH.sub.2 CH.sub.2 Cl                                                                     Me   OMe    CH                                 575  Q.sub.22                                                                              H      COOCH.sub.2 CH.sub.2 Cl                                                                     OMe  OMe    CH                                 576  Q.sub.22                                                                              H      COOCH.sub.2 CH.sub.2 Cl                                                                     Me   OMe    N                                  577  Q.sub.22                                                                              H      COOCH.sub.2 CHCH.sub.2                                                                      Me   OMe    CH                                 578  Q.sub.22                                                                              H      COOCH.sub.2 CHCH.sub.2                                                                      OMe  OMe    CH                                 579  Q.sub.22                                                                              H      COOCH.sub.2 CHCH.sub.2                                                                      Me   OMe    N                                  580  Q.sub.22                                                                              H      COOCH.sub.2 CCH                                                                             Me   OMe    CH                                 581  Q.sub.22                                                                              H      COOCH.sub.2 CCH                                                                             OMe  OMe    CH                                 582  Q.sub.22                                                                              H      COOCH.sub.2 CCH                                                                             Me   OMe    N                                  583  Q.sub.22                                                                              Me     COOMe        Me   Me     CH                                 584  Q.sub.22                                                                              Me     COOMe        Me   OMe    CH                                 585  Q.sub.22                                                                              Me     COOMe        OMe  OMe    CH                                 586  Q.sub.22                                                                              Me     COOMe        Me   OMe    N                                  587  Q.sub.22                                                                              Me     COOMe        OMe  OMe    N                                  588  Q.sub.22                                                                              Me     COOEt        Me   Me     CH                                 589  Q.sub.22                                                                              Me     COOEt        Me   OMe    CH                                 590  Q.sub.22                                                                              Me     COOEt        OMe  OMe    CH                                 591  Q.sub.22                                                                              Me     COOEt        Me   OMe    N                                  592  Q.sub.22                                                                              Me     COOEt        OMe  OMe    N                                  593  Q.sub.22                                                                              Cl     COOMe        Me   OMe    CH                                 594  Q.sub.22                                                                              Cl     COOMe        OMe  OMe    CH                                 595  Q.sub.22                                                                              Cl     COOMe        Me   OMe    N                                  596  Q.sub.22                                                                              Cl     COOEt        Me   OMe    CH                                 597  Q.sub.22                                                                              Cl     COOEt        OMe  OMe    CH                                 598  Q.sub.22                                                                              Cl     COOEt        Me   OMe    N                                  599  Q.sub.22                                                                              OMe    COOMe        Me   OMe    CH                                 600  Q.sub.22                                                                              OMe    COOMe        OMe  OMe    CH                                 601  Q.sub.22                                                                              OMe    COOMe        Me   OMe    N                                  602  Q.sub.22                                                                              OMe    COOEt        Me   OMe    CH                                 603  Q.sub.22                                                                              OMe    COOEt        OMe  OMe    CH                                 604  Q.sub.22                                                                              OMe    COOEt        Me   OMe    N                                  605  Q.sub.22                                                                              H      Cl           Me   OMe    CH                                 606  Q.sub.22                                                                              H      Cl           OMe  OMe    CH                                 607  Q.sub.22                                                                              H      Cl           Me   OMe    N                                  608  Q.sub.22                                                                              H      NO.sub.2     Me   OMe    CH                                 609  Q.sub.22                                                                              H      NO.sub.2     OMe  OMe    CH                                 610  Q.sub.22                                                                              H      NO.sub.2     Me   OMe    N                                  611  Q.sub.22                                                                              H      SO.sub.2 NMe.sub.2                                                                          Me   OMe    CH                                 612  Q.sub.22                                                                              H      SO.sub.2 NMe.sub.2                                                                          OMe  OMe    CH                                 613  Q.sub.22                                                                              H      SO.sub.2 NMe.sub.2                                                                          Me   OMe    N                                  614  Q.sub.22                                                                              H      CN           Me   OMe    CH                                 615  Q.sub.22                                                                              H      CN           OMe  OMe    CH                                 616  Q.sub.22                                                                              H      CN           Me   OMe    N                                  617  Q.sub.22                                                                              Me     CN           Me   OMe    CH                                 618  Q.sub.22                                                                              Me     CN           OMe  OMe    CH                                 619  Q.sub.22                                                                              Me     CN           Me   OMe    N                                  620  Q.sub.22                                                                              H      Me           Me   OMe    CH                                 621  Q.sub.22                                                                              H      Me           OMe  OMe    CH                                 622  Q.sub.22                                                                              H      Me           Me   OMe    N                                  623  Q.sub.22                                                                              H      Et           Me   OMe    CH                                 624  Q.sub.22                                                                              H      Et           OMe  OMe    CH                                 625  Q.sub.22                                                                              H      Et           Me   OMe    N                                  626  Q.sub.22                                                                              H      H            Me   OMe    CH                                 627  Q.sub.22                                                                              H      H            OMe  OMe    CH                                 628  Q.sub.22                                                                              H      H            Me   OMe    N                                  629  Q.sub.22                                                                              H      COPh         Me   OMe    CH                                 630  Q.sub.22                                                                              H      COPh         OMe  OMe    CH                                 631  Q.sub.22                                                                              H      COPh         Me   OMe    N                                  632  Me     Q.sub.22                                                                              COOMe        Me   OMe    CH                                 633  Me     Q.sub.22                                                                              COOMe        OMe  OMe    CH                                 634  Me     Q.sub.22                                                                              COOMe        Me   OMe    N                                  635  H      H      Q.sub.22     Me   OMe    CH                                 636  H      H      Q.sub.22     OMe  OMe    CH                                 637  H      H      Q.sub.22     Me   OMe    N                                  638  Me     H      Q.sub.22     Me   Me     CH                                 639  Me     H      Q.sub.22     Me   OMe    CH                                 640  Me     H      Q.sub.22     OMe  OMe    CH                                 641  Me     H      Q.sub.22     Me   OMe    N                                  642  Me     H      Q.sub.22     OMe  OMe    N                                  643  Me     Me     Q.sub.22     Me   OMe    CH                                 644  Me     Me     Q.sub.22     OMe  OMe    CH                                 645  Me     Me     Q.sub.22     Me   OMe    N                                  646  Q.sub.23                                                                              H      COOMe        Me   Me     CH                                 647  Q.sub.23                                                                              H      COOMe        Me   OMe    CH                                 648  Q.sub.23                                                                              H      COOMe        OMe  OMe    CH                                 649  Q.sub.23                                                                              H      COOMe        Me   OMe    N                                  650  Q.sub.23                                                                              H      COOMe        OMe  OMe    N                                  651  Q.sub.23                                                                              H      COOEt        Me   Me     CH                                 652  Q.sub.23                                                                              H      COOEt        Me   OMe    CH                                 653  Q.sub.23                                                                              H      COOEt        OMe  OMe    CH                                 654  Q.sub.23                                                                              H      COOEt        Me   OMe    N                                  655  Q.sub.23                                                                              H      COOEt        OMe  OMe    N                                  656  Q.sub.23                                                                              Me     COOMe        Me   OMe    CH                                 657  Q.sub.23                                                                              Me     COOMe        OMe  OMe    CH                                 658  Q.sub.23                                                                              Me     COOMe        Me   OMe    N                                  659  Q.sub.23                                                                              Me     COOEt        Me   OMe    CH                                 660  Q.sub.23                                                                              Me     COOEt        OMe  OMe    CH                                 661  Q.sub.23                                                                              Me     COOEt        Me   OMe    N                                  662  Q.sub.23                                                                              H      CN           Me   OMe    CH                                 663  Q.sub.23                                                                              H      CN           OMe  OMe    CH                                 664  Q.sub.23                                                                              H      CN           Me   OMe    N                                  665  Q.sub.23                                                                              H      H            Me   OMe    CH                                 666  Q.sub.23                                                                              H      H            OMe  OMe    CH                                 667  Q.sub.23                                                                              H      H            Me   OMe    N                                  668  Me     H      Q.sub.23     Me   Me     CH                                 669  Me     H      Q.sub.23     Me   OMe    CH                                 670  Me     H      Q.sub.23     OMe  OMe    CH                                 671  Me     H      Q.sub.23     Me   OMe    N                                  672  Me     H      Q.sub.23     OMe  OMe    N                                  673  Q.sub.24                                                                              H      COOMe        Me   Me     CH                                 674  Q.sub.24                                                                              H      COOMe        Me   OMe    CH                                 675  Q.sub.24                                                                              H      COOMe        OMe  OMe    CH                                 676  Q.sub.24                                                                              H      COOMe        Me   OMe    N                                  677  Q.sub.24                                                                              H      COOMe        OMe  OMe    N                                  678  Q.sub.24                                                                              H      COOEt        Me   Me     CH                                 679  Q.sub.24                                                                              H      COOEt        Me   OMe    CH                                 680  Q.sub.24                                                                              H      COOEt        OMe  OMe    CH                                 681  Q.sub.24                                                                              H      COOEt        Me   OMe    N                                  682  Q.sub.24                                                                              H      COOEt        OMe  OMe    N                                  683  Q.sub.24                                                                              Me     COOMe        Me   OMe    CH                                 684  Q.sub.24                                                                              Me     COOMe        OMe  OMe    CH                                 685  Q.sub.24                                                                              Me     COOMe        Me   OMe    N                                  686  Q.sub.24                                                                              Me     COOEt        Me   OMe    CH                                 687  Q.sub.24                                                                              Me     COOEt        OMe  OMe    CH                                 688  Q.sub.24                                                                              Me     COOEt        Me   OMe    N                                  689  Q.sub.24                                                                              H      CN           Me   OMe    CH                                 690  Q.sub.24                                                                              H      CN           OMe  OMe    CH                                 691  Q.sub.24                                                                              H      CN           Me   OMe    N                                  692  Q.sub.24                                                                              H      H            Me   OMe    CH                                 693  Q.sub.24                                                                              H      H            OMe  OMe    CH                                 694  Q.sub.24                                                                              H      H            Me   OMe    N                                  695  Me     H      Q.sub.24     Me   Me     CH                                 696  Me     H      Q.sub.24     Me   OMe    CH                                 697  Me     H      Q.sub.24     OMe  OMe    CH                                 698  Me     H      Q.sub.24     Me   OMe    N                                  699  Me     H      Q.sub.24     OMe  OMe    N                                  700  Q.sub.25                                                                              H      COOMe        Me   Me     CH                                 701  Q.sub.25                                                                              H      COOMe        Me   OMe    CH                                 702  Q.sub.25                                                                              H      COOMe        OMe  OMe    CH                                 703  Q.sub.25                                                                              H      COOMe        Me   OMe    N                                  704  Q.sub.25                                                                              H      COOMe        OMe  OMe    N                                  705  Q.sub.25                                                                              H      COOEt        Me   Me     CH                                 706  Q.sub.25                                                                              H      COOEt        Me   OMe    CH                                 707  Q.sub.25                                                                              H      COOEt        OMe  OMe    CH                                 708  Q.sub.25                                                                              H      COOEt        Me   OMe    N                                  709  Q.sub.25                                                                              H      COOEt        OMe  OMe    N                                  710  Q.sub.25                                                                              Me     COOMe        Me   OMe    CH                                 711  Q.sub.25                                                                              Me     COOMe        OMe  OMe    CH                                 712  Q.sub.25                                                                              Me     COOMe        Me   OMe    N                                  713  Q.sub.25                                                                              Me     COOEt        Me   OMe    CH                                 714  Q.sub.25                                                                              Me     COOEt        OMe  OMe    CH                                 715  Q.sub.25                                                                              Me     COOEt        Me   OMe    N                                  716  Q.sub.25                                                                              H      CN           Me   OMe    CH                                 717  Q.sub.25                                                                              H      CN           OMe  OMe    CH                                 718  Q.sub.25                                                                              H      CN           Me   OMe    N                                  719  Q.sub.25                                                                              H      H            Me   OMe    CH                                 720  Q.sub.25                                                                              H      H            OMe  OMe    CH                                 721  Q.sub.25                                                                              H      H            Me   OMe    N                                  722  Me     H      Q.sub.25     Me   Me     CH                                 723  Me     H      Q.sub.25     Me   OMe    CH                                 724  Me     H      Q.sub.25     OMe  OMe    CH                                 725  Me     H      Q.sub.25     Me   OMe    N                                  726  Me     H      Q.sub.25     OMe  OMe    N                                  727  Q.sub.26                                                                              H      COOMe        Me   OMe    CH                                 728  Q.sub.26                                                                              H      COOMe        OMe  OMe    CH                                 729  Q.sub.26                                                                              H      COOEt        Me   OMe    CH                                 730  Q.sub.26                                                                              H      COOEt        OMe  OMe    CH                                 731  Q.sub.26                                                                              Me     COOMe        Me   OMe    CH                                 732  Q.sub.26                                                                              Me     COOMe        OMe  OMe    CH                                 733  Q.sub.26                                                                              Me     COOEt        Me   OMe    CH                                 734  Q.sub.26                                                                              Me     COOEt        OMe  OMe    CH                                 735  Q.sub.26                                                                              H      H            Me   OMe    CH                                 736  Q.sub.26                                                                              H      H            OMe  OMe    CH                                 737  Me     H      Q.sub.26     Me   OMe    CH                                 738  Me     H      Q.sub.26     OMe  OMe    CH                                 739  Q.sub.27                                                                              H      COOMe        Me   OMe    CH                                 740  Q.sub.27                                                                              H      COOMe        OMe  OMe    CH                                 741  Q.sub.27                                                                              H      COOEt        Me   OMe    CH                                 742  Q.sub.27                                                                              H      COOEt        OMe  OMe    CH                                 743  Q.sub.27                                                                              Me     COOMe        Me   OMe    CH                                 744  Q.sub.27                                                                              Me     COOMe        OMe  OMe    CH                                 745  Q.sub.27                                                                              Me     COOEt        Me   OMe    CH                                 746  Q.sub.27                                                                              Me     COOEt        OMe  OMe    CH                                 747  Q.sub.27                                                                              H      H            Me   OMe    CH                                 748  Q.sub.27                                                                              H      H            OMe  OMe    CH                                 749  Me     H      Q.sub.27     Me   OMe    CH                                 750  Me     H      Q.sub.27     OMe  OMe    CH                                 751  Q.sub.28                                                                              H      COOMe        Me   OMe    CH                                 752  Q.sub.28                                                                              H      COOMe        OMe  OMe    CH                                 753  Q.sub.28                                                                              H      COOEt        Me   OMe    CH                                 754  Q.sub.28                                                                              H      COOEt        OMe  OMe    CH                                 755  Q.sub.28                                                                              Me     COOMe        Me   OMe    CH                                 756  Q.sub.28                                                                              Me     COOMe        OMe  OMe    CH                                 757  Q.sub.28                                                                              Me     COOEt        Me   OMe    CH                                 758  Q.sub.28                                                                              Me     COOEt        OMe  OMe    CH                                 759  Q.sub.28                                                                              H      H            Me   OMe    CH                                 760  Q.sub.28                                                                              H      H            OMe  OMe    CH                                 761  Me     H      Q.sub.28     Me   OMe    CH                                 762  Me     H      Q.sub.28     OMe  OMe    CH                                 763  Q.sub.29                                                                              H      COOMe        Me   OMe    CH                                 764  Q.sub.29                                                                              H      COOMe        OMe  OMe    CH                                 765  Q.sub.29                                                                              H      COOEt        Me   OMe    CH                                 766  Q.sub.29                                                                              H      COOEt        OMe  OMe    CH                                 767  Q.sub.29                                                                              Me     COOMe        Me   OMe    CH                                 768  Q.sub.29                                                                              Me     COOMe        OMe  OMe    CH                                 769  Q.sub.29                                                                              Me     COOEt        Me   OMe    CH                                 770  Q.sub.29                                                                              Me     COOEt        OMe  OMe    CH                                 771  Q.sub.29                                                                              H      H            Me   OMe    CH                                 772  Q.sub.29                                                                              H      H            OMe  OMe    CH                                 773  Me     H      Q.sub.29     Me   OMe    CH                                 774  Me     H      Q.sub.29     OMe  OMe    CH                                 775  Q.sub.30                                                                              H      COOMe        Me   OMe    CH                                 776  Q.sub.30                                                                              H      COOMe        OMe  OMe    CH                                 777  Q.sub.30                                                                              H      COOEt        Me   OMe    CH                                 778  Q.sub.30                                                                              H      COOEt        OMe  OMe    CH                                 779  Q.sub.30                                                                              Me     COOMe        Me   OMe    CH                                 780  Q.sub.30                                                                              Me     COOMe        OMe  OMe    CH                                 781  Q.sub.30                                                                              Me     COOEt        Me   OMe    CH                                 782  Q.sub.30                                                                              Me     COOEt        OMe  OMe    CH                                 783  Q.sub.30                                                                              H      H            Me   OMe    CH                                 784  Q.sub.30                                                                              H      H            OMe  OMe    CH                                 785  Me     H      Q.sub.30     Me   OMe    CH                                 786  Me     H      Q.sub.30     OMe  OMe    CH                                 787  Q.sub.31                                                                              H      COOMe        Me   OMe    CH                                 788  Q.sub. 31                                                                             H      COOMe        OMe  OMe    CH                                 789  Q.sub.31                                                                              H      COOEt        Me   OMe    CH                                 790  Q.sub.31                                                                              H      COOEt        OMe  OMe    CH                                 791  Q.sub.31                                                                              Me     COOMe        Me   OMe    CH                                 792  Q.sub.31                                                                              Me     COOMe        OMe  OMe    CH                                 793  Q.sub.31                                                                              Me     COOEt        Me   OMe    CH                                 794  Q.sub.31                                                                              Me     COOEt        OMe  OMe    CH                                 795  Q.sub.31                                                                              H      H            Me   OMe    CH                                 796  Q.sub.31                                                                              H      H            OMe  OMe    CH                                 797  Me     H      Q.sub.31     Me   OMe    CH                                 798  Me     H      Q.sub.31     OMe  OMe    CH                                 799  Q.sub.32                                                                              H      COOMe        Me   Me     CH                                 800  Q.sub.32                                                                              H      COOMe        Me   OMe    CH                                 801  Q.sub.32                                                                              H      COOMe        OMe  OMe    CH                                 802  Q.sub.32                                                                              H      COOMe        Me   OMe    N                                  803  Q.sub.32                                                                              H      COOMe        OMe  OMe    N                                  804  Q.sub.32                                                                              H      COOEt        Me   Me     CH                                 805  Q.sub.32                                                                              H      COOEt        Me   OMe    CH                                 806  Q.sub.32                                                                              H      COOEt        OMe  OMe    CH                                 807  Q.sub.32                                                                              H      COOEt        Me   OMe    N                                  808  Q.sub.32                                                                              H      COOEt        OMe  OMe    N                                  809  Q.sub.32                                                                              Me     COOMe        Me   OMe    CH                                 810  Q.sub.32                                                                              Me     COOMe        OMe  OMe    CH                                 811  Q.sub.32                                                                              Me     COOMe        Me   OMe    N                                  812  Q.sub.32                                                                              Me     COOEt        Me   OMe    CH                                 813  Q.sub.32                                                                              Me     COOEt        OMe  OMe    CH                                 814  Q.sub.32                                                                              Me     COOEt        Me   OMe    N                                  815  Q.sub.32                                                                              H      CN           Me   OMe    CH                                 816  Q.sub.32                                                                              H      CN           OMe  OMe    CH                                 817  Q.sub.32                                                                              H      CN           Me   OMe    N                                  818  Q.sub.32                                                                              H      H            Me   OMe    CH                                 819  Q.sub.32                                                                              H      H            OMe  OMe    CH                                 820  Q.sub.32                                                                              H      H            Me   OMe    N                                  821  Me     H      Q.sub.32     Me   Me     CH                                 822  Me     H      Q.sub.32     Me   OMe    CH                                 823  Me     H      Q.sub.32     OMe  OMe    CH                                 824  Me     H      Q.sub.32     Me   OMe    N                                  825  Me     H      Q.sub.32     OMe  OMe    N                                  826  Q.sub.33                                                                              H      COOMe        Me   OMe    CH                                 827  Q.sub.33                                                                              H      COOMe        OMe  OMe    CH                                 828  Q.sub.33                                                                              H      COOEt        Me   OMe    CH                                 829  Q.sub.33                                                                              H      COOEt        OMe  OMe    CH                                 830  Q.sub.33                                                                              Me     COOMe        Me   OMe    CH                                 831  Q.sub.33                                                                              Me     COOMe        OMe  OMe    CH                                 832  Q.sub.33                                                                              Me     COOEt        Me   OMe    CH                                 833  Q.sub.33                                                                              Me     COOEt        OMe  OMe    CH                                 834  Q.sub.33                                                                              H      H            Me   OMe    CH                                 835  Q.sub.33                                                                              H      H            OMe  OMe    CH                                 836  Me     H      Q.sub.33     Me   OMe    CH                                 837  Me     H      Q.sub.33     OMe  OMe    CH                                 838  Q.sub.34                                                                              H      COOMe        Me   OMe    CH                                 839  Q.sub.34                                                                              H      COOMe        OMe  OMe    CH                                 840  Q.sub.34                                                                              H      COOEt        Me   OMe    CH                                 841  Q.sub.34                                                                              H      COOEt        OMe  OMe    CH                                 842  Q.sub.34                                                                              Me     COOMe        Me   OMe    CH                                 843  Q.sub.34                                                                              Me     COOMe        OMe  OMe    CH                                 844  Q.sub.34                                                                              Me     COOEt        Me   OMe    CH                                 845  Q.sub.34                                                                              Me     COOEt        OMe  OMe    CH                                 846  Q.sub.34                                                                              H      H            Me   OMe    CH                                 847  Q.sub.34                                                                              H      H            OMe  OMe    CH                                 848  Me     H      Q.sub.34     Me   OMe    CH                                 849  Me     H      Q.sub.34     OMe  OMe    CH                                 850  Q.sub.35                                                                              H      COOMe        Me   OMe    CH                                 851  Q.sub.35                                                                              H      COOMe        OMe  OMe    CH                                 852  Q.sub.35                                                                              H      COOEt        Me   OMe    CH                                 853  Q.sub.35                                                                              H      COOEt        OMe  OMe    CH                                 854  Q.sub.35                                                                              Me     COOMe        Me   OMe    CH                                 855  Q.sub.35                                                                              Me     COOMe        OMe  OMe    CH                                 856  Q.sub.35                                                                              Me     COOEt        Me   OMe    CH                                 857  Q.sub.35                                                                              Me     COOEt        OMe  OMe    CH                                 858  Q.sub.35                                                                              H      H            Me   OMe    CH                                 859  Q.sub.35                                                                              H      H            OMe  OMe    CH                                 860  Me     H      Q.sub.35     Me   OMe    CH                                 861  Me     H      Q.sub.35     OMe  OMe    CH                                 862  Q.sub.36                                                                              H      COOMe        Me   OMe    CH                                 863  Q.sub.36                                                                              H      COOMe        OMe  OMe    CH                                 864  Q.sub.36                                                                              H      COOEt        Me   OMe    CH                                 865  Q.sub.36                                                                              H      COOEt        OMe  OMe    CH                                 866  Q.sub.36                                                                              Me     COOMe        Me   OMe    CH                                 867  Q.sub.36                                                                              Me     COOMe        OMe  OMe    CH                                 868  Q.sub.36                                                                              Me     COOEt        Me   OMe    CH                                 869  Q.sub.36                                                                              Me     COOEt        OMe  OMe    CH                                 870  Q.sub.36                                                                              H      H            Me   OMe    CH                                 871  Q.sub.36                                                                              H      H            OMe  OMe    CH                                 872  Me     H      Q.sub.36     Me   OMe    CH                                 873  Me     H      Q.sub.36     OMe  OMe    CH                                 874  Q.sub.37                                                                              H      COOMe        Me   OMe    CH                                 875  Q.sub.37                                                                              H      COOMe        OMe  OMe    CH                                 876  Q.sub.37                                                                              H      COOEt        Me   OMe    CH                                 877  Q.sub.37                                                                              H      COOEt        OMe  OMe    CH                                 878  Q.sub.37                                                                              Me     COOMe        Me   OMe    CH                                 879  Q.sub.37                                                                              Me     COOMe        OMe  OMe    CH                                 880  Q.sub.37                                                                              Me     COOEt        Me   OMe    CH                                 881  Q.sub.37                                                                              Me     COOEt        OMe  OMe    CH                                 882  Q.sub.37                                                                              H      H            Me   OMe    CH                                 883  Q.sub.37                                                                              H      H            OMe  OMe    CH                                 884  Me     H      Q.sub.37     Me   OMe    CH                                 885  Me     H      Q.sub.37     OMe  OMe    CH                                 886  Q.sub.38                                                                              H      COOMe        Me   OMe    CH                                 887  Q.sub.38                                                                              H      COOMe        OMe  OMe    CH                                 888  Q.sub.38                                                                              H      COOEt        Me   OMe    CH                                 889  Q.sub.38                                                                              H      COOEt        OMe  OMe    CH                                 890  Q.sub.38                                                                              Me     COOMe        Me   OMe    CH                                 891  Q.sub.38                                                                              Me     COOMe        OMe  OMe    CH                                 892  Q.sub.38                                                                              Me     COOEt        Me   OMe    CH                                 893  Q.sub.38                                                                              Me     COOEt        OMe  OMe    CH                                 932  Me     H      Q.sub.41     Me   OMe    CH                                 933  Me     H      Q.sub.41     OMe  OMe    CH                                 934  Q.sub.42                                                                              H      COOMe        Me   OMe    CH                                 935  Q.sub.42                                                                              H      COOMe        OMe  OMe    CH                                 936  Q.sub.42                                                                              H      COOEt        Me   OMe    CH                                 937  Q.sub.42                                                                              H      COOEt        OMe  OMe    CH                                 938  Q.sub.42                                                                              Me     COOMe        Me   OMe    CH                                 939  Q.sub.42                                                                              Me     COOMe        OMe  OMe    CH                                 940  Q.sub.42                                                                              Me     COOEt        Me   OMe    CH                                 941  Q.sub.42                                                                              Me     COOEt        OMe  OMe    CH                                 942  Q.sub.42                                                                              H      H            Me   OMe    CH                                 943  Q.sub.42                                                                              H      H            OMe  OMe    CH                                 944  Me     H      Q.sub.42     Me   OMe    CH                                 945  Me     H      Q.sub.42     OMe  OMe    CH                                 946  Q.sub.43                                                                              H      COOMe        Me   OMe    CH                                 947  Q.sub.43                                                                              H      COOMe        OMe  OMe    CH                                 948  Q.sub.43                                                                              H      COOEt        Me   OMe    CH                                 949  Q.sub.43                                                                              H      COOEt        OMe  OMe    CH                                 950  Q.sub.43                                                                              Me     COOMe        Me   OMe    CH                                 951  Q.sub.43                                                                              Me     COOMe        OMe  OMe    CH                                 952  Q.sub.43                                                                              Me     COOEt        Me   OMe    CH                                 953  Q.sub.43                                                                              Me     COOEt        OMe  OMe    CH                                 954  Q.sub.43                                                                              H      H            Me   OMe    CH                                 955  Q.sub.43                                                                              H      H            OMe  OMe    CH                                 956  Me     H      Q.sub.43     Me   OMe    CH                                 957  Me     H      Q.sub.43     OMe  OMe    CH                                 958  Q.sub.44                                                                              H      COOMe        Me   OMe    CH                                 959  Q.sub.44                                                                              H      COOMe        OMe  OMe    CH                                 960  Q.sub.44                                                                              H      COOEt        Me   OMe    CH                                 961  Q.sub.44                                                                              H      COOEt        OMe  OMe    CH                                 962  Q.sub.44                                                                              Me     COOMe        Me   OMe    CH                                 963  Q.sub.44                                                                              Me     COOMe        OMe  OMe    CH                                 964  Q.sub.44                                                                              Me     COOEt        Me   OMe    CH                                 965  Q.sub.44                                                                              Me     COOEt        OMe  OMe    CH                                 966  Q.sub.44                                                                              H      H            Me   OMe    CH                                 967  Q.sub.44                                                                              H      H            OMe  OMe    CH                                 968  Me     H      Q.sub.44     Me   OMe    CH                                 969  Me     H      Q.sub.44     OMe  OMe    CH                                 970  Q.sub.45                                                                              H      COOMe        Me   OMe    CH                                 971  Q.sub.45                                                                              H      COOMe        OMe  OMe    CH                                 972  Q.sub.45                                                                              H      COOEt        Me   OMe    CH                                 973  Q.sub.45                                                                              H      COOEt        OMe  OMe    CH                                 974  Q.sub.45                                                                              Me     COOMe        Me   OMe    CH                                 975  Q.sub.45                                                                              Me     COOMe        OMe  OMe    CH                                 976  Q.sub.45                                                                              Me     COOEt        Me   OMe    CH                                 977  Q.sub.45                                                                              Me     COOEt        OMe  OMe    CH                                 978  Q.sub.45                                                                              H      H            Me   OMe    CH                                 979  Q.sub.45                                                                              H      H            OMe  OMe    CH                                 980  Me     H      Q.sub.45     Me   OMe    CH                                 981  Me     H      Q.sub.45     OMe  OMe    CH                                 982  Q.sub.46                                                                              H      COOMe        Me   OMe    CH                                 983  Q.sub.46                                                                              H      COOMe        OMe  OMe    CH                                 984  Q.sub.46                                                                              H      COOEt        Me   OMe    CH                                 985  Q.sub.46                                                                              H      COOEt        OMe  OMe    CH                                 986  Q.sub.46                                                                              Me     COOMe        Me   OMe    CH                                 987  Q.sub.46                                                                              Me     COOMe        OMe  OMe    CH                                 988  Q.sub.46                                                                              Me     COOEt        Me   OMe    CH                                 989  Q.sub.46                                                                              Me     COOEt        OMe  OMe    CH                                 990  Q.sub.46                                                                              H      H            Me   OMe    CH                                 991  Q.sub.46                                                                              H      H            OMe  OMe    CH                                 992  Me     H      Q.sub.46     Me   OMe    CH                                 993  Me     H      Q.sub.46     OMe  OMe    CH                                 994  Q.sub.47                                                                              H      COOMe        Me   OMe    CH                                 995  Q.sub.47                                                                              H      COOMe        OMe  OMe    CH                                 996  Q.sub.47                                                                              H      COOEt        Me   OMe    CH                                 997  Q.sub.47                                                                              H      COOEt        OMe  OMe    CH                                 998  Q.sub.47                                                                              Me     COOMe        Me   OMe    CH                                 999  Q.sub.47                                                                              Me     COOMe        OMe  OMe    CH                                 1000 Q.sub.47                                                                              Me     COOEt        Me   OMe    CH                                 1001 Q.sub.47                                                                              Me     COOEt        OMe  OMe    CH                                 1002 Q.sub.47                                                                              H      H            Me   OMe    CH                                 1003 Q.sub.47                                                                              H      H            OMe  OMe    CH                                 1004 Me     H      Q.sub.47     Me   OMe    CH                                 1005 Me     H      Q.sub.47     OMe  OMe    CH                                 2001 Q.sub.48                                                                              H      COOMe        Me   Me     CH                                 2002 Q.sub.48                                                                              H      COOMe        Me   OMe    CH                                 2003 Q.sub.48                                                                              H      COOMe        OMe  OMe    CH                                 2004 Q.sub.48                                                                              H      COOEt        Me   OMe    CH                                 2005 Q.sub.48                                                                              H      COOEt        OMe  OMe    CH                                 2006 Q.sub.48                                                                              Me     COOMe        Me   Me     CH                                 2007 Q.sub.48                                                                              Me     COOMe        Me   OMe    CH                                 2008 Q.sub.48                                                                              Me     COOMe        OMe  OMe    CH                                 2009 Q.sub.48                                                                              Me     COOEt        Me   OMe    CH                                 2010 Q.sub.48                                                                              Me     COOEt        OMe  OMe    CH                                 2011 Q.sub.48                                                                              H      H            Me   OMe    CH                                 2012 Q.sub.48                                                                              H      H            OMe  OMe    CH                                 2013 Me     H      Q.sub.48     Me   OMe    CH                                 2014 Me     H      Q.sub.48     OMe  OMe    CH                                 2015 Q.sub.49                                                                              H      COOMe        Me   Me     CH                                 2016 Q.sub.49                                                                              H      COOMe        Me   OMe    CH                                 2017 Q.sub.49                                                                              H      COOMe        OMe  OMe    CH                                 2018 Q.sub.49                                                                              H      COOEt        Me   OMe    CH                                 2019 Q.sub.49                                                                              H      COOEt        OMe  OMe    CH                                 2020 Q.sub.49                                                                              Me     COOMe        Me   Me     CH                                 2021 Q.sub.49                                                                              Me     COOMe        Me   OMe    CH                                 2022 Q.sub.49                                                                              Me     COOMe        OMe  OMe    CH                                 2023 Q.sub.49                                                                              Me     COOEt        Me   OMe    CH                                 2024 Q.sub.49                                                                              Me     COOEt        OMe  OMe    CH                                 2025 Q.sub.49                                                                              H      H            Me   OMe    CH                                 2026 Q.sub.49                                                                              H      H            OMe  OMe    CH                                 2027 Me     H      Q.sub.49     Me   OMe    CH                                 2028 Me     H      Q.sub.49     OMe  OMe    CH                                 2029 Q.sub.50                                                                              H      COOMe        Me   Me     CH                                 2030 Q.sub.50                                                                              H      COOMe        Me   OMe    CH                                 2031 Q.sub.50                                                                              H      COOMe        OMe  OMe    CH                                 2032 Q.sub.50                                                                              H      COOEt        Me   OMe    CH                                 2033 Q.sub.50                                                                              H      COOEt        OMe  OMe    CH                                 2034 Q.sub.50                                                                              Me     COOMe        Me   Me     CH                                 2035 Q.sub.50                                                                              Me     COOMe        Me   OMe    CH                                 2036 Q.sub.50                                                                              Me     COOMe        OMe  OMe    CH                                 2037 Q.sub.50                                                                              Me     COOEt        Me   OMe    CH                                 2038 Q.sub.50                                                                              Me     COOEt        OMe  OMe    CH                                 2039 Q.sub.50                                                                              H      H            Me   OMe    CH                                 2040 Q.sub.50                                                                              H      H            OMe  OMe    CH                                 2041 Me     H      Q.sub.50     Me   OMe    CH                                 2042 Me     H      Q.sub.50     OMe  OMe    CH                                 2043 Q.sub.51                                                                              H      COOMe        Me   Me     CH                                 2044 Q.sub.51                                                                              H      COOMe        Me   OMe    CH                                 2045 Q.sub.51                                                                              H      COOMe        OMe  OMe    CH                                 2046 Q.sub.51                                                                              H      COOEt        Me   OMe    CH                                 2047 Q.sub.51                                                                              H      COOEt        OMe  OMe    CH                                 2048 Q.sub.51                                                                              Me     COOMe        Me   Me     CH                                 2049 Q.sub.51                                                                              Me     COOMe        Me   OMe    CH                                 2050 Q.sub.51                                                                              Me     COOMe        OMe  OMe    CH                                 2051 Q.sub.51                                                                              Me     COOEt        Me   OMe    CH                                 2052 Q.sub.51                                                                              Me     COOEt        OMe  OMe    CH                                 2053 Q.sub.51                                                                              H      H            Me   OMe    CH                                 2054 Q.sub.51                                                                              H      H            OMe  OMe    CH                                 2055 Me     H      Q.sub.51     Me   OMe    CH                                 2056 Me     H      Q.sub.51     OMe  OMe    CH                                 2057 Q.sub.52                                                                              H      COOMe        Me   Me     CH                                 2058 Q.sub.52                                                                              H      COOMe        Me   OMe    CH                                 2059 Q.sub.52                                                                              H      COOMe        OMe  OMe    CH                                 2060 Q.sub.52                                                                              H      COOEt        Me   OMe    CH                                 2061 Q.sub.52                                                                              H      COOEt        OMe  OMe    CH                                 2062 Q.sub.52                                                                              Me     COOMe        Me   Me     CH                                 2063 Q.sub.52                                                                              Me     COOMe        Me   OMe    CH                                 2064 Q.sub.52                                                                              Me     COOMe        OMe  OMe    CH                                 2065 Q.sub.52                                                                              Me     COOEt        Me   OMe    CH                                 2066 Q.sub.52                                                                              Me     COOEt        OMe  OMe    CH                                 2067 Q.sub.52                                                                              H      H            Me   OMe    CH                                 2068 Q.sub.52                                                                              H      H            OMe  OMe    CH                                 2069 Me     H      Q.sub.52     Me   OMe    CH                                 2070 Me     H      Q.sub.52     OMe  OMe    CH                                 2071 Q.sub.53                                                                              H      COOMe        Me   Me     CH                                 2072 Q.sub.53                                                                              H      COOMe        Me   OMe    CH                                 2073 Q.sub.53                                                                              H      COOMe        OMe  OMe    CH                                 2074 Q.sub.53                                                                              H      COOMe        Me   OMe    N                                  2075 Q.sub.53                                                                              H      COOMe        OMe  OMe    N                                  2076 Q.sub.53                                                                              H      COOEt        Me   Me     CH                                 2077 Q.sub.53                                                                              H      COOEt        Me   OMe    CH                                 2078 Q.sub.53                                                                              H      COOEt        OMe  OMe    CH                                 2079 Q.sub.53                                                                              H      COOEt        Me   OMe    N                                  2080 Q.sub.53                                                                              H      COOEt        OMe  OMe    N                                  2081 Q.sub.53                                                                              Me     COOMe        Me   Me     CH                                 2082 Q.sub.53                                                                              Me     COOMe        Me   OMe    CH                                 2083 Q.sub.53                                                                              Me     COOMe        OMe  OMe    CH                                 2084 Q.sub.53                                                                              Me     COOMe        Me   OMe    N                                  2085 Q.sub.53                                                                              Me     COOEt        Me   OMe    CH                                 2086 Q.sub.53                                                                              Me     COOEt        OMe  OMe    CH                                 2087 Q.sub.53                                                                              Me     COOEt        Me   OMe    N                                  2088 Q.sub.53                                                                              H      CN           Me   OMe    CH                                 2089 Q.sub.53                                                                              H      CN           OMe  OMe    CH                                 2090 Q.sub.53                                                                              H      CN           Me   OMe    N                                  2091 Q.sub.53                                                                              H      H            Me   OMe    CH                                 2092 Q.sub.53                                                                              H      H            OMe  OMe    CH                                 2093 Q.sub.53                                                                              H      H            Me   OMe    N                                  2094 Me     H      Q.sub.53     Me   Me     CH                                 2095 Me     H      Q.sub.53     Me   OMe    CH                                 2096 Me     H      Q.sub.53     OMe  OMe    CH                                 2097 Me     H      Q.sub.53     Me   OMe    N                                  2098 Me     H      Q.sub.53     OMe  OMe    N                                  2099 Q.sub.54                                                                              H      COOMe        Me   Me     CH                                 2100 Q.sub.54                                                                              H      COOMe        Me   OMe    CH                                 2101 Q.sub.54                                                                              H      COOMe        OMe  OMe    CH                                 2102 Q.sub.54                                                                              H      COOEt        Me   OMe    CH                                 2103 Q.sub.54                                                                              H      COOEt        OMe  OMe    CH                                 2104 Q.sub.54                                                                              Me     COOMe        Me   Me     CH                                 2105 Q.sub.54                                                                              Me     COOMe        Me   OMe    CH                                 2106 Q.sub.54                                                                              Me     COOMe        OMe  OMe    CH                                 2107 Q.sub.54                                                                              Me     COOEt        Me   OMe    CH                                 2108 Q.sub.54                                                                              Me     COOEt        OMe  OMe    CH                                 2109 Q.sub.54                                                                              H      H            Me   OMe    CH                                 2110 Q.sub.54                                                                              H      H            OMe  OMe    CH                                 2111 Me     H      Q.sub.54     Me   OMe    CH                                 2112 Me     H      Q.sub.54     OMe  OMe    CH                                 2113 Q.sub.55                                                                              H      COOMe        Me   Me     CH                                 2114 Q.sub.55                                                                              H      COOMe        Me   OMe    CH                                 2115 Q.sub.55                                                                              H      COOMe        OMe  OMe    CH                                 2116 Q.sub.55                                                                              H      COOEt        Me   OMe    CH                                 2117 Q.sub.55                                                                              H      COOEt        OMe  OMe    CH                                 2118 Q.sub.55                                                                              Me     COOMe        Me   Me     CH                                 2119 Q.sub.55                                                                              Me     COOMe        Me   OMe    CH                                 2120 Q.sub.55                                                                              Me     COOMe        OMe  OMe    CH                                 2121 Q.sub.55                                                                              Me     COOEt        Me   OMe    CH                                 2122 Q.sub.55                                                                              Me     COOEt        OMe  OMe    CH                                 2123 Q.sub.55                                                                              H      H            Me   OMe    CH                                 2124 Q.sub.55                                                                              H      H            OMe  OMe    CH                                 2125 Me     H      Q.sub.55     Me   OMe    CH                                 2126 Me     H      Q.sub.55     OMe  OMe    CH                                 2127 Q.sub.56                                                                              H      COOMe        Me   Me     CH                                 2128 Q.sub.56                                                                              H      COOMe        Me   OMe    CH                                 2129 Q.sub.56                                                                              H      COOMe        OMe  OMe    CH                                 2130 Q.sub.56                                                                              H      COOEt        Me   OMe    CH                                 2131 Q.sub.56                                                                              H      COOEt        OMe  OMe    CH                                 2132 Q.sub.56                                                                              Me     COOMe        Me   Me     CH                                 2133 Q.sub.56                                                                              Me     COOMe        Me   OMe    CH                                 2134 Q.sub.56                                                                              Me     COOMe        OMe  OMe    CH                                 2135 Q.sub.56                                                                              Me     COOEt        Me   OMe    CH                                 2136 Q.sub.56                                                                              Me     COOEt        OMe  OMe    CH                                 2137 Q.sub.56                                                                              H      H            Me   OMe    CH                                 2138 Q.sub.56                                                                              H      H            OMe  OMe    CH                                 2139 Me     H      Q.sub.56     Me   OMe    CH                                 2140 Me     H      Q.sub.56     OMe  OMe    CH                                 2141 Q.sub.57                                                                              H      COOMe        Me   Me     CH                                 2142 Q.sub.57                                                                              H      COOMe        Me   OMe    CH                                 2143 Q.sub.57                                                                              H      COOMe        OMe  OMe    CH                                 2144 Q.sub.57                                                                              H      COOEt        Me   OMe    CH                                 2145 Q.sub.57                                                                              H      COOEt        OMe  OMe    CH                                 2146 Q.sub.57                                                                              Me     COOMe        Me   Me     CH                                 2147 Q.sub.57                                                                              Me     COOMe        Me   OMe    CH                                 2148 Q.sub.57                                                                              Me     COOMe        OMe  OMe    CH                                 2149 Q.sub.57                                                                              Me     COOEt        Me   OMe    CH                                 2150 Q.sub.57                                                                              Me     COOEt        OMe  OMe    CH                                 2151 Q.sub.57                                                                              H      H            Me   OMe    CH                                 2152 Q.sub.57                                                                              H      H            OMe  OMe    CH                                 2153 Me     H      Q.sub.57     Me   OMe    CH                                 2154 Me     H      Q.sub.57     OMe  OMe    C                                  2155 Q.sub.58                                                                              H      COOMe        Me   Me     CH                                 2156 Q.sub.58                                                                              H      COOMe        Me   OMe    CH                                 2157 Q.sub.58                                                                              H      COOMe        OMe  OMe    CH                                 2158 Q.sub.58                                                                              H      COOEt        Me   OMe    CH                                 2159 Q.sub.58                                                                              H      COOEt        OMe  OMe    CH                                 2160 Q.sub.58                                                                              Me     COOMe        Me   Me     CH                                 2161 Q.sub.58                                                                              Me     COOMe        Me   OMe    CH                                 2162 Q.sub.58                                                                              Me     COOMe        OMe  OMe    CH                                 2163 Q.sub.58                                                                              Me     COOEt        Me   OMe    CH                                 2164 Q.sub.58                                                                              Me     COOEt        OMe  OMe    CH                                 2165 Q.sub.58                                                                              H      H            Me   OMe    CH                                 2166 Q.sub.58                                                                              H      H            OMe  OMe    CH                                 2167 Me     H      Q.sub.58     Me   OMe    CH                                 2168 Me     H      Q.sub.58     OMe  OMe    CH                                 2169 Q.sub.59                                                                              H      COOMe        Me   Me     CH                                 2170 Q.sub.59                                                                              H      COOMe        Me   OMe    CH                                 2171 Q.sub.59                                                                              H      COOMe        OMe  OMe    CH                                 2172 Q.sub.59                                                                              H      COOEt        Me   OMe    CH                                 2173 Q.sub.59                                                                              H      COOEt        OMe  OMe    CH                                 2174 Q.sub.59                                                                              Me     COOMe        Me   Me     CH                                 2175 Q.sub.59                                                                              Me     COOMe        Me   OMe    CH                                 2176 Q.sub.59                                                                              Me     COOMe        OMe  OMe    CH                                 2177 Q.sub.59                                                                              Me     COOEt        Me   OMe    CH                                 2178 Q.sub.59                                                                              Me     COOEt        OMe  OMe    CH                                 2179 Q.sub.59                                                                              H      H            Me   OMe    CH                                 2180 Q.sub.59                                                                              H      H            OMe  OMe    CH                                 2181 Me     H      Q.sub.59     Me   OMe    CH                                 2182 Me     H      Q.sub.59     OMe  OMe    CH                                 2183 Q.sub.60                                                                              H      COOMe        Me   Me     CH                                 2184 Q.sub.60                                                                              H      COOMe        Me   OMe    CH                                 2185 Q.sub.60                                                                              H      COOMe        OMe  OMe    CH                                 2186 Q.sub.60                                                                              H      COOMe        Me   OMe    N                                  2187 Q.sub.60                                                                              H      COOMe        OMe  OMe    N                                  2188 Q.sub.60                                                                              H      COOEt        Me   Me     CH                                 2189 Q.sub.60                                                                              H      COOEt        Me   OMe    CH                                 2190 Q.sub.60                                                                              H      COOEt        OMe  OMe    CH                                 2191 Q.sub.60                                                                              H      COOEt        Me   OMe    N                                  2192 Q.sub.60                                                                              H      COOEt        OMe  OMe    N                                  2193 Q.sub.60                                                                              Me     COOMe        Me   Me     CH                                 2194 Q.sub.60                                                                              Me     COOMe        Me   OMe    CH                                 2195 Q.sub.60                                                                              Me     COOMe        OMe  OMe    CH                                 2196 Q.sub.60                                                                              Me     COOMe        Me   OMe    N                                  2197 Q.sub.60                                                                              Me     COOEt        Me   OMe    CH                                 2198 Q.sub.60                                                                              Me     COOEt        OMe  OMe    CH                                 2199 Q.sub.60                                                                              Me     COOEt        Me   OMe    N                                  2200 Q.sub.60                                                                              H      CN           Me   OMe    CH                                 2201 Q.sub.60                                                                              H      CN           OMe  OMe    CH                                 2202 Q.sub.60                                                                              H      CN           Me   OMe    N                                  2203 Q.sub.60                                                                              H      H            Me   OMe    CH                                 2204 Q.sub.60                                                                              H      H            OMe  OMe    CH                                 2205 Q.sub.60                                                                              H      H            Me   OMe    N                                  2206 Me     H      Q.sub.60     Me   Me     CH                                 2207 Me     H      Q.sub.60     Me   OMe    CH                                 2208 Me     H      Q.sub.60     OMe  OMe    CH                                 2209 Me     H      Q.sub.60     Me   OMe    N                                  2210 Me     H      Q.sub.60     OMe  OMe    N                                  2211 Q.sub.61                                                                              H      COOMe        Me   Me     CH                                 2212 Q.sub.61                                                                              H      COOMe        Me   OMe    CH                                 2213 Q.sub.61                                                                              H      COOMe        OMe  OMe    CH                                 2214 Q.sub.61                                                                              H      COOEt        Me   OMe    CH                                 2215 Q.sub.61                                                                              H      COOEt        OMe  OMe    CH                                 2216 Q.sub.61                                                                              Me     COOMe        Me   Me     CH                                 2217 Q.sub.61                                                                              Me     COOMe        Me   OMe    CH                                 2218 Q.sub.61                                                                              Me     COOMe        OMe  OMe    CH                                 2219 Q.sub.61                                                                              Me     COOEt        Me   OMe    CH                                 2220 Q.sub.61                                                                              Me     COOEt        OMe  OMe    CH                                 2221 Q.sub.61                                                                              H      H            Me   OMe    CH                                 2222 Q.sub.61                                                                              H      H            OMe  OMe    CH                                 2223 Me     H      Q.sub.61     Me   OMe    CH                                 2234 Me     H      Q.sub.61     OMe  OMe    CH                                 2225 Q.sub.62                                                                              H      COOMe        Me   Me     CH                                 2226 Q.sub.62                                                                              H      COOMe        Me   OMe    CH                                 2227 Q.sub.62                                                                              H      COOMe        OMe  OMe    CH                                 2228 Q.sub.62                                                                              H      COOEt        Me   OMe    CH                                 2229 Q.sub.62                                                                              H      COOEt        OMe  OMe    CH                                 2230 Q.sub.62                                                                              Me     COOMe        Me   Me     CH                                 2231 Q.sub.62                                                                              Me     COOMe        Me   OMe    CH                                 2232 Q.sub.62                                                                              Me     COOMe        OMe  OMe    CH                                 2233 Q.sub.62                                                                              Me     COOEt        Me   OMe    CH                                 2234 Q.sub.62                                                                              Me     COOEt        OMe  OMe    CH                                 2235 Q.sub.62                                                                              H      H            Me   OMe    CH                                 2236 Q.sub.62                                                                              H      H            OMe  OMe    CH                                 2237 Me     H      Q.sub.62     Me   OMe    CH                                 2238 Me     H      Q.sub.62     OMe  OMe    CH                                 2239 Q.sub.63                                                                              H      COOMe        Me   Me     CH                                 2240 Q.sub.63                                                                              H      COOMe        Me   OMe    CH                                 2241 Q.sub.63                                                                              H      COOMe        OMe  OMe    CH                                 2242 Q.sub.63                                                                              H      COOEt        Me   OMe    CH                                 2243 Q.sub.63                                                                              H      COOEt        OMe  OMe    CH                                 2244 Q.sub.63                                                                              Me     COOMe        Me   Me     CH                                 2245 Q.sub.63                                                                              Me     COOMe        Me   OMe    CH                                 2246 Q.sub.63                                                                              Me     COOMe        OMe  OMe    CH                                 2247 Q.sub.63                                                                              Me     COOEt        Me   OMe    CH                                 2248 Q.sub.63                                                                              Me     COOEt        OMe  OMe    CH                                 2249 Q.sub.63                                                                              H      H            Me   OMe    CH                                 2250 Q.sub.63                                                                              H      H            OMe  OMe    CH                                 2251 Me     H      Q.sub.63     Me   OMe    CH                                 2252 Me     H      Q.sub.63     OMe  OMe    CH                                 2253 Q.sub.64                                                                              H      COOMe        Me   Me     CH                                 2254 Q.sub.64                                                                              H      COOMe        Me   OMe    CH                                 2255 Q.sub.64                                                                              H      COOMe        OMe  OMe    CH                                 2256 Q.sub.64                                                                              H      COOEt        Me   OMe    CH                                 2257 Q.sub.64                                                                              H      COOEt        OMe  OMe    CH                                 2258 Q.sub.64                                                                              Me     COOMe        Me   Me     CH                                 2259 Q.sub.64                                                                              Me     COOMe        Me   OMe    CH                                 2260 Q.sub.64                                                                              Me     COOMe        OMe  OMe    CH                                 2261 Q.sub.64                                                                              Me     COOEt        Me   OMe    CH                                 2262 Q.sub.64                                                                              Me     COOEt        OMe  OMe    CH                                 2263 Q.sub.64                                                                              H      H            Me   OMe    CH                                 2264 Q.sub.64                                                                              H      H            OMe  OMe    CH                                 2265 Me     H      Q.sub.64     Me   OMe    CH                                 2266 Me     H      Q.sub.64     OMe  OMe    CH                                 2267 Q.sub.65                                                                              H      COOMe        Me   Me     CH                                 2268 Q.sub.65                                                                              H      COOMe        Me   OMe    CH                                 2269 Q.sub.65                                                                              H      COOMe        OMe  OMe    CH                                 2270 Q.sub.65                                                                              H      COOMe        Me   OMe    N                                  2271 Q.sub.65                                                                              H      COOMe        OMe  OMe    N                                  2272 Q.sub.65                                                                              H      COOEt        Me   Me     CH                                 2273 Q.sub.65                                                                              H      COOEt        Me   OMe    CH                                 2274 Q.sub.65                                                                              H      COOEt        OMe  OMe    CH                                 2275 Q.sub.65                                                                              H      COOEt        Me   OMe    N                                  2276 Q.sub.65                                                                              H      COOEt        OMe  OMe    N                                  2277 Q.sub.65                                                                              Me     COOMe        Me   Me     CH                                 2278 Q.sub.65                                                                              Me     COOMe        Me   OMe    CH                                 2279 Q.sub.65                                                                              Me     COOMe        OMe  OMe    CH                                 2280 Q.sub.65                                                                              Me     COOMe        Me   OMe    N                                  2281 Q.sub.65                                                                              Me     COOEt        Me   OMe    CH                                 2282 Q.sub.65                                                                              Me     COOEt        OMe  OMe    CH                                 2283 Q.sub. 65                                                                             Me     COOEt        Me   OMe    N                                  2284 Q.sub.65                                                                              H      CN           Me   OMe    CH                                 2285 Q.sub.65                                                                              H      CN           OMe  OMe    CH                                 2286 Q.sub.65                                                                              H      CN           Me   OMe    N                                  2287 Q.sub.65                                                                              H      H            Me   OMe    CH                                 2288 Q.sub.65                                                                              H      H            OMe  OMe    CH                                 2289 Q.sub.65                                                                              H      H            Me   OMe    N                                  2290 Me     H      Q.sub.65     Me   Me     CH                                 2291 Me     H      Q.sub.65     Me   OMe    CH                                 2292 Me     H      Q.sub.65     OMe  OMe    CH                                 2293 Me     H      Q.sub.65     Me   OMe    N                                  2294 Me     H      Q.sub.65     OMe  OMe    N                                  2295 Q.sub.66                                                                              H      COOMe        Me   Me     CH                                 2296 Q.sub.66                                                                              H      COOMe        Me   OMe    CH                                 2297 Q.sub.66                                                                              H      COOMe        OMe  OMe    CH                                 2298 Q.sub.66                                                                              H      COOEt        Me   OMe    CH                                 2299 Q.sub.66                                                                              H      COOEt        OMe  OMe    CH                                 2300 Q.sub.66                                                                              Me     COOMe        Me   Me     CH                                 2301 Q.sub.66                                                                              Me     COOMe        Me   OMe    CH                                 2302 Q.sub.66                                                                              Me     COOMe        OMe  OMe    CH                                 2303 Q.sub.66                                                                              Me     COOEt        Me   OMe    CH                                 2304 Q.sub.66                                                                              Me     COOEt        OMe  OMe    CH                                 2305 Q.sub.66                                                                              H      H            Me   OMe    CH                                 2306 Q.sub.66                                                                              H      H            OMe  OMe    CH                                 2307 Me     H      Q.sub.66     Me   OMe    CH                                 2308 Me     H      Q.sub.66     OMe  OMe    CH                                 2309 Q.sub.67                                                                              H      COOMe        Me   Me     CH                                 2310 Q.sub.67                                                                              H      COOMe        Me   OMe    CH                                 2311 Q.sub.67                                                                              H      COOMe        OMe  OMe    CH                                 2312 Q.sub.67                                                                              H      COOEt        Me   OMe    CH                                 2313 Q.sub.67                                                                              H      COOEt        OMe  OMe    CH                                 2314 Q.sub.67                                                                              Me     COOMe        Me   Me     CH                                 2315 Q.sub.67                                                                              Me     COOMe        Me   OMe    CH                                 2316 Q.sub.67                                                                              Me     COOMe        OMe  OMe    CH                                 2317 Q.sub.67                                                                              Me     COOEt        Me   OMe    CH                                 2318 Q.sub.67                                                                              Me     COOEt        OMe  OMe    CH                                 2319 Q.sub.67                                                                              H      H            Me   OMe    CH                                 2320 Q.sub.67                                                                              H      H            OMe  OMe    CH                                 2321 Me     H      Q.sub.67     Me   OMe    CH                                 2322 Me     H      Q.sub.67     OMe  OMe    CH                                 2323 Q.sub.68                                                                              H      COOMe        Me   Me     CH                                 2324 Q.sub.68                                                                              H      COOMe        Me   OMe    CH                                 2325 Q.sub.68                                                                              H      COOMe        OMe  OMe    CH                                 2326 Q.sub.68                                                                              H      COOMe        Me   OMe    N                                  2327 Q.sub.68                                                                              H      COOMe        OMe  OMe    N                                  2328 Q.sub.68                                                                              H      COOEt        Me   Me     CH                                 2329 Q.sub.68                                                                              H      COOEt        Me   OMe    CH                                 2330 Q.sub.68                                                                              H      COOEt        OMe  OMe    CH                                 2331 Q.sub.68                                                                              H      COOEt        Me   OMe    N                                  2332 Q.sub.68                                                                              H      COOEt        OMe  OMe    N                                  2333 Q.sub.68                                                                              Me     COOMe        Me   Me     CH                                 2334 Q.sub.68                                                                              Me     COOMe        Me   OMe    CH                                 2335 Q.sub.68                                                                              Me     COOMe        OMe  OMe    CH                                 2336 Q.sub.68                                                                              Me     COOMe        Me   OMe    N                                  2337 Q.sub.68                                                                              Me     COOEt        Me   OMe    CH                                 2338 Q.sub.68                                                                              Me     COOEt        OMe  OMe    CH                                 2339 Q.sub.68                                                                              Me     COOEt        Me   OMe    N                                  2340 Q.sub.68                                                                              H      CN           Me   OMe    CH                                 2341 Q.sub.68                                                                              H      CN           OMe  OMe    CH                                 2342 Q.sub.68                                                                              H      CN           Me   OMe    N                                  2343 Q.sub.68                                                                              H      H            Me   OMe    CH                                 2344 Q.sub.68                                                                              H      H            OMe  OMe    CH                                 2345 Q.sub.68                                                                              H      H            Me   OMe    N                                  2346 Me     H      Q.sub.68     Me   Me     CH                                 2347 Me     H      Q.sub.68     Me   OMe    CH                                 2348 Me     H      Q.sub.68     OMe  OMe    CH                                 2349 Me     H      Q.sub.68     Me   OMe    N                                  2350 Me     H      Q.sub.68     OMe  OMe    N                                  2351 Q.sub.69                                                                              H      COOMe        Me   Me     CH                                 2352 Q.sub.69                                                                              H      COOMe        Me   OMe    CH                                 2353 Q.sub.69                                                                              H      COOMe        OMe  OMe    CH                                 2354 Q.sub.69                                                                              H      COOEt        Me   OMe    CH                                 2355 Q.sub.69                                                                              H      COOEt        OMe  OMe    CH                                 2356 Q.sub.69                                                                              Me     COOMe        Me   Me     CH                                 2357 Q.sub.69                                                                              Me     COOMe        Me   OMe    CH                                 2358 Q.sub.69                                                                              Me     COOMe        OMe  OMe    CH                                 2359 Q.sub.69                                                                              Me     COOEt        Me   OMe    CH                                 2360 Q.sub.69                                                                              Me     COOEt        OMe  OMe    CH                                 2361 Q.sub.69                                                                              H      H            Me   OMe    CH                                 2362 Q.sub.69                                                                              H      H            OMe  OMe    CH                                 2363 Me     H      Q.sub.69     Me   OMe    CH                                 2364 Me     H      Q.sub.69     OMe  OMe    CH                                 2365 Q.sub.70                                                                              H      COOMe        Me   Me     CH                                 2366 Q.sub.70                                                                              H      COOMe        Me   OMe    CH                                 2367 Q.sub.70                                                                              H      COOMe        OMe  OMe    CH                                 2368 Q.sub.70                                                                              H      COOEt        Me   OMe    CH                                 2369 Q.sub.70                                                                              H      COOEt        OMe  OMe    CH                                 2370 Q.sub.70                                                                              Me     COOMe        Me   Me     CH                                 2371 Q.sub.70                                                                              Me     COOMe        Me   OMe    CH                                 2372 Q.sub.70                                                                              Me     COOMe        OMe  OMe    CH                                 2373 Q.sub.70                                                                              Me     COOEt        Me   OMe    CH                                 2374 Q.sub.70                                                                              Me     COOEt        OMe  OMe    CH                                 2375 Q.sub.70                                                                              H      H            Me   OMe    CH                                 2376 Q.sub.70                                                                              H      H            OMe  OMe    CH                                 2377 Me     H      Q.sub.70     Me   OMe    CH                                 2378 Me     H      Q.sub.70     OMe  OMe    CH                                 2379 Q.sub.71                                                                              H      COOMe        Me   Me     CH                                 2380 Q.sub.71                                                                              H      COOMe        Me   OMe    CH                                 2381 Q.sub.71                                                                              H      COOMe        OMe  OMe    CH                                 2382 Q.sub.71                                                                              H      COOMe        Me   OMe    N                                  2383 Q.sub.71                                                                              H      COOMe        OMe  OMe    N                                  2384 Q.sub.71                                                                              H      COOEt        Me   Me     CH                                 2385 Q.sub.71                                                                              H      COOEt        Me   OMe    CH                                 2386 Q.sub.71                                                                              H      COOEt        OMe  OMe    CH                                 2387 Q.sub.71                                                                              H      COOEt        Me   OMe    N                                  2388 Q.sub.71                                                                              H      COOEt        OMe  OMe    N                                  2389 Q.sub.71                                                                              Me     COOMe        Me   Me     CH                                 2390 Q.sub.71                                                                              Me     COOMe        Me   OMe    CH                                 2391 Q.sub.71                                                                              Me     COOMe        OMe  OMe    CH                                 2392 Q.sub.71                                                                              Me     COOMe        Me   OMe    N                                  2393 Q.sub.71                                                                              Me     COOEt        Me   OMe    CH                                 2394 Q.sub.71                                                                              Me     COOEt        OMe  OMe    CH                                 2395 Q.sub.71                                                                              Me     COOEt        Me   OMe    N                                  2396 Q.sub.71                                                                              H      CN           Me   OMe    CH                                 2397 Q.sub.71                                                                              H      CN           OMe  OMe    CH                                 2398 Q.sub.71                                                                              H      CN           Me   OMe    N                                  2399 Q.sub.71                                                                              H      H            Me   OMe    CH                                 2400 Q.sub.71                                                                              H      H            OMe  OMe    CH                                 2401 Q.sub.71                                                                              H      H            Me   OMe    N                                  2402 Me     H      Q.sub.71     Me   Me     CH                                 2403 Me     H      Q.sub.71     Me   OMe    CH                                 2404 Me     H      Q.sub.71     OMe  OMe    CH                                 2405 Me     H      Q.sub.71     Me   OMe    N                                  2406 Me     H      Q.sub.71     OMe  OMe    N                                  2407 Q.sub.72                                                                              H      COOMe        Me   Me     CH                                 2408 Q.sub.72                                                                              H      COOMe        Me   OMe    CH                                 2409 Q.sub.72                                                                              H      COOMe        OMe  OMe    CH                                 2410 Q.sub.72                                                                              H      COOEt        Me   OMe    CH                                 2411 Q.sub.72                                                                              H      COOEt        OMe  OMe    CH                                 2412 Q.sub.72                                                                              Me     COOMe        Me   Me     CH                                 2413 Q.sub.72                                                                              Me     COOMe        Me   OMe    CH                                 2414 Q.sub.72                                                                              Me     COOMe        OMe  OMe    CH                                 2415 Q.sub.72                                                                              Me     COOEt        Me   OMe    CH                                 2416 Q.sub.72                                                                              Me     COOEt        OMe  OMe    CH                                 2417 Q.sub.72                                                                              H      H            Me   OMe    CH                                 2418 Q.sub.72                                                                              H      H            OMe  OMe    CH                                 2419 Me     H      Q.sub.72     Me   OMe    CH                                 2420 Me     H      Q.sub.72     OMe  OMe    CH                                 2421 Q.sub.73                                                                              H      COOMe        Me   Me     CH                                 2422 Q.sub.73                                                                              H      COOMe        Me   OMe    CH                                 2423 Q.sub.73                                                                              H      COOMe        OMe  OMe    CH                                 2424 Q.sub.73                                                                              H      COOEt        Me   OMe    CH                                 2425 Q.sub.73                                                                              H      COOEt        OMe  OMe    CH                                 2426 Q.sub.73                                                                              Me     COOMe        Me   Me     CH                                 2427 Q.sub.73                                                                              Me     COOMe        Me   OMe    CH                                 2428 Q.sub.73                                                                              Me     COOMe        OMe  OMe    CH                                 2429 Q.sub.73                                                                              Me     COOEt        Me   OMe    CH                                 2430 Q.sub.73                                                                              Me     COOEt        OMe  OMe    CH                                 2431 Q.sub.73                                                                              H      H            Me   OMe    CH                                 2432 Q.sub.73                                                                              H      H            OMe  OMe    CH                                 2433 Me     H      Q.sub.73     Me   OMe    CH                                 2434 Me     H      Q.sub.73     OMe  OMe    CH                                 2435 Q.sub.74                                                                              H      COOMe        Me   Me     CH                                 2436 Q.sub.74                                                                              H      COOMe        Me   OMe    CH                                 2437 Q.sub.74                                                                              H      COOMe        OMe  OMe    CH                                 2438 Q.sub.74                                                                              H      COOEt        Me   OMe    CH                                 2439 Q.sub.74                                                                              H      COOEt        OMe  OMe    CH                                 2440 Q.sub.74                                                                              Me     COOMe        Me   Me     CH                                 2441 Q.sub.74                                                                              Me     COOMe        Me   OMe    CH                                 2442 Q.sub.74                                                                              Me     COOMe        OMe  OMe    CH                                 2443 Q.sub.74                                                                              Me     COOEt        Me   OMe    CH                                 2444 Q.sub.74                                                                              Me     COOEt        OMe  OMe    CH                                 2445 Q.sub.74                                                                              H      H            Me   OMe    CH                                 2446 Q.sub.74                                                                              H      H            OMe  OMe    CH                                 2447 Me     H      Q.sub.74     Me   OMe    CH                                 2448 Me     H      Q.sub.74     OMe  OMe    CH                                 2449 Q.sub.75                                                                              H      COOMe        Me   Me     CH                                 2450 Q.sub.75                                                                              H      COOMe        Me   OMe    CH                                 2451 Q.sub.75                                                                              H      COOMe        OMe  OMe    CH                                 2452 Q.sub.75                                                                              H      COOEt        OMe  OMe    CH                                 2453 Q.sub.75                                                                              H      COOEt        OMe  OMe    CH                                 2454 Q.sub.75                                                                              Me     COOMe        Me   Me     CH                                 2455 Q.sub.75                                                                              Me     COOMe        Me   OMe    CH                                 2456 Q.sub.75                                                                              Me     COOMe        OMe  OMe    CH                                 2457 Q.sub.75                                                                              Me     COOEt        Me   OMe    CH                                 2458 Q.sub.75                                                                              Me     COOEt        OMe  OMe    CH                                 2459 Q.sub.75                                                                              H      H            Me   OMe    CH                                 2460 Q.sub.75                                                                              H      H            OMe  OMe    CH                                 2461 Me     H      Q.sub.75     Me   OMe    CH                                 2462 Me     H      Q.sub.75     OMe  OMe    CH                                 2463 Q.sub.76                                                                              H      COOMe        Me   Me     CH                                 2464 Q.sub.76                                                                              H      COOMe        Me   OMe    CH                                 2465 Q.sub.76                                                                              H      COOMe        OMe  OMe    CH                                 2466 Q.sub.76                                                                              H      COOEt        Me   OMe    CH                                 2467 Q.sub.76                                                                              H      COOEt        OMe  OMe    CH                                 2468 Q.sub.76                                                                              Me     COOMe        Me   Me     CH                                 2469 Q.sub.76                                                                              Me     COOMe        Me   OMe    CH                                 2470 Q.sub.76                                                                              Me     COOMe        OMe  OMe    CH                                 2471 Q.sub.76                                                                              Me     COOEt        Me   OMe    CH                                 2472 Q.sub.76                                                                              Me     COOEt        OMe  OMe    CH                                 2473 Q.sub.76                                                                              H      H            Me   OMe    CH                                 2474 Q.sub.76                                                                              H      H            OMe  OMe    CH                                 2475 Me     H      Q.sub.76     Me   OMe    CH                                 2476 Me     H      Q.sub.76     OMe  OMe    CH                                 2477 Q.sub.77                                                                              H      COOMe        Me   Me     CH                                 2478 Q.sub.77                                                                              H      COOMe        Me   OMe    CH                                 2479 Q.sub.77                                                                              H      COOMe        OMe  OMe    CH                                 2480 Q.sub.77                                                                              H      COOEt        OMe  OMe    CH                                 2481 Q.sub.77                                                                              H      COOEt        OMe  OMe    CH                                 2482 Q.sub.77                                                                              Me     COOMe        Me   Me     CH                                 2483 Q.sub. 77                                                                             Me     COOMe        Me   OMe    CH                                 2484 Q.sub.77                                                                              Me     COOMe        OMe  OMe    CH                                 2485 Q.sub.77                                                                              Me     COOEt        Me   OMe    CH                                 2486 Q.sub.77                                                                              Me     COOEt        OMe  OMe    CH                                 2487 Q.sub.77                                                                              H      H            Me   OMe    CH                                 2488 Q.sub.77                                                                              H      H            OMe  OMe    CH                                 2489 Me     H      Q.sub.77     Me   OMe    CH                                 2490 Me     H      Q.sub.77     OMe  OMe    CH                                 2491 Q.sub.78                                                                              H      COOMe        Me   Me     CH                                 2492 Q.sub.78                                                                              H      COOMe        Me   OMe    CH                                 2493 Q.sub.78                                                                              H      COOMe        OMe  OMe    CH                                 2494 Q.sub.78                                                                              H      COOEt        OMe  OMe    CH                                 2495 Q.sub.78                                                                              H      COOEt        OMe  OMe    CH                                 2496 Q.sub.78                                                                              Me     COOMe        Me   Me     CH                                 2497 Q.sub.78                                                                              Me     COOMe        Me   OMe    CH                                 2498 Q.sub.78                                                                              Me     COOMe        OMe  OMe    CH                                 2499 Q.sub.78                                                                              Me     COOEt        Me   OMe    CH                                 2500 Q.sub.78                                                                              Me     COOEt        OMe  OMe    CH                                 2501 Q.sub.78                                                                              H      H            Me   OMe    CH                                 2502 Q.sub.78                                                                              H      H            OMe  OMe    CH                                 2503 Me     H      Q.sub.78     Me   OMe    CH                                 2504 Me     H      Q.sub.78     OMe  OMe    CH                                 2505 Q.sub.79                                                                              H      COOMe        Me   Me     CH                                 2506 Q.sub.79                                                                              H      COOMe        Me   OMe    CH                                 2507 Q.sub.79                                                                              H      COOMe        OMe  OMe    CH                                 2508 Q.sub.79                                                                              H      COOEt        Me   OMe    CH                                 2509 Q.sub.79                                                                              H      COOEt        OMe  OMe    CH                                 2510 Q.sub.79                                                                              Me     COOMe        Me   Me     CH                                 2511 Q.sub.79                                                                              Me     COOMe        Me   OMe    CH                                 2512 Q.sub.79                                                                              Me     COOMe        OMe  OMe    CH                                 2513 Q.sub.79                                                                              Me     COOEt        Me   OMe    CH                                 2514 Q.sub.79                                                                              Me     COOEt        OMe  OMe    CH                                 2515 Q.sub.79                                                                              H      H            Me   OMe    CH                                 2516 Q.sub.79                                                                              H      H            OMe  OMe    CH                                 2517 Me     H      Q.sub.79     Me   OMe    CH                                 2518 Me     H      Q.sub.79     OMe  OMe    CH                                 2519 Q.sub.80                                                                              H      COOMe        Me   Me     CH                                 2520 Q.sub.80                                                                              H      COOMe        Me   OMe    CH                                 2521 Q.sub.80                                                                              H      COOMe        OMe  OMe    CH                                 2522 Q.sub.80                                                                              H      COOEt        Me   OMe    CH                                 2523 Q.sub.80                                                                              H      COOEt        OMe  OMe    CH                                 2524 Q.sub.80                                                                              Me     COOMe        Me   Me     CH                                 2525 Q.sub.80                                                                              Me     COOMe        Me   OMe    CH                                 2526 Q.sub.80                                                                              Me     COOMe        OMe  OMe    CH                                 2527 Q.sub.80                                                                              Me     COOEt        Me   OMe    CH                                 2528 Q.sub.80                                                                              Me     COOEt        OMe  OMe    CH                                 2529 Q.sub.80                                                                              H      H            Me   OMe    CH                                 2530 Q.sub.80                                                                              H      H            OMe  OMe    CH                                 2531 Me     H      Q.sub.80     Me   OMe    CH                                 2532 Me     H      Q.sub.80     OMe  OMe    CH                                 2533 Q.sub.81                                                                              H      COOMe        Me   Me     CH                                 2534 Q.sub.81                                                                              H      COOMe        Me   OMe    CH                                 2535 Q.sub.81                                                                              H      COOMe        OMe  OMe    CH                                 2536 Q.sub.81                                                                              H      COOEt        Me   OMe    CH                                 2537 Q.sub.81                                                                              H      COOEt        OMe  OMe    CH                                 2538 Q.sub.81                                                                              Me     COOMe        Me   Me     CH                                 2539 Q.sub.81                                                                              Me     COOMe        Me   OMe    CH                                 2540 Q.sub.81                                                                              Me     COOMe        OMe  OMe    CH                                 2541 Q.sub.81                                                                              Me     COOEt        Me   OMe    CH                                 2542 Q.sub.81                                                                              Me     COOEt        OMe  OMe    CH                                 2543 Q.sub.81                                                                              H      H            Me   OMe    CH                                 2544 Q.sub.81                                                                              H      H            OMe  OMe    CH                                 2545 Me     H      Q.sub.81     Me   OMe    CH                                 2546 Me     H      Q.sub.81     OMe  OMe    CH                                 2547 Q.sub.82                                                                              H      COOMe        Me   Me     CH                                 2548 Q.sub.82                                                                              H      COOMe        Me   OMe    CH                                 2549 Q.sub.82                                                                              H      COOMe        OMe  OMe    CH                                 2550 Q.sub.82                                                                              H      COOEt        Me   OMe    CH                                 2551 Q.sub.82                                                                              H      COOEt        OMe  OMe    CH                                 2552 Q.sub.82                                                                              Me     COOMe        Me   Me     CH                                 2553 Q.sub.82                                                                              Me     COOMe        Me   OMe    CH                                 2554 Q.sub.82                                                                              Me     COOMe        OMe  OMe    CH                                 2555 Q.sub.82                                                                              Me     COOEt        Me   OMe    CH                                 2556 Q.sub.82                                                                              Me     COOEt        OMe  OMe    CH                                 2557 Q.sub.82                                                                              H      H            Me   OMe    CH                                 2558 Q.sub.82                                                                              H      H            OMe  OMe    CH                                 2559 Me     H      Q.sub.82     Me   OMe    CH                                 2560 Me     H      Q.sub.82     OMe  OMe    CH                                 2561 Q.sub.83                                                                              H      COOMe        Me   Me     CH                                 2562 Q.sub.83                                                                              H      COOMe        Me   OMe    CH                                 2563 Q.sub.83                                                                              H      COOMe        OMe  OMe    CH                                 2564 Q.sub.83                                                                              H      COOEt        Me   OMe    CH                                 2565 Q.sub.83                                                                              H      COOEt        OMe  OMe    CH                                 2566 Q.sub.83                                                                              Me     COOMe        Me   Me     CH                                 2567 Q.sub.83                                                                              Me     COOMe        Me   OMe    CH                                 2568 Q.sub.83                                                                              Me     COOMe        OMe  OMe    CH                                 2569 Q.sub.83                                                                              Me     COOEt        Me   OMe    CH                                 2570 Q.sub.83                                                                              Me     COOEt        OMe  OMe    CH                                 2571 Q.sub.83                                                                              H      H            Me   OMe    CH                                 2572 Q.sub.83                                                                              H      H            OMe  OMe    CH                                 2573 Me     H      Q.sub.83     Me   OMe    CH                                 2574 Me     H      Q.sub.83     OMe  OMe    CH                                 2575 Q.sub.84                                                                              H      COOMe        Me   Me     CH                                 2576 Q.sub.84                                                                              H      COOMe        Me   OMe    CH                                 2577 Q.sub.84                                                                              H      COOMe        OMe  OMe    CH                                 2578 Q.sub.84                                                                              H      COOEt        Me   OMe    CH                                 2579 Q.sub.84                                                                              H      COOEt        OMe  OMe    CH                                 2580 Q.sub.84                                                                              Me     COOMe        Me   Me     CH                                 2581 Q.sub.84                                                                              Me     COOMe        Me   OMe    CH                                 2582 Q.sub.84                                                                              Me     COOMe        OMe  OMe    CH                                 2583 Q.sub.84                                                                              Me     COOEt        Me   OMe    CH                                 2584 Q.sub.84                                                                              Me     COOEt        OMe  OMe    CH                                 2585 Q.sub.84                                                                              H      H            Me   OMe    CH                                 2586 Q.sub.84                                                                              H      H            OMe  OMe    CH                                 2587 Me     H      Q.sub.84     Me   OMe    CH                                 2588 Me     H      Q.sub.84     OMe  OMe    CH                                 2589 Q.sub.85                                                                              H      COOMe        Me   Me     CH                                 2590 Q.sub.85                                                                              H      COOMe        Me   OMe    CH                                 2591 Q.sub.85                                                                              H      COOMe        OMe  OMe    CH                                 2592 Q.sub.85                                                                              H      COOEt        Me   OMe    CH                                 2593 Q.sub.85                                                                              H      COOEt        OMe  OMe    CH                                 2594 Q.sub.85                                                                              Me     COOMe        Me   Me     CH                                 2595 Q.sub.85                                                                              Me     COOMe        Me   OMe    CH                                 2596 Q.sub.85                                                                              Me     COOMe        OMe  OMe    CH                                 2597 Q.sub.85                                                                              Me     COOEt        Me   OMe    CH                                 2598 Q.sub.85                                                                              Me     COOEt        OMe  OMe    CH                                 2599 Q.sub.85                                                                              H      H            Me   OMe    CH                                 2600 Q.sub.85                                                                              H      H            OMe  OMe    CH                                 2601 Me     H      Q.sub.85     Me   OMe    CH                                 2602 Me     H      Q.sub.85     OMe  OMe    CH                                 2603 Q.sub.86                                                                              H      COOMe        Me   Me     CH                                 2604 Q.sub.86                                                                              H      COOMe        Me   OMe    CH                                 2605 Q.sub.86                                                                              H      COOMe        OMe  OMe    CH                                 2606 Q.sub.86                                                                              H      COOEt        Me   OMe    CH                                 2607 Q.sub.86                                                                              H      COOEt        OMe  OMe    CH                                 2608 Q.sub.86                                                                              Me     COOMe        Me   Me     CH                                 2609 Q.sub.86                                                                              Me     COOMe        Me   OMe    CH                                 2610 Q.sub.86                                                                              Me     COOMe        OMe  OMe    CH                                 2611 Q.sub.86                                                                              Me     COOEt        Me   OMe    CH                                 2612 Q.sub.86                                                                              Me     COOEt        OMe  OMe    CH                                 2613 Q.sub.86                                                                              H      H            Me   OMe    CH                                 2614 Q.sub.86                                                                              H      H            OMe  OMe    CH                                 2615 Me     H      Q.sub.86     Me   OMe    CH                                 2616 Me     H      Q.sub.86     OMe  OMe    CH                                 2617 Q.sub.87                                                                              H      COOMe        Me   Me     CH                                 2618 Q.sub.87                                                                              H      COOMe        Me   OMe    CH                                 2619 Q.sub.87                                                                              H      COOMe        OMe  OMe    CH                                 2620 Q.sub.87                                                                              H      COOEt        Me   OMe    CH                                 2621 Q.sub.87                                                                              H      COOEt        OMe  OMe    CH                                 2622 Q.sub.87                                                                              Me     COOMe        Me   Me     CH                                 2623 Q.sub.87                                                                              Me     COOMe        Me   OMe    CH                                 2624 Q.sub.87                                                                              Me     COOMe        OMe  OMe    CH                                 2625 Q.sub.87                                                                              Me     COOEt        Me   OMe    CH                                 2626 Q.sub. 87                                                                             Me     COOEt        OMe  OMe    CH                                 2627 Q.sub.87                                                                              H      H            Me   OMe    CH                                 2628 Q.sub.87                                                                              H      H            OMe  OMe    CH                                 2629 Me     H      Q.sub.87     Me   OMe    CH                                 2630 Me     H      Q.sub.87     OMe  OMe    CH                                 2631 Q.sub.88                                                                              H      COOMe        Me   Me     CH                                 2632 Q.sub.88                                                                              H      COOMe        Me   OMe    CH                                 2633 Q.sub.88                                                                              H      COOMe        OMe  OMe    CH                                 2634 Q.sub.88                                                                              H      COOEt        Me   OMe    CH                                 2635 Q.sub.88                                                                              H      COOEt        OMe  OMe    CH                                 2636 Q.sub.88                                                                              Me     COOMe        Me   Me     CH                                 2637 Q.sub.88                                                                              Me     COOMe        Me   OMe    CH                                 2638 Q.sub.88                                                                              Me     COOMe        OMe  OMe    CH                                 2639 Q.sub.88                                                                              Me     COOEt        Me   OMe    CH                                 2640 Q.sub.88                                                                              Me     COOEt        OMe  OMe    CH                                 2641 Q.sub.88                                                                              H      H            Me   OMe    CH                                 2642 Q.sub.88                                                                              H      H            OMe  OMe    CH                                 2643 Me     H      Q.sub.88     Me   OMe    CH                                 2644 Me     H      Q.sub.88     OMe  OMe    CH                                 2645 Q.sub.89                                                                              H      COOMe        Me   Me     CH                                 2646 Q.sub.89                                                                              H      COOMe        Me   OMe    CH                                 2647 Q.sub.89                                                                              H      COOMe        OMe  OMe    CH                                 2648 Q.sub.89                                                                              H      COOEt        Me   OMe    CH                                 2649 Q.sub.89                                                                              H      COOEt        OMe  OMe    CH                                 2650 Q.sub.89                                                                              Me     COOMe        Me   Me     CH                                 2651 Q.sub.89                                                                              Me     COOMe        Me   OMe    CH                                 2652 Q.sub.89                                                                              Me     COOMe        OMe  OMe    CH                                 2653 Q.sub.89                                                                              Me     COOEt        Me   OMe    CH                                 2654 Q.sub.89                                                                              Me     COOEt        OMe  OMe    CH                                 2655 Q.sub.89                                                                              H      H            Me   OMe    CH                                 2656 Q.sub.89                                                                              H      H            OMe  OMe    CH                                 2657 Me     H      Q.sub.89     Me   OMe    CH                                 2658 Me     H      Q.sub.89     OMe  OMe    CH                                 2659 Q.sub.90                                                                              H      COOMe        Me   Me     CH                                 2660 Q.sub.90                                                                              H      COOMe        Me   OMe    CH                                 2661 Q.sub.90                                                                              H      COOMe        OMe  OMe    CH                                 2662 Q.sub.90                                                                              H      COOMe        Me   OMe    N                                  2663 Q.sub.90                                                                              H      COOMe        OMe  OMe    N                                  2664 Q.sub.90                                                                              H      COOEt        Me   Me     CH                                 2665 Q.sub.90                                                                              H      COOEt        Me   OMe    CH                                 2666 Q.sub.90                                                                              H      COOEt        OMe  OMe    CH                                 2667 Q.sub.90                                                                              H      COOEt        Me   OMe    N                                  2668 Q.sub.90                                                                              H      COOEt        OMe  OMe    N                                  2669 Q.sub.90                                                                              Me     COOMe        Me   Me     CH                                 2670 Q.sub.90                                                                              Me     COOMe        Me   OMe    CH                                 2671 Q.sub.90                                                                              Me     COOMe        OMe  OMe    CH                                 2672 Q.sub.90                                                                              Me     COOMe        Me   OMe    N                                  2673 Q.sub.90                                                                              Me     COOEt        Me   OMe    CH                                 2674 Q.sub.90                                                                              Me     COOEt        OMe  OMe    CH                                 2675 Q.sub.90                                                                              Me     COOEt        Me   OMe    N                                  2676 Q.sub.90                                                                              H      CN           Me   OMe    CH                                 2677 Q.sub.90                                                                              H      CN           OMe  OMe    CH                                 2678 Q.sub.90                                                                              H      CN           Me   OMe    N                                  2679 Q.sub.90                                                                              H      H            Me   OMe    CH                                 2680 Q.sub.90                                                                              H      H            OMe  OMe    CH                                 2681 Q.sub.90                                                                              H      H            Me   OMe    N                                  2682 Me     H      Q.sub.90     Me   Me     CH                                 2683 Me     H      Q.sub. 90    Me   OMe    CH                                 2684 Me     H      Q.sub.90     OMe  OMe    CH                                 2685 Me     H      Q.sub.90     Me   OMe    N                                  2686 Me     H      Q.sub.90     OMe  OMe    N                                  2687 Q.sub.91                                                                              H      COOMe        Me   Me     CH                                 2688 Q.sub.91                                                                              H      COOMe        Me   OMe    CH                                 2689 Q.sub.91                                                                              H      COOMe        OMe  OMe    CH                                 2690 Q.sub.91                                                                              H      COOEt        Me   OMe    CH                                 2691 Q.sub.91                                                                              H      COOEt        OMe  OMe    CH                                 2692 Q.sub.91                                                                              Me     COOMe        Me   Me     CH                                 2693 Q.sub.91                                                                              Me     COOMe        Me   OMe    CH                                 2694 Q.sub.91                                                                              Me     COOMe        OMe  OMe    CH                                 2695 Q.sub.91                                                                              Me     COOEt        Me   OMe    CH                                 2696 Q.sub.91                                                                              Me     COOEt        OMe  OMe    CH                                 2697 Q.sub.91                                                                              H      H            Me   OMe    CH                                 2698 Q.sub.91                                                                              H      H            OMe  OMe    CH                                 2699 Me     H      Q.sub.91     Me   OMe    CH                                 2700 Me     H      Q.sub.91     OMe  OMe    CH                                 2701 Q.sub.92                                                                              H      COOMe        Me   Me     CH                                 2702 Q.sub.92                                                                              H      COOMe        Me   OMe    CH                                 2703 Q.sub.92                                                                              H      COOMe        OMe  OMe    CH                                 2704 Q.sub.92                                                                              H      COOMe        Me   OMe    N                                  2705 Q.sub.92                                                                              H      COOMe        OMe  OMe    N                                  2706 Q.sub.92                                                                              H      COOEt        Me   Me     CH                                 2707 Q.sub.92                                                                              H      COOEt        Me   OMe    CH                                 2708 Q.sub.92                                                                              H      COOEt        OMe  OMe    CH                                 2709 Q.sub.92                                                                              H      COOEt        Me   OMe    N                                  2710 Q.sub.92                                                                              H      COOEt        OMe  OMe    N                                  2711 Q.sub.92                                                                              Me     COOMe        Me   Me     CH                                 2712 Q.sub.92                                                                              Me     COOMe        Me   OMe    CH                                 2713 Q.sub.92                                                                              Me     COOMe        OMe  OMe    CH                                 2714 Q.sub.92                                                                              Me     COOMe        Me   OMe    N                                  2715 Q.sub.92                                                                              Me     COOEt        Me   OMe    CH                                 2716 Q.sub.92                                                                              Me     COOEt        OMe  OMe    CH                                 2717 Q.sub.92                                                                              Me     COOEt        Me   OMe    N                                  2718 Q.sub.92                                                                              H      CN           Me   OMe    CH                                 2719 Q.sub.92                                                                              H      CN           OMe  OMe    CH                                 2720 Q.sub.92                                                                              H      CN           Me   OMe    N                                  2721 Q.sub.92                                                                              H      H            Me   OMe    CH                                 2722 Q.sub.92                                                                              H      H            OMe  OMe    CH                                 2723 Q.sub.92                                                                              H      H            Me   OMe    N                                  2724 Me     H      Q.sub.92     Me   Me     CH                                 2725 Me     H      Q.sub.92     Me   OMe    CH                                 2726 Me     H      Q.sub.92     OMe  OMe    CH                                 2727 Me     H      Q.sub.92     Me   OMe    N                                  2728 Me     H      Q.sub.92     OMe  OMe    N                                  2729 Q.sub.93                                                                              H      COOMe        Me   Me     CH                                 2730 Q.sub.93                                                                              H      COOMe        Me   OMe    CH                                 2731 Q.sub.93                                                                              H      COOMe        OMe  OMe    CH                                 2732 Q.sub.93                                                                              H      COOEt        Me   OMe    CH                                 2733 Q.sub.93                                                                              H      COOEt        OMe  OMe    CH                                 2734 Q.sub.93                                                                              Me     COOMe        Me   Me     CH                                 2735 Q.sub.93                                                                              Me     COOMe        Me   OMe    CH                                 2736 Q.sub.93                                                                              Me     COOMe        OMe  OMe    CH                                 2737 Q.sub.93                                                                              Me     COOEt        Me   OMe    CH                                 2738 Q.sub.93                                                                              Me     COOEt        OMe  OMe    CH                                 2739 Q.sub.93                                                                              H      H            Me   OMe    CH                                 2740 Q.sub.93                                                                              H      H            OMe  OMe    CH                                 2741 Me     H      Q.sub.93     Me   OMe    CH                                 2742 Me     H      Q.sub.93     OMe  OMe    CH                                 2743 Q.sub.94                                                                              H      COOMe        Me   Me     CH                                 2744 Q.sub.94                                                                              H      COOMe        Me   OMe    CH                                 2745 Q.sub.94                                                                              H      COOMe        OMe  OMe    CH                                 2746 Q.sub.94                                                                              H      COOEt        Me   OMe    CH                                 2747 Q.sub.94                                                                              H      COOEt        OMe  OMe    CH                                 2748 Q.sub.94                                                                              Me     COOMe        Me   Me     CH                                 2749 Q.sub.94                                                                              Me     COOMe        Me   OMe    CH                                 2750 Q.sub.94                                                                              Me     COOMe        OMe  OMe    CH                                 2751 Q.sub.94                                                                              Me     COOEt        Me   OMe    CH                                 2752 Q.sub.94                                                                              Me     COOEt        OMe  OMe    CH                                 2753 Q.sub.94                                                                              H      H            Me   OMe    CH                                 2754 Q.sub.94                                                                              H      H            OMe  OMe    CH                                 2755 Me     H      Q.sub.94     Me   OMe    CH                                 2756 Me     H      Q.sub.94     OMe  OMe    CH                                 2757 Q.sub.95                                                                              H      COOMe        Me   Me     CH                                 2758 Q.sub.95                                                                              H      COOMe        Me   OMe    CH                                 2759 Q.sub.95                                                                              H      COOMe        OMe  OMe    CH                                 2760 Q.sub.95                                                                              H      COOEt        Me   OMe    CH                                 2761 Q.sub.95                                                                              H      COOEt        OMe  OMe    CH                                 2762 Q.sub.95                                                                              Me     COOMe        Me   Me     CH                                 2763 Q.sub.95                                                                              Me     COOMe        Me   OMe    CH                                 2764 Q.sub.95                                                                              Me     COOMe        OMe  OMe    CH                                 2765 Q.sub.95                                                                              Me     COOEt        Me   OMe    CH                                 2766 Q.sub.95                                                                              Me     COOEt        OMe  OMe    CH                                 2767 Q.sub.95                                                                              H      H            Me   OMe    CH                                 2768 Q.sub.95                                                                              H      H            OMe  OMe    CH                                 2769 Me     H      Q.sub.95     Me   OMe    CH                                 2770 Me     H      Q.sub.95     OMe  OMe    CH                                 2771 Q.sub.96                                                                              H      COOMe        Me   Me     CH                                 2772 Q.sub.96                                                                              H      COOMe        Me   OMe    CH                                 2773 Q.sub.96                                                                              H      COOMe        OMe  OMe    CH                                 2774 Q.sub.96                                                                              H      COOEt        Me   OMe    CH                                 2775 Q.sub.96                                                                              H      COOEt        OMe  OMe    CH                                 2776 Q.sub.96                                                                              Me     COOMe        Me   Me     CH                                 2777 Q.sub.96                                                                              Me     COOMe        Me   OMe    CH                                 2778 Q.sub.96                                                                              Me     COOMe        OMe  OMe    CH                                 2779 Q.sub.96                                                                              Me     COOEt        Me   OMe    CH                                 2780 Q.sub.96                                                                              Me     COOEt        OMe  OMe    CH                                 2781 Q.sub.96                                                                              H      H            Me   OMe    CH                                 2782 Q.sub.96                                                                              H      H            OMe  OMe    CH                                 2783 Me     H      Q.sub.96     Me   OMe    CH                                 2784 Me     H      Q.sub.96     OMe  OMe    CH                                 2785 Q.sub.97                                                                              H      COOMe        Me   Me     CH                                 2786 Q.sub.97                                                                              H      COOMe        Me   OMe    CH                                 2787 Q.sub.97                                                                              H      COOMe        OMe  OMe    CH                                 2788 Q.sub.97                                                                              H      COOEt        Me   OMe    CH                                 2789 Q.sub.97                                                                              H      COOEt        OMe  OMe    CH                                 2790 Q.sub.97                                                                              Me     COOMe        Me   Me     CH                                 2791 Q.sub.97                                                                              Me     COOMe        Me   OMe    CH                                 2792 Q.sub.97                                                                              Me     COOMe        OMe  OMe    CH                                 2793 Q.sub.97                                                                              Me     COOEt        Me   OMe    CH                                 2794 Q.sub.97                                                                              Me     COOEt        OMe  OMe    CH                                 2795 Q.sub.97                                                                              H      H            Me   OMe    CH                                 2796 Q.sub.97                                                                              H      H            OMe  OMe    CH                                 2797 Me     H      Q.sub.97     Me   OMe    CH                                 2798 Me     H      Q.sub.97     OMe  OMe    CH                                 2799 Q.sub.98                                                                              H      COOMe        Me   Me     CH                                 2800 Q.sub.98                                                                              H      COOMe        Me   OMe    CH                                 2801 Q.sub.98                                                                              H      COOMe        OMe  OMe    CH                                 2802 Q.sub.98                                                                              H      COOMe        Me   OMe    N                                  2803 Q.sub.98                                                                              H      COOMe        OMe  OMe    N                                  2804 Q.sub.98                                                                              H      COOEt        Me   Me     CH                                 2805 Q.sub.98                                                                              H      COOEt        Me   OMe    CH                                 2806 Q.sub.98                                                                              H      COOEt        OMe  OMe    CH                                 2807 Q.sub.98                                                                              H      COOEt        Me   OMe    N                                  2808 Q.sub.98                                                                              H      COOEt        OMe  OMe    N                                  2809 Q.sub.98                                                                              Me     COOMe        Me   OMe    CH                                 2810 Q.sub.98                                                                              Me     COOMe        OMe  OMe    CH                                 2811 Q.sub.98                                                                              Me     COOMe        Me   OMe    N                                  2812 Q.sub.98                                                                              Me     COOEt        Me   OMe    CH                                 2813 Q.sub.98                                                                              Me     COOEt        OMe  OMe    CH                                 2814 Q.sub.98                                                                              Me     COOEt        Me   OMe    N                                  2815 Q.sub.98                                                                              H      CN           Me   OMe    CH                                 2816 Q.sub.98                                                                              H      CN           OMe  OMe    CH                                 2817 Q.sub.98                                                                              H      CN           Me   OMe    N                                  2818 Q.sub.98                                                                              H      H            Me   OMe    CH                                 2819 Q.sub.98                                                                              H      H            OMe  OMe    CH                                 2820 Q.sub.98                                                                              H      H            Me   OMe    N                                  2821 Me     H      Q.sub.98     Me   Me     CH                                 2822 Me     H      Q.sub.98     Me   OMe    CH                                 2823 Me     H      Q.sub.98     OMe  OMe    CH                                 2824 Me     H      Q.sub.98     Me   OMe    N                                  2825 Me     H      Q.sub.98     OMe  OMe    N                                  2826 Q.sub.99                                                                              H      COOMe        Me   Me     CH                                 2827 Q.sub.99                                                                              H      COOMe        Me   OMe    CH                                 2828 Q.sub.99                                                                              H      COOMe        OMe  OMe    CH                                 2829 Q.sub.99                                                                              H      COOEt        Me   OMe    CH                                 2830 Q.sub.99                                                                              H      COOEt        OMe  OMe    CH                                 2831 Q.sub.99                                                                              Me     COOMe        Me   Me     CH                                 2832 Q.sub.99                                                                              Me     COOMe        Me   OMe    CH                                 2833 Q.sub.99                                                                              Me     COOMe        OMe  OMe    CH                                 2834 Q.sub.99                                                                              Me     COOEt        Me   OMe    CH                                 2835 Q.sub.99                                                                              Me     COOEt        OMe  OMe    CH                                 2836 Q.sub.99                                                                              H      H            Me   OMe    CH                                 2837 Q.sub.99                                                                              H      H            OMe  OMe    CH                                 2838 Me     H      Q.sub.99     Me   OMe    CH                                 2839 Me     H      Q.sub.99     OMe  OMe    CH                                 2840 Q.sub.100                                                                             H      COOMe        Me   Me     CH                                 2841 Q.sub.100                                                                             H      COOMe        Me   OMe    CH                                 2842 Q.sub.100                                                                             H      COOMe        OMe  OMe    CH                                 2843 Q.sub.100                                                                             H      COOMe        Me   OMe    N                                  2844 Q.sub.100                                                                             H      COOMe        OMe  OMe    N                                  2845 Q.sub.100                                                                             H      COOEt        Me   Me     CH                                 2846 Q.sub.100                                                                             H      COOEt        Me   OMe    CH                                 2847 Q.sub.100                                                                             H      COOEt        OMe  OMe    CH                                 2848 Q.sub.100                                                                             H      COOEt        Me   OMe    N                                  2849 Q.sub.100                                                                             H      COOEt        OMe  OMe    N                                  2850 Q.sub.100                                                                             Me     COOMe        Me   OMe    CH                                 2851 Q.sub.100                                                                             Me     COOMe        OMe  OMe    CH                                 2852 Q.sub.100                                                                             Me     COOMe        Me   OMe    N                                  2853 Q.sub.100                                                                             Me     COOEt        Me   OMe    CH                                 2854 Q.sub.100                                                                             Me     COOEt        OMe  OMe    CH                                 2855 Q.sub.100                                                                             Me     COOEt        Me   OMe    N                                  2856 Q.sub.100                                                                             H      CN           Me   OMe    CH                                 2857 Q.sub.100                                                                             H      CN           OMe  OMe    CH                                 2858 Q.sub.100                                                                             H      CN           Me   OMe    N                                  2859 Q.sub.100                                                                             H      H            Me   OMe    CH                                 2860 Q.sub.100                                                                             H      H            OMe  OMe    CH                                 2861 Q.sub.100                                                                             H      H            Me   OMe    N                                  2862 Me     H      Q.sub.100    Me   Me     CH                                 2863 Me     H      Q.sub.100    Me   OMe    CH                                 2864 Me     H      Q.sub.100    OMe  OMe    CH                                 2865 Me     H      Q.sub.100    Me   OMe    N                                  2866 Me     H      Q.sub.100    OMe  OMe    N                                  2867 Q.sub.101                                                                             H      COOMe        Me   Me     CH                                 2868 Q.sub.101                                                                             H      COOMe        Me   OMe    CH                                 2869 Q.sub.101                                                                             H      COOMe        OMe  OMe    CH                                 2870 Q.sub.101                                                                             H      COOEt        Me   OMe    CH                                 2871 Q.sub.101                                                                             H      COOEt        OMe  OMe    CH                                 2872 Q.sub.101                                                                             Me     COOMe        Me   Me     CH                                 2873 Q.sub.101                                                                             Me     COOMe        Me   OMe    CH                                 2874 Q.sub.101                                                                             Me     COOMe        OMe  OMe    CH                                 2875 Q.sub.101                                                                             Me     COOEt        Me   OMe    CH                                 2876 Q.sub.101                                                                             Me     COOEt        OMe  OMe    CH                                 2877 Q.sub.101                                                                             H      H            Me   OMe    CH                                 2878 Q.sub.101                                                                             H      H            OMe  OMe    CH                                 2879 Me     H      Q.sub.101    Me   OMe    CH                                 2880 Me     H      Q.sub.101    OMe  OMe    CH                                 2881 Q.sub.102                                                                             H      COOMe        Me   Me     CH                                 2882 Q.sub.102                                                                             H      COOMe        Me   OMe    CH                                 2883 Q.sub.102                                                                             H      COOMe        OMe  OMe    CH                                 2884 Q.sub.102                                                                             H      COOEt        Me   OMe    CH                                 2885 Q.sub.102                                                                             H      COOEt        OMe  OMe    CH                                 2886 Q.sub.102                                                                             Me     COOMe        Me   Me     CH                                 2887 Q.sub.102                                                                             Me     COOMe        Me   OMe    CH                                 2888 Q.sub.102                                                                             Me     COOMe        OMe  OMe    CH                                 2889 Q.sub.102                                                                             Me     COOEt        Me   OMe    CH                                 2890 Q.sub.102                                                                             Me     COOEt        OMe  OMe    CH                                 2891 Q.sub.102                                                                             H      H            Me   OMe    CH                                 2892 Q.sub.102                                                                             H      H            OMe  OMe    CH                                 2893 Me     H      Q.sub.102    Me   OMe    CH                                 2894 Me     H      Q.sub.102    OMe  OMe    CH                                 2895 Q.sub.103                                                                             H      COOMe        Me   Me     CH                                 2896 Q.sub.103                                                                             H      COOMe        Me   OMe    CH                                 2897 Q.sub.103                                                                             H      COOMe        OMe  OMe    CH                                 2898 Q.sub.103                                                                             H      COOEt        Me   OMe    CH                                 2899 Q.sub.103                                                                             H      COOEt        OMe  OMe    CH                                 2900 Q.sub.103                                                                             Me     COOMe        Me   Me     CH                                 2901 Q.sub.103                                                                             Me     COOMe        Me   OMe    CH                                 2902 Q.sub.103                                                                             Me     COOMe        OMe  OMe    CH                                 2903 Q.sub.103                                                                             Me     COOEt        Me   OMe    CH                                 2904 Q.sub.103                                                                             Me     COOEt        OMe  OMe    CH                                 2905 Q.sub.103                                                                             H      H            Me   OMe    CH                                 2906 Q.sub.103                                                                             H      H            OMe  OMe    CH                                 2907 Me     H      Q.sub.103    Me   OMe    CH                                 2908 Me     H      Q.sub.103    OMe  OMe    CH                                 2909 Q.sub.104                                                                             H      COOMe        Me   Me     CH                                 2910 Q.sub.104                                                                             H      COOMe        Me   OMe    CH                                 2911 Q.sub.104                                                                             H      COOMe        OMe  OMe    CH                                 2912 Q.sub.104                                                                             H      COOEt        Me   OMe    CH                                 2913 Q.sub.104                                                                             H      COOEt        OMe  OMe    CH                                 2914 Q.sub.104                                                                             Me     COOMe        Me   Me     CH                                 2915 Q.sub.104                                                                             Me     COOMe        Me   OMe    CH                                 2916 Q.sub.104                                                                             Me     COOMe        OMe  OMe    CH                                 2917 Q.sub.104                                                                             Me     COOEt        Me   OMe    CH                                 2918 Q.sub.104                                                                             Me     COOEt        OMe  OMe    CH                                 2919 Q.sub.104                                                                             H      H            Me   OMe    CH                                 2920 Q.sub.104                                                                             H      H            OMe  OMe    CH                                 2921 Me     H      Q.sub.104    Me   OMe    CH                                 2922 Me     H      Q.sub.104    OMe  OMe    CH                                 2923 Q.sub.105                                                                             H      COOMe        Me   Me     CH                                 2924 Q.sub.105                                                                             H      COOMe        Me   OMe    CH                                 2925 Q.sub.105                                                                             H      COOMe        OMe  OMe    CH                                 2926 Q.sub.105                                                                             H      COOEt        Me   OMe    CH                                 2927 Q.sub.105                                                                             H      COOEt        OMe  OMe    CH                                 2928 Q.sub.105                                                                             Me     COOMe        Me   Me     CH                                 2929 Q.sub.105                                                                             Me     COOMe        Me   OMe    CH                                 2930 Q.sub.105                                                                             Me     COOMe        OMe  OMe    CH                                 2931 Q.sub.105                                                                             Me     COOEt        Me   OMe    CH                                 2932 Q.sub.105                                                                             Me     COOEt        OMe  OMe    CH                                 2933 Q.sub.105                                                                             H      H            Me   OMe    CH                                 2934 Q.sub.105                                                                             H      H            OMe  OMe    CH                                 2935 Me     H      Q.sub.105    Me   OMe    CH                                 2936 Me     H      Q.sub.105    OMe  OMe    CH                                 2937 Q.sub.106                                                                             H      COOMe        Me   Me     CH                                 2938 Q.sub.106                                                                             H      COOMe        Me   OMe    CH                                 2939 Q.sub.106                                                                             H      COOMe        OMe  OMe    CH                                 2940 Q.sub.106                                                                             H      COOEt        Me   OMe    CH                                 2941 Q.sub.106                                                                             H      COOEt        OMe  OMe    CH                                 2942 Q.sub.106                                                                             Me     COOMe        Me   Me     CH                                 2943 Q.sub.106                                                                             Me     COOMe        Me   OMe    CH                                 2944 Q.sub.106                                                                             Me     COOMe        OMe  OMe    CH                                 2945 Q.sub.106                                                                             Me     COOEt        Me   OMe    CH                                 2946 Q.sub.106                                                                             Me     COOEt        OMe  OMe    CH                                 2947 Q.sub.106                                                                             H      H            Me   OMe    CH                                 2948 Q.sub.106                                                                             H      H            OMe  OMe    CH                                 2949 Me     H      Q.sub.106    Me   OMe    CH                                 2950 Me     H      Q.sub.106    OMe  OMe    CH                                 2951 Q.sub.107                                                                             H      COOMe        Me   Me     CH                                 2952 Q.sub.107                                                                             H      COOMe        Me   OMe    CH                                 2953 Q.sub.107                                                                             H      COOMe        OMe  OMe    CH                                 2954 Q.sub.107                                                                             H      COOEt        Me   OMe    CH                                 2955 Q.sub.107                                                                             H      COOEt        OMe  OMe    CH                                 2956 Q.sub.107                                                                             Me     COOMe        Me   Me     CH                                 2957 Q.sub.107                                                                             Me     COOMe        Me   OMe    CH                                 2958 Q.sub.107                                                                             Me     COOMe        OMe  OMe    CH                                 2959 Q.sub.107                                                                             Me     COOEt        Me   OMe    CH                                 2960 Q.sub.107                                                                             Me     COOEt        OMe  OMe    CH                                 2961 Q.sub.107                                                                             H      H            Me   OMe    CH                                 2962 Q.sub.107                                                                             H      H            OMe  OMe    CH                                 2963 Me     H      Q.sub.107    Me   OMe    CH                                 2964 Me     H      Q.sub.107    OMe  OMe    CH                                 2965 Q.sub.108                                                                             H      COOMe        Me   Me     CH                                 2966 Q.sub.108                                                                             H      COOMe        Me   OMe    CH                                 2967 Q.sub.108                                                                             H      COOMe        OMe  OMe    CH                                 2968 Q.sub.108                                                                             H      COOEt        Me   OMe    CH                                 2969 Q.sub. 108                                                                            H      COOEt        OMe  OMe    CH                                 2970 Q.sub.108                                                                             Me     COOMe        Me   Me     CH                                 2971 Q.sub.108                                                                             Me     COOMe        Me   OMe    CH                                 2972 Q.sub.108                                                                             Me     COOMe        OMe  OMe    CH                                 2973 Q.sub.108                                                                             Me     COOEt        Me   OMe    CH                                 2974 Q.sub.108                                                                             Me     COOEt        OMe  OMe    CH                                 2975 Q.sub.108                                                                             H      H            Me   OMe    CH                                 2976 Q.sub.108                                                                             H      H            OMe  OMe    CH                                 2977 Me     H      Q.sub.108    Me   OMe    CH                                 2978 Me     H      Q.sub.108    OMe  OMe    CH                                 2979 Q.sub.109                                                                             H      COOMe        Me   Me     CH                                 2980 Q.sub.109                                                                             H      COOMe        Me   OMe    CH                                 2981 Q.sub.109                                                                             H      COOMe        OMe  OMe    CH                                 2982 Q.sub.109                                                                             H      COOEt        Me   OMe    CH                                 2983 Q.sub.109                                                                             H      COOEt        OMe  OMe    CH                                 2984 Q.sub.109                                                                             Me     COOMe        Me   Me     CH                                 2985 Q.sub.109                                                                             Me     COOMe        Me   OMe    CH                                 2986 Q.sub.109                                                                             Me     COOMe        OMe  OMe    CH                                 2987 Q.sub.109                                                                             Me     COOEt        Me   OMe    CH                                 2988 Q.sub.109                                                                             Me     COOEt        OMe  OMe    CH                                 2989 Q.sub.109                                                                             H      H            Me   OMe    CH                                 2990 Q.sub.109                                                                             H      H            OMe  OMe    CH                                 2991 Me     H      Q.sub.109    Me   OMe    CH                                 2992 Me     H      Q.sub.109    OMe  OMe    CH                                 2993 Q.sub.110                                                                             H      COOMe        Me   Me     CH                                 2994 Q.sub.110                                                                             H      COOMe        Me   OMe    CH                                 2995 Q.sub.110                                                                             H      COOMe        OMe  OMe    CH                                 2996 Q.sub.110                                                                             H      COOEt        Me   OMe    CH                                 2997 Q.sub.110                                                                             H      COOEt        OMe  OMe    CH                                 2998 Q.sub.110                                                                             Me     COOMe        Me   Me     CH                                 2999 Q.sub.110                                                                             Me     COOMe        Me   OMe    CH                                 3000 Q.sub.110                                                                             Me     COOMe        OMe  OMe    CH                                 3001 Q.sub.110                                                                             Me     COOEt        Me   OMe    CH                                 3002 Q.sub.110                                                                             Me     COOEt        OMe  OMe    CH                                 3003 Q.sub.110                                                                             H      H            Me   OMe    CH                                 3004 Q.sub.110                                                                             H      H            OMe  OMe    CH                                 3005 Me     H      Q.sub.110    Me   OMe    CH                                 3006 Me     H      Q.sub.110    OMe  OMe    CH                                 3007 Q.sub.111                                                                             H      COOMe        Me   Me     CH                                 3008 Q.sub.111                                                                             H      COOMe        Me   OMe    CH                                 3009 Q.sub.111                                                                             H      COOMe        OMe  OMe    CH                                 3010 Q.sub.111                                                                             H      COOEt        Me   OMe    CH                                 3011 Q.sub.111                                                                             H      COOEt        OMe  OMe    CH                                 3012 Q.sub.111                                                                             Me     COOMe        Me   Me     CH                                 3013 Q.sub.111                                                                             Me     COOMe        Me   OMe    CH                                 3014 Q.sub.111                                                                             Me     COOMe        OMe  OMe    CH                                 3015 Q.sub.111                                                                             Me     COOEt        Me   OMe    CH                                 3016 Q.sub.111                                                                             Me     COOEt        OMe  OMe    CH                                 3017 Q.sub.111                                                                             H      H            Me   OMe    CH                                 3018 Q.sub.111                                                                             H      H            OMe  OMe    CH                                 3019 Me     H      Q.sub.111    Me   OMe    CH                                 3020 Me     H      Q.sub.111    OMe  OMe    CH                                 3021 Q.sub.112                                                                             H      COOMe        Me   Me     CH                                 3022 Q.sub.112                                                                             H      COOMe        Me   OMe    CH                                 3023 Q.sub.112                                                                             H      COOMe        OMe  OMe    CH                                 3024 Q.sub.112                                                                             H      COOEt        Me   OMe    CH                                 3025 Q.sub.112                                                                             H      COOEt        OMe  OMe    CH                                 3026 Q.sub.112                                                                             Me     COOMe        Me   Me     CH                                 3027 Q.sub.112                                                                             Me     COOMe        Me   OMe    CH                                 3028 Q.sub.112                                                                             Me     COOMe        OMe  OMe    CH                                 3029 Q.sub.112                                                                             Me     COOEt        Me   OMe    CH                                 3030 Q.sub.112                                                                             Me     COOEt        OMe  OMe    CH                                 3031 Q.sub.112                                                                             H      H            Me   OMe    CH                                 3032 Q.sub.112                                                                             H      H            OMe  OMe    CH                                 3033 Me     H      Q.sub.112    Me   OMe    CH                                 3034 Me     H      Q.sub.112    OMe  OMe    CH                                 3035 Q.sub.113                                                                             H      COOMe        Me   Me     CH                                 3036 Q.sub.113                                                                             H      COOMe        Me   OMe    CH                                 3037 Q.sub.113                                                                             H      COOMe        OMe  OMe    CH                                 3038 Q.sub.113                                                                             H      COOEt        Me   OMe    CH                                 3039 Q.sub.113                                                                             H      COOEt        OMe  OMe    CH                                 3040 Q.sub.113                                                                             Me     COOMe        Me   Me     CH                                 3041 Q.sub.113                                                                             Me     COOMe        Me   OMe    CH                                 3042 Q.sub.113                                                                             Me     COOMe        OMe  OMe    CH                                 3043 Q.sub.113                                                                             Me     COOEt        Me   OMe    CH                                 3044 Q.sub.113                                                                             Me     COOEt        OMe  OMe    CH                                 3045 Q.sub.113                                                                             H      H            Me   OMe    CH                                 3046 Q.sub.113                                                                             H      H            OMe  OMe    CH                                 3047 Me     H      Q.sub.113    Me   OMe    CH                                 3048 Me     H      Q.sub.113    OMe  OMe    CH                                 3049 Q.sub.114                                                                             H      COOMe        Me   Me     CH                                 3050 Q.sub.114                                                                             H      COOMe        Me   OMe    CH                                 3051 Q.sub.114                                                                             H      COOMe        OMe  OMe    CH                                 3052 Q.sub.114                                                                             H      COOEt        Me   OMe    CH                                 3053 Q.sub.114                                                                             H      COOEt        OMe  OMe    CH                                 3054 Q.sub.114                                                                             Me     COOMe        Me   Me     CH                                 3055 Q.sub.114                                                                             Me     COOMe        Me   OMe    CH                                 3056 Q.sub.114                                                                             Me     COOMe        OMe  OMe    CH                                 3057 Q.sub.114                                                                             Me     COOEt        Me   OMe    CH                                 3058 Q.sub.114                                                                             Me     COOEt        OMe  OMe    CH                                 3059 Q.sub.114                                                                             H      H            Me   OMe    CH                                 3060 Q.sub.114                                                                             H      H            OMe  OMe    CH                                 3061 Me     H      Q.sub.114    Me   OMe    CH                                 3062 Me     H      Q.sub.114    OMe  OMe    CH                                 3063 Q.sub.115                                                                             H      COOMe        Me   Me     CH                                 3064 Q.sub.115                                                                             H      COOMe        Me   OMe    CH                                 3065 Q.sub.115                                                                             H      COOMe        OMe  OMe    CH                                 3066 Q.sub.115                                                                             H      COOEt        Me   OMe    CH                                 3067 Q.sub.115                                                                             H      COOEt        OMe  OMe    CH                                 3068 Q.sub.115                                                                             Me     COOMe        Me   Me     CH                                 3069 Q.sub.115                                                                             Me     COOMe        Me   OMe    CH                                 3070 Q.sub.115                                                                             Me     COOMe        OMe  OMe    CH                                 3071 Q.sub.115                                                                             Me     COOEt        Me   OMe    CH                                 3072 Q.sub.115                                                                             Me     COOEt        OMe  OMe    CH                                 3073 Q.sub.115                                                                             H      H            Me   OMe    CH                                 3074 Q.sub.115                                                                             H      H            OMe  OMe    CH                                 3075 Me     H      Q.sub.115    Me   OMe    CH                                 3076 Me     H      Q.sub.115    OMe  OMe    CH                                 3077 Q.sub.116                                                                             H      COOMe        Me   Me     CH                                 3078 Q.sub.116                                                                             H      COOMe        Me   OMe    CH                                 3079 Q.sub.116                                                                             H      COOMe        OMe  OMe    CH                                 3080 Q.sub.116                                                                             H      COOEt        Me   OMe    CH                                 3081 Q.sub.116                                                                             H      COOEt        OMe  OMe    CH                                 3082 Q.sub.116                                                                             Me     COOMe        Me   Me     CH                                 3083 Q.sub.116                                                                             Me     COOMe        Me   OMe    CH                                 3084 Q.sub.116                                                                             Me     COOMe        OMe  OMe    CH                                 3085 Q.sub.116                                                                             Me     COOEt        Me   OMe    CH                                 3086 Q.sub.116                                                                             Me     COOEt        OMe  OMe    CH                                 3087 Q.sub.116                                                                             H      H            Me   OMe    CH                                 3088 Q.sub.116                                                                             H      H            OMe  OMe    CH                                 3089 Me     H      Q.sub.116    Me   OMe    CH                                 3090 Me     H      Q.sub.116    OMe  OMe    CH                                 3091 Q.sub.117                                                                             H      COOMe        Me   Me     CH                                 3092 Q.sub.117                                                                             H      COOMe        Me   OMe    CH                                 3093 Q.sub.117                                                                             H      COOMe        OMe  OMe    CH                                 3094 Q.sub.117                                                                             H      COOEt        Me   OMe    CH                                 3095 Q.sub.117                                                                             H      COOEt        OMe  OMe    CH                                 3096 Q.sub.117                                                                             Me     COOMe        Me   Me     CH                                 3097 Q.sub.117                                                                             Me     COOMe        Me   OMe    CH                                 3098 Q.sub.117                                                                             Me     COOMe        OMe  OMe    CH                                 3099 Q.sub.117                                                                             Me     COOEt        Me   OMe    CH                                 3100 Q.sub.117                                                                             Me     COOEt        OMe  OMe    CH                                 3101 Q.sub.117                                                                             H      H            Me   OMe    CH                                 3102 Q.sub.117                                                                             H      H            OMe  OMe    CH                                 3103 Me     H      Q.sub.117    Me   OMe    CH                                 3104 Me     H      Q.sub.117    OMe  OMe    CH                                 3105 Q.sub.118                                                                             H      COOMe        Me   Me     CH                                 3106 Q.sub.118                                                                             H      COOMe        Me   OMe    CH                                 3107 Q.sub.118                                                                             H      COOMe        OMe  OMe    CH                                 3108 Q.sub.118                                                                             H      COOEt        Me   OMe    CH                                 3109 Q.sub.118                                                                             H      COOEt        OMe  OMe    CH                                 3110 Q.sub.118                                                                             Me     COOMe        Me   Me     CH                                 3111 Q.sub.118                                                                             Me     COOMe        Me   OMe    CH                                 3112 Q.sub.118                                                                             Me     COOMe        OMe  OMe    CH                                 3113 Q.sub.118                                                                             Me     COOEt        Me   OMe    CH                                 3114 Q.sub.118                                                                             Me     COOEt        OMe  OMe    CH                                 3115 Q.sub.118                                                                             H      H            Me   OMe    CH                                 3116 Q.sub.118                                                                             H      H            OMe  OMe    CH                                 3117 Me     H      Q.sub.118    Me   OMe    CH                                 3118 Me     H      Q.sub.118    OMe  OMe    CH                                 3119 Q.sub.119                                                                             H      COOMe        Me   Me     CH                                 3120 Q.sub.119                                                                             H      COOMe        Me   OMe    CH                                 3121 Q.sub.119                                                                             H      COOMe        OMe  OMe    CH                                 3122 Q.sub.119                                                                             H      COOEt        Me   OMe    CH                                 3123 Q.sub.119                                                                             H      COOEt        OMe  OMe    CH                                 3124 Q.sub.119                                                                             Me     COOMe        Me   Me     CH                                 3125 Q.sub.119                                                                             Me     COOMe        Me   OMe    CH                                 3126 Q.sub.119                                                                             Me     COOMe        OMe  OMe    CH                                 3127 Q.sub.119                                                                             Me     COOEt        Me   OMe    CH                                 3128 Q.sub.119                                                                             Me     COOEt        OMe  OMe    CH                                 3129 Q.sub.119                                                                             H      H            Me   OMe    CH                                 3130 Q.sub.119                                                                             H      H            OMe  OMe    CH                                 3131 Me     H      Q.sub.119    Me   OMe    CH                                 3132 Me     H      Q.sub.119    OMe  OMe    CH                                 3133 Q.sub.120                                                                             H      COOMe        Me   Me     CH                                 3134 Q.sub.120                                                                             H      COOMe        Me   OMe    CH                                 3135 Q.sub.120                                                                             H      COOMe        OMe  OMe    CH                                 3136 Q.sub.120                                                                             H      COOEt        Me   OMe    CH                                 3137 Q.sub.120                                                                             H      COOEt        OMe  OMe    CH                                 3138 Q.sub.120                                                                             Me     COOMe        Me   Me     CH                                 3139 Q.sub.120                                                                             Me     COOMe        Me   OMe    CH                                 3140 Q.sub.120                                                                             Me     COOMe        OMe  OMe    CH                                 3141 Q.sub.120                                                                             Me     COOEt        Me   OMe    CH                                 3142 Q.sub.120                                                                             Me     COOEt        OMe  OMe    CH                                 3143 Me     H      Q.sub.120    Me   OMe    CH                                 3144 Me     H      Q.sub.120    OMe  OMe    CH                                 3145 Me     Me     Q.sub.120    Me   OMe    CH                                 3146 Me     Me     Q.sub.120    OMe  OMe    CH                                 3147 Q.sub.121                                                                             H      COOMe        Me   Me     CH                                 3148 Q.sub.121                                                                             H      COOMe        Me   OMe    CH                                 3149 Q.sub.121                                                                             H      COOMe        OMe  OMe    CH                                 3150 Q.sub.121                                                                             H      COOEt        Me   OMe    CH                                 3151 Q.sub.121                                                                             H      COOEt        OMe  OMe    CH                                 3152 Q.sub.121                                                                             Me     COOMe        Me   Me     CH                                 3153 Q.sub.121                                                                             Me     COOMe        Me   OMe    CH                                 3154 Q.sub.121                                                                             Me     COOMe        OMe  OMe    CH                                 3155 Q.sub.121                                                                             Me     COOEt        Me   OMe    CH                                 3156 Q.sub.121                                                                             Me     COOEt        OMe  OMe    CH                                 3157 Me     H      Q.sub.121    Me   OMe    CH                                 3158 Me     H      Q.sub.121    OMe  OMe    CH                                 3159 Me     Me     Q.sub.121    Me   OMe    CH                                 3160 Me     Me     Q.sub.121    OMe  OMe    CH                                 3161 Q.sub.122                                                                             H      COOMe        Me   Me     CH                                 3162 Q.sub.122                                                                             H      COOMe        Me   OMe    CH                                 3163 Q.sub.122                                                                             H      COOMe        OMe  OMe    CH                                 3164 Q.sub.122                                                                             H      COOEt        Me   OMe    CH                                 3165 Q.sub.122                                                                             H      COOEt        OMe  OMe    CH                                 3166 Q.sub.122                                                                             Me     COOMe        Me   Me     CH                                 3167 Q.sub.122                                                                             Me     COOMe        Me   OMe    CH                                 3168 Q.sub.122                                                                             Me     COOMe        OMe  OMe    CH                                 3169 Q.sub.122                                                                             Me     COOEt        Me   OMe    CH                                 3170 Q.sub.122                                                                             Me     COOEt        OMe  OMe    CH                                 3171 Me     H      Q.sub.122    Me   OMe    CH                                 3172 Me     H      Q.sub.122    OMe  OMe    CH                                 3173 Me     Me     Q.sub.122    Me   OMe    CH                                 3174 Me     Me     Q.sub.122    OMe  OMe    CH                                 3175 Q.sub.123                                                                             H      COOMe        Me   Me     CH                                 3176 Q.sub.123                                                                             H      COOMe        Me   OMe    CH                                 3177 Q.sub.123                                                                             H      COOMe        OMe  OMe    CH                                 3178 Q.sub.123                                                                             H      COOEt        Me   OMe    CH                                 3179 Q.sub.123                                                                             H      COOEt        OMe  OMe    CH                                 3180 Q.sub.123                                                                             Me     COOMe        Me   Me     CH                                 3181 Q.sub.123                                                                             Me     COOMe        Me   OMe    CH                                 3182 Q.sub.123                                                                             Me     COOMe        OMe  OMe    CH                                 3183 Q.sub.123                                                                             Me     COOEt        Me   OMe    CH                                 3184 Q.sub.123                                                                             Me     COOEt        OMe  OMe    CH                                 3185 Me     H      Q.sub.123    Me   OMe    CH                                 3186 Me     H      Q.sub.123    OMe  OMe    CH                                 3187 Me     Me     Q.sub.123    Me   OMe    CH                                 3188 Me     Me     Q.sub.123    OMe  OMe    CH                                 3189 Q.sub.124                                                                             H      COOMe        Me   Me     CH                                 3190 Q.sub.124                                                                             H      COOMe        Me   OMe    CH                                 3191 Q.sub.124                                                                             H      COOMe        OMe  OMe    CH                                 3192 Q.sub.124                                                                             H      COOEt        Me   OMe    CH                                 3193 Q.sub.124                                                                             H      COOEt        OMe  OMe    CH                                 3194 Q.sub.124                                                                             Me     COOMe        Me   Me     CH                                 3195 Q.sub.124                                                                             Me     COOMe        Me   OMe    CH                                 3196 Q.sub.124                                                                             Me     COOMe        OMe  OMe    CH                                 3197 Q.sub.124                                                                             Me     COOEt        Me   OMe    CH                                 3198 Q.sub.124                                                                             Me     COOEt        OMe  OMe    CH                                 3199 Me     H      Q.sub.124    Me   OMe    CH                                 3200 Me     H      Q.sub.124    OMe  OMe    CH                                 3201 Me     Me     Q.sub.124    Me   OMe    CH                                 3202 Me     Me     Q.sub.124    OMe  OMe    CH                                 3203 Q.sub.125                                                                             H      COOMe        Me   Me     CH                                 3204 Q.sub.125                                                                             H      COOMe        Me   OMe    CH                                 3205 Q.sub.125                                                                             H      COOMe        OMe  OMe    CH                                 3206 Q.sub.125                                                                             H      COOEt        Me   OMe    CH                                 3207 Q.sub.125                                                                             H      COOEt        OMe  OMe    CH                                 3208 Q.sub.125                                                                             Me     COOMe        Me   Me     CH                                 3209 Q.sub.125                                                                             Me     COOMe        Me   OMe    CH                                 3210 Q.sub.125                                                                             Me     COOMe        OMe  OMe    CH                                 3211 Q.sub.125                                                                             Me     COOEt        Me   OMe    CH                                 3212 Q.sub.125                                                                             Me     COOEt        OMe  OMe    CH                                 3213 Me     H      Q.sub.125    Me   OMe    CH                                 3214 Me     H      Q.sub.125    OMe  OMe    CH                                 3215 Me     Me     Q.sub.125    Me   OMe    CH                                 3216 Me     Me     Q.sub.125    OMe  OMe    CH                                 3217 Q.sub.126                                                                             H      COOMe        Me   Me     CH                                 3218 Q.sub.126                                                                             H      COOMe        Me   OMe    CH                                 3219 Q.sub.126                                                                             H      COOMe        OMe  OMe    CH                                 3220 Q.sub.126                                                                             H      COOEt        Me   OMe    CH                                 3221 Q.sub.126                                                                             H      COOEt        OMe  OMe    CH                                 3222 Q.sub.126                                                                             Me     COOMe        Me   Me     CH                                 3223 Q.sub.126                                                                             Me     COOMe        Me   OMe    CH                                 3224 Q.sub.126                                                                             Me     COOMe        OMe  OMe    CH                                 3225 Q.sub.126                                                                             Me     COOEt        Me   OMe    CH                                 3226 Q.sub.126                                                                             Me     COOEt        OMe  OMe    CH                                 3227 Me     H      Q.sub.126    Me   OMe    CH                                 3228 Me     H      Q.sub.126    OMe  OMe    CH                                 3229 Me     Me     Q.sub.126    Me   OMe    CH                                 3230 Me     Me     Q.sub.126    OMe  OMe    CH                                 3231 Q.sub.127                                                                             H      COOMe        Me   Me     CH                                 3232 Q.sub.127                                                                             H      COOMe        Me   OMe    CH                                 3233 Q.sub.127                                                                             H      COOMe        OMe  OMe    CH                                 3234 Q.sub.127                                                                             H      COOEt        Me   OMe    CH                                 3235 Q.sub.127                                                                             H      COOEt        OMe  OMe    CH                                 3236 Q.sub.127                                                                             Me     COOMe        Me   Me     CH                                 3237 Q.sub.127                                                                             Me     COOMe        Me   OMe    CH                                 3238 Q.sub.127                                                                             Me     COOMe        OMe  OMe    CH                                 3239 Q.sub.127                                                                             Me     COOEt        Me   OMe    CH                                 3240 Q.sub.127                                                                             Me     COOEt        OMe  OMe    CH                                 3241 Me     H      Q.sub.127    Me   OMe    CH                                 3242 Me     H      Q.sub.127    OMe  OMe    CH                                 3243 Me     Me     Q.sub.127    Me   OMe    CH                                 3244 Me     Me     Q.sub.127    OMe  OMe    CH                                 3245 Q.sub.128                                                                             H      COOMe        Me   Me     CH                                 3246 Q.sub.128                                                                             H      COOMe        Me   OMe    CH                                 3247 Q.sub.127                                                                             H      COOMe        OMe  OMe    CH                                 3248 Q.sub.128                                                                             H      COOEt        Me   OMe    CH                                 3249 Q.sub.128                                                                             H      COOEt        OMe  OMe    CH                                 3250 Q.sub.128                                                                             Me     COOMe        Me   Me     CH                                 3251 Q.sub.128                                                                             Me     COOMe        Me   OMe    CH                                 3252 Q.sub.128                                                                             Me     COOMe        OMe  OMe    CH                                 3253 Q.sub.128                                                                             Me     COOEt        Me   OMe    CH                                 3254 Q.sub.128                                                                             Me     COOEt        OMe  OMe    CH                                 3255 Me     H      Q.sub.128    Me   OMe    CH                                 3256 Me     H      Q.sub.128    OMe  OMe    CH                                 3257 Me     Me     Q.sub.128    Me   OMe    CH                                 3258 Me     Me     Q.sub.128    OMe  OMe    CH                                 3259 Q.sub.129                                                                             H      COOMe        Me   Me     CH                                 3260 Q.sub.129                                                                             H      COOMe        Me   OMe    CH                                 3261 Q.sub.129                                                                             H      COOMe        OMe  OMe    CH                                 3262 Q.sub.129                                                                             H      COOEt        Me   OMe    CH                                 3263 Q.sub.129                                                                             H      COOEt        OMe  OMe    CH                                 3264 Q.sub.129                                                                             Me     COOMe        Me   Me     CH                                 3265 Q.sub.129                                                                             Me     COOMe        Me   OMe    CH                                 3266 Q.sub.129                                                                             Me     COOMe        OMe  OMe    CH                                 3267 Q.sub.129                                                                             Me     COOEt        Me   OMe    CH                                 3268 Q.sub.129                                                                             Me     COOEt        OMe  OMe    CH                                 3269 Me     H      Q.sub.129    Me   OMe    CH                                 3270 Me     H      Q.sub.129    OMe  OMe    CH                                 3271 Me     Me     Q.sub.129    Me   OMe    CH                                 3272 Me     Me     Q.sub.129    OMe  OMe    CH                                 3273 Q.sub.130                                                                             H      COOMe        Me   Me     CH                                 3274 Q.sub.130                                                                             H      COOMe        Me   OMe    CH                                 3275 Q.sub.130                                                                             H      COOMe        OMe  OMe    CH                                 3276 Q.sub.130                                                                             H      COOEt        Me   OMe    CH                                 3277 Q.sub.130                                                                             H      COOEt        OMe  OMe    CH                                 3278 Q.sub.130                                                                             Me     COOMe        Me   Me     CH                                 3279 Q.sub.130                                                                             Me     COOMe        Me   OMe    CH                                 3280 Q.sub.130                                                                             Me     COOMe        OMe  OMe    CH                                 3281 Q.sub.130                                                                             Me     COOEt        Me   OMe    CH                                 3282 Q.sub.130                                                                             Me     COOEt        OMe  OMe    CH                                 3283 Me     H      Q.sub.130    Me   OMe    CH                                 3284 Me     H      Q.sub.130    OMe  OMe    CH                                 3285 Me     Me     Q.sub.130    Me   OMe    CH                                 3286 Me     Me     Q.sub.130    OMe  OMe    CH                                 3287 Q.sub.131                                                                             H      COOMe        Me   Me     CH                                 3288 Q.sub.131                                                                             H      COOMe        Me   OMe    CH                                 3289 Q.sub.131                                                                             H      COOMe        OMe  OMe    CH                                 3290 Q.sub.131                                                                             H      COOEt        Me   OMe    CH                                 3291 Q.sub.131                                                                             H      COOEt        OMe  OMe    CH                                 3292 Q.sub.131                                                                             Me     COOMe        Me   Me     CH                                 3293 Q.sub.131                                                                             Me     COOMe        Me   OMe    CH                                 3294 Q.sub.131                                                                             Me     COOMe        OMe  OMe    CH                                 3295 Q.sub.131                                                                             Me     COOEt        Me   OMe    CH                                 3296 Q.sub.131                                                                             Me     COOEt        OMe  OMe    CH                                 3297 Me     H      Q.sub.131    Me   OMe    CH                                 3298 Me     H      Q.sub.131    OMe  OMe    CH                                 3299 Me     Me     Q.sub.131    Me   OMe    CH                                 3300 Me     Me     Q.sub.131    OMe  OMe    CH                                 3301 Q.sub.132                                                                             H      COOMe        Me   Me     CH                                 3302 Q.sub.132                                                                             H      COOMe        Me   OMe    CH                                 3303 Q.sub.132                                                                             H      COOMe        OMe  OMe    CH                                 3304 Q.sub.132                                                                             H      COOEt        Me   OMe    CH                                 3305 Q.sub.132                                                                             H      COOEt        OMe  OMe    CH                                 3306 Q.sub.132                                                                             Me     COOMe        Me   Me     CH                                 3307 Q.sub.132                                                                             Me     COOMe        Me   OMe    CH                                 3308 Q.sub.132                                                                             Me     COOMe        OMe  OMe    CH                                 3309 Q.sub.132                                                                             Me     COOEt        Me   OMe    CH                                 3310 Q.sub.132                                                                             Me     COOEt        OMe  OMe    CH                                 3311 Me     H      Q.sub.132    Me   OMe    CH                                 3312 Me     H      Q.sub.132    OMe  OMe    CH                                 3313 Me     Me     Q.sub.132    Me   OMe    CH                                 3314 Me     Me     Q.sub.132    OMe  OMe    CH                                 ______________________________________                                    

                  TABLE 2                                                          ______________________________________                                          ##STR11##                                                                     No.   A      B       D       X      Y      Z                                   ______________________________________                                         1006  Q.sub.1                                                                               Me      Cl      Me     Me     CH                                  1007  Q.sub.1                                                                               Me      Cl      Me     OMe    CH                                  1008  Q.sub.1                                                                               Me      Cl      OMe    OMe    CH                                  1009  Q.sub.1                                                                               Me      Cl      Me     OMe    N                                   1010  Q.sub.1                                                                               Me      Cl      OMe    OMe    N                                   1011  Q.sub.1                                                                               Me      OMe     Me     OMe    CH                                  1012  Q.sub.1                                                                               Me      OMe     OMe    OMe    CH                                  1013  Q.sub.1                                                                               Me      OMe     Me     OMe    N                                   1014  Q.sub.1                                                                               CF.sub.3                                                                               Me      Me     OMe    CH                                  1015  Q.sub.1                                                                               CF.sub.3                                                                               Me      OMe    OMe    CH                                  1016  Q.sub.1                                                                               CF.sub.3                                                                               Me      Me     OMe    N                                   1017  Q.sub.1                                                                               Me      COOMe   Me     Me     CH                                  1018  Q.sub.1                                                                               Me      COOMe   Me     OMe    CH                                  1019  Q.sub.1                                                                               Me      COOMe   OMe    OMe    CH                                  1020  Q.sub.1                                                                               Me      COOMe   Me     OMe    N                                   1021  Q.sub.1                                                                               Me      COOMe   OMe    OMe    N                                   1022  Q.sub.1                                                                               Me      COOMe   Me     OCHF.sub.2                                                                            CH                                  1023  Q.sub.1                                                                               Me      COOMe   Me                                                                                     ##STR12##                                                                            CH                                  1024  Q.sub.1                                                                               Me      SO.sub.2 Me                                                                            Me     OMe    CH                                  1025  Q.sub.1                                                                               Me      SO.sub.2 Me                                                                            OMe    OMe    CH                                  1026  Q.sub.1                                                                               Me      SO.sub.2 Me                                                                            Me     OMe    N                                   1027  H      Q.sub.1 Me      Me     OMe    CH                                  1028  H      Q.sub.1 Me      OMe    OMe    CH                                  1029  H      Q.sub.1 Me      Me     OMe    N                                   1030  Me     Q.sub.1 Me      Me     OMe    CH                                  1031  Me     Q.sub.1 Me      OMe    OMe    CH                                  1032  Me     Q.sub.1 Me      Me     OMe    N                                   1033  Me     Q.sub.1 Cl      Me     OMe    CH                                  1034  Me     Q.sub.1 Cl      OMe    OMe    CH                                  1035  Me     Q.sub.1 Cl      Me     OMe    N                                   1036  Me     Q.sub.1 COOMe   Me     OMe    CH                                  1037  Me     Q.sub.1 COOMe   OMe    OMe    CH                                  1038  Me     Q.sub.1 COOMe   Me     OMe    N                                   1039  Me     Q.sub.1 Ph      Me     OMe    CH                                  1040  Me     Q.sub.1 Ph      OMe    OMe    CH                                  1041  Me     Q.sub.1 Ph      Me     OMe    N                                   1042  Me     Me      Q.sub.1 Me     OMe    CH                                  1043  Me     Me      Q.sub.1 OMe    OMe    CH                                  1044  Me     Me      Q.sub.1 Me     OMe    N                                   1045  Q.sub.2                                                                               Me      COOMe   Me     Me     CH                                  1046  Q.sub.2                                                                               Me      COOMe   Me     OMe    CH                                  1047  Q.sub.2                                                                               Me      COOMe   OMe    OMe    CH                                  1048  Q.sub.2                                                                               Me      COOMe   Me     OMe    N                                   1049  Q.sub.2                                                                               Me      COOMe   OMe    OMe    N                                   1050  Me     Q.sub.2 Me      Me     OMe    CH                                  1051  Me     Q.sub.2 Me      OMe    OMe    CH                                  1052  Me     Q.sub.2 Me      Me     OMe    N                                   1053  Me     Me      Q.sub.2 Me     OMe    CH                                  1054  Me     Me      Q.sub.2 OMe    OMe    CH                                  1055  Me     Me      Q.sub.2 Me     OMe    N                                   1056  Q.sub.3                                                                               Me      COOMe   Me     Me     CH                                  1057  Q.sub.3                                                                               Me      COOMe   Me     OMe    CH                                  1058  Q.sub.3                                                                               Me      COOMe   OMe    OMe    CH                                  1059  Q.sub.3                                                                               Me      COOMe   Me     OMe    N                                   1060  Q.sub.3                                                                               Me      COOMe   OMe    OMe    N                                   1061  Me     Q.sub.3 Me      Me     OMe    CH                                  1062  Me     Q.sub.3 Me      OMe    OMe    CH                                  1063  Me     Q.sub.3 Me      Me     OMe    N                                   1064  Me     Me      Q.sub.3 Me     OMe    CH                                  1065  Me     Me      Q.sub.3 OMe    OMe    CH                                  1066  Me     Me      Q.sub.3 Me     OMe    N                                   1067  Q.sub.4                                                                               Me      COOMe   Me     Me     CH                                  1068  Q.sub.4                                                                               Me      COOMe   Me     OMe    CH                                  1069  Q.sub.4                                                                               Me      COOMe   OMe    OMe    CH                                  1070  Q.sub.4                                                                               Me      COOMe   Me     OMe    N                                   1071  Q.sub.4                                                                               Me      COOMe   OMe    OMe    N                                   1072  Me     Q.sub.4 Me      Me     OMe    CH                                  1073  Me     Q.sub.4 Me      OMe    OMe    CH                                  1074  Me     Q.sub.4 Me      Me     OMe    N                                   1075  Me     Me      Q.sub.4 Me     OMe    CH                                  1076  Me     Me      Q.sub.4 OMe    OMe    CH                                  1077  Me     Me      Q.sub.4 Me     OMe    N                                   1078  Q.sub.5                                                                               Me      COOMe   Me     Me     CH                                  1079  Q.sub.5                                                                               Me      COOMe   Me     OMe    CH                                  1080  Q.sub.5                                                                               Me      COOMe   OMe    OMe    CH                                  1081  Q.sub.5                                                                               Me      COOMe   Me     OMe    N                                   1082  Q.sub.5                                                                               Me      COOMe   OMe    OMe    N                                   1083  Me     Q.sub.5 Me      Me     OMe    CH                                  1084  Me     Q.sub.5 Me      OMe    OMe    CH                                  1085  Me     Q.sub.5 Me      Me     OMe    N                                   1086  Me     Me      Q.sub.5 Me     OMe    CH                                  1087  Me     Me      Q.sub.5 OMe    OMe    CH                                  1088  Me     Me      Q.sub.5 Me     OMe    N                                   1089  Q.sub.6                                                                               Me      COOMe   Me     Me     CH                                  1090  Q.sub.6                                                                               Me      COOMe   Me     OMe    CH                                  1091  Q.sub.6                                                                               Me      COOMe   OMe    OMe    CH                                  1092  Q.sub.6                                                                               Me      COOMe   Me     OMe    N                                   1093  Q.sub.6                                                                               Me      COOMe   OMe    OMe    N                                   1094  Me     Q.sub.6 Me      Me     OMe    CH                                  1095  Me     Q.sub.6 Me      OMe    OMe    CH                                  1096  Me     Q.sub.6 Me      Me     OMe    N                                   1097  Me     Me      Q.sub.6 Me     OMe    CH                                  1098  Me     Me      Q.sub.6 OMe    OMe    CH                                  1099  Me     Me      Q.sub.6 Me     OMe    N                                   1100  Q.sub.7                                                                               Me      COOMe   Me     OMe    CH                                  1101  Q.sub.7                                                                               Me      COOMe   OMe    OMe    CH                                  1102  Q.sub.7                                                                               Me      COOMe   Me     OMe    N                                   1103  Me     Me      Q.sub.7 OMe    OMe    CH                                  1104  Me     Me      Q.sub.7 Me     OMe    N                                   1105  Q.sub. 8                                                                              Me      COOMe   Me     OMe    CH                                  1106  Q.sub.8                                                                               Me      COOMe   OMe    OMe    CH                                  1107  Q.sub.8                                                                               Me      COOMe   Me     OMe    N                                   1108  Me     Me      Q.sub.8 OMe    OMe    CH                                  1109  Me     Me      Q.sub.8 Me     OMe    N                                   1110  Q.sub.9                                                                               Me      COOMe   Me     OMe    CH                                  1111  Q.sub.9                                                                               Me      COOMe   OMe    OMe    CH                                  1112  Q.sub.9                                                                               Me      COOMe   Me     OMe    N                                   1113  Me     Me      Q.sub.9 OMe    OMe    CH                                  1114  Me     Me      Q.sub.9 Me     OMe    N                                   1115  Q.sub.10                                                                              Me      COOMe   Me     OMe    CH                                  1116  Q.sub.10                                                                              Me      COOMe   OMe    OMe    CH                                  1117  Q.sub.10                                                                              Me      COOMe   Me     OMe    N                                   1118  Me     Me      Q.sub.10                                                                               OMe    OMe    CH                                  1119  Me     Me      Q.sub.10                                                                               Me     OMe    N                                   1120  Q.sub.11                                                                              Me      COOMe   Me     Me     CH                                  1121  Q.sub.11                                                                              Me      COOMe   Me     OMe    CH                                  1122  Q.sub.11                                                                              Me      COOMe   OMe    OMe    CH                                  1123  Q.sub.11                                                                              Me      COOMe   Me     OMe    N                                   1124  Q.sub.11                                                                              Me      COOMe   OMe    OMe    N                                   1125  Me     Q.sub.11                                                                               Me      Me     OMe    CH                                  1126  Me     Q.sub.11                                                                               Me      OMe    OMe    CH                                  1127  Me     Q.sub.11                                                                               Me      Me     OMe    N                                   1128  Me     Me      Q.sub.11                                                                               Me     OMe    CH                                  1129  Me     Me      Q.sub.11                                                                               OMe    OMe    CH                                  1130  Me     Me      Q.sub.11                                                                               Me     OMe    N                                   1131  Q.sub.12                                                                              Me      Cl      Me     Me     CH                                  1132  Q.sub.12                                                                              Me      Cl      Me     OMe    CH                                  1133  Q.sub.12                                                                              Me      Cl      OMe    OMe    CH                                  1134  Q.sub.12                                                                              Me      Cl      Me     OMe    N                                   1135  Q.sub.12                                                                              Me      Cl      OMe    OMe    N                                   1136  Q.sub.12                                                                              Me      OMe     Me     OMe    CH                                  1137  Q.sub.12                                                                              Me      OMe     OMe    OMe    CH                                  1138  Q.sub.12                                                                              Me      OMe     Me     OMe    N                                   1139  Q.sub.12                                                                              CF.sub.3                                                                               Me      Me     OMe    CH                                  1140  Q.sub.12                                                                              CF.sub.3                                                                               Me      OMe    OMe    CH                                  1141  Q.sub.12                                                                              CF.sub.3                                                                               Me      Me     OMe    N                                   1142  Q.sub.12                                                                              Me      COOMe   Me     Me     CH                                  1143  Q.sub.12                                                                              Me      COOMe   Me     OMe    CH                                  1144  Q.sub.12                                                                              Me      COOMe   OMe    OMe    CH                                  1145  Q.sub.12                                                                              Me      COOMe   Me     OMe    N                                   1146  Q.sub.12                                                                              Me      COOMe   OMe    OMe    N                                   1147  Q.sub.12                                                                              Me      COOMe   Me     OCHF.sub.2                                                                            CH                                  1148  Q.sub.12                                                                              Me      COOMe   Me                                                                                     ##STR13##                                                                            CH                                  1149  Q.sub.12                                                                              Me      SO.sub.2 Me                                                                            Me     OMe    CH                                  1150  Q.sub.12                                                                              Me      SO.sub.2 Me                                                                            OMe    OMe    CH                                  1151  Q.sub.12                                                                              Me      SO.sub.2 Me                                                                            Me     OMe    N                                   1152  H      Q.sub.12                                                                               Me      Me     OMe    CH                                  1153  H      Q.sub.12                                                                               Me      OMe    OMe    CH                                  1154  H      Q.sub.12                                                                               Me      Me     OMe    N                                   1155  Me     Q.sub.12                                                                               Me      Me     OMe    CH                                  1156  Me     Q.sub.12                                                                               Me      OMe    OMe    CH                                  1157  Me     Q.sub.12                                                                               Me      Me     OMe    N                                   1158  Me     Q.sub.12                                                                               Cl      Me     OMe    CH                                  1159  Me     Q.sub.12                                                                               Cl      OMe    OMe    CH                                  1160  Me     Q.sub.12                                                                               Cl      Me     OMe    N                                   1161  Me     Q.sub.12                                                                               COOMe   Me     OMe    CH                                  1162  Me     Q.sub.12                                                                               COOMe   OMe    OMe    CH                                  1163  Me     Q.sub.12                                                                               COOMe   Me     OMe    N                                   1164  Me     Q.sub.12                                                                               Ph      Me     OMe    CH                                  1165  Me     Q.sub.12                                                                               Ph      OMe    OMe    CH                                  1166  Me     Q.sub.12                                                                               Ph      Me     OMe    N                                   1167  Me     Me      Q.sub.12                                                                               Me     OMe    CH                                  1168  Me     Me      Q.sub.12                                                                               OMe    OMe    CH                                  1169  Me     Me      Q.sub.12                                                                               Me     OMe    N                                   1170  Q.sub.13                                                                              Me      COOMe   Me     Me     CH                                  1171  Q.sub.13                                                                              Me      COOMe   Me     OMe    CH                                  1172  Q.sub.13                                                                              Me      COOMe   OMe    OMe    CH                                  1173  Q.sub.13                                                                              Me      COOMe   Me     OMe    N                                   1174  Q.sub.13                                                                              Me      COOMe   OMe    OMe    N                                   1175  Me     Q.sub.13                                                                               Me      Me     OMe    CH                                  1176  Me     Q.sub.13                                                                               Me      OMe    OMe    CH                                  1177  Me     Q.sub.13                                                                               Me      Me     OMe    N                                   1178  Me     Me      Q.sub.13                                                                               Me     OMe    CH                                  1179  Me     Me      Q.sub.13                                                                               OMe    OMe    CH                                  1180  Me     Me      Q.sub.13                                                                               Me     OMe    N                                   1181  Q.sub.14                                                                              Me      COOMe   Me     Me     CH                                  1182  Q.sub.14                                                                              Me      COOMe   Me     OMe    CH                                  1183  Q.sub.14                                                                              Me      COOMe   OMe    OMe    CH                                  1184  Q.sub.14                                                                              Me      COOMe   Me     OMe    N                                   1185  Q.sub.14                                                                              Me      COOMe   OMe    OMe    N                                   1186  Me     Q.sub.14                                                                               Me      Me     OMe    CH                                  1187  Me     Q.sub.14                                                                               Me      OMe    OMe    CH                                  1188  Me     Q.sub.14                                                                               Me      Me     OMe    N                                   1189  Me     Me      Q.sub.14                                                                               Me     OMe    CH                                  1190  Me     Me      Q.sub.14                                                                               OMe    OMe    CH                                  1191  Me     Me      Q.sub.14                                                                               Me     OMe    N                                   1192  Q.sub.15                                                                              Me      COOMe   Me     OMe    CH                                  1193  Q.sub.15                                                                              Me      COOMe   OMe    OMe    CH                                  1194  Q.sub.15                                                                              Me      COOMe   Me     OMe    N                                   1195  Me     Me      Q.sub.15                                                                               OMe    OMe    CH                                  1196  Me     Me      Q.sub.15                                                                               Me     OMe    N                                   1197  Q.sub.17                                                                              Me      COOMe   Me     OMe    CH                                  1198  Q.sub.16                                                                              Me      COOMe   OMe    OMe    CH                                  1199  Q.sub.16                                                                              Me      COOMe   Me     OMe    N                                   1200  Me     Me      Q.sub.16                                                                               OMe    OMe    CH                                  1201  Me     Me      Q.sub.16                                                                               Me     OMe    N                                   1202  Q.sub.17                                                                              Me      COOMe   Me     OMe    CH                                  1203  Q.sub.17                                                                              Me      COOMe   OMe    OMe    CH                                  1204  Q.sub.17                                                                              Me      COOMe   Me     OMe    N                                   1205  Me     Me      Q.sub.17                                                                               OMe    OMe    CH                                  1206  Me     Me      Q.sub.17                                                                               Me     OMe    N                                   1207  Q.sub.18                                                                              Me      COOMe   Me     OMe    CH                                  1208  Q.sub.18                                                                              Me      COOMe   OMe    OMe    CH                                  1209  Q.sub.18                                                                              Me      COOMe   Me     OMe    N                                   1210  Me     Me      Q.sub.18                                                                               OMe    OMe    CH                                  1211  Me     Me      Q.sub.18                                                                               Me     OMe    N                                   1212  Q.sub.19                                                                              Me      COOMe   Me     Me     CH                                  1213  Q.sub.19                                                                              Me      COOMe   Me     OMe    CH                                  1214  Q.sub.19                                                                              Me      COOMe   OMe    OMe    CH                                  1215  Q.sub.19                                                                              Me      COOMe   Me     OMe    N                                   1216  Q.sub.19                                                                              Me      COOMe   OMe    OMe    N                                   1217  Me     Q.sub.19                                                                               Me      Me     OMe    CH                                  1218  Me     Q.sub.19                                                                               Me      OMe    OMe    CH                                  1219  Me     Q.sub.19                                                                               Me      Me     OMe    N                                   1220  Me     Me      Q.sub.19                                                                               Me     OMe    CH                                  1221  Me     Me      Q.sub.19                                                                               OMe    OMe    CH                                  1222  Me     Me      Q.sub.19                                                                               Me     OMe    N                                   1223  Q.sub.20                                                                              Me      COOMe   Me     OMe    CH                                  1224  Q.sub.20                                                                              Me      COOMe   OMe    OMe    CH                                  1225  Q.sub.20                                                                              Me      COOMe   Me     OMe    N                                   1226  Me     Me      Q.sub.20                                                                               OMe    OMe    CH                                  1227  Me     Me      Q.sub.20                                                                               Me     OMe    N                                   1228  Q.sub.21                                                                              Me      COOMe   Me     OMe    CH                                  1229  Q.sub.21                                                                              Me      COOMe   OMe    OMe    CH                                  1230  Q.sub.21                                                                              Me      COOMe   Me     OMe    N                                   1231  Me     Me      Q.sub.21                                                                               OMe    OMe    CH                                  1232  Me     Me      Q.sub.21                                                                               Me     OMe    N                                   1233  Q.sub.22                                                                              Me      Cl      Me     Me     CH                                  1234  Q.sub.22                                                                              Me      Cl      Me     OMe    CH                                  1235  Q.sub.22                                                                              Me      Cl      OMe    OMe    CH                                  1236  Q.sub.22                                                                              Me      Cl      Me     OMe    N                                   1237  Q.sub.22                                                                              Me      Cl      OMe    OMe    N                                   1238  Q.sub.22                                                                              Me      OMe     Me     OMe    CH                                  1239  Q.sub.22                                                                              Me      OMe     OMe    OMe    CH                                  1240  Q.sub.22                                                                              Me      OMe     Me     OMe    N                                   1241  Q.sub.22                                                                              CF.sub.3                                                                               Me      Me     OMe    CH                                  1242  Q.sub.22                                                                              CF.sub.3                                                                               Me      OMe    OMe    CH                                  1243  Q.sub.22                                                                              CF.sub.3                                                                               Me      Me     OMe    N                                   1244  Q.sub.22                                                                              Me      COOMe   Me     Me     CH                                  1245  Q.sub. 22                                                                             Me      COOMe   Me     OMe    CH                                  1246  Q.sub.22                                                                              Me      COOMe   OMe    OMe    CH                                  1247  Q.sub.22                                                                              Me      COOMe   Me     OMe    N                                   1248  Q.sub.22                                                                              Me      COOMe   OMe    OMe    N                                   1249  Q.sub.22                                                                              Me      COOMe   Me     OCHF.sub.2                                                                            CH                                  1250  Q.sub.22                                                                              Me      COOMe   Me                                                                                     ##STR14##                                                                            CH                                  1251  Q.sub.22                                                                              Me      SO.sub.2 Me                                                                            Me     OMe    CH                                  1252  Q.sub.22                                                                              Me      SO.sub.2 Me                                                                            OMe    OMe    CH                                  1253  Q.sub.22                                                                              Me      SO.sub.2 Me                                                                            Me     OMe    N                                   1254  H      Q.sub.22                                                                               Me      Me     OMe    CH                                  1255  H      Q.sub.22                                                                               Me      OMe    OMe    CH                                  1256  H      Q.sub.22                                                                               Me      Me     OMe    N                                   1257  Me     Q.sub.22                                                                               Me      Me     OMe    CH                                  1258  Me     Q.sub.22                                                                               Me      OMe    OMe    CH                                  1259  Me     Q.sub.22                                                                               Me      Me     OMe    N                                   1260  Me     Q.sub.22                                                                               Cl      Me     OMe    CH                                  1261  Me     Q.sub.22                                                                               Cl      OMe    OMe    CH                                  1262  Me     Q.sub.22                                                                               Cl      Me     OMe    N                                   1263  Me     Q.sub.22                                                                               COOMe   Me     OMe    CH                                  1264  Me     Q.sub.22                                                                               COOMe   OMe    OMe    CH                                  1265  Me     Q.sub.22                                                                               COOMe   Me     OMe    N                                   1266  Me     Q.sub.22                                                                               Ph      Me     OMe    CH                                  1267  Me     Q.sub.22                                                                               Ph      OMe    OMe    CH                                  1268  Me     Q.sub.22                                                                               Ph      Me     OMe    N                                   1269  Me     Me      Q.sub.22                                                                               Me     OMe    CH                                  1270  Me     Me      Q.sub.22                                                                               OMe    OMe    CH                                  1271  Me     Me      Q.sub.22                                                                               Me     OMe    N                                   1272  Q.sub.23                                                                              Me      COOMe   Me     Me     CH                                  1273  Q.sub.23                                                                              Me      COOMe   Me     OMe    CH                                  1274  Q.sub.23                                                                              Me      COOMe   OMe    OMe    CH                                  1275  Q.sub.23                                                                              Me      COOMe   Me     OMe    N                                   1276  Q.sub.23                                                                              Me      COOMe   OMe    OMe    N                                   1277  Me     Q.sub.23                                                                               Me      Me     OMe    CH                                  1278  Me     Q.sub.23                                                                               Me      OMe    OMe    CH                                  1279  Me     Q.sub.23                                                                               Me      Me     OMe    N                                   1280  Me     Me      Q.sub.23                                                                               Me     OMe    CH                                  1281  Me     Me      Q.sub.23                                                                               OMe    OMe    CH                                  1282  Me     Me      Q.sub.23                                                                               Me     OMe    N                                   1283  Q.sub.24                                                                              Me      COOMe   Me     Me     CH                                  1284  Q.sub.24                                                                              Me      COOMe   Me     OMe    CH                                  1285  Q.sub.24                                                                              Me      COOMe   OMe    OMe    CH                                  1286  Q.sub.24                                                                              Me      COOMe   Me     OMe    N                                   1287  Q.sub.24                                                                              Me      COOMe   OMe    OMe    N                                   1288  Me     Q.sub.24                                                                               Me      Me     OMe    CH                                  1289  Me     Q.sub.24                                                                               Me      OMe    OMe    CH                                  1290  Me     Q.sub.24                                                                               Me      Me     OMe    N                                   1291  Me     Me      Q.sub.24                                                                               Me     OMe    CH                                  1292  Me     Me      Q.sub.24                                                                               OMe    OMe    CH                                  1293  Me     Me      Q.sub.24                                                                               Me     OMe    N                                   1294  Q.sub.25                                                                              Me      COOMe   Me     Me     CH                                  1295  Q.sub.25                                                                              Me      COOMe   Me     OMe    CH                                  1296  Q.sub.25                                                                              Me      COOMe   OMe    OMe    CH                                  1297  Q.sub.25                                                                              Me      COOMe   Me     OMe    N                                   1298  Q.sub.25                                                                              Me      COOMe   OMe    OMe    N                                   1299  Me     Q.sub.25                                                                               Me      Me     OMe    CH                                  1300  Me     Q.sub. 25                                                                              Me      OMe    OMe    CH                                  1301  Me     Q.sub.25                                                                               Me      Me     OMe    N                                   1302  Me     Me      Q.sub.25                                                                               Me     OMe    CH                                  1303  Me     Me      Q.sub.25                                                                               OMe    OMe    CH                                  1304  Me     Me      Q.sub.25                                                                               Me     OMe    N                                   1305  Q.sub.26                                                                              Me      COOMe   Me     OMe    CH                                  1306  Q.sub.26                                                                              Me      COOMe   OMe    OMe    CH                                  1307  Q.sub.26                                                                              Me      COOMe   Me     OMe    N                                   1308  Me     Me      Q.sub.26                                                                               OMe    OMe    CH                                  1309  Me     Me      Q.sub.26                                                                               Me     OMe    N                                   1310  Q.sub.27                                                                              Me      COOMe   Me     OMe    CH                                  1311  Q.sub.27                                                                              Me      COOMe   OMe    OMe    CH                                  1312  Q.sub.27                                                                              Me      COOMe   Me     OMe    N                                   1313  Me     Me      Q.sub.27                                                                               OMe    OMe    CH                                  1314  Me     Me      Q.sub.27                                                                               Me     OMe    N                                   1315  Q.sub.28                                                                              Me      COOMe   Me     OMe    CH                                  1316  Q.sub.28                                                                              Me      COOMe   OMe    OMe    CH                                  1317  Q.sub.28                                                                              Me      COOMe   Me     OMe    N                                   1318  Me     Me      Q.sub.28                                                                               OMe    OMe    CH                                  1319  Me     Me      Q.sub.28                                                                               Me     OMe    N                                   1320  Q.sub.29                                                                              Me      COOMe   Me     OMe    CH                                  1321  Q.sub.29                                                                              Me      COOMe   OMe    OMe    CH                                  1322  Q.sub.29                                                                              Me      COOMe   Me     OMe    N                                   1323  Me     Me      Q.sub.29                                                                               OMe    OMe    CH                                  1324  Me     Me      Q.sub.29                                                                               Me     OMe    N                                   1325  Q.sub.30                                                                              Me      COOMe   Me     OMe    CH                                  1326  Q.sub.30                                                                              Me      COOMe   OMe    OMe    CH                                  1327  Q.sub.30                                                                              Me      COOMe   Me     OMe    N                                   1328  Me     Me      Q.sub.30                                                                               OMe    OMe    CH                                  1329  Me     Me      Q.sub.30                                                                               Me     OMe    N                                   1330  Q.sub.31                                                                              Me      COOMe   Me     OMe    CH                                  1331  Q.sub.31                                                                              Me      COOMe   OMe    OMe    CH                                  1332  Q.sub.31                                                                              Me      COOMe   Me     OMe    N                                   1333  Me     Me      Q.sub.31                                                                               OMe    OMe    CH                                  1334  Me     Me      Q.sub.31                                                                               Me     OMe    N                                   1335  Q.sub.32                                                                              Me      COOMe   Me     Me     CH                                  1336  Q.sub.32                                                                              Me      COOMe   Me     OMe    CH                                  1337  Q.sub.32                                                                              Me      COOMe   OMe    OMe    CH                                  1338  Q.sub.32                                                                              Me      COOMe   Me     OMe    N                                   1339  Q.sub.32                                                                              Me      COOMe   OMe    OMe    N                                   1340  Me     Q.sub.32                                                                               Me      Me     OMe    CH                                  1341  Me     Q.sub.32                                                                               Me      OMe    OMe    CH                                  1342  Me     Q.sub.32                                                                               Me      Me     OMe    N                                   1343  Me     Me      Q.sub.32                                                                               Me     OMe    CH                                  1344  Me     Me      Q.sub.32                                                                               OMe    OMe    CH                                  1345  Me     Me      Q.sub.32                                                                               Me     OMe    N                                   1346  Q.sub.33                                                                              Me      COOMe   Me     OMe    CH                                  1347  Q.sub.33                                                                              Me      COOMe   OMe    OMe    CH                                  1348  Q.sub.33                                                                              Me      COOMe   Me     OMe    N                                   1349  Me     Me      Q.sub.33                                                                               OMe    OMe    CH                                  1350  Me     Me      Q.sub.33                                                                               Me     OMe    N                                   1351  Q.sub.34                                                                              Me      COOMe   Me     OMe    CH                                  1352  Q.sub.34                                                                              Me      COOMe   OMe    OMe    CH                                  1353  Q.sub.34                                                                              Me      COOMe   Me     OMe    N                                   1354  Me     Me      Q.sub.34                                                                               OMe    OMe    CH                                  1355  Me     Me      Q.sub.34                                                                               Me     OMe    N                                   1356  Q.sub.35                                                                              Me      COOMe   Me     OMe    CH                                  1357  Q.sub.35                                                                              Me      COOMe   OMe    OMe    CH                                  1358  Q.sub.35                                                                              Me      COOMe   Me     OMe    N                                   1359  Me     Me      Q.sub.35                                                                               OMe    OMe    CH                                  1360  Me     Me      Q.sub.35                                                                               Me     OMe    N                                   1361  Q.sub.36                                                                              Me      COOMe   Me     OMe    CH                                  1362  Q.sub.36                                                                              Me      COOMe   OMe    OMe    CH                                  1363  Q.sub.36                                                                              Me      COOMe   Me     OMe    N                                   1364  Me     Me      Q.sub.36                                                                               OMe    OMe    CH                                  1365  Me     Me      Q.sub.36                                                                               Me     OMe    N                                   1366  Q.sub.37                                                                              Me      COOMe   Me     OMe    CH                                  1367  Q.sub.37                                                                              Me      COOMe   OMe    OMe    CH                                  1368  Q.sub.37                                                                              Me      COOMe   Me     OMe    N                                   1369  Me     Me      Q.sub.37                                                                               OMe    OMe    CH                                  1370  Me     Me      Q.sub.37                                                                               Me     OMe    N                                   1371  Q.sub.38                                                                              Me      COOMe   Me     OMe    CH                                  1372  Q.sub.38                                                                              Me      COOMe   OMe    OMe    CH                                  1373  Q.sub.38                                                                              Me      COOMe   Me     OMe    N                                   1374  Me     Me      Q.sub.38                                                                               OMe    OMe    CH                                  1375  Me     Me      Q.sub.38                                                                               Me     OMe    N                                   1376  Q.sub.39                                                                              Me      COOMe   Me     OMe    CH                                  1377  Q.sub.39                                                                              Me      COOMe   OMe    OMe    CH                                  1378  Q.sub.39                                                                              Me      COOMe   Me     OMe    N                                   1379  Me     Me      Q.sub.39                                                                               OMe    OMe    CH                                  1380  Me     Me      Q.sub.39                                                                               Me     OMe    N                                   1381  Q.sub.40                                                                              Me      COOMe   Me     OMe    CH                                  1382  Q.sub.40                                                                              Me      COOMe   OMe    OMe    CH                                  1383  Q.sub.40                                                                              Me      COOMe   Me     OMe    N                                   1384  Me     Me      Q.sub.40                                                                               OMe    OMe    CH                                  1385  Me     Me      Q.sub.40                                                                               Me     OMe    N                                   1386  Q.sub.41                                                                              Me      COOMe   Me     OMe    CH                                  1387  Q.sub.41                                                                              Me      COOMe   OMe    OMe    CH                                  1388  Q.sub.41                                                                              Me      COOMe   Me     OMe    N                                   1389  Me     Me      Q.sub.41                                                                               OMe    OMe    CH                                  1390  Me     Me      Q.sub.41                                                                               Me     OMe    N                                   1391  Q.sub.42                                                                              Me      COOMe   Me     OMe    CH                                  1392  Q.sub.42                                                                              Me      COOMe   OMe    OMe    CH                                  1393  Q.sub.42                                                                              Me      COOMe   Me     OMe    N                                   1394  Me     Me      Q.sub.42                                                                               OMe    OMe    CH                                  1395  Me     Me      Q.sub.42                                                                               Me     OMe    N                                   1396  Q.sub.43                                                                              Me      COOMe   Me     OMe    CH                                  1397  Q.sub.43                                                                              Me      COOMe   OMe    OMe    CH                                  1398  Q.sub.43                                                                              Me      COOMe   Me     OMe    N                                   1399  Me     Me      Q.sub.43                                                                               OMe    OMe    CH                                  1400  Me     Me      Q.sub.43                                                                               Me     OMe    N                                   1401  Q.sub.44                                                                              Me      COOMe   Me     OMe    CH                                  1402  Q.sub.44                                                                              Me      COOMe   OMe    OMe    CH                                  1403  Q.sub.44                                                                              Me      COOMe   Me     OMe    N                                   1404  Me     Me      Q.sub.44                                                                               OMe    OMe    CH                                  1405  Me     Me      Q.sub.44                                                                               Me     OMe    N                                   1406  Q.sub.45                                                                              Me      COOMe   Me     OMe    CH                                  1407  Q.sub.45                                                                              Me      COOMe   OMe    OMe    CH                                  1408  Q.sub.45                                                                              Me      COOMe   Me     OMe    N                                   1409  Me     Me      Q.sub.45                                                                               OMe    OMe    CH                                  1410  Me     Me      Q.sub.45                                                                               Me     OMe    N                                   1411  Q.sub.46                                                                              Me      COOMe   Me     OMe    CH                                  1412  Q.sub.46                                                                              Me      COOMe   OMe    OMe    CH                                  1413  Q.sub.46                                                                              Me      COOMe   Me     OMe    N                                   1414  Me     Me      Q.sub.46                                                                               OMe    OMe    CH                                  1415  Me     Me      Q.sub.46                                                                               Me     OMe    N                                   1416  Q.sub.47                                                                              Me      COOMe   Me     OMe    CH                                  1417  Q.sub.47                                                                              Me      COOMe   OMe    OMe    CH                                  1418  Q.sub.47                                                                              Me      COOMe   Me     OMe    N                                   1419  Me     Me      Q.sub.47                                                                               OMe    OMe    CH                                  1420  Me     Me      Q.sub.47                                                                               Me     OMe    N                                   3315  Q.sub.48                                                                              Me      COOMe   OMe    OMe    CH                                  3316  Me     Q.sub.48                                                                               Me      Me     Me     CH                                  3317  Me     Q.sub.48                                                                               Me      Me     OMe    CH                                  3318  Me     Q.sub.48                                                                               Me      OMe    OMe    CH                                  3319  Me     Me      Q.sub.48                                                                               Me     Me     CH                                  3320  Me     Me      Q.sub.48                                                                               Me     OMe    CH                                  3321  Me     Me      Q.sub.48                                                                               OMe    OMe    CH                                  3322  H      Me      Q.sub.48                                                                               OMe    OMe    CH                                  3323  Q.sub.49                                                                              Me      COOMe   OMe    OMe    CH                                  3324  Me     Q.sub.49                                                                               Me      Me     Me     CH                                  3325  Me     Q.sub.49                                                                               Me      Me     OMe    CH                                  3326  Me     Q.sub.49                                                                               Me      OMe    OMe    CH                                  3327  Me     Me      Q.sub.49                                                                               Me     Me     CH                                  3328  Me     Me      Q.sub.49                                                                               Me     OMe    CH                                  3329  Me     Me      Q.sub.49                                                                               OMe    OMe    CH                                  3330  H      Me      Q.sub.49                                                                               OMe    OMe    CH                                  3331  Q.sub.50                                                                              Me      COOMe   OMe    OMe    CH                                  3332  Me     Q.sub.50                                                                               Me      Me     Me     CH                                  3333  Me     Q.sub.50                                                                               Me      Me     OMe    CH                                  3334  Me     Q.sub.50                                                                               Me      OMe    OMe    CH                                  3335  Me     Me      Q.sub.50                                                                               Me     Me     CH                                  3336  Me     Me      Q.sub.50                                                                               Me     OMe    CH                                  3337  Me     Me      Q.sub.50                                                                               OMe    OMe    CH                                  3338  H      Me      Q.sub.50                                                                               OMe    OMe    CH                                  3339  Q.sub.51                                                                              Me      COOMe   OMe    OMe    CH                                  3340  Me     Q.sub.51                                                                               Me      Me     Me     CH                                  3341  Me     Q.sub.51                                                                               Me      Me     OMe    CH                                  3342  Me     Q.sub.51                                                                               Me      OMe    OMe    CH                                  3343  Me     Me      Q.sub.51                                                                               Me     Me     CH                                  3344  Me     Me      Q.sub.51                                                                               Me     OMe    CH                                  3345  Me     Me      Q.sub.51                                                                               OMe    OMe    CH                                  3346  H      Me      Q.sub.51                                                                               OMe    OMe    CH                                  3347  Q.sub.52                                                                              Me      COOMe   OMe    OMe    CH                                  3348  Me     Q.sub.52                                                                               Me      Me     Me     CH                                  3349  Me     Q.sub.52                                                                               Me      Me     OMe    CH                                  3350  Me     Q.sub.52                                                                               Me      OMe    OMe    CH                                  3351  Me     Me      Q.sub.52                                                                               Me     Me     CH                                  3352  Me     Me      Q.sub.52                                                                               Me     OMe    CH                                  3353  Me     Me      Q.sub.52                                                                               OMe    OMe    CH                                  3354  H      Me      Q.sub.52                                                                               OMe    OMe    CH                                  3355  Q.sub.53                                                                              Me      COOMe   Me     Me     CH                                  3356  Q.sub.53                                                                              Me      COOMe   Me     OMe    CH                                  3357  Q.sub.53                                                                              Me      COOMe   OMe    OMe    CH                                  3358  Q.sub.53                                                                              Me      COOMe   Me     OMe    N                                   3359  Q.sub.53                                                                              Me      COOMe   OMe    OMe    N                                   3360  Me     Q.sub.53                                                                               Me      Me     OMe    CH                                  3361  Me     Q.sub.53                                                                               Me      OMe    OMe    CH                                  3362  Me     Q.sub.53                                                                               Me      Me     OMe    N                                   3363  Me     Me      Q.sub.53                                                                               Me     OMe    CH                                  3364  Me     Me      Q.sub.53                                                                               OMe    OMe    CH                                  3365  Me     Me      Q.sub.53                                                                               Me     OMe    N                                   3366  H      Me      Q.sub.53                                                                               OMe    OMe    CH                                  3367  Q.sub.54                                                                              Me      COOMe   OMe    OMe    CH                                  3368  Me     Q.sub.54                                                                               Me      Me     Me     CH                                  3369  Me     Q.sub.54                                                                               Me      Me     OMe    CH                                  3370  Me     Q.sub.54                                                                               Me      OMe    OMe    CH                                  3371  Me     Me      Q.sub.54                                                                               Me     Me     CH                                  3372  Me     Me      Q.sub.54                                                                               Me     OMe    CH                                  3373  Me     Me      Q.sub.54                                                                               OMe    OMe    CH                                  3374  H      Me      Q.sub.54                                                                               OMe    OMe    CH                                  3375  Q.sub.55                                                                              Me      COOMe   OMe    OMe    CH                                  3376  Me     Q.sub.55                                                                               Me      Me     Me     CH                                  3377  Me     Q.sub.55                                                                               Me      Me     OMe    CH                                  3378  Me     Q.sub.55                                                                               Me      OMe    OMe    CH                                  3379  Me     Me      Q.sub.55                                                                               Me     Me     CH                                  3380  Me     Me      Q.sub.55                                                                               Me     OMe    CH                                  3381  Me     Me      Q.sub.55                                                                               OMe    OMe    CH                                  3382  H      Me      Q.sub.55                                                                               OMe    OMe    CH                                  3383  Q.sub.56                                                                              Me      COOMe   OMe    OMe    CH                                  3384  Me     Q.sub.56                                                                               Me      Me     Me     CH                                  3385  Me     Q.sub.56                                                                               Me      Me     OMe    CH                                  3386  Me     Q.sub.56                                                                               Me      OMe    OMe    CH                                  3387  Me     Me      Q.sub.56                                                                               Me     Me     CH                                  3388  Me     Me      Q.sub.56                                                                               Me     OMe    CH                                  3389  Me     Me      Q.sub.56                                                                               OMe    OMe    CH                                  3390  H      Me      Q.sub.56                                                                               OMe    OMe    CH                                  3391  Q.sub.57                                                                              Me      COOMe   OMe    OMe    CH                                  3392  Me     Q.sub.57                                                                               Me      Me     Me     CH                                  3393  Me     Q.sub.57                                                                               Me      Me     OMe    CH                                  3394  Me     Q.sub.57                                                                               Me      OMe    OMe    CH                                  3395  Me     Me      Q.sub.57                                                                               Me     Me     CH                                  3396  Me     Me      Q.sub.57                                                                               Me     OMe    CH                                  3397  Me     Me      Q.sub.57                                                                               OMe    OMe    CH                                  3398  H      Me      Q.sub.57                                                                               OMe    OMe    CH                                  3399  Q.sub.58                                                                              Me      COOMe   OMe    OMe    CH                                  3400  Me     Q.sub.58                                                                               Me      Me     Me     CH                                  3401  Me     Q.sub.58                                                                               Me      Me     OMe    CH                                  3402  Me     Q.sub.58                                                                               Me      OMe    OMe    CH                                  3403  Me     Me      Q.sub.58                                                                               Me     Me     CH                                  3404  Me     Me      Q.sub.58                                                                               Me     OMe    CH                                  3405  Me     Me      Q.sub.58                                                                               OMe    OMe    CH                                  3406  H      Me      Q.sub.58                                                                               OMe    OMe    CH                                  3407  Q.sub.59                                                                              Me      COOMe   OMe    OMe    CH                                  3408  Me     Q.sub.59                                                                               Me      Me     Me     CH                                  3409  Me     Q.sub.59                                                                               Me      Me     OMe    CH                                  3410  Me     Q.sub.59                                                                               Me      OMe    OMe    CH                                  3411  Me     Me      Q.sub.59                                                                               Me     Me     CH                                  3412  Me     Me      Q.sub.59                                                                               Me     OMe    CH                                  3413  Me     Me      Q.sub.59                                                                               OMe    OMe    CH                                  3414  H      Me      Q.sub.59                                                                               OMe    OMe    CH                                  3415  Q.sub.60                                                                              Me      COOMe   Me     Me     CH                                  3416  Q.sub.60                                                                              Me      COOMe   Me     OMe    CH                                  3417  Q.sub.60                                                                              Me      COOMe   OMe    OMe    CH                                  3418  Q.sub.60                                                                              Me      COOMe   Me     OMe    N                                   3419  Q.sub.60                                                                              Me      COOMe   OMe    OMe    N                                   3420  Me     Q.sub.60                                                                               Me      Me     OMe    CH                                  3421  Me     Q.sub.60                                                                               Me      OMe    OMe    CH                                  3422  Me     Q.sub.60                                                                               Me      Me     OMe    N                                   3423  Me     Me      Q.sub.60                                                                               Me     OMe    CH                                  3424  Me     Me      Q.sub.60                                                                               OMe    OMe    CH                                  3425  Me     Me      Q.sub.60                                                                               Me     OMe    N                                   3426  H      Me      Q.sub.60                                                                               OMe    OMe    CH                                  3427  Q.sub.61                                                                              Me      COOMe   OMe    OMe    CH                                  3428  Me     Q.sub.61                                                                               Me      Me     Me     CH                                  3429  Me     Q.sub.61                                                                               Me      Me     OMe    CH                                  3430  Me     Q.sub.61                                                                               Me      OMe    OMe    CH                                  3431  Me     Me      Q.sub.61                                                                               Me     Me     CH                                  3432  Me     Me      Q.sub.61                                                                               Me     OMe    CH                                  3433  Me     Me      Q.sub.61                                                                               OMe    OMe    CH                                  3434  H      Me      Q.sub.61                                                                               OMe    OMe    CH                                  3435  Q.sub.62                                                                              Me      COOMe   OMe    OMe    CH                                  3436  Me     Q.sub.62                                                                               Me      Me     Me     CH                                  3437  Me     Q.sub.62                                                                               Me      Me     OMe    CH                                  3438  Me     Q.sub.62                                                                               Me      OMe    OMe    CH                                  3439  Me     Me      Q.sub.62                                                                               Me     Me     CH                                  3440  Me     Me      Q.sub.62                                                                               Me     OMe    CH                                  3441  Me     Me      Q.sub.62                                                                               OMe    OMe    CH                                  3442  H      Me      Q.sub.62                                                                               OMe    OMe    CH                                  3443  Q.sub.63                                                                              Me      COOMe   OMe    OMe    CH                                  3444  Me     Q.sub.63                                                                               Me      Me     Me     CH                                  3445  Me     Q.sub.63                                                                               Me      Me     OMe    CH                                  3446  Me     Q.sub.63                                                                               Me      OMe    OMe    CH                                  3447  Me     Me      Q.sub.63                                                                               Me     Me     CH                                  3448  Me     Me      Q.sub.63                                                                               Me     OMe    CH                                  3449  Me     Me      Q.sub.63                                                                               OMe    OMe    CH                                  3450  H      Me      Q.sub.63                                                                               OMe    OMe    CH                                  3451  Q.sub.64                                                                              Me      COOMe   OMe    OMe    CH                                  3452  Me     Q.sub.64                                                                               Me      Me     Me     CH                                  3453  Me     Q.sub.64                                                                               Me      Me     OMe    CH                                  3454  Me     Q.sub.64                                                                               Me      OMe    OMe    CH                                  3455  Me     Me      Q.sub.64                                                                               Me     Me     CH                                  3456  Me     Me      Q.sub.64                                                                               Me     OMe    CH                                  3457  Me     Me      Q.sub.64                                                                               OMe    OMe    CH                                  3458  H      Me      Q.sub.64                                                                               OMe    OMe    CH                                  3459  Q.sub.65                                                                              Me      COOMe   Me     Me     CH                                  3460  Q.sub.65                                                                              Me      COOMe   Me     OMe    CH                                  3461  Q.sub.65                                                                              Me      COOMe   OMe    OMe    CH                                  3462  Q.sub.65                                                                              Me      COOMe   Me     OMe    N                                   3463  Q.sub.65                                                                              Me      COOMe   OMe    OMe    N                                   3464  Me     Q.sub.65                                                                               Me      Me     OMe    CH                                  3465  Me     Q.sub.65                                                                               Me      OMe    OMe    CH                                  3466  Me     Q.sub.65                                                                               Me      Me     OMe    N                                   3467  Me     Me      Q.sub.65                                                                               Me     OMe    CH                                  3468  Me     Me      Q.sub.65                                                                               OMe    OMe    CH                                  3469  Me     Me      Q.sub.65                                                                               Me     OMe    N                                   3470  H      Me      Q.sub.65                                                                               OMe    OMe    CH                                  3471  Q.sub.66                                                                              Me      COOMe   OMe    OMe    CH                                  3472  Me     Q.sub.66                                                                               Me      Me     Me     CH                                  3473  Me     Q.sub.66                                                                               Me      Me     OMe    CH                                  3474  Me     Q.sub.66                                                                               Me      OMe    OMe    CH                                  3475  Me     Me      Q.sub.66                                                                               Me     Me     CH                                  3476  Me     Me      Q.sub.66                                                                               Me     OMe    CH                                  3477  Me     Me      Q.sub.66                                                                               OMe    OMe    CH                                  3478  H      Me      Q.sub.66                                                                               OMe    OMe    CH                                  3479  Q.sub.67                                                                              Me      COOMe   OMe    OMe    CH                                  3480  Me     Q.sub.67                                                                               Me      Me     Me     CH                                  3481  Me     Q.sub.67                                                                               Me      Me     OMe    CH                                  3482  Me     Q.sub.67                                                                               Me      OMe    OMe    CH                                  3483  Me     Me      Q.sub.67                                                                               Me     Me     CH                                  3484  Me     Me      Q.sub.67                                                                               Me     OMe    CH                                  3485  Me     Me      Q.sub.67                                                                               OMe    OMe    CH                                  3486  H      Me      Q.sub.67                                                                               OMe    OMe    CH                                  3487  Q.sub.68                                                                              Me      COOMe   Me     Me     CH                                  3488  Q.sub.68                                                                              Me      COOMe   Me     OMe    CH                                  3489  Q.sub.68                                                                              Me      COOMe   OMe    OMe    CH                                  3490  Q.sub.68                                                                              Me      COOMe   Me     OMe    N                                   3491  Q.sub.68                                                                              Me      COOMe   OMe    OMe    N                                   3492  Me     Q.sub.68                                                                               Me      Me     OMe    CH                                  3493  Me     Q.sub.68                                                                               Me      OMe    OMe    CH                                  3494  Me     Q.sub.68                                                                               Me      Me     OMe    N                                   3495  Me     Me      Q.sub.68                                                                               Me     OMe    CH                                  3496  Me     Me      Q.sub.68                                                                               OMe    OMe    CH                                  3497  Me     Me      Q.sub.68                                                                               Me     OMe    N                                   3498  H      Me      Q.sub.68                                                                               OMe    OMe    CH                                  3499  Q.sub.69                                                                              Me      COOMe   OMe    OMe    CH                                  3500  Me     Q.sub.69                                                                               Me      Me     Me     CH                                  3501  Me     Q.sub.69                                                                               Me      Me     OMe    CH                                  3502  Me     Q.sub.69                                                                               Me      OMe    OMe    CH                                  3503  Me     Me      Q.sub.69                                                                               Me     Me     CH                                  3504  Me     Me      Q.sub.69                                                                               Me     OMe    CH                                  3505  Me     Me      Q.sub.69                                                                               OMe    OMe    CH                                  3506  H      Me      Q.sub.69                                                                               OMe    OMe    CH                                  3507  Q.sub.70                                                                              Me      COOMe   OMe    OMe    CH                                  3508  Me     Q.sub.70                                                                               Me      Me     Me     CH                                  3509  Me     Q.sub.70                                                                               Me      Me     OMe    CH                                  3510  Me     Q.sub.70                                                                               Me      OMe    OMe    CH                                  3511  Me     Me      Q.sub.70                                                                               Me     Me     CH                                  3512  Me     Me      Q.sub.70                                                                               Me     OMe    CH                                  3513  Me     Me      Q.sub.70                                                                               OMe    OMe    CH                                  3514  H      Me      Q.sub.70                                                                               OMe    OMe    CH                                  3515  Q.sub.71                                                                              Me      COOMe   Me     Me     CH                                  3516  Q.sub.71                                                                              Me      COOMe   Me     OMe    CH                                  3517  Q.sub.71                                                                              Me      COOMe   OMe    OMe    CH                                  3518  Q.sub.71                                                                              Me      COOMe   Me     OMe    N                                   3519  Q.sub.71                                                                              Me      COOMe   OMe    OMe    N                                   3520  Me     Q.sub.71                                                                               Me      Me     OMe    CH                                  3519  Me     Q.sub.71                                                                               Me      OMe    OMe    CH                                  3520  Me     Q.sub.71                                                                               Me      Me     OMe    N                                   3521  Me     Me      Q.sub.71                                                                               Me     OMe    CH                                  3522  Me     Me      Q.sub.71                                                                               OMe    OMe    CH                                  3523  Me     Me      Q.sub.71                                                                               Me     OMe    N                                   3524  H      Me      Q.sub.71                                                                               OMe    OMe    CH                                  3525  Q.sub.72                                                                              Me      COOMe   OMe    OMe    CH                                  3526  Me     Q.sub.72                                                                               Me      Me     Me     CH                                  3527  Me     Q.sub.72                                                                               Me      Me     OMe    CH                                  3528  Me     Q.sub.72                                                                               Me      OMe    OMe    CH                                  3529  Me     Me      Q.sub.72                                                                               Me     Me     CH                                  3530  Me     Me      Q.sub.72                                                                               Me     OMe    CH                                  3531  Me     Me      Q.sub.72                                                                               OMe    OMe    CH                                  3532  H      Me      Q.sub.72                                                                               OMe    OMe    CH                                  3533  Q.sub.73                                                                              Me      COOMe   OMe    OMe    CH                                  3534  Me     Q.sub.73                                                                               Me      Me     Me     CH                                  3535  Me     Q.sub.73                                                                               Me      Me     OMe    CH                                  3536  Me     Q.sub.73                                                                               Me      OMe    OMe    CH                                  3537  Me     Me      Q.sub.73                                                                               Me     Me     CH                                  3538  Me     Me      Q.sub.73                                                                               Me     OMe    CH                                  3539  Me     Me      Q.sub.73                                                                               OMe    OMe    CH                                  3540  H      Me      Q.sub.73                                                                               OMe    OMe    CH                                  3541  Q.sub.74                                                                              Me      COOMe   OMe    OMe    CH                                  3542  Me     Q.sub.74                                                                               Me      Me     Me     CH                                  3543  Me     Q.sub.74                                                                               Me      Me     OMe    CH                                  3544  Me     Q.sub.74                                                                               Me      OMe    OMe    CH                                  3545  Me     Me      Q.sub.74                                                                               Me     Me     CH                                  3546  Me     Me      Q.sub.74                                                                               Me     OMe    CH                                  3547  Me     Me      Q.sub.74                                                                               OMe    OMe    CH                                  3548  H      Me      Q.sub.74                                                                               OMe    OMe    CH                                  3549  Q.sub.75                                                                              Me      COOMe   OMe    OMe    CH                                  3550  Me     Q.sub.75                                                                               Me      Me     Me     CH                                  3551  Me     Q.sub.75                                                                               Me      Me     OMe    CH                                  3552  Me     Q.sub.75                                                                               Me      OMe    OMe    CH                                  3553  Me     Me      Q.sub.75                                                                               Me     Me     CH                                  3554  Me     Me      Q.sub.75                                                                               Me     OMe    CH                                  3555  Me     Me      Q.sub.75                                                                               OMe    OMe    CH                                  3556  H      Me      Q.sub.75                                                                               OMe    OMe    CH                                  3557  Q.sub.76                                                                              Me      COOMe   OMe    OMe    CH                                  3558  Me     Q.sub.76                                                                               Me      Me     Me     CH                                  3559  Me     Q.sub.76                                                                               Me      Me     OMe    CH                                  3560  Me     Q.sub.76                                                                               Me      OMe    OMe    CH                                  3561  Me     Me      Q.sub.76                                                                               Me     Me     CH                                  3562  Me     Me      Q.sub.76                                                                               Me     OMe    CH                                  3563  Me     Me      Q.sub.76                                                                               OMe    OMe    CH                                  3564  H      Me      Q.sub.76                                                                               OMe    OMe    CH                                  3565  Q.sub.77                                                                              Me      COOMe   OMe    OMe    CH                                  3566  Me     Q.sub.77                                                                               Me      Me     Me     CH                                  3567  Me     Q.sub.77                                                                               Me      Me     OMe    CH                                  3568  Me     Q.sub.77                                                                               Me      OMe    OMe    CH                                  3569  Me     Me      Q.sub.77                                                                               Me     Me     CH                                  3570  Me     Me      Q.sub.77                                                                               Me     OMe    CH                                  3571  Me     Me      Q.sub.77                                                                               OMe    OMe    CH                                  3572  H      Me      Q.sub.77                                                                               OMe    OMe    CH                                  3573  Q.sub.78                                                                              Me      COOMe   OMe    OMe    CH                                  3574  Me     Q.sub.78                                                                               Me      Me     Me     CH                                  3575  Me     Q.sub.78                                                                               Me      Me     OMe    CH                                  3576  Me     Q.sub.78                                                                               Me      OMe    OMe    CH                                  3577  Me     Me      Q.sub.78                                                                               Me     Me     CH                                  3578  Me     Me      Q.sub.78                                                                               Me     OMe    CH                                  3579  Me     Me      Q.sub.78                                                                               OMe    OMe    CH                                  3580  H      Me      Q.sub.78                                                                               OMe    OMe    CH                                  3581  Q.sub.79                                                                              Me      COOMe   OMe    OMe    CH                                  3582  Me     Q.sub.79                                                                               Me      Me     Me     CH                                  3583  Me     Q.sub.79                                                                               Me      Me     OMe    CH                                  3584  Me     Q.sub.79                                                                               Me      OMe    OMe    CH                                  3585  Me     Me      Q.sub.79                                                                               Me     Me     CH                                  3586  Me     Me      Q.sub.79                                                                               Me     OMe    CH                                  3587  Me     Me      Q.sub.79                                                                               OMe    OMe    CH                                  3588  H      Me      Q.sub.79                                                                               OMe    OMe    CH                                  3589  Q.sub.80                                                                              Me      COOMe   OMe    OMe    CH                                  3590  Me     Q.sub.80                                                                               Me      Me     Me     CH                                  3591  Me     Q.sub.80                                                                               Me      Me     OMe    CH                                  3592  Me     Q.sub.80                                                                               Me      OMe    OMe    CH                                  3593  Me     Me      Q.sub.80                                                                               Me     Me     CH                                  3594  Me     Me      Q.sub.80                                                                               Me     OMe    CH                                  3595  Me     Me      Q.sub.80                                                                               OMe    OMe    CH                                  3596  H      Me      Q.sub.80                                                                               OMe    OMe    CH                                  3597  Q.sub.81                                                                              Me      COOMe   OMe    OMe    CH                                  3598  Me     Q.sub.81                                                                               Me      Me     Me     CH                                  3599  Me     Q.sub.81                                                                               Me      Me     OMe    CH                                  3600  Me     Q.sub.81                                                                               Me      OMe    OMe    CH                                  3601  Me     Me      Q.sub.81                                                                               Me     Me     CH                                  3602  Me     Me      Q.sub.81                                                                               Me     OMe    CH                                  3603  Me     Me      Q.sub.81                                                                               OMe    OMe    CH                                  3604  H      Me      Q.sub.81                                                                               OMe    OMe    CH                                  3605  Q.sub.79                                                                              Me      COOMe   OMe    OMe    CH                                  3606  Me     Q.sub.82                                                                               Me      Me     Me     CH                                  3607  Me     Q.sub.82                                                                               Me      Me     OMe    CH                                  3608  Me     Q.sub.82                                                                               Me      OMe    OMe    CH                                  3609  Me     Me      Q.sub.82                                                                               Me     Me     CH                                  3610  Me     Me      Q.sub.82                                                                               Me     OMe    CH                                  3611  Me     Me      Q.sub.82                                                                               OMe    OMe    CH                                  3612  H      Me      Q.sub.82                                                                               OMe    OMe    CH                                  3613  Q.sub.83                                                                              Me      COOMe   OMe    OMe    CH                                  3614  Me     Q.sub.83                                                                               Me      Me     Me     CH                                  3615  Me     Q.sub.83                                                                               Me      Me     OMe    CH                                  3616  Me     Q.sub.83                                                                               Me      OMe    OMe    CH                                  3617  Me     Me      Q.sub.83                                                                               Me     Me     CH                                  3618  Me     Me      Q.sub.83                                                                               Me     OMe    CH                                  3619  Me     Me      Q.sub.83                                                                               OMe    OMe    CH                                  3620  H      Me      Q.sub.83                                                                               OMe    OMe    CH                                  3619  Q.sub.84                                                                              Me      COOMe   OMe    OMe    CH                                  3620  Me     Q.sub.84                                                                               Me      Me     Me     CH                                  3621  Me     Q.sub.84                                                                               Me      Me     OMe    CH                                  3622  Me     Q.sub.84                                                                               Me      OMe    OMe    CH                                  3623  Me     Me      Q.sub.84                                                                               Me     Me     CH                                  3624  Me     Me      Q.sub.84                                                                               Me     OMe    CH                                  3625  Me     Me      Q.sub.84                                                                               OMe    OMe    CH                                  3626  H      Me      Q.sub.84                                                                               OMe    OMe    CH                                  3627  Q.sub.85                                                                              Me      COOMe   OMe    OMe    CH                                  3628  Me     Q.sub.85                                                                               Me      Me     Me     CH                                  3629  Me     Q.sub.85                                                                               Me      Me     OMe    CH                                  3630  Me     Q.sub.85                                                                               Me      OMe    OMe    CH                                  3631  Me     Me      Q.sub.85                                                                               Me     Me     CH                                  3632  Me     Me      Q.sub.85                                                                               Me     OMe    CH                                  3633  Me     Me      Q.sub.85                                                                               OMe    OMe    CH                                  3634  H      Me      Q.sub.85                                                                               OMe    OMe    CH                                  3635  Q.sub.86                                                                              Me      COOMe   OMe    OMe    CH                                  3636  Me     Q.sub.86                                                                               Me      Me     Me     CH                                  3637  Me     Q.sub.86                                                                               Me      Me     OMe    CH                                  3638  Me     Q.sub.86                                                                               Me      OMe    OMe    CH                                  3639  Me     Me      Q.sub.86                                                                               Me     Me     CH                                  3640  Me     Me      Q.sub.86                                                                               Me     OMe    CH                                  3641  Me     Me      Q.sub.86                                                                               OMe    OMe    CH                                  3642  H      Me      Q.sub.86                                                                               OMe    OMe    CH                                  3643  Q.sub.87                                                                              Me      COOMe   OMe    OMe    CH                                  3644  Me     Q.sub.87                                                                               Me      Me     Me     CH                                  3645  Me     Q.sub.87                                                                               Me      Me     OMe    CH                                  3646  Me     Q.sub.87                                                                               Me      OMe    OMe    CH                                  3647  Me     Me      Q.sub.87                                                                               Me     Me     CH                                  3648  Me     Me      Q.sub.87                                                                               Me     OMe    CH                                  3649  Me     Me      Q.sub.87                                                                               OMe    OMe    CH                                  3650  H      Me      Q.sub.87                                                                               OMe    OMe    CH                                  3651  Q.sub.88                                                                              Me      COOMe   OMe    OMe    CH                                  3652  Me     Q.sub.88                                                                               Me      Me     Me     CH                                  3653  Me     Q.sub.88                                                                               Me      Me     OMe    CH                                  3654  Me     Q.sub.88                                                                               Me      OMe    OMe    CH                                  3655  Me     Me      Q.sub.88                                                                               Me     Me     CH                                  3656  Me     Me      Q.sub.88                                                                               Me     OMe    CH                                  3657  Me     Me      Q.sub.88                                                                               OMe    OMe    CH                                  3658  H      Me      Q.sub.88                                                                               OMe    OMe    CH                                  3659  Q.sub.89                                                                              Me      COOMe   OMe    OMe    CH                                  3660  Me     Q.sub.89                                                                               Me      Me     Me     CH                                  3661  Me     Q.sub.89                                                                               Me      Me     OMe    CH                                  3662  Me     Q.sub.89                                                                               Me      OMe    OMe    CH                                  3663  Me     Me      Q.sub.89                                                                               Me     Me     CH                                  3664  Me     Me      Q.sub.89                                                                               Me     OMe    CH                                  3665  Me     Me      Q.sub.89                                                                               OMe    OMe    CH                                  3666  H      Me      Q.sub.89                                                                               OMe    OMe    CH                                  3667  Q.sub.90                                                                              Me      COOMe   Me     Me     CH                                  3668  Q.sub.90                                                                              Me      COOMe   Me     OMe    CH                                  3669  Q.sub.90                                                                              Me      COOMe   OMe    OMe    CH                                  3670  Q.sub.90                                                                              Me      COOMe   Me     OMe    N                                   3671  Q.sub.90                                                                              Me      COOMe   OMe    OMe    N                                   3672  Me     Q.sub.90                                                                               Me      Me     OMe    CH                                  3673  Me     Q.sub.90                                                                               Me      OMe    OMe    CH                                  3674  Me     Q.sub.90                                                                               Me      Me     OMe    N                                   3675  Me     Me      Q.sub.90                                                                               Me     OMe    CH                                  3676  Me     Me      Q.sub.90                                                                               OMe    OMe    CH                                  3677  Me     Me      Q.sub.90                                                                               Me     OMe    N                                   3678  H      Me      Q.sub.90                                                                               OMe    OMe    CH                                  3679  Q.sub.91                                                                              Me      COOMe   OMe    OMe    CH                                  3680  Me     Q.sub.91                                                                               Me      Me     Me     CH                                  3681  Me     Q.sub.91                                                                               Me      Me     OMe    CH                                  3682  Me     Q.sub.91                                                                               Me      OMe    OMe    CH                                  3683  Me     Me      Q.sub.91                                                                               Me     Me     CH                                  3684  Me     Me      Q.sub.91                                                                               Me     OMe    CH                                  3685  Me     Me      Q.sub.91                                                                               OMe    OMe    CH                                  3686  H      Me      Q.sub.91                                                                               OMe    OMe    CH                                  3687  Q.sub.92                                                                              Me      COOMe   Me     Me     CH                                  3688  Q.sub.92                                                                              Me      COOMe   Me     OMe    CH                                  3689  Q.sub.92                                                                              Me      COOMe   OMe    OMe    CH                                  3690  Q.sub.92                                                                              Me      COOMe   Me     OMe    N                                   3691  Q.sub.92                                                                              Me      COOMe   OMe    OMe    N                                   3692  Me     Q.sub.92                                                                               Me      Me     OMe    CH                                  3693  Me     Q.sub.92                                                                               Me      OMe    OMe    CH                                  3694  Me     Q.sub.92                                                                               Me      Me     OMe    N                                   3695  Me     Me      Q.sub.92                                                                               Me     OMe    CH                                  3696  Me     Me      Q.sub.92                                                                               OMe    OMe    CH                                  3697  Me     Me      Q.sub.92                                                                               Me     OMe    N                                   3698  H      Me      Q.sub.92                                                                               OMe    OMe    CH                                  3699  Q.sub.93                                                                              Me      COOMe   OMe    OMe    CH                                  3700  Me     Q.sub.93                                                                               Me      Me     Me     CH                                  3701  Me     Q.sub.93                                                                               Me      Me     OMe    CH                                  3702  Me     Q.sub.93                                                                               Me      OMe    OMe    CH                                  3703  Me     Me      Q.sub.93                                                                               Me     Me     CH                                  3704  Me     Me      Q.sub. 93                                                                              Me     OMe    CH                                  3705  Me     Me      Q.sub.93                                                                               OMe    OMe    CH                                  3706  H      Me      Q.sub.93                                                                               OMe    OMe    CH                                  3707  Q.sub.94                                                                              Me      COOMe   OMe    OMe    CH                                  3708  Me     Q.sub.94                                                                               Me      Me     Me     CH                                  3709  Me     Q.sub.94                                                                               Me      Me     OMe    CH                                  3710  Me     Q.sub.94                                                                               Me      OMe    OMe    CH                                  3711  Me     Me      Q.sub.94                                                                               Me     Me     CH                                  3712  Me     Me      Q.sub.94                                                                               Me     OMe    CH                                  3713  Me     Me      Q.sub.94                                                                               OMe    OMe    CH                                  3714  H      Me      Q.sub.94                                                                               OMe    OMe    CH                                  3715  Q.sub.95                                                                              Me      COOMe   OMe    OMe    CH                                  3716  Me     Q.sub.95                                                                               Me      Me     Me     CH                                  3717  Me     Q.sub.95                                                                               Me      Me     OMe    CH                                  3718  Me     Q.sub.95                                                                               Me      OMe    OMe    CH                                  3719  Me     Me      Q.sub.95                                                                               Me     Me     CH                                  3720  Me     Me      Q.sub.95                                                                               Me     OMe    CH                                  3721  Me     Me      Q.sub.95                                                                               OMe    OMe    CH                                  3722  H      Me      Q.sub.95                                                                               OMe    OMe    CH                                  3723  Q.sub.96                                                                              Me      COOMe   OMe    OMe    CH                                  3724  Me     Q.sub.96                                                                               Me      Me     Me     CH                                  3725  Me     Q.sub.96                                                                               Me      Me     OMe    CH                                  3726  Me     Q.sub.96                                                                               Me      OMe    OMe    CH                                  3727  Me     Me      Q.sub.96                                                                               Me     Me     CH                                  3728  Me     Me      Q.sub.96                                                                               Me     OMe    CH                                  3729  Me     Me      Q.sub.96                                                                               OMe    OMe    CH                                  3730  H      Me      Q.sub.96                                                                               OMe    OMe    CH                                  3731  Q.sub.97                                                                              Me      COOMe   OMe    OMe    CH                                  3732  Me     Q.sub.97                                                                               Me      Me     Me     CH                                  3733  Me     Q.sub.97                                                                               Me      Me     OMe    CH                                  3734  Me     Q.sub.97                                                                               Me      OMe    OMe    CH                                  3735  Me     Me      Q.sub.97                                                                               Me     Me     CH                                  3736  Me     Me      Q.sub.97                                                                               Me     OMe    CH                                  3737  Me     Me      Q.sub.97                                                                               OMe    OMe    CH                                  3738  H      Me      Q.sub.97                                                                               OMe    OMe    CH                                  3739  Q.sub.98                                                                              Me      COOMe   Me     Me     CH                                  3740  Q.sub.98                                                                              Me      COOMe   Me     OMe    CH                                  3741  Q.sub.98                                                                              Me      COOMe   OMe    OMe    CH                                  3742  Q.sub.98                                                                              Me      COOMe   Me     OMe    N                                   3743  Q.sub.98                                                                              Me      COOMe   OMe    OMe    N                                   3744  Me     Q.sub.98                                                                               Me      Me     OMe    CH                                  3745  Me     Q.sub.98                                                                               Me      OMe    OMe    CH                                  3746  Me     Q.sub.98                                                                               Me      Me     OMe    N                                   3747  Me     Me      Q.sub.98                                                                               Me     OMe    CH                                  3748  Me     Me      Q.sub.98                                                                               OMe    OMe    CH                                  3749  Me     Me      Q.sub.98                                                                               Me     OMe    N                                   3750  H      Me      Q.sub.98                                                                               OMe    OMe    CH                                  3751  Q.sub.99                                                                              Me      COOMe   OMe    OMe    CH                                  3752  Me     Q.sub.99                                                                               Me      Me     Me     CH                                  3753  Me     Q.sub.99                                                                               Me      Me     OMe    CH                                  3754  Me     Q.sub.99                                                                               Me      OMe    OMe    CH                                  3755  Me     Me      Q.sub.99                                                                               Me     Me     CH                                  3756  Me     Me      Q.sub.99                                                                               Me     OMe    CH                                  3757  Me     Me      Q.sub.99                                                                               OMe    OMe    CH                                  3758  H      Me      Q.sub.99                                                                               OMe    OMe    CH                                  3759  Q.sub.100                                                                             Me      COOMe   Me     Me     CH                                  3760  Q.sub.100                                                                             Me      COOMe   Me     OMe    CH                                  3761  Q.sub.100                                                                             Me      COOMe   OMe    OMe    CH                                  3762  Q.sub.100                                                                             Me      COOMe   Me     OMe    N                                   3763  Q.sub.100                                                                             Me      COOMe   OMe    OMe    N                                   3764  Me     Q.sub.100                                                                              Me      Me     OMe    CH                                  3765  Me     Q.sub.100                                                                              Me      OMe    OMe    CH                                  3766  Me     Q.sub.100                                                                              Me      Me     OMe    N                                   3767  Me     Me      Q.sub.100                                                                              Me     OMe    CH                                  3768  Me     Me      Q.sub.100                                                                              OMe    OMe    CH                                  3769  Me     Me      Q.sub.100                                                                              Me     OMe    N                                   3770  H      Me      Q.sub.100                                                                              OMe    OMe    CH                                  3771  Q.sub.101                                                                             Me      COOMe   OMe    OMe    CH                                  3772  Me     Q.sub.101                                                                              Me      Me     Me     CH                                  3773  Me     Q.sub.101                                                                              Me      Me     OMe    CH                                  3774  Me     Q.sub.101                                                                              Me      OMe    OMe    CH                                  3775  Me     Me      Q.sub.101                                                                              Me     Me     CH                                  3776  Me     Me      Q.sub.101                                                                              Me     OMe    CH                                  3777  Me     Me      Q.sub.101                                                                              OMe    OMe    CH                                  3778  H      Me      Q.sub.101                                                                              OMe    OMe    CH                                  3779  Q.sub.102                                                                             Me      COOMe   OMe    OMe    CH                                  3780  Me     Q.sub.102                                                                              Me      Me     Me     CH                                  3781  Me     Q.sub.102                                                                              Me      Me     OMe    CH                                  3782  Me     Q.sub.102                                                                              Me      OMe    OMe    CH                                  3783  Me     Me      Q.sub.102                                                                              Me     Me     CH                                  3784  Me     Me      Q.sub.102                                                                              Me     OMe    CH                                  3785  Me     Me      Q.sub.102                                                                              OMe    OMe    CH                                  3786  H      Me      Q.sub.102                                                                              OMe    OMe    CH                                  3787  Q.sub.103                                                                             Me      COOMe   OMe    OMe    CH                                  3788  Me     Q.sub.103                                                                              Me      Me     Me     CH                                  3789  Me     Q.sub.103                                                                              Me      Me     OMe    CH                                  3790  Me     Q.sub.103                                                                              Me      OMe    OMe    CH                                  3791  Me     Me      Q.sub.103                                                                              Me     Me     CH                                  3792  Me     Me      Q.sub.103                                                                              Me     OMe    CH                                  3793  Me     Me      Q.sub.103                                                                              OMe    OMe    CH                                  3794  H      Me      Q.sub.103                                                                              OMe    OMe    CH                                  3795  Q.sub.104                                                                             Me      COOMe   OMe    OMe    CH                                  3796  Me     Q.sub.104                                                                              Me      Me     Me     CH                                  3797  Me     Q.sub.104                                                                              Me      Me     OMe    CH                                  3798  Me     Q.sub.104                                                                              Me      OMe    OMe    CH                                  3799  Me     Me      Q.sub.104                                                                              Me     Me     CH                                  3800  Me     Me      Q.sub.104                                                                              Me     OMe    CH                                  3801  Me     Me      Q.sub.104                                                                              OMe    OMe    CH                                  3802  H      Me      Q.sub.104                                                                              OMe    OMe    CH                                  3803  Q.sub.105                                                                             Me      COOMe   OMe    OMe CH                                     3804  Me     Q.sub.105                                                                              Me      Me     Me     CH                                  3805  Me     Q.sub.105                                                                              Me      Me     OMe    CH                                  3806  Me     Q.sub.105                                                                              Me      OMe    OMe    CH                                  3807  Me     Me      Q.sub.105                                                                              Me     Me     CH                                  3808  Me     Me      Q.sub.105                                                                              Me     OMe    CH                                  3809  Me     Me      Q.sub.105                                                                              OMe    OMe    CH                                  3810  H      Me      Q.sub.105                                                                              OMe    OMe    CH                                  3811  Q.sub.106                                                                             Me      COOMe   OMe    OMe    CH                                  3812  Me     Q.sub.106                                                                              Me      Me     Me     CH                                  3813  Me     Q.sub.106                                                                              Me      Me     OMe    CH                                  3814  Me     Q.sub.106                                                                              Me      OMe    OMe    CH                                  3815  Me     Me      Q.sub.106                                                                              Me     Me     CH                                  3816  Me     Me      Q.sub.106                                                                              Me     OMe    CH                                  3817  Me     Me      Q.sub.106                                                                              OMe    OMe    CH                                  3818  H      Me      Q.sub.106                                                                              OMe    OMe    CH                                  3819  Q.sub.107                                                                             Me      COOMe   OMe    OMe    CH                                  3820  Me     Q.sub.107                                                                              Me      Me     Me     CH                                  3819  Me     Q.sub.107                                                                              Me      Me     OMe    CH                                  3820  Me     Q.sub.107                                                                              Me      OMe    OMe    CH                                  3821  Me     Me      Q.sub.107                                                                              Me     Me     CH                                  3822  Me     Me      Q.sub.107                                                                              Me     OMe    CH                                  3823  Me     Me      Q.sub.107                                                                              OMe    OMe    CH                                  3824  H      Me      Q.sub.107                                                                              OMe    OMe    CH                                  3825  Q.sub.108                                                                             Me      COOMe   OMe    OMe    CH                                  3826  Me     Q.sub.108                                                                              Me      Me     Me     CH                                  3827  Me     Q.sub.108                                                                              Me      Me     OMe    CH                                  3828  Me     Q.sub.108                                                                              Me      OMe    OMe    CH                                  3829  Me     Me      Q.sub.108                                                                              Me     Me     CH                                  3830  Me     Me      Q.sub.108                                                                              Me     OMe    CH                                  3831  Me     Me      Q.sub.108                                                                              OMe    OMe    CH                                  3832  H      Me      Q.sub.108                                                                              OMe    OMe    CH                                  3833  Q.sub.109                                                                             Me      COOMe   OMe    OMe    CH                                  3834  Me     Q.sub.109                                                                              Me      Me     Me     CH                                  3835  Me     Q.sub.109                                                                              Me      Me     OMe    CH                                  3836  Me     Q.sub.109                                                                              Me      OMe    OMe    CH                                  3837  Me     Me      Q.sub.109                                                                              Me     Me     CH                                  3838  Me     Me      Q.sub.109                                                                              Me     OMe    CH                                  3839  Me     Me      Q.sub.109                                                                              OMe    OMe    CH                                  3840  H      Me      Q.sub.109                                                                              OMe    OMe    CH                                  3841  Q.sub.110                                                                             Me      COOMe   OMe    OMe    CH                                  3842  Me     Q.sub.110                                                                              Me      Me     Me     CH                                  3843  Me     Q.sub.110                                                                              Me      Me     OMe    CH                                  3844  Me     Q.sub.110                                                                              Me      OMe    OMe    CH                                  3845  Me     Me      Q.sub.110                                                                              Me     Me     CH                                  3846  Me     Me      Q.sub.110                                                                              Me     OMe    CH                                  3847  Me     Me      Q.sub.110                                                                              OMe    OMe    CH                                  3848  H      Me      Q.sub.110                                                                              OMe    OMe    CH                                  3849  Q.sub.111                                                                             Me      COOMe   OMe    OMe    CH                                  3850  Me     Q.sub.111                                                                              Me      Me     Me     CH                                  3851  Me     Q.sub.111                                                                              Me      Me     OMe    CH                                  3852  Me     Q.sub.111                                                                              Me      OMe    OMe    CH                                  3853  Me     Me      Q.sub.111                                                                              Me     Me     CH                                  3854  Me     Me      Q.sub.111                                                                              Me     OMe    CH                                  3855  Me     Me      Q.sub.111                                                                              OMe    OMe    CH                                  3856  H      Me      Q.sub.111                                                                              OMe    OMe    CH                                  3857  Q.sub.112                                                                             Me      COOMe   OMe    OMe    CH                                  3858  Me     Q.sub.112                                                                              Me      Me     Me     CH                                  3859  Me     Q.sub.112                                                                              Me      Me     OMe    CH                                  3860  Me     Q.sub.112                                                                              Me      OMe    OMe    CH                                  3861  Me     Me      Q.sub.112                                                                              Me     Me     CH                                  3862  Me     Me      Q.sub.112                                                                              Me     OMe    CH                                  3863  Me     Me      Q.sub.112                                                                              OMe    OMe    CH                                  3864  H      Me      Q.sub.112                                                                              OMe    OMe    CH                                  3865  Q.sub.113                                                                             Me      COOMe   OMe    OMe    CH                                  3866  Me     Q.sub.113                                                                              Me      Me     Me     CH                                  3867  Me     Q.sub.113                                                                              Me      Me     OMe    CH                                  3868  Me     Q.sub.113                                                                              Me      OMe    OMe    CH                                  3869  Me     Me      Q.sub.113                                                                              Me     Me     CH                                  3870  Me     Me      Q.sub.113                                                                              Me     OMe    CH                                  3871  Me     Me      Q.sub.113                                                                              OMe    OMe    CH                                  3872  H      Me      Q.sub.113                                                                              OMe    OMe    CH                                  3873  Q.sub.114                                                                             Me      COOMe   OMe    OMe    CH                                  3874  Me     Q.sub.114                                                                              Me      Me     Me     CH                                  3875  Me     Q.sub.114                                                                              Me      Me     OMe    CH                                  3876  Me     Q.sub.114                                                                              Me      OMe    OMe    CH                                  3877  Me     Me      Q.sub.114                                                                              Me     Me     CH                                  3878  Me     Me      Q.sub.114                                                                              Me     OMe    CH                                  3879  Me     Me      Q.sub.114                                                                              OMe    OMe    CH                                  3880  H      Me      Q.sub.114                                                                              OMe    OMe    CH                                  3881  Q.sub.115                                                                             Me      COOMe   OMe    OMe    CH                                  3882  Me     Q.sub.115                                                                              Me      Me     Me     CH                                  3883  Me     Q.sub.115                                                                              Me      Me     OMe    CH                                  3884  Me     Q.sub.115                                                                              Me      OMe    OMe    CH                                  3885  Me     Me      Q.sub.115                                                                              Me     Me     CH                                  3886  Me     Me      Q.sub.115                                                                              Me     OMe    CH                                  3887  Me     Me      Q.sub.115                                                                              OMe    OMe    CH                                  3888  H      Me      Q.sub.115                                                                              OMe    OMe    CH                                  3889  Q.sub.116                                                                             Me      COOMe   OMe    OMe    CH                                  3890  Me     Q.sub.116                                                                              Me      Me     Me     CH                                  3891  Me     Q.sub.116                                                                              Me      Me     OMe    CH                                  3892  Me     Q.sub.116                                                                              Me      OMe    OMe    CH                                  3893  Me     Me      Q.sub.116                                                                              Me     Me     CH                                  3894  Me     Me      Q.sub.116                                                                              Me     OMe    CH                                  3895  Me     Me      Q.sub.116                                                                              OMe    OMe    CH                                  3896  H      Me      Q.sub.116                                                                              OMe    OMe    CH                                  3897  Q.sub.117                                                                             Me      COOMe   OMe    OMe    CH                                  3898  Me     Q.sub.117                                                                              Me      Me     Me     CH                                  3899  Me     Q.sub.117                                                                              Me      Me     OMe    CH                                  3900  Me     Q.sub.117                                                                              Me      OMe    OMe    CH                                  3901  Me     Me      Q.sub.117                                                                              Me     Me     CH                                  3902  Me     Me      Q.sub. 117                                                                             Me     OMe    CH                                  3903  Me     Me      Q.sub.117                                                                              OMe    OMe    CH                                  3904  H      Me      Q.sub.117                                                                              OMe    OMe    CH                                  3905  Q.sub.118                                                                             Me      COOMe   OMe    OMe    CH                                  3906  Me     Q.sub.118                                                                              Me      Me     Me     CH                                  3907  Me     Q.sub.118                                                                              Me      Me     OMe    CH                                  3908  Me     Q.sub.118                                                                              Me      OMe    OMe    CH                                  3909  Me     Me      Q.sub.118                                                                              Me     Me     CH                                  3910  Me     Me      Q.sub.118                                                                              Me     OMe    CH                                  3911  Me     Me      Q.sub.118                                                                              OMe    OMe    CH                                  3912  H      Me      Q.sub.118                                                                              OMe    OMe    CH                                  3913  Q.sub.119                                                                             Me      COOMe   OMe    OMe    CH                                  3914  Me     Q.sub.119                                                                              Me      Me     Me     CH                                  3915  Me     Q.sub.119                                                                              Me      Me     OMe    CH                                  3916  Me     Q.sub.119                                                                              Me      OMe    OMe    CH                                  3917  Me     Me      Q.sub.119                                                                              Me     Me     CH                                  3918  Me     Me      Q.sub.119                                                                              Me     OMe    CH                                  3919  Me     Me      Q.sub.119                                                                              OMe    OMe    CH                                  3920  H      Me      Q.sub.119                                                                              OMe    OMe    CH                                  3919  Q.sub.120                                                                             Me      COOMe   OMe    OMe    CH                                  3920  Me     Q.sub.120                                                                              Me      Me     Me     CH                                  3921  Me     Q.sub.120                                                                              Me      Me     OMe    CH                                  3922  Me     Q.sub.120                                                                              Me      OMe    OMe    CH                                  3923  Me     Me      Q.sub.120                                                                              Me     Me     CH                                  3924  Me     Me      Q.sub.120                                                                              Me     OMe    CH                                  3925  Me     Me      Q.sub.120                                                                              OMe    OMe    CH                                  3926  H      Me      Q.sub.120                                                                              OMe    OMe    CH                                  3927  Q.sub.121                                                                             Me      COOMe   OMe    OMe    CH                                  3928  Me     Q.sub.121                                                                              Me      Me     Me     CH                                  3929  Me     Q.sub.121                                                                              Me      Me     OMe    CH                                  3930  Me     Q.sub.121                                                                              Me      OMe    OMe    CH                                  3931  Me     Me      Q.sub.121                                                                              Me     Me     CH                                  3932  Me     Me      Q.sub.121                                                                              Me     OMe    CH                                  3933  Me     Me      Q.sub.121                                                                              OMe    OMe    CH                                  3934  H      Me      Q.sub.121                                                                              OMe    OMe    CH                                  3935  Q.sub.122                                                                             Me      COOMe   OMe    OMe    CH                                  3936  Me     Q.sub.122                                                                              Me      Me     Me     CH                                  3937  Me     Q.sub.122                                                                              Me      Me     OMe    CH                                  3938  Me     Q.sub.122                                                                              Me      OMe    OMe    CH                                  3939  Me     Me      Q.sub.122                                                                              Me     Me     CH                                  3940  Me     Me      Q.sub.122                                                                              Me     OMe    CH                                  3941  Me     Me      Q.sub.122                                                                              OMe    OMe    CH                                  3942  H      Me      Q.sub.122                                                                              OMe    OMe    CH                                  3943  Q.sub.123                                                                             Me      COOMe   OMe    OMe    CH                                  3944  Me     Q.sub.123                                                                              Me      Me     Me     CH                                  3945  Me     Q.sub.123                                                                              Me      Me     OMe    CH                                  3946  Me     Q.sub.123                                                                              Me      OMe    OMe    CH                                  3947  Me     Me      Q.sub.123                                                                              Me     Me     CH                                  3948  Me     Me      Q.sub.123                                                                              Me     OMe    CH                                  3949  Me     Me      Q.sub.123                                                                              OMe    OMe    CH                                  3950  H      Me      Q.sub.123                                                                              OMe    OMe    CH                                  3951  Q.sub.124                                                                             Me      COOMe   OMe    OMe    CH                                  3952  Me     Q.sub.124                                                                              Me      Me     Me     CH                                  3953  Me     Q.sub.124                                                                              Me      Me     OMe    CH                                  3954  Me     Q.sub.124                                                                              Me      OMe    OMe    CH                                  3955  Me     Me      Q.sub.124                                                                              Me     Me     CH                                  3956  Me     Me      Q.sub.124                                                                              Me     OMe    CH                                  3957  Me     Me      Q.sub.124                                                                              OMe    OMe    CH                                  3958  H      Me      Q.sub.124                                                                              OMe    OMe    CH                                  3959  Q.sub.125                                                                             Me      COOMe   OMe    OMe    CH                                  3960  Me     Q.sub.125                                                                              Me      Me     Me     CH                                  3961  Me     Q.sub.125                                                                              Me      Me     OMe    CH                                  3962  Me     Q.sub.125                                                                              Me      OMe    OMe    CH                                  3963  Me     Me      Q.sub.125                                                                              Me     Me     CH                                  3964  Me     Me      Q.sub.125                                                                              Me     OMe    CH                                  3965  Me     Me      Q.sub.125                                                                              OMe    OMe    CH                                  3966  H      Me      Q.sub.125                                                                              OMe    OMe    CH                                  3967  Q.sub.126                                                                             Me      COOMe   OMe    OMe    CH                                  3968  Me     Q.sub.126                                                                              Me      Me     Me     CH                                  3969  Me     Q.sub.126                                                                              Me      Me     OMe    CH                                  3970  Me     Q.sub.126                                                                              Me      OMe    OMe    CH                                  3971  Me     Me      Q.sub.126                                                                              Me     Me     CH                                  3972  Me     Me      Q.sub.126                                                                              Me     OMe    CH                                  3973  Me     Me      Q.sub.126                                                                              OMe    OMe    CH                                  3974  H      Me      Q.sub.126                                                                              OMe    OMe    CH                                  3975  Q.sub.127                                                                             Me      COOMe   OMe    OMe    CH                                  3976  Me     Q.sub.127                                                                              Me      Me     Me     CH                                  3977  Me     Q.sub.127                                                                              Me      Me     OMe    CH                                  3978  Me     Q.sub.127                                                                              Me      OMe    OMe    CH                                  3979  Me     Me      Q.sub.127                                                                              Me     Me     CH                                  3980  Me     Me      Q.sub.127                                                                              Me     OMe    CH                                  3981  Me     Me      Q.sub.127                                                                              OMe    OMe    CH                                  3982  H      Me      Q.sub.127                                                                              OMe    OMe    CH                                  3983  Q.sub.128                                                                             Me      COOMe   OMe    OMe    CH                                  3984  Me     Q.sub.128                                                                              Me      Me     Me     CH                                  3985  Me     Q.sub.128                                                                              Me      Me     OMe    CH                                  3986  Me     Q.sub.128                                                                              Me      OMe    OMe    CH                                  3987  Me     Me      Q.sub.128                                                                              Me     Me     CH                                  3988  Me     Me      Q.sub.128                                                                              Me     OMe    CH                                  3989  Me     Me      Q.sub.128                                                                              OMe    OMe    CH                                  3990  H      Me      Q.sub.128                                                                              OMe    OMe    CH                                  3991  Q.sub.129                                                                             Me      COOMe   OMe    OMe    CH                                  3992  Me     Q.sub.129                                                                              Me      Me     Me     CH                                  3993  Me     Q.sub.129                                                                              Me      Me     OMe    CH                                  3994  Me     Q.sub.129                                                                              Me      OMe    OMe    CH                                  3995  Me     Me      Q.sub.129                                                                              Me     Me     CH                                  3996  Me     Me      Q.sub.129                                                                              Me     OMe    CH                                  3997  Me     Me      Q.sub.129                                                                              OMe    OMe    CH                                  3998  H      Me      Q.sub.129                                                                              OMe    OMe    CH                                  3999  Q.sub.130                                                                             Me      COOMe   OMe    OMe    CH                                  4000  Me     Q.sub.130                                                                              Me      Me     Me     CH                                  4001  Me     Q.sub.130                                                                              Me      Me     OMe    CH                                  4002  Me     Q.sub.130                                                                              Me      OMe    OMe    CH                                  4003  Me     Me      Q.sub.130                                                                              Me     Me     CH                                  4004  Me     Me      Q.sub.130                                                                              Me     OMe    CH                                  4005  Me     Me      Q.sub.130                                                                              OMe    OMe    CH                                  4006  H      Me      Q.sub.130                                                                              OMe    OMe    CH                                  4007  Q.sub.131                                                                             Me      COOMe   OMe    OMe    CH                                  4008  Me     Q.sub.131                                                                              Me      Me     Me     CH                                  4009  Me     Q.sub.131                                                                              Me      Me     OMe    CH                                  4010  Me     Q.sub.131                                                                              Me      OMe    OMe    CH                                  4011  Me     Me      Q.sub.131                                                                              Me     Me     CH                                  4012  Me     Me      Q.sub.131                                                                              Me     OMe    CH                                  4013  Me     Me      Q.sub.131                                                                              OMe    OMe    CH                                  4014  H      Me      Q.sub.131                                                                              OMe    OMe    CH                                  4015  Q.sub.132                                                                             Me      COOMe   OMe    OMe    CH                                  4016  Me     Q.sub.132                                                                              Me      Me     Me     CH                                  4017  Me     Q.sub.132                                                                              Me      Me     OMe    CH                                  4018  Me     Q.sub.132                                                                              Me      OMe    OMe    CH                                  4019  Me     Me      Q.sub.132                                                                              Me     Me     CH                                  4020  Me     Me      Q.sub.132                                                                              Me     OMe    CH                                  4021  Me     Me      Q.sub.132                                                                              OMe    OMe    CH                                  4022  H      Me      Q.sub.132                                                                              OMe    OMe    CH                                  ______________________________________                                    

                  TABLE 3                                                          ______________________________________                                          ##STR15##                                                                     No.    A        B         D    X     Y     Z                                   ______________________________________                                         1421   Q.sub.1  H         H    Me    OMe   CH                                  1422   Q.sub.1  H         H    OMe   OMe   CH                                  1423   Q.sub.1  H         H    Me    OMe   N                                   1424   Q.sub.1  Me        H    Me    OMe   CH                                  1425   Q.sub.1  Me        H    OMe   OMe   CH                                  1426   Q.sub.1  Me        H    Me    OMe   N                                   1427   Q.sub.1  Cl        H    Me    OMe   CH                                  1428   Q.sub.1  Cl        H    OMe   OMe   CH                                  1429   Q.sub.1  Cl        H    Me    OMe   N                                   1430   Q.sub.1  Br        H    Me    OMe   CH                                  1431   Q.sub.1  Br        H    OMe   OMe   CH                                  1432   Q.sub.1  Br        H    Me    OMe   N                                   1433   Q.sub.1  COOMe     H    Me    OMe   CH                                  1434   Q.sub.1  COOMe     H    OMe   OMe   CH                                  1435   Q.sub.1  COOMe     H    Me    OMe   N                                   1436   Q.sub.1  COOEt     H    Me    OMe   CH                                  1437   Q.sub.1  COOEt     H    OMe   OMe   CH                                  1438   Q.sub.1  COOEt     H    Me    OMe   N                                   1439   Me       Q.sub.1   H    Me    Me    CH                                  1440   Me       Q.sub.1   H    Me    OMe   CH                                  1441   Me       Q.sub.1   H    OMe   OMe   CH                                  1442   Me       Q.sub.1   H    Me    OMe   N                                   1443   Me       Q.sub.1   H    OMe   OMe   N                                   1444   COMe     Q.sub.1   H    Me    OMe   CH                                  1445   COMe     Q.sub.1   H    OMe   OMe   CH                                  1446   COMe     Q.sub.1   H    Me    OMe   N                                   1447   Q.sub.2  H         H    Me    OMe   CH                                  1448   Q.sub.2  H         H    OMe   OMe   CH                                  1449   Q.sub.2  H         H    Me    OMe   N                                   1450   Q.sub.2  Cl        H    Me    OMe   CH                                  1451   Q.sub.2  Cl        H    OMe   OMe   CH                                  1452   Q.sub.2  Cl        H    Me    OMe   N                                   1453   Q.sub.2  COOMe     H    Me    OMe   CH                                  1454   Q.sub.2  COOMe     H    OMe   OMe   CH                                  1455   Q.sub.2  COOMe     H    Me    OMe   N                                   1456   Me       Q.sub.2   H    Me    OMe   CH                                  1457   Me       Q.sub.2   H    OMe   OMe   CH                                  1458   Me       Q.sub.2   H    Me    OMe   N                                   1459   Q.sub. 3 H         H    Me    OMe   CH                                  1460   Q.sub.3  H         H    OMe   OMe   CH                                  1461   Q.sub.3  H         H    Me    OMe   N                                   1462   Q.sub.3  Cl        H    Me    OMe   CH                                  1463   Q.sub.3  Cl        H    OMe   OMe   CH                                  1464   Q.sub. 3 Cl        H    Me    OMe   N                                   1465   Q.sub.3  COOMe     H    Me    OMe   CH                                  1466   Q.sub.3  COOMe     H    OMe   OMe   CH                                  1467   Q.sub.3  COOMe     H    Me    OMe   N                                   1468   Me       Q.sub.3   H    Me    OMe   CH                                  1469   Me       Q.sub.3   H    OMe   OMe   CH                                  1470   Me       Q.sub.3   H    Me    OMe   N                                   1471   Q.sub.4  H         H    Me    OMe   CH                                  1471   Q.sub.4  H         H    OMe   OMe   CH                                  1473   Q.sub.4  H         H    Me    OMe   N                                   1474   Q.sub.4  Cl        H    Me    OMe   CH                                  1475   Q.sub.4  Cl        H    OMe   OMe   CH                                  1476   Q.sub.4  Cl        H    Me    OMe   N                                   1477   Q.sub.4  COOMe     H    Me    OMe   CH                                  1478   Q.sub.4  COOMe     H    OMe   OMe   CH                                  1479   Q.sub.4  COOMe     H    Me    OMe   N                                   1480   Me       Q.sub.4   H    Me    OMe   CH                                  1481   Me       Q.sub.4   H    OMe   OMe   CH                                  1482   Me       Q.sub.4   H    Me    OMe   N                                   1483   Q.sub.5  H         H    Me    OMe   CH                                  1484   Q.sub.5  H         H    OMe   OMe   CH                                  1485   Q.sub.5  H         H    Me    OMe   N                                   1486   Q.sub.5  Cl        H    Me    OMe   CH                                  1487   Q.sub.5  Cl        H    OMe   OMe   CH                                  1488   Q.sub.5  Cl        H    Me    OMe   N                                   1489   Q.sub.5  COOMe     H    Me    OMe   CH                                  1490   Q.sub.5  COOMe     H    OMe   OMe   CH                                  1491   Q.sub.5  COOMe     H    Me    OMe   N                                   1492   Me       Q.sub.5   H    Me    OMe   CH                                  1493   Me       Q.sub.5   H    OMe   OMe   CH                                  1494   Me       Q.sub.5   H    Me    OMe   N                                   1495   Q.sub.6  H         H    Me    OMe   CH                                  1496   Q.sub.6  H         H    OMe   OMe   CH                                  1497   Q.sub.6  H         H    Me    OMe   N                                   1498   Q.sub.6  Cl        H    Me    OMe   CH                                  1499   Q.sub.6  Cl        H    OMe   OMe   CH                                  1500   Q.sub.6  Cl        H    Me    OMe   N                                   1501   Q.sub.6  COOMe     H    Me    OMe   CH                                  1502   Q.sub.6  COOMe     H    OMe   OMe   CH                                  1503   Q.sub.6  COOMe     H    Me    OMe   N                                   1504   Me       Q.sub.6   H    Me    OMe   CH                                  1505   Me       Q.sub.6   H    OMe   OMe   CH                                  1506   Me       Q.sub.6   H    Me    OMe   N                                   1507   Q.sub.7  Cl        H    Me    OMe   CH                                  1508   Q.sub.7  Cl        H    OMe   OMe   CH                                  1509   Q.sub.7  Cl        H    Me    OMe   N                                   1510   Q.sub.7  COOMe     H    Me    OMe   CH                                  1511   Q.sub.7  COOMe     H    OMe   OMe   CH                                  1512   Q.sub.7  COOMe     H    Me    OMe   N                                   1513   Me       Q.sub.7   H    Me    OMe   CH                                  1514   Me       Q.sub.7   H    OMe   OMe   CH                                  1515   Me       Q.sub.7   H    Me    OMe   N                                   1516   Q.sub.8  Cl        H    Me    OMe   CH                                  1517   Q.sub.8  Cl        H    OMe   OMe   CH                                  1518   Q.sub.8  Cl        H    Me    OMe   N                                   1519   Q.sub.8  COOMe     H    Me    OMe   CH                                  1520   Q.sub.8  COOMe     H    OMe   OMe   CH                                  1521   Q.sub.8  COOMe     H    Me    OMe   N                                   1522   Me       Q.sub.8   H    Me    OMe   CH                                  1523   Me       Q.sub.8   H    OMe   OMe   CH                                  1524   Me       Q.sub.8   H    Me    OMe   N                                   1525   Q.sub.9  Cl        H    Me    OMe   CH                                  1526   Q.sub.9  Cl        H    OMe   OMe   CH                                  1527   Q.sub.9  Cl        H    Me    OMe   N                                   1528   Q.sub.9  COOMe     H    Me    OMe   CH                                  1529   Q.sub.9  COOMe     H    OMe   OMe   CH                                  1530   Q.sub.9  COOMe     H    Me    OMe   N                                   1531   Me       Q.sub.9   H    Me    OMe   CH                                  1532   Me       Q.sub.9   H    OMe   OMe   CH                                  1533   Me       Q.sub.9   H    Me    OMe   N                                   1534   Q.sub.10 Cl        H    Me    OMe   CH                                  1535   Q.sub.10 Cl        H    OMe   OMe   CH                                  1536   Q.sub.10 Cl        H    Me    OMe   N                                   1537   Q.sub.10 COOMe     H    Me    OMe   CH                                  1538   Q.sub.10 COOMe     H    OMe   OMe   CH                                  1539   Q.sub.10 COOMe     H    Me    OMe   N                                   1540   Me       Q.sub.10  H    Me    OMe   CH                                  1541   Me       Q.sub.10  H    OMe   OMe   CH                                  1542   Me       Q.sub.10  H    Me    OMe   N                                   1543   Q.sub.11 H         H    Me    OMe   CH                                  1544   Q.sub.11 H         H    OMe   OMe   CH                                  1545   Q.sub.11 H         H    Me    OMe   N                                   1546   Q.sub.11 Cl        H    Me    OMe   CH                                  1547   Q.sub.11 Cl        H    OMe   OMe   CH                                  1548   Q.sub.11 Cl        H    Me    OMe   N                                   1549   Q.sub.11 COOMe     H    Me    OMe   CH                                  1550   Q.sub.11 COOMe     H    OMe   OMe   CH                                  1551   Q.sub.11 COOMe     H    Me    OMe   N                                   1552   Me       Q.sub.11  H    Me    OMe   CH                                  1553   Me       Q.sub.11  H    OMe   OMe   CH                                  1554   Me       Q.sub.11  H    Me    OMe   N                                   1555   Q.sub.12 H         H    Me    OMe   CH                                  1556   Q.sub.12 H         H    OMe   OMe   CH                                  1557   Q.sub.12 H         H    Me    OMe   N                                   1558   Q.sub.12 Me        H    Me    OMe   CH                                  1559   Q.sub.12 Me        H    OMe   OMe   CH                                  1560   Q.sub.12 Me        H    Me    OMe   N                                   1561   Q.sub.12 Cl        H    Me    OMe   CH                                  1562   Q.sub.12 Cl        H    OMe   OMe   CH                                  1563   Q.sub.12 Cl        H    Me    OMe   N                                   1564   Q.sub.12 Br        H    Me    OMe   CH                                  1565   Q.sub.12 Br        H    OMe   OMe   CH                                  1566   Q.sub.12 Br        H    Me    OMe   N                                   1567   Q.sub.12 COOMe     H    Me    OMe   CH                                  1568   Q.sub.12 COOMe     H    OMe   OMe   CH                                  1569   Q.sub.12 COOMe     H    Me    OMe   N                                   1570   Q.sub.12 COOEt     H    Me    OMe   CH                                  1571   Q.sub.12 COOEt     H    OMe   OMe   CH                                  1572   Q.sub.12 COOEt     H    Me    OMe   N                                   1573   Me       Q.sub.12  H    Me    Me    CH                                  1574   Me       Q.sub.12  H    Me    OMe   CH                                  1575   Me       Q.sub.12  H    OMe   OMe   CH                                  1576   Me       Q.sub.12  H    Me    OMe   N                                   1577   Me       Q.sub.12  H    OMe   OMe   N                                   1578   COMe     Q.sub.12  H    Me    OMe   CH                                  1579   COMe     Q.sub.12  H    OMe   OMe   CH                                  1580   COMe     Q.sub.12  H    Me    OMe   N                                   1581   Q.sub.13 H         H    Me    OMe   CH                                  1582   Q.sub.13 H         H    OMe   OMe   CH                                  1583   Q.sub.13 H         H    Me    OMe   N                                   1584   Q.sub.13 Cl        H    Me    OMe   CH                                  1585   Q.sub.13 Cl        H    OMe   OMe   CH                                  1586   Q.sub.13 Cl        H    Me    OMe   N                                   1587   Q.sub.13 COOMe     H    Me    OMe   CH                                  1588   Q.sub.13 COOMe     H    OMe   OMe   CH                                  1589   Q.sub.13 COOMe     H    Me    OMe   N                                   1590   Me       Q.sub.13  H    Me    OMe   CH                                  1591   Me       Q.sub.13  H    OMe   OMe   CH                                  1592   Me       Q.sub.13  H    Me    OMe   N                                   1593   Q.sub.14 H         H    Me    OMe   CH                                  1594   Q.sub.14 H         H    OMe   OMe   CH                                  1595   Q.sub.14 H         H    Me    OMe   N                                   1596   Q.sub.14 Cl        H    Me    OMe   CH                                  1597   Q.sub.14 Cl        H    OMe   OMe   CH                                  1598   Q.sub.14 Cl        H    Me    OMe   N                                   1599   Q.sub.14 COOMe     H    Me    OMe   CH                                  1600   Q.sub.14 COOMe     H    OMe   OMe   CH                                  1601   Q.sub.14 COOMe     H    Me    OMe   N                                   1602   Me       Q.sub.14  H    Me    OMe   CH                                  1603   Me       Q.sub.14  H    OMe   OMe   CH                                  1604   Me       Q.sub.14  H    Me    OMe   N                                   1605   Q.sub.15 Cl        H    Me    OMe   CH                                  1606   Q.sub.15 Cl        H    OMe   OMe   CH                                  1607   Q.sub.15 Cl        H    Me    OMe   N                                   1608   Q.sub.15 COOMe     H    Me    OMe   CH                                  1609   Q.sub.15 COOMe     H    OMe   OMe   CH                                  1610   Q.sub.15 COOMe     H    Me    OMe   N                                   1611   Me       Q.sub.15  H    Me    OMe   CH                                  1612   Me       Q.sub.15  H    OMe   OMe   CH                                  1613   Me       Q.sub.15  H    Me    OMe   N                                   1614   Q.sub.16 Cl        H    Me    OMe   CH                                  1615   Q.sub.16 Cl        H    OMe   OMe   CH                                  1616   Q.sub.16 Cl        H    Me    OMe   N                                   1617   Q.sub.16 COOMe     H    Me    OMe   CH                                  1618   Q.sub.16 COOMe     H    OMe   OMe   CH                                  1619   Q.sub.16 COOMe     H    Me    OMe   N                                   1620   Me       Q.sub.16  H    Me    OMe   CH                                  1621   Me       Q.sub.16  H    OMe   OMe   CH                                  1622   Me       Q.sub.16  H    Me    OMe   N                                   1623   Q.sub.17 Cl        H    Me    OMe   CH                                  1624   Q.sub.17 Cl        H    OMe   OMe   CH                                  1625   Q.sub.17 Cl        H    Me    OMe   N                                   1626   Q.sub.17 COOMe     H    Me    OMe   CH                                  1627   Q.sub.17 COOMe     H    OMe   OMe   CH                                  1628   Q.sub.17 COOMe     H    Me    OMe   N                                   1629   Me       Q.sub.17  H    Me    OMe   CH                                  1630   Me       Q.sub.17  H    OMe   OMe   CH                                  1631   Me       Q.sub.17  H    Me    OMe   N                                   1632   Q.sub.18 Cl        H    Me    OMe   CH                                  1633   Q.sub.18 Cl        H    OMe   OMe   CH                                  1634   Q.sub.18 Cl        H    Me    OMe   N                                   1635   Q.sub.18 COOMe     H    Me    OMe   CH                                  1636   Q.sub.18 COOMe     H    OMe   OMe   CH                                  1637   Q.sub.18 COOMe     H    Me    OMe   N                                   1638   Me       Q.sub.18  H    Me    OMe   CH                                  1639   Me       Q.sub.18  H    OMe   OMe   CH                                  1640   Me       Q.sub.18  H    Me    OMe   N                                   1641   Q.sub.19 H         H    Me    OMe   CH                                  1642   Q.sub.19 H         H    OMe   OMe   CH                                  1643   Q.sub.19 H         H    Me    OMe   N                                   1644   Q.sub.19 Cl        H    Me    OMe   CH                                  1645   Q.sub.19 Cl        H    OMe   OMe   CH                                  1646   Q.sub.19 Cl        H    Me    OMe   N                                   1647   Q.sub.19 COOMe     H    Me    OMe   CH                                  1648   Q.sub.19 COOMe     H    OMe   OMe   CH                                  1649   Q.sub.19 COOMe     H    Me    OMe   N                                   1650   Me       Q.sub.19  H    Me    OMe   CH                                  1651   Me       Q.sub.19  H    OMe   OMe   CH                                  1652   Me       Q.sub.19  H    Me    OMe   N                                   1653   Q.sub.20 Cl        H    Me    OMe   CH                                  1654   Q.sub.20 Cl        H    OMe   OMe   CH                                  1655   Q.sub.20 Cl        H    Me    OMe   N                                   1656   Q.sub.20 COOMe     H    Me    OMe   CH                                  1657   Q.sub.20 COOMe     H    OMe   OMe   CH                                  1658   Q.sub.20 COOMe     H    Me    OMe   N                                   1659   Me       Q.sub.20  H    Me    OMe   CH                                  1660   Me       Q.sub.20  H    OMe   OMe   CH                                  1661   Me       Q.sub.20  H    Me    OMe   N                                   1662   Q.sub.21 Cl        H    Me    OMe   CH                                  1663   Q.sub.21 Cl        H    OMe   OMe   CH                                  1664   Q.sub. 21                                                                               Cl        H    Me    OMe   N                                   1665   Q.sub.21 COOMe     H    Me    OMe   CH                                  1666   Q.sub.21 COOMe     H    OMe   OMe   CH                                  1667   Q.sub.21 COOMe     H    Me    OMe   N                                   1668   Me       Q.sub.21  H    Me    OMe   CH                                  1669   Me       Q.sub.21  H    OMe   OMe   CH                                  1670   Me       Q.sub.21  H    Me    OMe   N                                   1671   Q.sub.22 H         H    Me    OMe   CH                                  1672   Q.sub.22 H         H    OMe   OMe   CH                                  1673   Q.sub.22 H         H    Me    OMe   N                                   1674   Q.sub.22 Me        H    Me    OMe   CH                                  1675   Q.sub.22 Me        H    OMe   OMe   CH                                  1676   Q.sub.22 Me        H    Me    OMe   N                                   1677   Q.sub.22 Cl        H    Me    OMe   CH                                  1678   Q.sub.22 Cl        H    OMe   OMe   CH                                  1679   Q.sub.22 Cl        H    Me    OMe   N                                   1680   Q.sub.22 Br        H    Me    OMe   CH                                  1681   Q.sub.22 Br        H    OMe   OMe   CH                                  1682   Q.sub.22 Br        H    Me    OMe   N                                   1683   Q.sub.22 COOMe     H    Me    OMe   CH                                  1684   Q.sub.22 COOMe     H    OMe   OMe   CH                                  1685   Q.sub.22 COOMe     H    Me    OMe   N                                   1686   Q.sub.22 COOEt     H    Me    OMe   CH                                  1687   Q.sub.22 COOEt     H    OMe   OMe   CH                                  1688   Q.sub.22 COOEt     H    Me    OMe   N                                   1689   Me       Q.sub.22  H    Me    Me    CH                                  1690   Me       Q.sub.22  H    Me    OMe   CH                                  1691   Me       Q.sub.22  H    OMe   OMe   CH                                  1692   Me       Q.sub.22  H    Me    OMe   N                                   1693   Me       Q.sub.22  H    OMe   OMe   N                                   1694   COMe     Q.sub.22  H    Me    OMe   CH                                  1695   COMe     Q.sub.22  H    OMe   OMe   CH                                  1696   COMe     Q.sub.22  H    Me    OMe   N                                   1697   Q.sub.23 H         H    Me    OMe   CH                                  1698   Q.sub.23 H         H    OMe   OMe   CH                                  1699   Q.sub.23 H         H    Me    OMe   N                                   1700   Q.sub.23 Cl        H    Me    OMe   CH                                  1701   Q.sub.23 Cl        H    OMe   OMe   CH                                  1702   Q.sub.23 Cl        H    Me    OMe   N                                   1703   Q.sub.23 COOMe     H    Me    OMe   CH                                  1704   Q.sub.23 COOMe     H    OMe   OMe   CH                                  1705   Q.sub.23 COOMe     H    Me    OMe   N                                   1706   Me       Q.sub.23  H    Me    OMe   CH                                  1707   Me       Q.sub.23  H    OMe   OMe   CH                                  1708   Me       Q.sub.23  H    Me    OMe   N                                   1709   Q.sub.24 H         H    Me    OMe   CH                                  1710   Q.sub.24 H         H    OMe   OMe   CH                                  1711   Q.sub.24 H         H    Me    OMe   N                                   1712   Q.sub.24 Cl        H    Me    OMe   CH                                  1713   Q.sub.24 Cl        H    OMe   OMe   CH                                  1714   Q.sub.24 Cl        H    Me    OMe   N                                   1715   Q.sub.24 COOMe     H    Me    OMe   CH                                  1716   Q.sub.24 COOMe     H    OMe   OMe   CH                                  1717   Q.sub.24 COOMe     H    Me    OMe   N                                   1718   Me       Q.sub.24  H    Me    OMe   CH                                  1719   Me       Q.sub.24  H    OMe   OMe   CH                                  1720   Me       Q.sub.24  H    Me    OMe   N                                   1721   Q.sub.25 H         H    Me    OMe   CH                                  1722   Q.sub.25 H         H    OMe   OMe   CH                                  1723   Q.sub.25 H         H    Me    OMe   N                                   1724   Q.sub.25 Cl        H    Me    OMe   CH                                  1725   Q.sub.25 Cl        H    OMe   OMe   CH                                  1726   Q.sub.25 Cl        H    Me    OMe   N                                   1727   Q.sub.25 COOMe     H    Me    OMe   CH                                  1728   Q.sub.25 COOMe     H    OMe   OMe   CH                                  1729   Q.sub.25 COOMe     H    Me    OMe   N                                   1730   Me       Q.sub.25  H    Me    OMe   CH                                  1731   Me       Q.sub.25  H    OMe   OMe   CH                                  1732   Me       Q.sub.25  H    Me    OMe   N                                   1733   Q.sub.26 Cl        H    Me    OMe   CH                                  1734   Q.sub.26 Cl        H    OMe   OMe   CH                                  1735   Q.sub.26 Cl        H    Me    OMe   N                                   1736   Q.sub.26 COOMe     H    Me    OMe   CH                                  1737   Q.sub.26 COOMe     H    OMe   OMe   CH                                  1738   Q.sub.26 COOMe     H    Me    OMe   N                                   1739   Me       Q.sub.26  H    Me    OMe   CH                                  1740   Me       Q.sub.26  H    OMe   OMe   CH                                  1741   Me       Q.sub.26  H    Me    OMe   N                                   1742   Q.sub.27 Cl        H    Me    OMe   CH                                  1743   Q.sub.27 Cl        H    OMe   OMe   CH                                  1744   Q.sub.27 Cl        H    Me    OMe   N                                   1745   Q.sub.27 COOMe     H    Me    OMe   CH                                  1746   Q.sub.27 COOMe     H    OMe   OMe   CH                                  1747   Q.sub.27 COOMe     H    Me    OMe   N                                   1748   Me       Q.sub.47  H    Me    OMe   CH                                  1749   Me       Q.sub.47  H    OMe   OMe   CH                                  1750   Me       Q.sub.47  H    Me    OMe   N                                   1751   Q.sub.28 Cl        H    Me    OMe   CH                                  1752   Q.sub.28 Cl        H    OMe   OMe   CH                                  1753   Q.sub.28 Cl        H    Me    OMe   N                                   1754   Q.sub.28 COOMe     H    Me    OMe   CH                                  1755   Q.sub.28 COOMe     H    OMe   OMe   CH                                  1756   Q.sub.28 COOMe     H    Me    OMe   N                                   1757   Me       Q.sub.28  H    Me    OMe   CH                                  1758   Me       Q.sub.28  H    OMe   OMe   CH                                  1759   Me       Q.sub.28  H    Me    OMe   N                                   1760   Q.sub.29 Cl        H    Me    OMe   CH                                  1761   Q.sub.29 Cl        H    OMe   OMe   CH                                  1762   Q.sub.29 Cl        H    Me    OMe   N                                   1763   Q.sub.29 COOMe     H    Me    OMe   CH                                  1764   Q.sub.29 COOMe     H    OMe   OMe   CH                                  1765   Q.sub.29 COOMe     H    Me    OMe   N                                   1766   Me       Q.sub.29  H    Me    OMe   CH                                  1767   Me       Q.sub.29  H    OMe   OMe   CH                                  1768   Me       Q.sub.29  H    Me    OMe   N                                   1769   Q.sub.30 Cl        H    Me    OMe   CH                                  1770   Q.sub.30 Cl        H    OMe   OMe   CH                                  1771   Q.sub.30 Cl        H    Me    OMe   N                                   1772   Q.sub.30 COOMe     H    Me    OMe   CH                                  1773   Q.sub.30 COOMe     H    OMe   OMe   CH                                  1774   Q.sub.30 COOMe     H    Me    OMe   N                                   1775   Me       Q.sub.30  H    Me    OMe   CH                                  1776   Me       Q.sub.30  H    OMe   OMe   CH                                  1777   Me       Q.sub.30  H    Me    OMe   N                                   1778   Q.sub.31 Cl        H    Me    OMe   CH                                  1779   Q.sub.31 Cl        H    OMe   OMe   CH                                  1780   Q.sub.31 Cl        H    Me    OMe   N                                   1781   Q.sub.31 COOMe     H    Me    OMe   CH                                  1782   Q.sub.31 COOMe     H    OMe   OMe   CH                                  1783   Q.sub.31 COOMe     H    Me    OMe   N                                   1784   Me       Q.sub.31  H    Me    OMe   CH                                  1785   Me       Q.sub.31  H    OMe   OMe   CH                                  1786   Me       Q.sub.31  H    Me    OMe   N                                   1787   Q.sub.32 H         H    Me    OMe   CH                                  1788   Q.sub.32 H         H    OMe   OMe   CH                                  1789   Q.sub.32 H         H    Me    OMe   N                                   1790   Q.sub.32 Cl        H    Me    OMe   CH                                  1791   Q.sub.32 Cl        H    OMe   OMe   CH                                  1792   Q.sub.32 Cl        H    Me    OMe   N                                   1793   Q.sub.32 COOMe     H    Me    OMe   CH                                  1794   Q.sub.32 COOMe     H    OMe   OMe   CH                                  1795   Q.sub.32 COOMe     H    Me    OMe   N                                   1796   Me       Q.sub.32  H    Me    OMe   CH                                  1797   Me       Q.sub.32  H    OMe   OMe   CH                                  1798   Me       Q.sub.32  H    Me    OMe   N                                   1799   Q.sub.33 Cl        H    Me    OMe   CH                                  1800   Q.sub.33 Cl        H    OMe   OMe   CH                                  1801   Q.sub.33 Cl        H    Me    OMe   N                                   1802   Q.sub.33 COOMe     H    Me    OMe   CH                                  1803   Q.sub.33 COOMe     H    OMe   OMe   CH                                  1804   Q.sub.33 COOMe     H    Me    OMe   N                                   1805   Me       Q.sub.33  H    Me    OMe   CH                                  1806   Me       Q.sub.33  H    OMe   OMe   CH                                  1807   Me       Q.sub.33  H    Me    OMe   N                                   1808   Q.sub.34 Cl        H    Me    OMe   CH                                  1809   Q.sub.34 Cl        H    OMe   OMe   CH                                  1810   Q.sub.34 Cl        H    Me    OMe   N                                   1811   Q.sub.34 COOMe     H    Me    OMe   CH                                  1812   Q.sub.34 COOMe     H    OMe   OMe   CH                                  1813   Q.sub.34 COOMe     H    Me    OMe   N                                   1814   Me       Q.sub.34  H    Me    OMe   CH                                  1815   Me       Q.sub.34  H    OMe   OMe   CH                                  1816   Me       Q.sub.34  H    Me    OMe   N                                   1817   Q.sub.35 Cl        H    Me    OMe   CH                                  1818   Q.sub.35 Cl        H    OMe   OMe   CH                                  1819   Q.sub.35 Cl        H    Me    OMe   N                                   1820   Q.sub.35 COOMe     H    Me    OMe   CH                                  1821   Q.sub.35 COOMe     H    OMe   OMe   CH                                  1822   Q.sub.35 COOMe     H    Me    OMe   N                                   1823   Me       Q.sub.35  H    Me    OMe   CH                                  1824   Me       Q.sub.35  H    OMe   OMe   CH                                  1825   Me       Q.sub.35  H    Me    OMe   N                                   1826   Q.sub.36 Cl        H    Me    OMe   CH                                  1827   Q.sub.36 Cl        H    OMe   OMe   CH                                  1828   Q.sub.36 Cl        H    Me    OMe   N                                   1829   Q.sub.36 COOMe     H    Me    OMe   CH                                  1830   Q.sub.36 COOMe     H    OMe   OMe   CH                                  1831   Q.sub.36 COOMe     H    Me    OMe   N                                   1832   Me       Q.sub.36  H    Me    OMe   CH                                  1833   Me       Q.sub.36  H    OMe   OMe   CH                                  1834   Me       Q.sub.36  H    Me    OMe   N                                   1835   Q.sub.37 Cl        H    Me    OMe   CH                                  1836   Q.sub.37 Cl        H    OMe   OMe   CH                                  1837   Q.sub.37 Cl        H    Me    OMe   N                                   1838   Q.sub.37 COOMe     H    Me    OMe   CH                                  1839   Q.sub.37 COOMe     H    OMe   OMe   CH                                  1840   Q.sub.37 COOMe     H    Me    OMe   N                                   1841   Me       Q.sub.37  H    Me    OMe   CH                                  1842   Me       Q.sub.37  H    OMe   OMe   CH                                  1843   Me       Q.sub.37  H    Me    OMe   N                                   1844   Q.sub.38 Cl        H    Me    OMe   CH                                  1845   Q.sub.38 Cl        H    OMe   OMe   CH                                  1846   Q.sub.38 Cl        H    Me    OMe   N                                   1847   Q.sub.38 COOMe     H    Me    OMe   CH                                  1848   Q.sub.38 COOMe     H    OMe   OMe   CH                                  1849   Q.sub.38 COOMe     H    Me    OMe   N                                   1850   Me       Q.sub.38  H    Me    OMe   CH                                  1851   Me       Q.sub.38  H    OMe   OMe   CH                                  1852   Me       Q.sub.38  H    Me    OMe   N                                   1853   Q.sub.39 Cl        H    Me    OMe   CH                                  1854   Q.sub.39 Cl        H    OMe   OMe   CH                                  1855   Q.sub.39 Cl        H    Me    OMe   N                                   1856   Q.sub.39 COOMe     H    Me    OMe   CH                                  1857   Q.sub.39 COOMe     H    OMe   OMe   CH                                  1858   Q.sub.39 COOMe     H    Me    OMe   N                                   1859   Me       Q.sub.39  H    Me    OMe   CH                                  1860   Me       Q.sub.39  H    OMe   OMe   CH                                  1861   Me       Q.sub.39  H    Me    OMe   N                                   1862   Q.sub.40 Cl        H    Me    OMe   CH                                  1863   Q.sub.40 Cl        H    OMe   OMe   CH                                  1864   Q.sub.40 Cl        H    Me    OMe   N                                   1865   Q.sub.40 COOMe     H    Me    OMe   CH                                  1866   Q.sub.40 COOMe     H    OMe   OMe   CH                                  1867   Q.sub.40 COOMe     H    Me    OMe   N                                   1868   Me       Q.sub.40  H    Me    OMe   CH                                  1869   Me       Q.sub.40  H    OMe   OMe   CH                                  1870   Me       Q.sub.40  H    Me    OMe   N                                   1871   Q.sub.41 Cl        H    Me    OMe   CH                                  1872   Q.sub.41 Cl        H    OMe   OMe   CH                                  1873   Q.sub.41 Cl        H    Me    OMe   N                                   1874   Q.sub.41 COOMe     H    Me    OMe   CH                                  1875   Q.sub.41 COOMe     H    OMe   OMe   CH                                  1876   Q.sub.41 COOMe     H    Me    OMe   N                                   1877   Me       Q.sub.41  H    Me    OMe   CH                                  1878   Me       Q.sub.41  H    OMe   OMe   CH                                  1879   Me       Q.sub.41  H    Me    OMe   N                                   1880   Q.sub.42 Cl        H    Me    OMe   CH                                  1881   Q.sub.42 Cl        H    OMe   OMe   CH                                  1882   Q.sub.42 Cl        H    Me    OMe   N                                   1883   Q.sub.42 COOMe     H    Me    OMe   CH                                  1884   Q.sub.42 COOMe     H    OMe   OMe   CH                                  1885   Q.sub.42 COOMe     H    Me    OMe   N                                   1886   Me       Q.sub.42  H    Me    OMe   CH                                  1887   Me       Q.sub.42  H    OMe   OMe   CH                                  1888   Me       Q.sub.42  H    Me    OMe   N                                   1889   Q.sub.43 Cl        H    Me    OMe   CH                                  1890   Q.sub.43 Cl        H    OMe   OMe   CH                                  1891   Q.sub.43 Cl        H    Me    OMe   N                                   1892   Q.sub.43 COOMe     H    Me    OMe   CH                                  1893   Q.sub.43 COOMe     H    OMe   OMe   CH                                  1894   Q.sub.43 COOMe     H    Me    OMe   N                                   1895   Me       Q.sub.43  H    Me    OMe   CH                                  1896   Me       Q.sub.43  H    OMe   OMe   CH                                  1897   Me       Q.sub.43  H    Me    OMe   N                                   1898   Q.sub.44 Cl        H    Me    OMe   CH                                  1899   Q.sub.44 Cl        H    OMe   OMe   CH                                  1900   Q.sub.44 Cl        H    Me    OMe   N                                   1901   Q.sub.44 COOMe     H    Me    OMe   CH                                  1902   Q.sub.44 COOMe     H    OMe   OMe   CH                                  1903   Q.sub.44 COOMe     H    Me    OMe   N                                   1904   Me       Q.sub.44  H    Me    OMe   CH                                  1905   Me       Q.sub.44  H    OMe   OMe   CH                                  1906   Me       Q.sub.44  H    Me    OMe   N                                   1907   Q.sub.45 Cl        H    Me    OMe   CH                                  1908   Q.sub.45 Cl        H    OMe   OMe   CH                                  1909   Q.sub.45 Cl        H    Me    OMe   N                                   1910   Q.sub.45 COOMe     H    Me    OMe   CH                                  1911   Q.sub.45 COOMe     H    OMe   OMe   CH                                  1912   Q.sub.45 COOMe     H    Me    OMe   N                                   1913   Me       Q.sub.45  H    Me    OMe   CH                                  1914   Me       Q.sub.45  H    OMe   OMe   CH                                  1915   Me       Q.sub.45  H    Me    OMe   N                                   1916   Q.sub.46 Cl        H    Me    OMe   CH                                  1917   Q.sub.46 Cl        H    OMe   OMe   CH                                  1918   Q.sub.46 Cl        H    Me    OMe   N                                   1919   Q.sub.46 COOMe     H    Me    OMe   CH                                  1920   Q.sub.46 COOMe     H    OMe   OMe   CH                                  1921   Q.sub.46 COOMe     H    Me    OMe   N                                   1922   Me       Q.sub.46  H    Me    OMe   CH                                  1923   Me       Q.sub.46  H    OMe   OMe   CH                                  1924   Me       Q.sub.46  H    Me    OMe   N                                   1925   Q.sub.47 Cl        H    Me    OMe   CH                                  1926   Q.sub.47 Cl        H    OMe   OMe   CH                                  1927   Q.sub.47 Cl        H    Me    OMe   N                                   1928   Q.sub.47 COOMe     H    Me    OMe   CH                                  1929   Q.sub.47 COOMe     H    OMe   OMe   CH                                  1930   Q.sub.47 COOMe     H    Me    OMe   N                                   1931   Me       Q.sub.47  H    Me    OMe   CH                                  1932   Me       Q.sub.47  H    OMe   OMe   CH                                  1933   Me       Q.sub.47  H    Me    OMe   N                                   4023   Q.sub.48 Br        H    Me    OMe   CH                                  4024   Q.sub.48 Br        H    OMe   OMe   CH                                  4025   Q.sub.48 Br        H    Me    OMe   N                                   4026   Me       Q.sub.48  H    OMe   OMe   CH                                  4027   Q.sub.49 Br        H    Me    OMe   CH                                  4028   Q.sub.49 Br        H    OMe   OMe   CH                                  4029   Q.sub.49 Br        H    Me    OMe   N                                   4030   Me       Q.sub.49  H    OMe   OMe   CH                                  4031   Q.sub.48 Br        H    Me    OMe   CH                                  4032   Q.sub.48 Br        H    OMe   OMe   CH                                  4033   Q.sub.48 Br        H    Me    OMe   N                                   4034   Me       Q.sub.48  H    OMe   OMe   CH                                  4035   Q.sub.50 Br        H    Me    OMe   CH                                  4036   Q.sub.50 Br        H    OMe   OMe   CH                                  4037   Q.sub.50 Br        H    Me    OMe   N                                   4038   Me       Q.sub.50  H    OMe   OMe   CH                                  4039   Q.sub.51 Br        H    Me    OMe   CH                                  4040   Q.sub.51 Br        H    OMe   OMe   CH                                  4041   Q.sub.51 Br        H    Me    OMe   N                                   4042   Me       Q.sub.51  H    OMe   OMe   CH                                  4043   Q.sub.52 Br        H    Me    OMe   CH                                  4044   Q.sub.52 Br        H    OMe   OMe   CH                                  4045   Q.sub.52 Br        H    Me    OMe   N                                   4046   Me       Q.sub.52  H    OMe   OMe   CH                                  4047   Q.sub.53 Br        H    Me    OMe   CH                                  4048   Q.sub.53 Br        H    OMe   OMe   CH                                  4049   Q.sub.53 Br        H    Me    OMe   N                                   4050   Me       Q.sub.53  H    OMe   OMe   CH                                  4051   Q.sub.54 Br        H    Me    OMe   CH                                  4052   Q.sub. 54                                                                               Br        H    OMe   OMe   CH                                  4053   Q.sub.54 Br        H    Me    OMe   N                                   4054   Me       Q.sub.54  H    OMe   OMe   CH                                  4055   Q.sub.55 Br        H    Me    OMe   CH                                  4056   Q.sub.55 Br        H    OMe   OMe   CH                                  4057   Q.sub.55 Br        H    Me    OMe   N                                   4058   Me       Q.sub.55  H    OMe   OMe   CH                                  4059   Q.sub.56 Br        H    Me    OMe   CH                                  4060   Q.sub.56 Br        H    OMe   OMe   CH                                  4061   Q.sub.56 Br        H    Me    OMe   N                                   4062   Me       Q.sub.56  H    OMe   OMe   CH                                  4063   Q.sub.57 Br        H    Me    OMe   CH                                  4064   Q.sub.57 Br        H    OMe   OMe   CH                                  4065   Q.sub.57 Br        H    Me    OMe   N                                   4066   Me       Q.sub.57  H    OMe   OMe   CH                                  4067   Q.sub.58 Br        H    Me    OMe   CH                                  4068   Q.sub.58 Br        H    OMe   OMe   CH                                  4069   Q.sub.58 Br        H    Me    OMe   N                                   4070   Me       Q.sub.58  H    OMe   OMe   CH                                  4071   Q.sub.59 Br        H    Me    OMe   CH                                  4072   Q.sub.59 Br        H    OMe   OMe   CH                                  4073   Q.sub.59 Br        H    Me    OMe   N                                   4074   Me       Q.sub.59  H    OMe   OMe   CH                                  4075   Q.sub.60 Br        H    Me    OMe   CH                                  4076   Q.sub.60 Br        H    OMe   OMe   CH                                  4077   Q.sub.60 Br        H    Me    OMe   N                                   4078   Me       Q.sub.60  H    OMe   OMe   CH                                  4079   Q.sub.61 Br        H    Me    OMe   CH                                  4080   Q.sub.61 Br        H    OMe   OMe   CH                                  4081   Q.sub.61 Br        H    Me    OMe   N                                   4082   Me       Q.sub.61  H    OMe   OMe   CH                                  4083   Q.sub.62 Br        H    Me    OMe   CH                                  4084   Q.sub.62 Br        H    OMe   OMe   CH                                  4085   Q.sub.62 Br        H    Me    OMe   N                                   4086   Me       Q.sub.62  H    OMe   OMe   CH                                  4087   Q.sub.63 Br        H    Me    OMe   CH                                  4088   Q.sub.63 Br        H    OMe   OMe   CH                                  4089   Q.sub.69 Br        H    Me    OMe   N                                   4090   Me       Q.sub.63  H    OMe   OMe   CH                                  4091   Q.sub.64 Br        H    Me    OMe   CH                                  4092   Q.sub.64 Br        H    OMe   OMe   CH                                  4093   Q.sub.64 Br        H    Me    OMe   N                                   4094   Me       Q.sub.64  H    OMe   OMe   CH                                  4095   Q.sub.65 Br        H    Me    OMe   CH                                  4096   Q.sub.65 Br        H    OMe   OMe   CH                                  4097   Q.sub.65 Br        H    Me    OMe   N                                   4098   Me       Q.sub.65  H    OMe   OMe   CH                                  4099   Q.sub.66 Br        H    Me    OMe   CH                                  4100   Q.sub.66 Br        H    OMe   OMe   CH                                  4101   Q.sub.66 Br        H    Me    OMe   N                                   4102   Me       Q.sub.66  H    OMe   OMe   CH                                  4103   Q.sub.67 Br        H    Me    OMe   CH                                  4104   Q.sub.67 Br        H    OMe   OMe   CH                                  4105   Q.sub.67 Br        H    Me    OMe   N                                   4106   Me       Q.sub.67  H    OMe   OMe   CH                                  4107   Q.sub.68 Br        H    Me    OMe   CH                                  4108   Q.sub.68 Br        H    OMe   OMe   CH                                  4109   Q.sub.68 Br        H    Me    OMe   N                                   4110   Me       Q.sub.68  H    OMe   OMe   CH                                  4111   Q.sub.69 Br        H    Me    OMe   CH                                  4112   Q.sub.69 Br        H    OMe   OMe   CH                                  4113   Q.sub.69 Br        H    Me    OMe   N                                   4114   Me       Q.sub.69  H    OMe   OMe   CH                                  4115   Q.sub.70 Br        H    Me    OMe   CH                                  4116   Q.sub.70 Br        H    OMe   OMe   CH                                  4117   Q.sub.70 Br        H    Me    OMe   N                                   4118   Me       Q.sub.70  H    OMe   OMe   CH                                  4119   Q.sub.71 Br        H    Me    OMe   CH                                  4120   Q.sub.71 Br        H    OMe   OMe   CH                                  4121   Q.sub.71 Br        H    Me    OMe   N                                   4122   Me       Q.sub.71  H    OMe   OMe   CH                                  4123   Q.sub.72 Br        H    Me    OMe   CH                                  4124   Q.sub.72 Br        H    OMe   OMe   CH                                  4125   Q.sub.72 Br        H    Me    OMe   N                                   4126   Me       Q.sub.72  H    OMe   OMe   CH                                  4127   Q.sub.73 Br        H    Me    OMe   CH                                  4128   Q.sub.73 Br        H    OMe   OMe   CH                                  4129   Q.sub.73 Br        H    Me    OMe   N                                   4130   Me       Q.sub.73  H    OMe   OMe   CH                                  4131   Q.sub.74 Br        H    Me    OMe   CH                                  4132   Q.sub.74 Br        H    OMe   OMe   CH                                  4133   Q.sub.74 Br        H    Me    OMe   N                                   4134   Me       Q.sub.74  H    OMe   OMe   CH                                  4135   Q.sub.75 Br        H    Me    OMe   CH                                  4136   Q.sub.75 Br        H    OMe   OMe   CH                                  4137   Q.sub.75 Br        H    Me    OMe   N                                   4138   Me       Q.sub.75  H    OMe   OMe   CH                                  4139   Q.sub.76 Br        H    Me    OMe   CH                                  4140   Q.sub.76 Br        H    OMe   OMe   CH                                  4141   Q.sub.76 Br        H    Me    OMe   N                                   4142   Me       Q.sub.76  H    OMe   OMe   CH                                  4143   Q.sub.77 Br        H    Me    OMe   CH                                  4144   Q.sub.77 Br        H    OMe   OMe   CH                                  4145   Q.sub.77 Br        H    Me    OMe   N                                   4146   Me       Q.sub.77  H    OMe   OMe   CH                                  4147   Q.sub.78 Br        H    Me    OMe   CH                                  4148   Q.sub.78 Br        H    OMe   OMe   CH                                  4149   Q.sub.78 Br        H    Me    OMe   N                                   4150   Me       Q.sub.78  H    OMe   OMe   CH                                  4151   Q.sub.79 Br        H    Me    OMe   CH                                  4152   Q.sub.79 Br        H    OMe   OMe   CH                                  4153   Q.sub. 79                                                                               Br        H    Me    OMe   N                                   4154   Me       Q.sub.79  H    OMe   OMe   CH                                  4155   Q.sub.80 Br        H    Me    OMe   CH                                  4156   Q.sub.80 Br        H    OMe   OMe   CH                                  4157   Q.sub.80 Br        H    Me    OMe   N                                   4158   Me       Q.sub.80  H    OMe   OMe   CH                                  4159   Q.sub.81 Br        H    Me    OMe   CH                                  4160   Q.sub.81 Br        H    OMe   OMe   CH                                  4161   Q.sub.81 Br        H    Me    OMe   N                                   4162   Me       Q.sub.81  H    OMe   OMe   CH                                  4163   Q.sub.82 Br        H    Me    OMe   CH                                  4164   Q.sub.82 Br        H    OMe   OMe   CH                                  4165   Q.sub.82 Br        H    Me    OMe   N                                   4166   Me       Q.sub.82  H    OMe   OMe   CH                                  4167   Q.sub.83 Br        H    Me    OMe   CH                                  4168   Q.sub.83 Br        H    OMe   OMe   CH                                  4169   Q.sub.83 Br        H    Me    OMe   N                                   4170   Me       Q.sub.83  H    OMe   OMe   CH                                  4171   Q.sub.83 Br        H    Me    OMe   CH                                  4172   Q.sub.83 Br        H    OMe   OMe   CH                                  4173   Q.sub.83 Br        H    Me    OMe   N                                   4174   Me       Q.sub.83  H    OMe   OMe   CH                                  4175   Q.sub.84 Br        H    Me    OMe   CH                                  4176   Q.sub.84 Br        H    OMe   OMe   CH                                  4177   Q.sub.84 Br        H    Me    OMe   N                                   4178   Me       Q.sub.84  H    OMe   OMe   CH                                  4179   Q.sub.85 Br        H    Me    OMe   CH                                  4180   Q.sub.85 Br        H    OMe   OMe   CH                                  4181   Q.sub.85 Br        H    Me    OMe   N                                   4182   Me       Q.sub.85  H    OMe   OMe   CH                                  4183   Q.sub.86 Br        H    Me    OMe   CH                                  4184   Q.sub.86 Br        H    OMe   OMe   CH                                  4185   Q.sub.86 Br        H    Me    OMe   N                                   4186   Me       Q.sub.86  H    OMe   OMe   CH                                  4187   Q.sub.87 Br        H    Me    OMe   CH                                  4188   Q.sub.87 Br        H    OMe   OMe   CH                                  4189   Q.sub.87 Br        H    Me    OMe   N                                   4190   Me       Q.sub.87  H    OMe   OMe   CH                                  4191   Q.sub.88 Br        H    Me    OMe   CH                                  4192   Q.sub.88 Br        H    OMe   OMe   CH                                  4193   Q.sub.88 Br        H    Me    OMe   N                                   4194   Me       Q.sub.88  H    OMe   OMe   CH                                  4195   Q.sub.89 Br        H    Me    OMe   CH                                  4196   Q.sub.89 Br        H    OMe   OMe   CH                                  4197   Q.sub.89 Br        H    Me    OMe   N                                   4198   Me       Q.sub.89  H    OMe   OMe   CH                                  4199   Q.sub.90 Br        H    Me    OMe   CH                                  4200   Q.sub.90 Br        H    OMe   OMe   CH                                  4201   Q.sub.90 Br        H    Me    OMe   N                                   4202   Me       Q.sub.90  H    OMe   OMe   CH                                  4203   Q.sub.91 Br        H    Me    OMe   CH                                  4204   Q.sub.91 Br        H    OMe   OMe   CH                                  4205   Q.sub.91 Br        H    Me    OMe   N                                   4206   Me       Q.sub.91  H    OMe   OMe   CH                                  4207   Q.sub.92 Br        H    Me    OMe   CH                                  4208   Q.sub.92 Br        H    OMe   OMe   CH                                  4209   Q.sub.92 Br        H    Me    OMe   N                                   4210   Me       Q.sub. 92 H    OMe   OMe   CH                                  4211   Q.sub.93 Br        H    Me    OMe   CH                                  4212   Q.sub.93 Br        H    OMe   OMe   CH                                  4213   Q.sub.93 Br        H    Me    OMe   N                                   4214   Me       Q.sub.93  H    OMe   OMe   CH                                  4215   Q.sub.94 Br        H    Me    OMe   CH                                  4216   Q.sub.94 Br        H    OMe   OMe   CH                                  4217   Q.sub.94 Br        H    Me    OMe   N                                   4218   Me       Q.sub.94  H    OMe   OMe   CH                                  4219   Q.sub.95 Br        H    Me    OMe   CH                                  4220   Q.sub.95 Br        H    OMe   OMe   CH                                  4221   Q.sub.95 Br        H    Me    OMe   N                                   4222   Me       Q.sub.95  H    OMe   OMe   CH                                  4223   Q.sub.96 Br        H    Me    OMe   CH                                  4224   Q.sub.96 Br        H    OMe   OMe   CH                                  4225   Q.sub.96 Br        H    Me    OMe   N                                   4226   Me       Q.sub.96  H    OMe   OMe   CH                                  4227   Q.sub.97 Br        H    Me    OMe   CH                                  4228   Q.sub.97 Br        H    OMe   OMe   CH                                  4229   Q.sub.97 Br        H    Me    OMe   N                                   4230   Me       Q.sub.97  H    OMe   OMe   CH                                  4231   Q.sub.98 Br        H    Me    OMe   CH                                  4232   Q.sub.98 Br        H    OMe   OMe   CH                                  4233   Q.sub.98 Br        H    Me    OMe   N                                   4234   Me       Q.sub.98  H    OMe   OMe   CH                                  4235   Q.sub.99 Br        H    Me    OMe   CH                                  4236   Q.sub.99 Br        H    OMe   OMe   CH                                  4237   Q.sub.99 Br        H    Me    OMe   N                                   4238   Me       Q.sub.99  H    OMe   OMe   CH                                  4239   Q.sub.100                                                                               Br        H    Me    OMe   CH                                  4240   Q.sub.100                                                                               Br        H    OMe   OMe   CH                                  4241   Q.sub.100                                                                               Br        H    Me    OMe   N                                   4242   Me       Q.sub.100 H    OMe   OMe   CH                                  4243   Q.sub.101                                                                               Br        H    Me    OMe   CH                                  4244   Q.sub.101                                                                               Br        H    OMe   OMe   CH                                  4245   Q.sub.101                                                                               Br        H    Me    OMe   N                                   4246   Me       Q.sub.101 H    OMe   OMe   CH                                  4247   Q.sub.102                                                                               Br        H    Me    OMe   CH                                  4248   Q.sub.102                                                                               Br        H    OMe   OMe   CH                                  4249   Q.sub.102                                                                               Br        H    Me    OMe   N                                   4250   Me       Q.sub.102 H    OMe   OMe   CH                                  4251   Q.sub.103                                                                               Br        H    Me    OMe   CH                                  4252   Q.sub.103                                                                               Br        H    OMe   OMe   CH                                  4253   Q.sub.103                                                                               Br        H    Me    OMe   N                                   4254   Me       Q.sub.103 H    OMe   OMe   CH                                  4255   Q.sub.104                                                                               Br        H    Me    OMe   CH                                  4256   Q.sub.104                                                                               Br        H    OMe   OMe   CH                                  4257   Q.sub.104                                                                               Br        H    Me    OMe   N                                   4258   Me       Q.sub.104 H    OMe   OMe   CH                                  4259   Q.sub.105                                                                               Br        H    Me    OMe   CH                                  4260   Q.sub.105                                                                               Br        H    OMe   OMe   CH                                  4261   Q.sub.105                                                                               Br        H    Me    OMe   N                                   4262   Me       Q.sub.105 H    OMe   OMe   CH                                  4263   Q.sub.106                                                                               Br        H    Me    OMe   CH                                  4264   Q.sub.106                                                                               Br        H    OMe   OMe   CH                                  4265   Q.sub.106                                                                               Br        H    Me    OMe   N                                   4266   Me       Q.sub.106 H    OMe   OMe   CH                                  4267   Q.sub.107                                                                               Br        H    Me    OMe   CH                                  4268   Q.sub.107                                                                               Br        H    OMe   OMe   CH                                  4269   Q.sub.107                                                                               Br        H    Me    OMe   N                                   4270   Me       Q.sub.107 H    OMe   OMe   CH                                  4271   Q.sub.108                                                                               Br        H    Me    OMe   CH                                  4272   Q.sub.108                                                                               Br        H    OMe   OMe   CH                                  4273   Q.sub.108                                                                               Br        H    Me    OMe   N                                   4274   Me       Q.sub.108 H    OMe   OMe   CH                                  4275   Q.sub.109                                                                               Br        H    Me    OMe   CH                                  4276   Q.sub.109                                                                               Br        H    OMe   OMe   CH                                  4277   Q.sub.109                                                                               Br        H    Me    OMe   N                                   4278   Me       Q.sub.108 H    OMe   OMe   CH                                  4279   Q.sub.110                                                                               Br        H    Me    OMe   CH                                  4280   Q.sub.110                                                                               Br        H    OMe   OMe   CH                                  4281   Q.sub.110                                                                               Br        H    Me    OMe   N                                   4282   Me       Q.sub.110 H    OMe   OMe   CH                                  4283   Q.sub.111                                                                               Br        H    Me    OMe   CH                                  4284   Q.sub.111                                                                               Br        H    OMe   OMe   CH                                  4285   Q.sub.111                                                                               Br        H    Me    OMe   N                                   4286   Me       Q.sub.111 H    OMe   OMe   CH                                  4287   Q.sub.112                                                                               Br        H    Me    OMe   CH                                  4288   Q.sub.112                                                                               Br        H    OMe   OMe   CH                                  4289   Q.sub.112                                                                               Br        H    Me    OMe   N                                   4290   Me       Q.sub.112 H    OMe   OMe   CH                                  4291   Q.sub.113                                                                               Br        H    Me    OMe   CH                                  4292   Q.sub.113                                                                               Br        H    OMe   OMe   CH                                  4293   Q.sub.113                                                                               Br        H    Me    OMe   N                                   4294   Me       Q.sub.113 H    OMe   OMe   CH                                  4295   Q.sub.114                                                                               Br        H    Me    OMe   CH                                  4296   Q.sub.114                                                                               Br        H    OMe   OMe   CH                                  4297   Q.sub.114                                                                               Br        H    Me    OMe   N                                   4298   Me       Q.sub.114 H    OMe   OMe   CH                                  4299   Q.sub.115                                                                               Br        H    Me    OMe   CH                                  4300   Q.sub.115                                                                               Br        H    OMe   OMe   CH                                  4301   Q.sub.115                                                                               Br        H    Me    OMe   N                                   4302   Me       Q.sub.115 H    OMe   OMe   CH                                  4303   Q.sub.116                                                                               Br        H    Me    OMe   CH                                  4304   Q.sub.116                                                                               Br        H    OMe   OMe   CH                                  4305   Q.sub.116                                                                               Br        H    Me    OMe   N                                   4306   Me       Q.sub.116 H    OMe   OMe   CH                                  4307   Q.sub.117                                                                               Br        H    Me    OMe   CH                                  4308   Q.sub.117                                                                               Br        H    OMe   OMe   CH                                  4309   Q.sub.117                                                                               Br        H    Me    OMe   N                                   4310   Me       Q.sub.117 H    OMe   OMe   CH                                  4311   Q.sub.118                                                                               Br        H    Me    OMe   CH                                  4312   Q.sub.118                                                                               Br        H    OMe   OMe   CH                                  4313   Q.sub.118                                                                               Br        H    Me    OMe   N                                   4314   Me       Q.sub.118 H    OMe   OMe   CH                                  4315   Q.sub.119                                                                               Br        H    Me    OMe   CH                                  4316   Q.sub.119                                                                               Br        H    OMe   OMe   CH                                  4317   Q.sub.119                                                                               Br        H    Me    OMe   N                                   4318   Me       Q.sub.119 H    OMe   OMe   CH                                  4319   Q.sub.120                                                                               Br        H    Me    OMe   CH                                  4320   Q.sub.120                                                                               Br        H    OMe   OMe   CH                                  4321   Q.sub.120                                                                               Br        H    Me    OMe   N                                   4322   Me       Q.sub.120 H    OMe   OMe   CH                                  4323   Q.sub.121                                                                               Br        H    Me    OMe   CH                                  4324   Q.sub.121                                                                               Br        H    OMe   OMe   CH                                  4325   Q.sub.121                                                                               Br        H    Me    OMe   N                                   4326   Me       Q.sub.121 H    OMe   OMe   CH                                  4327   Q.sub.122                                                                               Br        H    Me    OMe   CH                                  4328   Q.sub.122                                                                               Br        H    OMe   OMe   CH                                  4329   Q.sub.122                                                                               Br        H    Me    OMe   N                                   4330   Me       Q.sub.122 H    OMe   OMe   CH                                  4331   Q.sub.123                                                                               Br        H    Me    OMe   CH                                  4332   Q.sub.123                                                                               Br        H    OMe   OMe   CH                                  4333   Q.sub.123                                                                               Br        H    Me    OMe   N                                   4334   Me       Q.sub.123 H    OMe   OMe   CH                                  4335   Q.sub.124                                                                               Br        H    Me    OMe   CH                                  4336   Q.sub.124                                                                               Br        H    OMe   OMe   CH                                  4337   Q.sub.124                                                                               Br        H    Me    OMe   N                                   4338   Me       Q.sub.124 H    OMe   OMe   CH                                  4339   Q.sub.125                                                                               Br        H    Me    OMe   CH                                  4340   Q.sub.125                                                                               Br        H    OMe   OMe   CH                                  4341   Q.sub.125                                                                               Br        H    Me    OMe   N                                   4342   Me       Q.sub.125 H    OMe   OMe   CH                                  4343   Q.sub.126                                                                               Br        H    Me    OMe   CH                                  4344   Q.sub.126                                                                               Br        H    OMe   OMe   CH                                  4345   Q.sub.126                                                                               Br        H    Me    OMe   N                                   4346   Me       Q.sub.126 H    OMe   OMe   CH                                  4347   Q.sub.127                                                                               Br        H    Me    OMe   CH                                  4348   Q.sub.127                                                                               Br        H    OMe   OMe   CH                                  4349   Q.sub.127                                                                               Br        H    Me    OMe   N                                   4350   Me       Q.sub.127 H    OMe   OMe   CH                                  4351   Q.sub.128                                                                               Br        H    Me    OMe   CH                                  4352   Q.sub.128                                                                               Br        H    OMe   OMe   CH                                  4353   Q.sub. 128                                                                              Br        H    Me    OMe   N                                   4354   Me       Q.sub.128 H    OMe   OMe   CH                                  4355   Q.sub.129                                                                               Br        H    Me    OMe   CH                                  4356   Q.sub.129                                                                               Br        H    OMe   OMe   CH                                  4357   Q.sub.129                                                                               Br        H    Me    OMe   N                                   4358   Me       Q.sub.129 H    OMe   OMe   CH                                  4359   Q.sub.130                                                                               Br        H    Me    OMe   CH                                  4360   Q.sub.130                                                                               Br        H    OMe   OMe   CH                                  4361   Q.sub.130                                                                               Br        H    Me    OMe   N                                   4362   Me       Q.sub.130 H    OMe   OMe   CH                                  4363   Q.sub.131                                                                               Br        H    Me    OMe   CH                                  4364   Q.sub.131                                                                               Br        H    OMe   OMe   CH                                  4365   Q.sub.131                                                                               Br        H    Me    OMe   N                                   4366   Me       Q.sub.131 H    OMe   OMe   CH                                  4367   Q.sub.132                                                                               Br        H    Me    OMe   CH                                  4368   Q.sub.132                                                                               Br        H    OMe   OMe   CH                                  4369   Q.sub.132                                                                               Br        H    Me    OMe   N                                   4370   Me       Q.sub.132 H    OMe   OMe   CH                                  ______________________________________                                    

                                      TABLE 4                                      __________________________________________________________________________      ##STR16##                                                                     No.                                                                               A  B  D    E        W    X   Y  Z                                           __________________________________________________________________________     1934                                                                              Q.sub.1                                                                           H  COOMe                                                                               H        S    Me  OMe                                                                               CH                                          1935                                                                              Q.sub.1                                                                           H  COOMe                                                                               H        S    OMe OMe                                                                               CH                                          1936                                                                              Q.sub.1                                                                           H  COOEt                                                                               H        S    Me  OMe                                                                               CH                                          1937                                                                              Q.sub.1                                                                           H  COOEt                                                                               H        S    OMe OMe                                                                               CH                                          1938                                                                              Q.sub.1                                                                           H  COOMe                                                                               Me       O    Me  OMe                                                                               CH                                          1939                                                                              Q.sub.1                                                                           H  COOMe                                                                               Me       O    OMe OMe                                                                               CH                                          1940                                                                              Q.sub.1                                                                           H  COOEt                                                                               Me       O    OMe OMe                                                                               CH                                          1941                                                                              Q.sub.1                                                                           H  COOMe                                                                               OMe      O    Me  OMe                                                                               CH                                          1942                                                                              Q.sub.1                                                                           H  COOMe                                                                               OMe      O    OMe OMe                                                                               CH                                          1943                                                                              Q.sub.1                                                                           H  COOEt                                                                               OMe      O    OMe OMe                                                                               CH                                          1944                                                                              Q.sub.1                                                                           H  COOMe                                                                               CH.sub.2 CHCH.sub.2                                                                     O    Me  OMe                                                                               CH                                          1945                                                                              Q.sub.1                                                                           H  COOMe                                                                               CH.sub.2 CHCH.sub.2                                                                     O    OMe OMe                                                                               CH                                          1946                                                                              Q.sub.1                                                                           H  COOEt                                                                               CH.sub.2 CHCH.sub.2                                                                     O    OMe OMe                                                                               CH                                          1947                                                                              Q.sub.1                                                                           H  COOMe                                                                               CH.sub.2 CCH                                                                            O    Me  OMe                                                                               CH                                          1948                                                                              Q.sub.1                                                                           H  COOMe                                                                               CH.sub.2 CCH                                                                            O    OMe OMe                                                                               CH                                          1949                                                                              Q.sub.1                                                                           H  COOEt                                                                               CH.sub.2 CCH                                                                            O    OMe OMe                                                                               CH                                          1950                                                                              Q.sub.12                                                                          H  COOMe                                                                               H        S    Me  OMe                                                                               CH                                          1951                                                                              Q.sub.12                                                                          H  COOMe                                                                               H        S    OMe OMe                                                                               CH                                          1952                                                                              Q.sub.12                                                                          H  COOEt                                                                               H        S    Me  OMe                                                                               CH                                          1953                                                                              Q.sub.12                                                                          H  COOEt                                                                               H        S    OMe OMe                                                                               CH                                          1954                                                                              Q.sub.12                                                                          H  COOMe                                                                               Me       O    Me  OMe                                                                               CH                                          1955                                                                              Q.sub.12                                                                          H  COOMe                                                                               Me       O    OMe OMe                                                                               CH                                          1956                                                                              Q.sub.12                                                                          H  COOEt                                                                               Me       O    OMe OMe                                                                               CH                                          1957                                                                              Q.sub.12                                                                          H  COOMe                                                                               OMe      O    Me  OMe                                                                               CH                                          1958                                                                              Q.sub.12                                                                          H  COOMe                                                                               OMe      O    OMe OMe                                                                               CH                                          1959                                                                              Q.sub.12                                                                          H  COOEt                                                                               OMe      O    OMe OMe                                                                               CH                                          1960                                                                              Q.sub.12                                                                          H  COOMe                                                                               CH.sub.2 CHCH.sub.2                                                                     O    Me  OMe                                                                               CH                                          1961                                                                              Q.sub.12                                                                          H  COOMe                                                                               CH.sub.2 CHCH.sub.2                                                                     O    OMe OMe                                                                               CH                                          1962                                                                              Q.sub.12                                                                          H  COOEt                                                                               CH.sub.2 CHCH.sub.2                                                                     O    OMe OMe                                                                               CH                                          1963                                                                              Q.sub.12                                                                          H  COOMe                                                                               CH.sub.2 CCH                                                                            O    Me  OMe                                                                               CH                                          1964                                                                              Q.sub.12                                                                          H  COOMe                                                                               CH.sub.2 CCH                                                                            O    OMe OMe                                                                               CH                                          1965                                                                              Q.sub.12                                                                          H  COOEt                                                                               CH.sub.2 CCH                                                                            O    OMe OMe                                                                               CH                                          1966                                                                              Q.sub.22                                                                          H  COOMe                                                                               H        S    Me  OMe                                                                               CH                                          1967                                                                              Q.sub.22                                                                          H  COOMe                                                                               H        S    OMe OMe                                                                               CH                                          1968                                                                              Q.sub.22                                                                          H  COOEt                                                                               H        S    Me  OMe                                                                               CH                                          1969                                                                              Q.sub.22                                                                          H  COOEt                                                                               H        S    OMe OMe                                                                               CH                                          1970                                                                              Q.sub.22                                                                          H  COOMe                                                                               Me       O    Me  OMe                                                                               CH                                          1971                                                                              Q.sub.22                                                                          H  COOMe                                                                               Me       O    OMe OMe                                                                               CH                                          1972                                                                              Q.sub.22                                                                          H  COOEt                                                                               Me       O    OMe OMe                                                                               CH                                          1973                                                                              Q.sub.22                                                                          H  COOMe                                                                               OMe      O    Me  OMe                                                                               CH                                          1974                                                                              Q.sub.22                                                                          H  COOMe                                                                               OMe      O    OMe OMe                                                                               CH                                          1975                                                                              Q.sub.22                                                                          H  COOEt                                                                               OMe      O    OMe OMe                                                                               CH                                          1976                                                                              Q.sub.22                                                                          H  cOOMe                                                                               CH.sub.2 CHCH.sub.2                                                                     O    Me  OMe                                                                               CH                                          1977                                                                              Q.sub.22                                                                          H  COOMe                                                                               CH.sub.2 CHCH.sub.2                                                                     O    OMe OMe                                                                               CH                                          1978                                                                              Q.sub.22                                                                          H  COOEt                                                                               CH.sub.2 CHCH.sub.2                                                                     O    OMe OMe                                                                               CH                                          1979                                                                              Q.sub.22                                                                          H  COOMe                                                                               CH.sub.2 CCH                                                                            O    Me  OMe                                                                               CH                                          1980                                                                              Q.sub.22                                                                          H  COOMe                                                                               CH.sub.2 CCH                                                                            O    OMe OMe                                                                               CH                                          1981                                                                              Q.sub.22                                                                          H  COOEt                                                                               CH.sub.2 CCH                                                                            O    OMe OMe                                                                               CH                                          4371                                                                              Q.sub.1                                                                           H  COOMe                                                                               H        NOMe Me  OMe                                                                               CH                                          4372                                                                              Q.sub.1                                                                           H  COOMe                                                                               H        NOMe OMe OMe                                                                               CH                                          4373                                                                              Q.sub.1                                                                           H  COOEt                                                                               H        NOMe Me  OMe                                                                               CH                                          4374                                                                              Q.sub.1                                                                           H  COOEt                                                                               H        NOMe OMe OMe                                                                               CH                                          4375                                                                              Q.sub.1                                                                           H  COOMe                                                                               H        NOEe Me  OMe                                                                               CH                                          4376                                                                              Q.sub.1                                                                           H  COOMe                                                                               H        NOEe OMe OMe                                                                               CH                                          4377                                                                              Q.sub.1                                                                           H  COOEt                                                                               H        NOEe Me  OMe                                                                               CH                                          4378                                                                              Q.sub. 1                                                                          H  COOEt                                                                               H        NOEe OMe OMe                                                                               CH                                          4379                                                                              Q.sub.1                                                                           H  COOMe                                                                               H        NMe  Me  OMe                                                                               CH                                          4380                                                                              Q.sub.1                                                                           H  COOMe                                                                               H        NMe  OMe OMe                                                                               CH                                          4381                                                                              Q.sub.1                                                                           H  COOEt                                                                               H        NMe  Me  OMe                                                                               CH                                          4382                                                                              Q.sub.1                                                                           H  COOEt                                                                               H        NMe  OMe OMe                                                                               CH                                          4383                                                                              Q.sub.1                                                                           H  COOMe                                                                               H        NH   Me  OMe                                                                               CH                                          4384                                                                              Q.sub.1                                                                           H  COOMe                                                                               H        NH   OMe OMe                                                                               CH                                          4385                                                                              Q.sub.1                                                                           H  COOEt                                                                               H        NH   Me  OMe                                                                               CH                                          4386                                                                              Q.sub.1                                                                           H  COOEt                                                                               H        NH   OMe OMe                                                                               CH                                          4387                                                                              Q.sub.12                                                                          H  COOMe                                                                               H        NOMe Me  OMe                                                                               CH                                          4388                                                                              Q.sub.12                                                                          H  COOMe                                                                               H        NOMe OMe OMe                                                                               CH                                          4389                                                                              Q.sub.12                                                                          H  COOEt                                                                               H        NOMe Me  OMe                                                                               CH                                          4390                                                                              Q.sub.12                                                                          H  COOEt                                                                               H        NOMe OMe OMe                                                                               CH                                          4391                                                                              Q.sub.12                                                                          H  COOMe                                                                               H        NOEe Me  OMe                                                                               CH                                          4392                                                                              Q.sub.12                                                                          H  COOMe                                                                               H        NOEe OMe OMe                                                                               CH                                          4393                                                                              Q.sub.12                                                                          H  COOEt                                                                               H        NOEe Me  OMe                                                                               CH                                          4394                                                                              Q.sub.12                                                                          H  COOEt                                                                               H        NOEe OMe OMe                                                                               CH                                          4395                                                                              Q.sub.12                                                                          H  COOMe                                                                               H        NMe  Me  OMe                                                                               CH                                          4396                                                                              Q.sub.12                                                                          H  COOMe                                                                               H        NMe  OMe OMe                                                                               CH                                          4397                                                                              Q.sub.12                                                                          H  COOEt                                                                               H        NMe  Me  OMe                                                                               CH                                          4398                                                                              Q.sub.12                                                                          H  COOEt                                                                               H        NMe  OMe OMe                                                                               CH                                          4399                                                                              Q.sub.12                                                                          H  COOMe                                                                               H        NH   Me  OMe                                                                               CH                                          4400                                                                              Q.sub.12                                                                          H  COOMe                                                                               H        NH   OMe OMe                                                                               CH                                          4401                                                                              Q.sub.12                                                                          H  COOEt                                                                               H        NH   Me  OMe                                                                               CH                                          4402                                                                              Q.sub.12                                                                          H  COOEt                                                                               H        NH   OMe OMe                                                                               CH                                          4403                                                                              Q.sub.22                                                                          H  COOMe                                                                               H        NOMe Me  OMe                                                                               CH                                          4404                                                                              Q.sub.22                                                                          H  COOMe                                                                               H        NOMe OMe OMe                                                                               CH                                          4405                                                                              Q.sub.22                                                                          H  COOEt                                                                               H        NOMe Me  OMe                                                                               CH                                          4406                                                                              Q.sub.22                                                                          H  COOEt                                                                               H        NOMe OMe OMe                                                                               CH                                          4407                                                                              Q.sub.22                                                                          H  COOMe                                                                               H        NOEe Me  OMe                                                                               CH                                          4408                                                                              Q.sub.22                                                                          H  COOMe                                                                               H        NOEe OMe OMe                                                                               CH                                          4409                                                                              Q.sub.22                                                                          H  COOEt                                                                               H        NOEe Me  OMe                                                                               CH                                          4410                                                                              Q.sub.22                                                                          H  COOEt                                                                               H        NOEe OMe OMe                                                                               CH                                          4411                                                                              Q.sub.22                                                                          H  COOMe                                                                               H        NMe  Me  OMe                                                                               CH                                          4412                                                                              Q.sub.22                                                                          H  COOMe                                                                               H        NMe  OMe OMe                                                                               CH                                          4413                                                                              Q.sub.22                                                                          H  COOEt                                                                               H        NMe  Me  OMe                                                                               CH                                          4414                                                                              Q.sub.22                                                                          H  COOEt                                                                               H        NMe  OMe OMe                                                                               CH                                          4415                                                                              Q.sub.22                                                                          H  COOMe                                                                               H        NH   Me  OMe                                                                               CH                                          4416                                                                              Q.sub.22                                                                          H  COOMe                                                                               H        NH   OMe OMe                                                                               CH                                          4417                                                                              Q.sub.22                                                                          H  COOEt                                                                               H        NH   Me  OMe                                                                               CH                                          4418                                                                              Q.sub.22                                                                          H  COOEt                                                                               H        NH   OMe OMe                                                                               CH                                          __________________________________________________________________________

                  TABLE 5                                                          ______________________________________                                          ##STR17##                                                                     No.     A      B       D      X.sup.1                                                                               Y.sup.1                                                                             Z                                    ______________________________________                                         1982    Q.sub.1                                                                               H       COOMe  Me     Me   CH                                   1983    Q.sub.1                                                                               H       COOMe  Me     OMe  CH                                   1984    Q.sub.1                                                                               H       COOEt  Me     Me   CH                                   1985    Q.sub.1                                                                               H       COOEt  Me     OMe  CH                                   1986    Q.sub.1                                                                               H       COOEt  Me     Me   N                                    1987    Q.sub.12                                                                              H       COOMe  Me     Me   CH                                   1988    Q.sub.12                                                                              H       COOMe  Me     OMe  CH                                   1989    Q.sub.22                                                                              H       COOMe  Me     Me   CH                                   1990    Q.sub.22                                                                              H       COOMe  Me     OMe  CH                                   ______________________________________                                    

                  TABLE 6                                                          ______________________________________                                          ##STR18##                                                                     No.    A         B     D         X.sup.2                                                                             Y.sup.2                                  ______________________________________                                         1991   Q.sub.1   H     COOMe     Me   Me                                       1992   Q.sub.1   H     COOMe     OMe  Me                                       1993   Q.sub.1   H     COOMe     SMe  Me                                       1994   Q.sub.1   H     COOEt     Me   Me                                       1995   Q.sub.1   H     COOEt     OMe  Me                                       1996   Q.sub.1   H     COOEt     SMe  Me                                       1997   Q.sub.12  H     COOMe     Me   Me                                       1998   Q.sub.12  H     COOMe     OMe  Me                                       1999   Q.sub.22  H     COOMe     Me   Me                                       2000   Q.sub.22  H     COOMe     OMe  Me                                       ______________________________________                                    

                  TABLE 7                                                          ______________________________________                                          ##STR19##                                                                     No.  A       B      D       Y.sup.4                                                                               X.sup.3                                                                              Y.sup.3                                                                             Z.sup.1                          ______________________________________                                         4419 Q.sub.1 H      COOMe   COOMe  Me    Me   CH                               4420 Q.sub.1 H      COOMe   CN     Me    Me   CH                               4421 Q.sub.1 H      COOMe   Me     OMe   OMe  N                                4422 Q.sub.1 H      COOEt   COOMe  Me    Me   CH                               4423 Q.sub.1 H      COOEt   CN     Me    Me   CH                               4424 Q.sub.1 H      COOEt   Me     OMe   OMe  N                                4425 Q.sub.1 Me     COOMe   COOMe  Me    Me   CH                               4426 Q.sub.1 Me     COOMe   CN     Me    Me   CH                               4427 Q.sub.1 Me     COOMe   Me     OMe   OMe  N                                4428 Q.sub.1 Me     COOEt   COOMe  Me    Me   CH                               4429 Q.sub.1 Me     COOEt   CN     Me    Me   CH                               4430 Q.sub.1 Me     COOEt   Me     OMe   OMe  N                                4431 Q.sub.12                                                                               H      COOMe   COOMe  Me    Me   CH                               4432 Q.sub.12                                                                               H      COOMe   CN     Me    Me   CH                               4433 Q.sub.12                                                                               H      COOMe   Me     OMe   OMe  N                                4434 Q.sub.12                                                                               H      COOEt   COOMe  Me    Me   CH                               4435 Q.sub.12                                                                               H      COOEt   CN     Me    Me   CH                               4436 Q.sub.12                                                                               H      COOEt   Me     OMe   OMe  N                                4437 Q.sub.12                                                                               Me     COOMe   COOMe  Me    Me   CH                               4438 Q.sub.12                                                                               Me     COOMe   CN     Me    Me   CH                               4439 Q.sub.12                                                                               Me     COOMe   Me     OMe   OMe  N                                4440 Q.sub.12                                                                               Me     COOEt   COOMe  Me    Me   CH                               4441 Q.sub.12                                                                               Me     COOEt   CN     Me    Me   CH                               4442 Q.sub.12                                                                               Me     COOEt   Me     OMe   OMe  N                                4443 Q.sub.22                                                                               H      COOMe   COOMe  Me    Me   CH                               4444 Q.sub.22                                                                               H      COOMe   CN     Me    Me   CH                               4445 Q.sub.22                                                                               H      COOMe   Me     OMe   OMe  N                                4446 Q.sub.22                                                                               H      COOEt   COOMe  Me    Me   CH                               4447 Q.sub.22                                                                               H      COOEt   CN     Me    Me   CH                               4448 Q.sub.22                                                                               H      COOEt   Me     OMe   OMe  N                                4449 Q.sub.22                                                                               Me     COOMe   COOMe  Me    Me   CH                               4450 Q.sub.22                                                                               Me     COOMe   CN     Me    Me   CH                               4451 Q.sub.22                                                                               Me     COOMe   Me     OMe   OMe  N                                4452 Q.sub.22                                                                               Me     COOET   COOMe  Me    Me   CH                               4453 Q.sub.22                                                                               Me     COOEt   CN     Me    Me   CH                               4454 Q.sub.22                                                                               Me     COOEt   Me     OMe   OMe  N                                ______________________________________                                    

Q₁ to Q₁₃₂ in Tables 1 to 7 each have the meanings shown below: ##STR20##

The compounds shown in Table 1 to Table 7 can be synthesized following the procedures in Examples 1 and 2 or the procedures described above. Properties of some of these compounds are shown in Table 8. In Table 8, the compound number correspond to the compound number in Table 1 to Table 7.

                  TABLE 8                                                          ______________________________________                                         Comp. No.     m.p. (°C.)                                                ______________________________________                                          9            169-173                                                           10           169-173                                                           11           179-193                                                          313           215-216                                                          314           212-213                                                          315           213-214                                                          ______________________________________                                    

In application of the compounds of this invention as herbicides, they can be applied by mixing with suitable carriers such as solid carriers, including for example clay, talc, bentonite, diatomaceous earth and others, or liquid carriers, including for example water, alcohols (methanol, ethanol and the like), aromatic hydrocarbons (benzene, toluene, xylene and the like), chlorinated hydrocarbons, ethers, ketones, esters (ethyl acetate, etc.), acid amides (dimethylformamide, etc.) and others. They can be provided for practical use with addition of any desired additive selected from an emulsifier, a dispersing agent, a suspending agent, a penetrating agent, a spreader and a stablizer and in any desired form such as a soluble concentrate, an emulsifiable concentrate, a wettable powder, a dust, a granule, etc.

In the following, there are shown examples of formulations of herbicides containing the compounds of this invention as active ingredients, but they are not limitative of this invention. In the exemplary formulations shown below, "parts" means "parts by weight".

EXEMPLARY FORMULATION 1 Wettable powder

Compound No. 9 of this invention: 50 parts

Zeeklite PFP: 46 parts

(kaolin type clay; trade name; produced by Zeeklite Kogyo Co., Ltd.)

Solpol 5039: 5 parts

(anionic surfactant; trade name; produced by Toho Kagaku Co., Ltd.)

Carplex (anticaking agent): 2 parts

(white carbon; trade name, produced by Shionogi Seiyaku Co., Ltd.)

All of the above components are mixed and pulverized homogeneously to prepare a wettable powder.

EXEMPLARY FORMULATION 2 Wettable powder

Compound No. 315 of this invention: 45 parts

Zeeklite A: 48 parts

(kaolin type clay; trade name; produced by Zeeklite Kogyo Co., Ltd.)

Solpol 5039: 5 parts

(anionic surfactant; trade name; produced by Toho Kagaku Co., Ltd.)

Carplex (anticaking agent): 4 parts

(white carbon; trade name; produced by Shionogi Seiyaku Co., Ltd.)

The above components are mixed and pulverized homogeneously to prepare a wettable powder.

EXEMPLARY FORMULATION 3 Emulsifiable concentrate

Compound No. 313 of this invention: 2 parts

Xylene: 73 parts

Dimethylformamide: 15 parts

Solpol 2680: 10 parts

(mixture of nonionic surfactant and anionic surfactant; trade name; produced by Toho Kagaku Co., Ltd.)

The above components are homogeneously mixed to prepare an emulsifiable concentrate.

In use, the above emulsifiable concentrate is diluted to 10 to 10,000 times and sprayed in an amount of the active ingredient of 0.005 to 10 kg per hectare.

EXEMPLARY FORMULATION 4 Flowable

Compound No. 11 of this invention: 25 parts

Agrisol S-710: 10 parts

(nonionic surfactant; trade name; produced by Kao Co., Ltd.)

Runox 1000 C: 0.5 part

(anionic surfactant; trade name; produced by Toho Kagaku Co., Ltd.)

1% Rodopol water: 20 parts

(thickener; trade name; produced by Rhone-Poulenc Co., Ltd.)

Water: 44.5 parts

The above components are mixed homogeneously to provide a flowable agent.

EXEMPLARY FORMULATION 5 Granule

Compound No. 314 of this invention: 0.1 part

Bentonite: 55.0 parts

Talc: 44.9 parts

All of the above components are mixed and pulverized homogeneously, then a little amount of water is added and the whole is stirred, kneaded and granulated by excluding granulator, then dried to prepare a granule.

EXEMPLARY FORMULATION 6 Granule

Compound No. 315 of this invention: 0.5 part

Bentonite: 55.0 parts

Talc: 44.5 parts

All of the above components are mixed and pulverized homogenerously, then a little amount of water is added and the whole is stirred, kneaded and granulated by excluding granulator, then dried to prepare a granule.

If desired, the compound of this invention may be applied as a mixture with other kinds of herbicides, various insecticides, sterilizers or adjuvants during preparation or spraying In particular, when applied in beet fields, useful ones include phenmedipham, desmedipham, lenacil, PAC., ethofumesate and so on.

As the other kinds of herbicides mentioned above, there may be included compounds as described in Farm Chemicals Handbook (1986).

The compounds of this invention can also be applied, in addition to the agricultural and horticultural fields such as farm fields, paddy fields, fruit gardens and the like, to the non-agricultural fields such as athletic grounds, vacant lands, belts along railroads and others in order to prevent and eliminate various weeds. The amounts of the herbicide to be applied, which may differ depending on the scenes to be applied, the time of application, the application method, the kinds of the objective grasses and the crops harvested, may generally range suitably from about 0.25 g to about 10 kg per hectare in terms of the active ingredient. When applied to beets in particular, it may range suitably from 0.25 to 1000 g/ha, preferably from 0.5 to 500 g/ha.

The following test examples are set forth for illustration of the utility of the compounds of this invention as herbicides.

TEST EXAMPLE 1 Herbicidal effect test by soil treatment

In a plastic box of 15 cm length, 22 cm width and 6 cm depth, there was placed a sterilized deluvium soil, and seeds of (A) rice (Oryza sativa), (B) barnyardgrass (Echinochloa crusgalli), (C) large crabgrass (Digitaria adscendens), (D) annual sedge (Cyperus microiria), (E) black nightshade (Solanum nigrum L.), (F) hairly galinosoga (Galinosoga ciliata), (G) rorippa spp. (Rorippa indica), (H) corn (Zea mays), (I) wheat (Triticum vulgare), (J) soybean (Glysine max) and (K) cotton (Gossypium spp) were sown mixedly. After covering soil to about 1.5 cm over the seeds, herbicides were sprayed evenly on the soil surface to predetermined proportions of the active ingredient.

In spraying, the wettable powder as shown in the foregoing exemplary formulations was diluted with water and sprayed over the entire surface by means of a small sprayer. Four weeks after spraying, the herbicidal effect on crops including rice, etc. and the various weeds were examined according to the judgement criteria shown below.

The results are shown in Table 9.

Some of the compounds of this invention show the selectivity on certain crops.

Judgement criteria

5 . . . Growth control rates of more than 90% (almost completely withered)

4 . . . Growth control rates of 70 to 90%

3 . . . Growth control rates of 40 to 70%

2 . . . Growth control rates of 20 to 40%

1 . . . Growth control rates of 5 to 20%

0 . . . Growth control rates of less than 5% (substantially no effect)

The above growth control rates are determined by measuring the top fresh weights of the treated plants and those of the non-treated plants, and calculated from the following formula: ##EQU1##

TEST EXAMPLE 2 Herbicidal effect test by foliage treatment

In a plastic box of 15 cm length, 22 cm width and 6 cm depth, there was placed a sterilized deluvium soil, seeds of (A) rice (Oryza sativa), (B) barnyardgrass (Echinochloa crusgalli), (C) large crabgrass (Digitaria adscendens), (D) annual sedge (Cyperus microiria), (E) black nightshade (Solanum nigrum L.), (F) hairly galinosoga (Galinosoga ciliata), (G) rorippa ssp. (Rorippa indica), (H) corn (Zea mays), (I) wheat (Triticum vulgare), (J) soybean (Glysine max), (K) cotton (Gossypium spp) and (L) sugar beet (Beta vulgaris) were sown in shapes of spots, respectively, followed by covering of soil to about 1.5 cm over the seeds. After respective plants have grown to the second and the third leaf stage, herbicides were sprayed evenly onto the foliage portion at predetermined proportions of the active ingredient. In spraying, the wettable powder as shown in the foregoing exemplary formulations was diluted with water and sprayed over the entire surface of the foliage portions of various weeds by means of a small sprayer. Four weeks after spraying, the herbicidal effect on crops including rice, etc. and the various weeds were examined according to the judgement criteria as shown in Test example 1.

The results are shown in Table 10.

TEST EXAMPLE 3 Agricultural chemical damage test on sugar beet

In a plastic box of 15 cm length, 22 cm width and 6 cm depth, there was placed a sterilized deluvium soil, and seeds of (L) sugar beet (Beta vulgaris), (M) groundsel (Senecio vulgaris), (N) common field-speedwell (Veronica persica), (O) wild mustard (Sinapis arvensis) and (P) cleavers (Galium aparine) were sown in shapes of spots, respectively, followed by covering of soil to about 1.5 cm over the seeds. After respective plants have grown to the second and the third leaf stage, herbicides were sprayed evenly onto the stem-leaf portion at predetermined proportions of the active ingredient.

On 20 days after treatment, the herbicidal effects on weeds and agricultural chemical damages on sugar beet were examined. The results are shown in Table 11.

                                      TABLE 9                                      __________________________________________________________________________           Amount of                                                                      active                                                                         ingredient                                                               Compound                                                                             applied                                                                  No.   kg/ha (A)                                                                               (B)                                                                               (C)                                                                               (D)                                                                               (E)                                                                               (F)                                                                               (G)                                                                               (H)                                                                               (I)                                                                               (J)                                                                               (K)                                                                               (L)                               __________________________________________________________________________      9    0.16  4  5  2  5  5  5  5  0  0  5  3  --                                      0.32  5  5  5  5  5  5  5  1  1  5  5  --                                 10   0.63  5  5  5  5  5  5  5  0  0  5  5  --                                 11   0.16  5  5  2  5  5  5  5  5  0  5  5  --                                      0.32  5  5  5  5  5  5  5  5  0  5  0  --                                313   0.32  5  5  5  5  5  5  5  5  5  5  0  --                                314   0.16  3  4  2  5  5  5  5  5  5  4  0  --                                      0.32  5  5  5  5  5  5  5  5  5  5  0  --                                315   0.82  0  5  2  5  5  5  5  5  5  5  0  --                                      0.16  0  5  5  5  5  5  5  5  5  5  0  --                                __________________________________________________________________________      (A) rice (oryza sativa),                                                       (B) barnyardgrass (Echinochloa crusgalli),                                     (C) large crabgrass (Digitaria adscendens),                                    (D) annual sedge (Cyperus microiria),                                          (E) black nightshade (Solanum nigrum L.),                                      (F) hairly galinosoga (Galinosoga ciliata),                                    (G) rorippa spp. (Rorippa indica),                                             (H) corn (Zea mays),                                                           (I) wheat (Triticum vulgare),                                                  (J) soybean (Glysine max),                                                     (K) cotton (Gossypium spp) and                                                 (L) sugar beet (Beta vulgaris).                                          

                                      TABLE 10                                     __________________________________________________________________________           Amount of                                                                      active                                                                         ingredient                                                               Compound                                                                             applied                                                                  No.   kg/ha (A)                                                                               (B)                                                                               (C)                                                                               (D)                                                                               (E)                                                                               (F)                                                                               (G)                                                                               (H)                                                                               (I)                                                                               (J)                                                                               (K)                                                                               (L)                               __________________________________________________________________________      9    0.04  4  4  2  5  5  5  5  0  0  5  5  5                                       0.08  5  5  4  5  5  5  5  1  1  5  5  5                                  10   0.63  5  5  2  5  5  5  5  4  1  5  1  5                                  11   0.08  4  5  2  5  5  5  5  4  0  5  0  0                                       0.16  5  5  5  5  5  5  5  5  0  5  0  0                                 313   0.16  0  4  2  5  5  5  5  5  0  5  5  5                                       0.32  0  5  4  5  5  5  5  5  0  5  5  5                                 314   0.08  0  4  2  5  5  5  5  5  0  5  5  4                                       0.16  0  5  5  5  5  5  5  5  0  5  5  5                                 315   0.04  0  4  2  5  5  5  5  5  4  5  5  0                                       0.08  0  5  4  5  5  5  5  5  5  5  5  0                                 __________________________________________________________________________      (A) rice (oryza sativa),                                                       (B) barnyardgrass (Echinochloa crusgalli),                                     (C) large crabgrass (Digitaria adscendens),                                    (D) annual sedge (Cyperus microiria),                                          (E) black nightshade (Solanum nigrum L.),                                      (F) hairly galinosoga (Galinosoga ciliata),                                    (G) rorippa spp. (Rorippa indica),                                             (H) corn (Zea mays),                                                           (I) wheat (Triticum vulgare),                                                  (J) soybean (Glysine max),                                                     (K) cotton (Gossypium spp) and                                                 (L) sugar beet (Beta vulgaris).                                          

                  TABLE 11                                                         ______________________________________                                                   Amount of                                                                      active                                                                         ingredient                                                           Compound  applied                                                              No.       kg/ha     M        N   O     P   L                                   ______________________________________                                          11       0.04      5        5   5     5   0                                             0.08      5        5   5     5   0                                             0.16      5        5   5     5   0                                   315       0.04      5        5   5     5   0                                             0.08      5        5   5     5   0                                             0.16      5        5   5     5   0                                   ______________________________________                                          (L) sugar beet (Beta vulgaris),                                                (M) groundsel (Senecio vulgaris),                                              (N) common fieldspeedwell (Veronica persica),                                  (O) wild mustard (Sinapis arvensis) and                                        (P) cleavers (Galium aparine).                                            

We claim:
 1. A pyrazolesulfonamide derivative represented by Formula (I): ##STR21## wherein Q represents a group of; ##STR22## wherein R¹, R³, R⁹ and R¹⁰ each represent a hydrogen atom, a halogen atom, a C₁ -C₈ alkyl group, a cyano group or a group of CO₂ R¹³ ;R² and R⁴ each represent a hydrogen atom, a halogen atom, a nitro group, a C₁ -C₈ alkyl group, a halogenated C₁ -C₈ alkyl group or a C₁ -C₈ alkoxy group; R⁵ represents a hydrogen atom, a halogen atom, a C₁ -C₈ alkylgroup, a C₁ -C₈ alkoxy group or a group of S(O)_(n) R¹² ; R⁶ represents a hydrogen atom, a halogen atom, a nitro group, a C₁ -C₈ alkyl group, a halogenated C₁ -C₈ alkyl group, a C₁ -C₈ alkoxy group or a group of CO₂ R¹³ ; R⁷ represents a hydrogen atom, a halogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkoxy group or a dialkylamino group; R⁸ represents a hydrogen atom, a halogen atom, a C₁ -C₈ alkyl group or a nitro group; R¹¹ represents a hydrogen atom, a halogen atom, a C₁ -C₈ alkyl group or a halogenated C₁ -C₈ alkyl group; W¹ represents an oxygen atom, a sulfur atom or a group of NR¹³ ; R¹² represents a C₁ -C₈ alkyl group; R¹³ represents a hydrogen atom or a C₁ -C₈ alkyl group; and n represents an integer of 0, 1 or 2;B and D each independently represent a hydrogen atom, a halogen atom, a nitro group, a C₁ -C₈ alkyl group, a C₁ -C₈ alkenyl group, a C₁ -C₈ alkynyl group a C₁ -C₈ alkoxy group, a C₁ -C₈ alkoxy-C₁ -C₈ alkyl group, a C₁ -C₈ alkylthio-C₁ -C₈ alkyl group, a halogenated C₁ -C₈ alkyl group, a group of COOR¹⁴, a group of CH₂ COOR¹⁴, a group of CONR¹⁵ R¹⁶, a group of S(O)_(n) R¹⁷, a cyano group, a group of CH₂ CN, a group of NR¹⁸ R¹⁹, a group of SO₂ NR²⁰ R²¹, a group of COR¹³, a group of OH, a benzoyl group which may be substituted (the substituent is selected from a halogen atom or a C₁ -C₈ alkyl group) or a phenyl group which may be substituted (the substituent is selected from a halogen atom, a nitro group, a group of COOR¹³ or a C₁ -C₈ alkyl group); R¹⁴ represents a hydrogen atom, an unsubstituted C₁ -C₈ alkyl group (or a C₁ -C₈ alkyl group substituted with an unsubstituted C₁ -C₈ alkoxy group or a C₁ -C₈ alkoxy group substituted with a group of OR¹³, a halogenated C₁ -C₈ alkoxy group, a cyano group, a phenoxy group, a C₁ -C₈ alkoxycarbonyl group, a group of NR¹² R¹³, a C₃ -C₇ cycloalkyl group, a C₁ -C₈ alkylthio group or a C₁ -C₈ alkylcarbonyl group), an unsubstituted C₁ -C₈ alkenyl group or a C₁ -C₈ alkenyl group substituted with a halogen atom, an unsubstituted C₁ -C₈ alkynyl group or a C₁ -C₈ alkynyl group substituted with a halogen atom, a halogenated C₁ -C₈ alkyl group, a C₃ -C₇ cycloalkyl group or a benzyl group; R¹⁵ represents a hydrogen atom, a C₁ -C₈ alkyl group or a phenyl group; R¹⁶ represents a hydrogen atom, a C₁ -C₈ alkyl group or a C₁ -C₈ alkoxy group; R¹⁷ represents a C₁ -C₈ alkyl group, a C₁ -C₈ alkoxy group, a phenyl group, a halogenated C₁ -C₈ alkyl group, a C₁ -C₈ alkenyloxy group or a C₁ -C₈ alkynyloxy group; n represents an integer of 0, 1 or 2; R¹⁸ and R¹⁹ each independently represent a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkylcarbonyl group or a C₁ -C₈ alkylsulfonyl group; R²⁰ and R²¹ each independently represent a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkenyl group or a C₁ -C₈ alkynyl group; E represents a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkenyl group, a C₁ -C₈ alkynyl group or a C₁ -C₈ alkoxy group; W represents an oxygen atom, a sulfur atom or a group of NR¹⁶ ; G represents ##STR23## wherein X and Y each independently represent a hydrogen atom, a halogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkoxy group, a C₁ -C₈ alkoxyalkyl group, a halogenated C₁ -C₈ alkyl group, a halogenated C₁ -C₈ alkoxy group, a group of NR²² R²³, a group of OCH(R¹³)COOR¹³, a group of COOR¹³, a cyclopropyl group, a group of CH(OR²⁴)₂, a C₁ -C₈ alkylthio group or a halogenated C₁ -C₈ alkylthio group; R²² and R²³ each independently represent a hydrogen atom, a C₁ -C₈ alkyl group or a C₁ -C₈ alkoxy group; R²⁴ represents a C₁ -C₈ alkyl group; X¹ and Y¹ each independently represent a hydrogen atom, a halogen atom, a C₁ -C₈ alkyl group or a C₁ -C₈ alkoxy group; Z represents a group of C--R²⁵ ; R²⁵ represents a hydrogen atom, a C₁ -C₈ alkyl group, a halogenated C₁ -C₈ alkyl group, a halogen atom, a C₁ -C₈ alkoxy group or a 5-membered ring structure containing an oxygen atom together with Y or Y¹ ;with the proviso that the group: ##STR24## in Formula (I) is not substituted on the nitrogen atom in the pyrazole ring, and, when Q is not substituted on the nitrogen atom in the pyrazole ring, the substituent for B or D on the nitrogen atom is selected from a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkenyl group, a C₁ -C₈ alkynyl group, a group of --CH₂ CN, a C₁ -C₈ alkoxy-C₁ -C₈ alkyl group, a C₁ -C₈ alkylthio-C₁ -C₈ alkyl group, a group of --CH₂ COOR¹³, a group of --COR¹³, a group of --SO₂ R²⁴, a group of --SO₂ NR¹³ R²⁴ or a phenyl group which may be substituted (the substituent is selected from a halogen atom, a nitro group, a group of COOR¹³ or a C₁ -C₈ alkyl group).
 2. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is represented by the formula: ##STR25##
 3. The pyrazolesulfonamide derivative according to claim 2, wereinB represents a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkoxy group, a halogen atom; D represents a hydrogen atom, a halogen atom, a C₁ -C₈ alkyl group, a group of COOR¹⁴, a group of S(O)_(n) R¹⁷, a group of SO₂ NR²⁰ R²¹ or COR¹³ ; W represents an oxygen atom; E represents a hydrogen atom; and G represents a group of ##STR26##
 4. The pyrazolesulfonamide derivative according to claim 3, whereinD represents a group of --COOR¹⁴ (wherein R¹⁴ is selected from the group of a C₁ -C₈ alkyl group which may be substituted with a C₁ -C₈ alkoxy group or a halogen atom, a C₁ -C₈ alkenyl group and a C₁ -C₈ alkynyl group); X and Y each represent a C₁ -C₈ alkyl group, a C₁ -C₈ alkoxy group, a halogen atom or a group of --OCHF₂ ; and Z represents a nitrogen atom or a group of --CH.
 5. The pyrazolesulfonamide derivative according to claim 3, whereinQ represents ##STR27##
 6. The pyrazolesulfonamide derivative according to claim 3, whereinQ represents ##STR28##
 7. The pyrazolesulfonamide derivative according to claim 3, whereinQ represents ##STR29##
 8. The pyrazolesulfonamide derivative according to claim 3, whereinQ represents ##STR30##
 9. The pyrazolesulfonamide derivative according to claim 3, whereinQ represents ##STR31##
 10. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is represented by the formula: ##STR32##
 11. The pyrazolesulfonamide derivative according to claim 10, whereinB represents a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkenyl group, a C₁ -C₈ alkynyl group, C₁ -C₈ alkoxyalkyl group or a phenyl group which may be substituted (The substituent is selected from a halogen atom, a nitro group, a group of COOR¹³ or a C₁ -C₈ alkyl group); D represents a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkoxy group, a halogen atom; W represents an oxygen atom; E represents a hydrogen atom; and G represents a group of ##STR33##
 12. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is represents by the formula: ##STR34##
 13. The pyrazolesulfonamide derivative according to claim 12, whereinB represents a C₁ -C₈ alkyl group, a C₁ -C₈ alkenyl group, a C₁ -C₈ alkynyl group or a C₁ -C₈ alkoxyalkyl group; D represents a hydrogen atom or a C₁ -C₈ alkyl group; W represents an oxygen atom; E represents a hydrogen atom; and G represents a group of ##STR35##
 14. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is represented by the formula: ##STR36##
 15. The pyrazolesulfonamide derivative according to claim 2, whereinB represents a hydrogen atom or a C₁ -C₈ alkyl group; D represents a hydrogen atom, a C₁ -C₈ alkyl group or a halogen atom; W represents an oxygen atom; E represents a hydrogen atom; and G represents a group of ##STR37##
 16. The pyrazolesulfonamide derivative according to claim 1, whereinQ represents ##STR38## B represents a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkenyl group, a C₁ -C₈ alkynyl group, a C₁ -C₈ alkoxyalkyl group or a phenyl group which may be substituted (the substituent is selected from a halogen atom, a nitro group, a group of COOR¹³ or a C₁ -C₈ alkyl group); D represents a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkoxyl group, a halogen atom; W represents an oxygen atom; E represents a hydrogen atom; G represents the group ##STR39## and Z represents CH.
 17. The pyrazolesulfonamide derivative according to claim 16, wherein the derivative is represented by the formula; ##STR40##
 18. The pyrazolesulfonamide derivative according to claim 16, wherein the derivative is represented by the formula: ##STR41##
 19. The pyrazolesulfonamide derivative according to claim 16, wherein the derivative is represented by the formula: ##STR42##
 20. The pyrazolesulfonamide derivative according to claim 16, wherein the derivative is represented by the formula: ##STR43##
 21. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-4-ethoxycarbonyl-1-(2-quinolyl)pyrazole-5-sulfonamide.
 22. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-4-ethoxycarbonyl-3-methyl-1-(2-quinolyl)pyrazole-5-sulfonamide.
 23. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-4-methoxycarbonyl-1-(2-quinolyl)pyrazole-5-sulfonamide.
 24. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-4-methoxycarbonyl-3-methyl-1-(2-quinolyl)pyrazole-5-sulfonamide.
 25. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-4-ethoxycarbonyl-1-(1-isoquinolyl)pyrazole-5-sulfonamide.
 26. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-4-ethoxycarbonyl-3-methyl-1-(1-isoquinolyl)pyrazole-5-sulfonamide.
 27. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-4-methoxycarbonyl-1-(1-isoquinolyl)pyrazole-5-sulfonamide.
 28. The pyrazolesulfonamide derivative according to claim 1, wherein the derivative is N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-4-methoxycarbonyl-3-methyl-1-(1-isoquinolyl)pyrazole-5-sulfonamide.
 29. A herbicidal composition comprising an agricultural carrier and as an active component one or more kinds of a pyrazolesulfonamide derivative represented by Formula (I): ##STR44## wherein Q represents a group of; ##STR45## wherein R¹, R³, R⁹ and R¹⁰ each represent a hydrogen atom, a halogen atom, a C₁ -C₈ alkyl group, a cyano group or a group of CO₂ R¹³ ;R² and R⁴ each represent a hydrogen atom, a halogen atom, a nitro group, a C₁ -C₈ alkyl group, a halogenated C₁ -C₈ alkyl group or a C₁ -C₈ alkoxy group; R⁵ represents a hydrogen atom, a halogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkoxy group or a group of S(O)_(n) R¹² ; R⁶ represents a hydrogen atom, a halogen atom, a nitro group, a C₁ -C₈ alkyl group, a halogenated C₁ -C₈ alkyl group, a C₁ -C₈ alkoxy group or a group of CO₂ R¹³ ; R⁷ represents a hydrogen atom, a halogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkoxy group or a dialkylamino group; R⁸ represents a hydrogen atom, a halogen atom, a C₁ -C₈ alkyl group or a nitro group; R¹¹ represents a hydrogen atom, a halogen atom, a C₁ -C₈ alkyl group or a halogenated C₁ -C₈ alkyl group; W¹ represents an oxygen atom, a sulfur atom or a group of NR¹³ ; R¹² represents a C₁ -C₈ alkyl group; R¹³ represents a hydrogen atom or a C₁ -C₈ alkyl group; and n represents an integer of 0, 1 or 2;B and D each independently represent a hydrogen atom, a halogen atom, a nitro group, a C₁ -C₈ alkyl group, a C₁ -C₈ alkenyl group, a C₁ -C₈ alkynyl group a C₁ -C₈ alkoxy group, a C₁ -C₈ alkoxy-C₁ -C₈ alkyl group, a C₁ -C₈ alkylthio-C₁ -C₈ alkyl group, a halogenated C₁ -C₈ alkyl group, a group of COOR¹⁴, a group of CH₂ COOR¹⁴, a group of CONR¹⁵ R¹⁶, a group of S(O)_(n) R¹⁷, a cyano group, a group of CH₂ CN, a group of NR¹⁸ R¹⁹, a group of SO₂ NR²⁰ R²¹, a group of COR¹³, a group of OH, a benzoyl group which may be substituted (the substituent is selected from a halogen atom or a C₁ -C₈ alkyl group) or a phenyl group which may be substituted (the substituent is selected from a halogen atom, a nitro group, a group of COOR¹³ or a C₁ -C₈ alkyl group); R¹⁴ represents a hydrogen atom, an unsubstituted C₁ -C₈ alkyl group (or a C₁ -C₈ alkyl group substituted with an unsubstituted C₁ -C₈ alkoxy group or a C₁ -C₈ alkoxy group substituted with a group of OR¹³, a halogenated C₁ -C₈ alkoxy group, a cyano group, a phenoxy group, a C₁ -C₈ alkoxycarbonyl group, a group of NR¹² R¹³, a C₃ -C₇ cycloalkyl group, a C₁ -C₈ alkylthio group or a C₁ -C₈ alkylcarbonyl group), an unsubstituted C₁ -C₈ alkenyl group or a C₁ -C₈ alkenyl group substituted with a halogen atom, an unsubstituted C₁ -C₈ alkynyl group or a C₁ -C₈ alkynyl group substituted with a halogen atom, a halogenated C₁ -C₈ alkyl group, a C₃ -C₇ cycloalkyl group or a benzyl group; R¹⁵ represents a hydrogen atom, a C₁ -C₈ alkyl group or a phenyl group; R¹⁶ represents a hydrogen atom, a C₁ -C₈ alkyl group or a C₁ -C₈ alkoxy group; R¹⁷ represents a C₁ -C₈ alkyl group, a C₁ -C₈ alkoxy group, a phenyl group, a halogenated C₁ -C₈ alkyl group, a C₁ -C₈ alkenyloxy group or a C₁ -C₈ alkynyloxy group; n represents an integer of 0, 1 or 2; R¹⁸ and R¹⁹ each independently represent a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkylcarbonyl group or a C₁ -C₈ alkylsulfonyl group; R²⁰ and R²¹ each independently represent a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkenyl group or a C₁ -C₈ alkynyl group; E represents a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkenyl group, a C₁ -C₈ alkynyl group or a C₁ -C₈ alkoxy group; W represents an oxygen atom, a sulfur atom or a group of NR¹⁶ ; G represents ##STR46## wherein X and Y each independently represent a hydrogen atom, a halogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkoxy group, a C₁ -C₈ alkoxyalkyl group, a halogenated C₁ -C₈ alkyl group, a halogenated C₁ -C₈ alkoxy group, a group of NR²² R²³, a group of OCH(R¹³)COOR¹³, a group of COOR¹³, a cyclopropyl group, a group of CH(OR²⁴)₂, a C₁ -C₈ alkylthio group or a halogenated C₁ -C₈ alkylthio group; R²² and R²³ each independently represent a hydrogen atom, a C₁ -C₈ alkyl group or a C₁ -C₈ alkoxy group; R²⁴ represents a C₁ -C₈ alkyl group; X¹ and Y¹ each independently represent a hydrogen atom, a halogen atom, a C₁ -C₈ alkyl group or a C₁ -C₈ alkoxy group; Z represents a group of C--R²⁵ ; R²⁵ represents a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ halogenated alkyl group, a halogen atom, a C₁ -C₈ alkoxy group or a 5-membered ring structure containing an oxygen atom together with Y or Y¹ ;with the proviso that the group: ##STR47## in Formula (I) is not substituted on the nitrogen atom in the pyrazole ring, and, when Q is not substituted on the nitrogen atom in the pyrazole ring, the substituent for B or D on the nitrogen atom is selected from a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkenyl group, a C₁ -C₈ alkynyl group, a group of --CH₂ CN, a C₁ -C₈ alkoxy-C₁ -C₈ alkyl group, a C₁ -C₈ alkylthio-C₁ -C₈ alkyl group, a group of --CH₂ COOR¹³, a group of --COR¹³, a group of --SO₂ R²⁴, a group of --SO₂ NR¹³ R²⁴ or a phenyl group which may be substituted (the substituent is selected from a halogen atom, a nitro group, a group of COOR¹³ or a C₁ -C₈ alkyl group); and an agriculturally acceptable salt thereof.
 30. The herbicidal composition according to claim 29, whereinQ represents ##STR48## B represents a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkenyl group, a C₁ -C₈ alkynyl group, a C₁ -C₈ alkoxyalkyl group or a phenyl group which may be substituted (the substituent is selected from a halogen atom, a nitro group, a group of COOR¹³ or a C₁ -C₈ alkyl group); D represents a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkoxyl group, a halogen atom W represents an oxygen atom; E represents a hydrogen atom; G represents the group ##STR49## Z represents CH.
 31. The herbicidal composition according to claim 24, wherein the derivative is represented by the formula; ##STR50##
 32. The herbicidal composition according to claim 30, wherein the derivative is represented by the formula: ##STR51##
 33. The herbicidal composition according to claim 30, wherein the derivative is represented by the formula: ##STR52##
 34. The herbicidal composition according to claim 30, wherein the derivative is represented by the formula: ##STR53## 